880
Views
77
CrossRef citations to date
0
Altmetric
Research Article

The PI3K/AKT cell signaling pathway is involved in regulation of osteoporosis

, , , , , & show all
Pages 640-645 | Received 12 Mar 2015, Accepted 08 Apr 2015, Published online: 22 Sep 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Zhiguo Zhong, Yuyun Li, Yan Chen, Wen Chen, Siyan Li, Xiaohua Lv & Shiying Luo. (2021) Predicting and Exploring the Mechanisms of Erzhi Pill in Prevention and Treatment of Osteoporosis Based on Network Pharmacology and Zebrafish Experiments. Drug Design, Development and Therapy 15, pages 817-827.
Read now
Bingyuan Lin & Zhijun Pan. (2021) Consensus gene modules related to levels of bone mineral density (BMD) among smokers and nonsmokers. Bioengineered 12:2, pages 10134-10146.
Read now

Articles from other publishers (75)

Wenyun Zhou, Weijun Zhou, Zibin Zhou, Yonghao Bi, Zhigao Zhou, Shaozhe Chen, Zihong Lin, Jiajie Ye, Gang Xie, Wenjie Liu, Dantao Xie, Zhen Lian, Ruiwu Zheng, Xianghua Hu, Xinjia Wang, Guixin Yuan & Guanfeng Yao. (2024) Urolithin A attenuates osteoclast differentiation and compensates for ovariectomy-induced bone loss in mice by inhibiting PI3K/AKT/mTOR signaling pathway. Phytomedicine Plus 4:1, pages 100495.
Crossref
Nur Julia N. Nasir, Norsyahida Arifin, Khairul Bariah A.A. Noordin & Norhayati Yusop. (2023) Bone repair and key signalling pathways for cell-based bone regenerative therapy: A review. Journal of Taibah University Medical Sciences 18:6, pages 1350-1363.
Crossref
Mariana de S. Santos, Virgínia T. M. Lima, Breno R. Barrioni, Juliana P. Vago, José Alcides A. de Arruda, Pedro D. Prazeres, Flávio A. Amaral, Tarcília A. Silva & Soraia Macari. (2023) Targeting phosphatidylinositol‐3‐kinase for inhibiting maxillary bone resorption. Journal of Cellular Physiology 238:11, pages 2651-2667.
Crossref
Dong-min Cao & Tao Liu. (2023) Identification of Active Compounds of Pueraria Lobata and their Mechanisms of Action by LC-MS/MS and Network Pharmacology. Current Chinese Science 3:5, pages 398-406.
Crossref
Sirikool Thamnium, Chavee Laomeephol, Prasit Pavasant, Thanaphum Osathanon, Yasuhiko Tabata, Chao Wang & Jittima A. Luckanagul. (2023) Osteogenic induction of asiatic acid derivatives in human periodontal ligament stem cells. Scientific Reports 13:1.
Crossref
Xinyan Zhou, Shuxin Sun, Yuefu Chen, Chengcheng Liu, Dan Li, Qun Cheng, Min He, Ying Li, Kailiang Xu & Dean Ta. (2023) Pulsed frequency modulated ultrasound promotes therapeutic effects of osteoporosis induced by ovarian failure in mice. Ultrasonics 132, pages 106973.
Crossref
Chenfeng Wang, Liang Wang, Qisheng Li, Weiqing Wu, Jincan Yuan, Haibin Wang & Xuhua Lu. (2023) Computational Drug Discovery in Ankylosing Spondylitis–Induced Osteoporosis Based on Data Mining and Bioinformatics Analysis. World Neurosurgery 174, pages e8-e16.
Crossref
El-Shaimaa A. Arafa, Noran O. Elgendy, Mai A. Elhemely, Eglal A. Abdelaleem & Wafaa R. Mohamed. (2023) Diosmin mitigates dexamethasone-induced osteoporosis in vivo: Role of Runx2, RANKL/OPG, and oxidative stress. Biomedicine & Pharmacotherapy 161, pages 114461.
