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Pharmaceutical Development and Technology Volume 18, 2013 - Issue 3
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Research Article

Preparation and characterization of metformin hydrochloride loaded-Eudragit®RSPO and Eudragit®RSPO/PLGA nanoparticles

Meltem Cetina Department of Pharmaceutical Technology, Ankara, TurkeyCorrespondence[email protected] [email protected]
,
Alptug Atilab Department of Analytical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Ankara, Turkey
,
Selma Sahinc Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey
&
Imran Vuralc Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey
Pages 570-576 | Received 21 Feb 2011, Accepted 17 Jun 2011, Published online: 24 Aug 2011

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Kainat Nousheen, Fakhar Ud Din, Humzah Jamshaid, Rabia Afza, Saif Ullah Khan, Maimoona Malik, Zakir Ali, Sibgha Batool, Alam Zeb, Abid Mehmood Yousaf, Ali H. Almari, Saud Alqahtani, Salman Khan & Gul Majid Khan. (2023) Metformin HCl-loaded transethosomal gel; development, characterization, and antidiabetic potential evaluation in the diabetes-induced rat model. Drug Delivery 30:1.
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Leila Faramarzi, Mehdi Dadashpour, Hadi Sadeghzadeh, Majid Mahdavi & Nosratollah Zarghami. (2019) Enhanced anti-proliferative and pro-apoptotic effects of metformin encapsulated PLGA-PEG nanoparticles on SKOV3 human ovarian carcinoma cells. Artificial Cells, Nanomedicine, and Biotechnology 47:1, pages 737-746.
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Meltem Cetin & Selma Sahin. (2016) Microparticulate and nanoparticulate drug delivery systems for metformin hydrochloride. Drug Delivery 23:8, pages 2796-2805.
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Vineet Kumar Rai, Nidhi Mishra, Ashish Kumar Agrawal, Sanyog Jain & Narayan Prasad Yadav. (2016) Novel drug delivery system: an immense hope for diabetics. Drug Delivery 23:7, pages 2371-2390.
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Milind Alai & Wen Jen Lin. (2015) Application of nanoparticles for oral delivery of acid-labile lansoprazole in the treatment of gastric ulcer: in vitro and in vivo evaluations. International Journal of Nanomedicine 10, pages 4029-4041.
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Yifei Wang, Wei Song, Yiming Li, Zhekun Zhou, Chenkai Li, Weilin Yu & Yaohua He. (2023) Metformin-loaded PLGA microspheres combined with an in situ-formed injectable SA/BG hydrogel alleviate rotator cuff muscle degeneration. Materials Today Bio 23, pages 100874.
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Pankaj V. Dixit, Dinesh K. Mishra, Sanjay Sharma & Rupesh K. Gautam. (2023) Nanocarriers and Diabetes: New Vistas and the Way Ahead. Current Pharmaceutical Biotechnology 24:11, pages 1420-1429.
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Gopalakrishnan Thamilselvan, Helma David, Anusree Sajeevan, Shobana Rajaramon, Adline Princy Solomon, Ramya Devi Durai & Vedha Hari B. Narayanan. (2023) Polymer based dual drug delivery system for targeted treatment of fluoroquinolone resistant Staphylococcus aureus mediated infections. Scientific Reports 13:1.
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Sumeyye Cesur, Muhammet Emin CamFatih Serdar Sayın, Sena Su, Anthony HarkerMohan Edirisinghe & Oguzhan Gunduz. (2021) Metformin-Loaded Polymer-Based Microbubbles/Nanoparticles Generated for the Treatment of Type 2 Diabetes Mellitus. Langmuir 38:17, pages 5040-5051.
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Xiaowei Yang, Qi Lai, Xinmin Yang, Banglin Xie, Bin Zhang, Xiaoyong Zhang & Yen Wei. (2022) Recent development and advances in the fabrication and biomedical applications of nanoparticle-based drug delivery systems for metformin. Materials Chemistry Frontiers 6:2, pages 128-144.
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Gunjan Jeswani, Lipika Chablani, Umesh Gupta, Rakesh K. Sahoo, Kartik T. Nakhate & Ajazuddin. (2021) Development and optimization of paclitaxel loaded Eudragit/PLGA nanoparticles by simplex lattice mixture design: Exploration of improved hemocompatibility and in vivo kinetics. Biomedicine & Pharmacotherapy 144, pages 112286.
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A. Alper Öztürkİrem NamlıAbdurrahman Aygül. (2021) Cefaclor Monohydrate-Loaded Colon-Targeted Nanoparticles for Use in COVID-19 Dependent Coinfections and Intestinal Symptoms: Formulation, Characterization, Release Kinetics, and Antimicrobial Activity. ASSAY and Drug Development Technologies 19:3, pages 156-175.
