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Journal of Receptors and Signal Transduction Volume 19, 1999 - Issue 1-4
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Original Article

Fluorine-18 Radiolabelling, Biodistribution Studies and Preliminary Pet Evaluation of a New Memantine Derivative for Imaging the NMDA Receptor

S. M. Ametamey Center for Radiopharmaceutical Science of ETH, Paul Scherrer Institute and Division of Nuclear Medicine, University Hospital Zurich, CH-5232, Villigen-PSI, Switzerland
,
S. Samnick Center for Radiopharmaceutical Science of ETH, Paul Scherrer Institute and Division of Nuclear Medicine, University Hospital Zurich, CH-5232, Villigen-PSI, Switzerland
,
K. L. Leenders PET Program, Paul Scherrer Institute, CH-5232, Villigen-PSI, Switzerland
,
P. Vontobel PET Program, Paul Scherrer Institute, CH-5232, Villigen-PSI, Switzerland
,
G. Quack Merz+ Co. GmbH Co., D-60318 Frankfurt/Main, Germany
,
C. G. Parsons Merz+ Co. GmbH Co., D-60318 Frankfurt/Main, Germany
&
P. A. Schubiger Center for Radiopharmaceutical Science of ETH, Paul Scherrer Institute and Division of Nuclear Medicine, University Hospital Zurich, CH-5232, Villigen-PSI, Switzerland
 show all
Pages 129-141 | Published online: 10 Jul 2009

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Marko Kokic, Michael Honer, Lea J. Kessler, Matthias Grauert, Pius A. Schubiger & Simon M. Ametamey. (2002) SYNTHESIS AND IN VITRO AND IN VIVO EVALUATION OF [11C]METHYL-BIII277CL FOR IMAGING THE PCP-BINDING SITE OF THE NMDA RECEPTOR BY PET. Journal of Receptors and Signal Transduction 22:1-4, pages 123-139.
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Articles from other publishers (31)

Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn & Tangui Maurice. (2024) Fluoroethylnormemantine (FENM) shows synergistic protection in combination with a sigma-1 receptor agonist in a mouse model of Alzheimer's disease. Neuropharmacology 242, pages 109733.
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Simon Couly, Morgane Denus, Mélanie Bouchet, Gilles Rubinstenn & Tangui Maurice. (2021) Anti-Amnesic and Neuroprotective Effects of Fluoroethylnormemantine in a Pharmacological Mouse Model of Alzheimer’s Disease. International Journal of Neuropsychopharmacology 24:2, pages 142-157.
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Jong-Hoon Kim, János Marton, Simon Mensah Ametamey & Paul Cumming. (2020) A Review of Molecular Imaging of Glutamate Receptors. Molecules 25:20, pages 4749.
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Marie Beaurain, Anne-Sophie Salabert, Maria Joao Ribeiro, Nicolas Arlicot, Philippe Damier, Florence Le Jeune, Jean-François Demonet & Pierre Payoux. (2019) Innovative Molecular Imaging for Clinical Research, Therapeutic Stratification, and Nosography in Neuroscience. Frontiers in Medicine 6.
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Md. Tanvir Kabir, Mohammad A. Sufian, Md. Sahab Uddin, Mst. Marium Begum, Shammi Akhter, Ariful Islam, Bijo Mathew, Md. Siddiqul Islam, Md. Shah Amran & Ghulam Md. Ashraf. (2019) NMDA Receptor Antagonists: Repositioning of Memantine as a Multitargeting Agent for Alzheimer's Therapy. Current Pharmaceutical Design 25:33, pages 3506-3518.
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Hualong Fu, Zhen Chen, Lee Josephson, Zijing Li & Steven H. Liang. (2018) Positron Emission Tomography (PET) Ligand Development for Ionotropic Glutamate Receptors: Challenges and Opportunities for Radiotracer Targeting N -Methyl- d -aspartate (NMDA), α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA), and Kainate Receptors . Journal of Medicinal Chemistry 62:2, pages 403-419.