Crossref
Samantha Maurotti, Yvelise Ferro, Roberta Pujia, Miriam Frosina, Angela Sciacqua, Rosario Mare, Elisa Mazza, Nadia Geirola, Stefano Romeo, Arturo Pujia & Tiziana Montalcini. (2023) Effects of a Functional Ice Cream Enriched with Milk Proteins on Bone Metabolism: A Feasibility Clinical Study and In Vitro Investigation. Nutrients 15:2, pages 344.
Crossref
志梁 范. (2023) Mechanism of Astragaloside Intervention in Osteoporosis Based on Network Pharmacology and Molecular Docking Technology. Hans Journal of Medicinal Chemistry 11:03, pages 204-211.
Crossref
Bowen Yang, Qiuwen Zhu, Xiaodong Wang, Jingxin Mao & Shuqing Zhou. (2022) Using network pharmacology and molecular docking verification to explore the mechanism of ursolic acid in the treatment of osteoporosis. Medicine 101:49, pages e32222.
Crossref
Yibo Song, Zhaolei Meng, Shanshan Zhang, Nianguo Li, Wei Hu & Hong Li. (2022) miR-4739/ITGA10/PI3K signaling regulates differentiation and apoptosis of osteoblast. Regenerative Therapy 21, pages 342-350.
Crossref
Qingchan Wang, Ping Huang, Chenjie Xia & Danqing Fu. (2022) Network pharmacology-based strategy to investigate pharmacological mechanism of Liuwei Dihuang Pill against postmenopausal osteoporosis. Medicine 101:47, pages e31387.
Crossref
Muhamed Lahtif Nor Muhamad, Sophia Ogechi Ekeuku, Sok-Kuan Wong & Kok-Yong Chin. (2022) A Scoping Review of the Skeletal Effects of Naringenin. Nutrients 14:22, pages 4851.
Crossref
Sen Zhang, Shihong Shen, Pei Ma & Daidi Fan. (2022) Biochemical Targets and Molecular Mechanism of Ginsenoside Compound K in Treating Osteoporosis Based on Network Pharmacology. International Journal of Molecular Sciences 23:22, pages 13921.
Crossref
Kohei Yamaura, Anna Laura Nelson, Haruki Nishimura, Joan C. Rutledge, Sudheer K. Ravuri, Chelsea Bahney, Marc J. Philippon & Johnny Huard. (2022) The effects of fisetin on bone and cartilage: A systematic review. Pharmacological Research 185, pages 106504.
Crossref
Ding Wang, Chun-Xiao Dang, Ying-Xin HaoXiao Yu, Peng-Fei Liu & Jin-Song Li. (2022) Relationship between osteoporosis and Cushing syndrome based on bioinformatics. Medicine 101:43, pages e31283.
Crossref
Haixiong Lin, Xiaotong Wang, Zige Li, Minling Huang, Junjie Feng, Huamei Chen, Junyan Gao, Yuanlan Feng, Jingjing Wu, Shengyao Tang, Ruoyu Zhou, Yueyi Ren, Feng Huang & Ziwei Jiang. (2022) Total flavonoids of Rhizoma drynariae promote angiogenesis and osteogenesis in bone defects . Phytotherapy Research 36:9, pages 3584-3600.
Crossref
Lucija Ana Vrščaj, Janja Marc & Barbara Ostanek. (2022) Interactome of PTH-Regulated miRNAs and Their Predicted Target Genes for Investigating the Epigenetic Effects of PTH (1–34) in Bone Metabolism. Genes 13:8, pages 1443.
Crossref
Keliang Wu, Linjing Han, Ying Zhao, Qinghua XiaoZhen ZhangXiaosheng Lin. (2022) Deciphering the molecular mechanism underlying the effects of epimedium on osteoporosis through system bioinformatic approach. Medicine 101:32, pages e29844.
Crossref
LiNa Wang, Ming Dong, DongMei Shi, CaiHui Yang, Shuo Liu, Lu Gao & WeiDong Niu. (2022) Role of PI3K in the bone resorption of apical periodontitis. BMC Oral Health 22:1.