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Ragavee Ambalavanan, Arul Daniel John & Asha Devi Selvaraj. (2020) Nano‐encapsulated Tinospora cordifolia (Willd.) using poly (D, L‐lactide) nanoparticles educe effective control in streptozotocin‐induced type 2 diabetic rats . IET Nanobiotechnology 14:9, pages 803-808.
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Santwana Padhi, Amit Kumar Nayak & Anindita Behera. (2020) Type II diabetes mellitus: a review on recent drug based therapeutics. Biomedicine & Pharmacotherapy 131, pages 110708.
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Shuai Wang, Fang Xiang Song, Li Zhang, Xue Zhang & Yan Li. (2019) Organic Functionalization of Mesoporous Silica Spheres as a Nanovehicle for DOX pH-Triggered Delivery. Nano 14:08, pages 1950094.
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A Ragavee & SelvarajAsha Devi. (2019) Nanoencapsulation of Tinospora cordifolia (Willd.) using poly (D, L-lactide) nanoparticles: Yield optimization by response surface methodology and in silico modeling with insulin receptor tyrosine kinase. Pharmacognosy Magazine 15:64, pages 218.
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Siddharth Uppal, Kishan S. Italiya, Deepak Chitkara & Anupama Mittal. (2018) Nanoparticulate-based drug delivery systems for small molecule anti-diabetic drugs: An emerging paradigm for effective therapy. Acta Biomaterialia 81, pages 20-42.
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Yu Xiao, Shuang Wang, Qingyu Zong & Zongning Yin. (2018) Co-delivery of Metformin and Paclitaxel Via Folate-Modified pH-Sensitive Micelles for Enhanced Anti-tumor Efficacy. AAPS PharmSciTech 19:5, pages 2395-2406.
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Shahrzad Javidfar, Younes Pilehvar-Soltanahmadi, Raana Farajzadeh, Javid Lotfi-Attari, Vahid Shafiei-Irannejad, Mehrdad Hashemi & Nosratollah Zarghami. (2018) The inhibitory effects of nano-encapsulated metformin on growth and hTERT expression in breast cancer cells. Journal of Drug Delivery Science and Technology 43, pages 19-26.
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Chandran Murugan, Srinivasan Venkatesan & Soundarapandian Kannan. (2017) Cancer Therapeutic Proficiency of Dual-Targeted Mesoporous Silica Nanocomposite Endorses Combination Drug Delivery. ACS Omega 2:11, pages 7959-7975.
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Ruma Rani, Shakti Dahiya, Dinesh Dhingra, Neeraj Dilbaghi, Ki-Hyun Kim & Sandeep Kumar. (2017) Evaluation of anti-diabetic activity of glycyrrhizin-loaded nanoparticles in nicotinamide-streptozotocin-induced diabetic rats. European Journal of Pharmaceutical Sciences 106, pages 220-230.
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Bentley Lim, Michael Zimmermann, Natasha A. Barry & Andrew L. Goodman. (2017) Engineered Regulatory Systems Modulate Gene Expression of Human Commensals in the Gut. Cell 169:3, pages 547-558.e15.
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Yi Zhao, Wei Wang, Shutao Guo, Yuhua Wang, Lei Miao, Yang Xiong & Leaf Huang. (2016) PolyMetformin combines carrier and anticancer activities for in vivo siRNA delivery. Nature Communications 7:1.
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Atul Kumar Sahu & Amita Verma. (2016) Development and statistical optimization of chitosan and eudragit based gastroretentive controlled release multiparticulate system for bioavailability enhancement of metformin HCl. Journal of Pharmaceutical Investigation 46:3, pages 239-252.
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Naser Mirazi, Jamileh Shoaei, Ardeshir Khazaei & Abdolkarim Hosseini. (2014) A comparative study on effect of metformin and metformin-conjugated nanotubes on blood glucose homeostasis in diabetic rats. European Journal of Drug Metabolism and Pharmacokinetics 40:3, pages 343-348.
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Milind Alai & Wen Jen Lin. (2014) Novel Lansoprazole-Loaded Nanoparticles for the Treatment of Gastric Acid Secretion-Related Ulcers: In Vitro and In Vivo Pharmacokinetic Pharmacodynamic Evaluation. The AAPS Journal 16:3, pages 361-372.
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Mark R. Battig & Yong Wang. 2014. Natural and Synthetic Biomedical Polymers. Natural and Synthetic Biomedical Polymers 287 299 .

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