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Anne Stankewitz, Till Sprenger, Michael Valet & Thomas R. Tölle. 2019. Praktische Schmerzmedizin. Praktische Schmerzmedizin 37 49 .
Anne Stankewitz, Till Sprenger, Michael Valet & Thomas R. Tölle. 2018. Praktische Schmerzmedizin. Praktische Schmerzmedizin 1 13 .
Anne-Sophie Salabert, Caroline Fonta, Charlotte Fontan, Djilali Adel, Mathieu Alonso, Carine Pestourie, Hafid Belhadj-Tahar, Mathieu Tafani & Pierre Payoux. (2015) Radiolabeling of [18F]-fluoroethylnormemantine and initial in vivo evaluation of this innovative PET tracer for imaging the PCP sites of NMDA receptors. Nuclear Medicine and Biology 42:8, pages 643-653.
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Anne Stankewitz, Till Sprenger, Michael Valet & Thomas R. Tölle. 2013. Praktische Schmerzmedizin. Praktische Schmerzmedizin 1 20 .
Franck Sobrio. (2013) Radiosynthesis of carbon-11 and fluorine-18 labelled radiotracers to image the ionotropic and metabotropic glutamate receptors. Journal of Labelled Compounds and Radiopharmaceuticals 56:3-4, pages 180-186.
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Vattoly J. Majo, Jaya Prabhakaran, J. John Mann & J.S. Dileep Kumar. (2013) PET and SPECT tracers for glutamate receptors. Drug Discovery Today 18:3-4, pages 173-184.
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Till Sprenger, Michael Valet & Thomas R. Tölle. 2011. Praktische Schmerztherapie. Praktische Schmerztherapie 105 116 .
R. E. Nordquist, T. Steckler, J. G. Wettstein, C. Mackie & W. Spooren. (2008) Metabotropic glutamate receptor modulation, translational methods, and biomarkers: relationships with anxiety. Psychopharmacology 199:3, pages 389-402.
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Anat Biegon, Andrew Gibbs, Maritza Alvarado, Michele Ono & Scott Taylor. (2007) In vitro and in vivo characterization of [ 3 H]CNS‐5161—A use‐dependent ligand for the N ‐methyl‐ d ‐aspartate receptor in rat brain . Synapse 61:8, pages 577-586.
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T. Sprenger, M. Valet & T. R. Tölle. 2007. Praktische Schmerztherapie. Praktische Schmerztherapie 91 99 .
Rikki N. Waterhouse, Raymond C. Chang, Jun Zhao & Patty E. Carambot. (2006) In vivo evaluation in rats of [18F]1-(2-fluoroethyl)-4-[(4-cyanophenoxy)methyl]piperidine as a potential radiotracer for PET assessment of CNS sigma-1 receptors. Nuclear Medicine and Biology 33:2, pages 211-215.
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Jun Zhao, Raymond Chang, Patty Carambot & Rikki N. Waterhouse. (2005) Radiosynthesis and in vivo study of [ 18 F]1‐(2‐fluoroethyl)‐4‐[(4‐cyanophenoxy)methyl]piperidine: a promising new sigma‐1 receptor ligand . Journal of Labelled Compounds and Radiopharmaceuticals 48:8, pages 547-555.
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Till Sprenger, Achim Berthele, Stefan Platzer, Henning Boecker & Thomas Rudolf Tölle. (2005) What to learn from in vivo opioidergic brain imaging?. European Journal of Pain 9:2, pages 117-121.
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S.K. Sonkusare, C.L. Kaul & P. Ramarao. (2005) Dementia of Alzheimer’s disease and other neurodegenerative disorders—memantine, a new hope. Pharmacological Research 51:1, pages 1-17.