Crossref
Jinhua Wang, Miao Fu, Siying He, Pengfei Cai, Xi Xiang & Liping Fang. (2022) Expression profile analysis of lncRNA in bone marrow mesenchymal stem cells exosomes of postmenopausal osteoporosis patients through microarray and bioinformatics analyses. Pathology - Research and Practice 236, pages 153985.
Crossref
Xiang-Yu Ma, Dong Cui, Zheng Wang, Bing Liu, Hai-Long Yu, Hong Yuan, Liang-Bi Xiang & Da-Peng Zhou. (2022) Silk Fibroin/Hydroxyapatite Coating Improved Osseointegration of Porous Titanium Implants under Diabetic Conditions via Activation of the PI3K/Akt Signaling Pathway. ACS Biomaterials Science & Engineering 8:7, pages 2908-2919.
Crossref
Haiheng Peng, Yifeng Yu, Huiyun Gu, Baiwen Qi & Aixi Yu. (2022) MicroRNA-483-5p inhibits osteogenic differentiation of human bone marrow mesenchymal stem cells by targeting the RPL31-mediated RAS/MEK/ERK signaling pathway. Cellular Signalling 93, pages 110298.
Crossref
Lili Cao, Jiawei Wang, Yujuan Zhang, Feng Tian & Chunfang Wang. (2022) Osteoprotective effects of flavonoids: Evidence from in vivo and in vitro studies (Review) . Molecular Medicine Reports 25:6.
Crossref
Yanjun Wang, Lin Liu, Zechao Qu, Dong Wang, Wangli Huang, Lingbo Kong & Liang Yan. (2022) Tanshinone Ameliorates Glucocorticoid-Induced Bone Loss via Activation of AKT1 Signaling Pathway. Frontiers in Cell and Developmental Biology 10.
Crossref
Fuyu Tang, Peng Zhang, Wenhua Zhao, Guangye Zhu, Gengyang Shen, Honglin Chen, Xiang Yu, Zhida Zhang, Qi Shang, De Liang, Xiaobing Jiang & Hui Ren. (2022) Research on the Mechanism of Kaempferol for Treating Senile Osteoporosis by Network Pharmacology and Molecular Docking. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-12.
Crossref
Yifeng Yuan, Jiangang Sun, Hang Zhou, Shen Wang, Caijian He, Tianpeng Chen, Mouhao Fang, Shaohua Li, Shifa Kang, Xiaosheng Huang, Binbin Tang, Bocheng Liang, Yingdelong Mao, Jianyou Li, Xiaolin Shi & Kang Liu. (2022) The effect of QiangGuYin on osteoporosis through the AKT/mTOR/autophagy signaling pathway mediated by CKIP-1. Aging 14:2, pages 892-906.
Crossref
Hao Lv, Jiuxiang Wang, Yujun Zhu & Ting Jiang. (2022) Study on the Mechanism of Compound Kidney-Invigorating Granule for Osteoporosis based on Network Pharmacology and Experimental Verification. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-20.
Crossref
Wen-qian Kang, Pei-feng Wei, Li Ou, Min Li & Chun-yu Liu. (2022) The mechanism study of inhibition effect of prepared Radix Rehmanniainon combined with Radix Astragali osteoporosis through PI3K-AKT signaling pathway. Acta Cirúrgica Brasileira 37:11.
Crossref
Yan Shao, Song Chen, Ke Zhou, Kaifeng Gan, Jin Li & Chenjie Xia. (2022) Network pharmacology explores the mechanisms of Eucommia ulmoides cortex against postmenopausal osteoporosis. Medicine 101:19, pages e29257.
Crossref
Wei Lin, Huijun Kang, Yingzhen Niu, Jinghui Niu, Chongyi Fan, Xunkai Feng & Fei Wang. (2022) Cartilage degeneration is associated with activation of the PI3K/AKT signaling pathway in a growing rat experimental model of developmental trochlear dysplasia. Journal of Advanced Research 35, pages 109-116.
Crossref
Sarocha Suthon, Jianjian Lin, Rachel S. Perkins, John R. CrockarellJr.Jr., Gustavo A. Miranda-Carboni & Susan A. Krum. (2022) Estrogen receptor alpha and NFATc1 bind to a bone mineral density-associated SNP to repress WNT5B in osteoblasts. The American Journal of Human Genetics 109:1, pages 97-115.
Crossref
Miao Fu, Liping Fang, Xi Xiang, Xijing Fan, Junqi Wu & Jinhua Wang. (2021) Microarray analysis of circRNAs sequencing profile in exosomes derived from bone marrow mesenchymal stem cells in postmenopausal osteoporosis patients. Journal of Clinical Laboratory Analysis 36:1.
Crossref
Wei-Li You & Zheng-Long Xu. (2021) Curculigoside promotes osteogenic differentiation of ADSCs to prevent ovariectomized-induced osteoporosis. Journal of Orthopaedic Surgery and Research 16:1.
Crossref
M. Zhu, P. Yin, F. Hu, J. Jiang, L. Yin, Y. Li & S. Wang. (2021) Integrating genome-wide association and transcriptome prediction model identifies novel target genes for osteoporosis. Osteoporosis International 32:12, pages 2493-2503.
Crossref
Xiao Yuan, Yonghe Wu, Kailin Yang, Huiping Liu & Guomin Zhang. (2021) Exploring the Effect of Jiawei Buguzhi Pills on TGF-β-Smad Pathway in Postmenopausal Osteoporosis Based on Integrated Pharmacological Strategy. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-18.
Crossref
Li Gao, Ye Li, Yong-Jie Yang & Dong-Yan Zhang. (2021) The Effect of Moderate-Intensity Treadmill Exercise on Bone Mass and the Transcription of Peripheral Blood Mononuclear Cells in Ovariectomized Rats. Frontiers in Physiology 12.
Crossref
Jiangtao Ma, Maolin Ye, Ying Li, Shuang Chai, Hong Huang, Xiaohang Lian & Hongxing Huang. (2021) Zhuanggu Zhitong Capsule alleviates osteosarcopenia in rats by up-regulating PI3K/Akt/Bcl2 signaling pathway. Biomedicine & Pharmacotherapy 142, pages 111939.
Crossref
Dimitrios Agas, Reem Hanna, Stefano Benedicenti, Nicola De Angelis, Maria Giovanna Sabbieti & Andrea Amaroli. (2021) Photobiomodulation by Near-Infrared 980-nm Wavelengths Regulates Pre-Osteoblast Proliferation and Viability through the PI3K/Akt/Bcl-2 Pathway. International Journal of Molecular Sciences 22:14, pages 7586.
Crossref
Yiguang Bai, Qiong Zhang, Qiaoling Chen, Quan Zhou, Yanan Zhang, Zhuohua Shi, Haibin Nong, Mingfu Liu, Gaofeng Zeng & Shaohui Zong. (2020) Conditional knockout of the PDK‐1 gene in osteoblasts affects osteoblast differentiation and bone formation. Journal of Cellular Physiology 236:7, pages 5432-5445.
Crossref
Patricia Garcia-Garcia, Ricardo Reyes, José Antonio Rodriguez, Tomas Martín, Carmen Evora, Patricia Díaz-Rodríguez & Araceli Delgado. (2021) The Bone Regeneration Capacity of BMP-2 + MMP-10 Loaded Scaffolds Depends on the Tissue Status. Pharmaceutics 13:7, pages 979.
Crossref
Junsheng Liu, Jun Liu, Liu Liu, Guangwen Zhang & Xichun Peng. (2021) Reprogrammed intestinal functions in Astragalus polysaccharide-alleviated osteoporosis: combined analysis of transcriptomics and DNA methylomics demonstrates the significance of the gut–bone axis in treating osteoporosis . Food & Function 12:10, pages 4458-4470.