Crossref
Rikki N. Waterhouse, Mark Slifstein, Filip Dumont, Jun Zhao, Raymond C. Chang, Yasuhiko Sudo, Abida Sultana, Andrew Balter & Marc Laruelle. (2004) In vivo evaluation of [11C]N-(2-chloro-5-thiomethylphenyl)-N′- (3-methoxy-phenyl)-N′-methylguanidine ([11C]GMOM) as a potential PET radiotracer for the PCP/NMDA receptor. Nuclear Medicine and Biology 31:7, pages 939-948.
Crossref
J A Quiroz, J Singh, T D Gould, K D Denicoff, C A ZarateJrJr & H K Manji. (2004) Emerging experimental therapeutics for bipolar disorder: clues from the molecular pathophysiology. Molecular Psychiatry 9:8, pages 756-776.
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CARLOS A. ZARATEJR.JR., JING DU, JORGE QUIROZ, NEIL A. GRAY, KIRK D. DENICOFF, JASKARAN SINGH, DENNIS S. CHARNEY & HUSSEINI K. MANJI. (2003) Regulation of Cellular Plasticity Cascades in the Pathophysiology and Treatment of Mood Disorders. Annals of the New York Academy of Sciences 1003:1, pages 273-291.
Crossref
Rikki N Waterhouse. (2003) Imaging the PCP site of the NMDA ion channel. Nuclear Medicine and Biology 30:8, pages 869-878.
Crossref
Rikki N. Waterhouse, Filip Dumont, Abida Sultana, Norman Simpson & Marc Laruelle. (2002) Synthesis of [ 11 C] N ‐(2‐chloro‐5‐thiomethylphenyl)‐ N ′‐(3‐methoxyphenyl)‐ N ′‐methylguanidine ([ 11 C]GMOM): a candidate PET tracer for imaging the PCP site of the NMDA ion channel . Journal of Labelled Compounds and Radiopharmaceuticals 45:11, pages 955-964.
Crossref
Filip Dumont, Abida Sultana & Rikki N Waterhouse. (2002) Synthesis and in vitro evaluation of N,N′-diphenyl and N-naphthyl-N′-phenylguanidines as N-methyl-d-aspartate receptor ion-channel ligands. Bioorganic & Medicinal Chemistry Letters 12:12, pages 1583-1586.
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Andrew R. Gibbs, Hiromi Morimoto, Henry F. VanBrocklin, Philip G. Williams & Anat Biegon. (2002) Synthesis of N ‐(2‐chloro‐5‐methylthiophenyl)‐ N ′‐(3‐methyl‐thiophenyl)‐ N ′‐[ 3 H 3 ]methylguanidine, {[ 3 H 3 ]CNS‐5161} . Journal of Labelled Compounds and Radiopharmaceuticals 45:5, pages 395-400.
Crossref
S.M. Ametamey, M. Bruehlmeier, S. Kneifel, M. Kokic, M. Honer, M. Arigoni, A. Buck, C. Burger, S. Samnick, G. Quack & P.A. Schubiger. (2002) PET studies of 18 F-memantine in healthy volunteers. Nuclear Medicine and Biology 29:2, pages 227-231.
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Csaba Juhász, Harry T. Chugani, Otto Muzik & Diane C. Chugani. 2002. Epilepsy, Infantile Spasms, and Development Encephalopathy. Epilepsy, Infantile Spasms, and Development Encephalopathy 37 55 .
Rosa Maria Moresco, Cristina Messa, Giovanni Lucignani, Giovanna Rizzo G, Sergio Todde, Maria Carla Gilardi, Adelmo Grimaldi & Ferruccio Fazio. (2001) PET in Psychopharmacology. Pharmacological Research 44:3, pages 151-159.
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Andrew L Stoll, Perry F Renshaw, Deborah A Yurgelun-Todd & Bruce M Cohen. (2000) Neuroimaging in bipolar disorder: what have we learned?. Biological Psychiatry 48:6, pages 505-517.
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