Crossref
Fujiang Zhao, Yier Xu, Yulong Ouyang, Zhexu Wen, Guihao Zheng, Ting Wan & Guicai Sun. (2021) Silencing of miR-483-5p alleviates postmenopausal osteoporosis by targeting SATB2 and PI3K/AKT pathway. Aging 13:5, pages 6945-6956.
Crossref
Chao Liang, Xijiao Yu, Naping Xiong, Zhichang Zhang, Zhenyu Sun & Yang Dong. (2021) Pictilisib Enhances the Antitumor Effect of Doxorubicin and Prevents Tumor-Mediated Bone Destruction by Blockade of PI3K/AKT Pathway. Frontiers in Oncology 10.
Crossref
Chaoqun Feng, Min Zhao, Leiming Jiang, Ziang Hu & Xiaohong Fan. (2021) Mechanism of Modified Danggui Sini Decoction for Knee Osteoarthritis Based on Network Pharmacology and Molecular Docking. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-11.
Crossref
Karin L. Gustafsson, Helen H. Farman, Karin H. Nilsson, Petra Henning, Sofia Movérare-Skrtic, Vikte Lionikaite, Lina Lawenius, Cecilia Engdahl, Claes Ohlsson & Marie K. Lagerquist. (2021) Arginine site 264 in murine estrogen receptor-α is dispensable for the regulation of the skeleton. American Journal of Physiology-Endocrinology and Metabolism 320:1, pages E160-E168.
Crossref
Yun-Hui Xu, Yi-Chun Sun, Jie Liu, Hui-Xin Li, Chun-Yue Huang, Yuan-Yuan Pang, Tong Wu & Xiao Hu. (2021) Serum Pharmacochemistry Analysis Combined with Network Pharmacology Approach to Investigate the Antiosteoporosis Effect of Xianlinggubao Capsule in vivo. Pharmaceutical Fronts 02:04, pages e168-e178.
Crossref
Suryaji Patil, Kai Dang, Xin Zhao, Yongguang Gao & Airong Qian. (2020) Role of LncRNAs and CircRNAs in Bone Metabolism and Osteoporosis. Frontiers in Genetics 11.
Crossref
Huichao Wang, Kaifeng Zhou, Fangzhu Xiao, Zhongyue Huang, Jun Xu, Guangnan Chen, Youwen Liu & Huijie Gu. (2020) Identification of circRNA-associated ceRNA network in BMSCs of OVX models for postmenopausal osteoporosis. Scientific Reports 10:1.
Crossref
Huadong Yin, Haorong He, Xinao Cao, Xiaoxu Shen, Shunshun Han, Can Cui, Jing Zhao, Yuanhang Wei, Yuqi Chen, Lu Xia, Yan Wang, Diyan Li & Qing Zhu. (2020) MiR-148a-3p Regulates Skeletal Muscle Satellite Cell Differentiation and Apoptosis via the PI3K/AKT Signaling Pathway by Targeting Meox2. Frontiers in Genetics 11.
Crossref
Xiaoxia Ying, Xiyun Jin, Pingping Wang, Yuzhu He, Haomiao Zhang, Xiang Ren, Songling Chai, Wenqi Fu, Pengcheng Zhao, Chen Chen, Guowu Ma & Huiying Liu. (2020) Integrative Analysis for Elucidating Transcriptomics Landscapes of Glucocorticoid-Induced Osteoporosis. Frontiers in Cell and Developmental Biology 8.
Crossref
Hai Hu, Xiaodi He, Yazhong Zhang, Rongrong Wu, Jiajia Chen, Yuxin Lin & Bairong Shen. (2020) MicroRNA Alterations for Diagnosis, Prognosis, and Treatment of Osteoporosis: A Comprehensive Review and Computational Functional Survey. Frontiers in Genetics 11.
Crossref
Huijie Gu, Zhongyue Huang, Guangnan Chen, Kaifeng Zhou, Yiming Zhang, Jiong Chen, Jun Xu & Xiaofan Yin. (2020) Network and pathway-based analyses of genes associated with osteoporosis. Medicine 99:8, pages e19120.
Crossref
Wen-Ning Xu, Huo-Liang Zheng, Run-Ze Yang, Lei-Sheng Jiang & Sheng-Dan Jiang. (2020) HIF-1α Regulates Glucocorticoid-Induced Osteoporosis Through PDK1/AKT/mTOR Signaling Pathway. Frontiers in Endocrinology 10.
Crossref
Hammad Qamar, Muhammad Waqas, Aoyun Li, Mudassar Iqbal, Khalid Mehmood & Jiakui Li. (2019) Plastrum Testudinis Extract Mitigates Thiram Toxicity in Broilers via Regulating PI3K/AKT Signaling. Biomolecules 9:12, pages 784.
Crossref
Shan WuFan ZhaoJing ZhaoHui LiJunyu ChenYang XiaJunwei WangBenzheng ZhaoShuhua ZhaoNa Li. (2019) Dioscin improves postmenopausal osteoporosis through inducing bone formation and inhibiting apoptosis in ovariectomized rats. BioScience Trends 13:5, pages 394-401.
Crossref
S Jiang, X.L. Wu, M.L. Jin, X.Z. Wang, Q Tang, Y.X. Sun & H.W. Cheng. (2019) Pathophysiological characteristics and gene transcriptional profiling of bone microstructure in a low calcium diet fed laying hens. Poultry Science 98:10, pages 4359-4368.
Crossref
Kaixin Li, Xiaoxia Shi, Mengxin Luo, Inam-u-llah, Pingan Wu, Mengren Zhang, Cong Zhang, Qiujuan Li, Yachen Wang & Fengyuan Piao. (2019) Taurine protects against myelin damage of sciatic nerve in diabetic peripheral neuropathy rats by controlling apoptosis of schwann cells via NGF/Akt/GSK3β pathway. Experimental Cell Research 383:2, pages 111557.
Crossref
Zihao Wang, Ke-Gang Linghu, Yuanjia Hu, Huali Zuo, Hao Yi, Shi-Hang Xiong, Jinjian Lu, Ging Chan, Hua Yu & Run-Yue Huang. (2019) Deciphering the Pharmacological Mechanisms of the Huayu-Qiangshen-Tongbi Formula Through Integrating Network Pharmacology and In Vitro Pharmacological Investigation. Frontiers in Pharmacology 10.
Crossref
Dandan Wang, Weijie Zhou, Jingyu Chen & Wei Wei. (2019) Upstream regulators of phosphoinositide 3‐kinase and their role in diseases. Journal of Cellular Physiology 234:9, pages 14460-14472.
Crossref
Jonas A. Gustafson, Sarah S. Park & Michael L. Cunningham. (2019) Calvarial osteoblast gene expression in patients with craniosynostosis leads to novel polygenic mouse model. PLOS ONE 14:8, pages e0221402.
Crossref
Emiko OhashiKeizo KohnoNorie AraiAkira HarashimaToshio AriyasuShimpei Ushio. (2019) Adenosine N1-Oxide Exerts Anti-inflammatory Effects through the PI3K/Akt/GSK-3β Signaling Pathway and Promotes Osteogenic and Adipocyte Differentiation. Biological and Pharmaceutical Bulletin 42:6, pages 968-976.
Crossref
Sok Wong, Nur-Vaizura Mohamad, Nurul Ibrahim, Kok-Yong Chin, Ahmad Shuid & Soelaiman Ima-Nirwana. (2019) The Molecular Mechanism of Vitamin E as a Bone-Protecting Agent: A Review on Current Evidence. International Journal of Molecular Sciences 20:6, pages 1453.
Crossref
Hui Ren, Xiang Yu, Gengyang Shen, Zhida Zhang, Qi Shang, Wenhua Zhao, Jinjing Huang, Peiyuan Yu, Meiqi Zhan, Yongqiang Lu, Ziyang Liang, Jingjing Tang, De Liang, Zhensong Yao, Zhidong Yang & Xiaobing Jiang. (2019) miRNA-seq analysis of human vertebrae provides insight into the mechanism underlying GIOP. Bone 120, pages 371-386.
Crossref
Qiuke Hou, Yongquan Huang, Yamei Liu, Yiwen Luo, Bin Wang, Rudong Deng, Saixia Zhang, Fengbin Liu & Dongfeng Chen. (2018) Profiling the miRNA-mRNA-lncRNA interaction network in MSC osteoblast differentiation induced by (+)-cholesten-3-one. BMC Genomics 19:1.
Crossref
Jiancheng Xi, Qinggui Li, Xiaobo Luo, Yipeng Wang, Jinlong Li, Lixin Guo & Guangseng Wu. (2018) Celastrol inhibits glucocorticoid‑induced osteoporosis in rat via the PI3K/AKT and Wnt signaling pathways. Molecular Medicine Reports.
Crossref
Yan Zhang, Feng Cai, Ju Liu, Hongze Chang, Liang Liu, Anli Yang & Xiaodong Liu. (2018) Transfer RNA-derived fragments as potential exosome tRNA-derived fragment biomarkers for osteoporosis. International Journal of Rheumatic Diseases 21:9, pages 1659-1669.
Crossref
Chuangxin Lin, Yan Shao, Chun Zeng, Chang Zhao, Hang Fang, Liping Wang, Jianying Pan, Liangliang Liu, Weizhong Qi, Xiaofeng Feng, Hong Qiu, Haiyang Zhang, Yuhui Chen, Hong Wang, Daozhang Cai & Cory J. Xian. (2018) Blocking PI3K/AKT signaling inhibits bone sclerosis in subchondral bone and attenuates post‐traumatic osteoarthritis. Journal of Cellular Physiology 233:8, pages 6135-6147.
Crossref
Rui Li, Yanqing Wu, Shuang Zou, Xiaofang Wang, Yiyang Li, Ke Xu, Fanghua Gong, Yanlong Liu, Jian Wang, Yi Liao, Xiaokun Li & Jian Xiao. (2017) NGF Attenuates High Glucose-Induced ER Stress, Preventing Schwann Cell Apoptosis by Activating the PI3K/Akt/GSK3β and ERK1/2 Pathways. Neurochemical Research 42:11, pages 3005-3018.
Crossref
Delu Zheng, Chenli Cui, Meng Yu, Xiang Li, Lu Wang, Xinyan Chen & Yichen Lin. (2017) Coenzyme Q10 promotes osteoblast proliferation and differentiation and protects against ovariectomy-induced osteoporosis. Molecular Medicine Reports.
Crossref
Si Chen, Yunfei Zheng, Shan Zhang, Lingfei Jia & Yongsheng Zhou. (2017) Promotion Effects of miR-375 on the Osteogenic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells. Stem Cell Reports 8:3, pages 773-786.
Crossref
Xiaofei Yan, Haixia Wu, Zhiyuan Wu, Fei Hua, Dong Liang, Hong Sun, Yong Yang, Dejian Huang & Jin-Song Bian. (2017) The New Synthetic H2S-Releasing SDSS Protects MC3T3-E1 Osteoblasts against H2O2-Induced Apoptosis by Suppressing Oxidative Stress, Inhibiting MAPKs, and Activating the PI3K/Akt Pathway. Frontiers in Pharmacology 08.
Crossref
Ke Ke, Qi Li, Xiaofeng Yang, Zhijian Xie, Yu Wang, Jue Shi, Linfeng Chi, Weijian Xu, Lingling Hu & Huali Shi. (2016) Asperosaponin VI promotes bone marrow stromal cell osteogenic differentiation through the PI3K/AKT signaling pathway in an osteoporosis model. Scientific Reports 6:1.
Crossref
Mengge Sun, Xiaoya Zhou, Lili Chen, Shishu Huang, Victor Leung, Nan Wu, Haobo Pan, Wanxin Zhen, William Lu & Songlin Peng. (2016) The Regulatory Roles of MicroRNAs in Bone Remodeling and Perspectives as Biomarkers in Osteoporosis. BioMed Research International 2016, pages 1-11.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.