1,067
Views
49
CrossRef citations to date
0
Altmetric
Research Article

A combined experimental and modeling approach to study the effects of high-shear wet granulation process parameters on granule characteristics

, , , , &
Pages 210-224 | Received 07 Feb 2012, Accepted 24 May 2012, Published online: 11 Jul 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Preetanshu Pandey, Christopher Levins, Steve Pafiakis, Brian Zacour, Dilbir S. Bindra, Jade Trinh, David Buckley, Shruti Gour, Shasad Sharif & Howard Stamato. (2018) Enhancing tablet disintegration characteristics of a highly water-soluble high-drug-loading formulation by granulation process. Pharmaceutical Development and Technology 23:6, pages 587-595.
Read now
Futoshi Shikata, Susumu Kimura, Yusuke Hattori & Makoto Otsuka. (2018) Application of near-infrared spectroscopy to optimize dissolution profiles of tablets according to the granulation mechanism. Drug Development and Industrial Pharmacy 44:5, pages 713-722.
Read now
Mohamed H. Fayed, Sayed I. Abdel-Rahman, Fars K. Alanazi, Mahrous O. Ahmed, Hesham M. Tawfeek & Ramadan I. Al-Shdefat. (2017) New gentle-wing high-shear granulator: impact of processing variables on granules and tablets characteristics of high-drug loading formulation using design of experiment approach. Drug Development and Industrial Pharmacy 43:10, pages 1584-1600.
Read now
Preetanshu Pandey & Sherif Badawy. (2016) A quality by design approach to scale-up of high-shear wet granulation process. Drug Development and Industrial Pharmacy 42:2, pages 175-189.
Read now

Articles from other publishers (45)

Ana Baumgartner & Odon Planinšek. (2023) Effect of process parameters in high shear granulation on characteristics of a novel co-processed mesoporous silica material. European Journal of Pharmaceutical Sciences 188, pages 106528.
Crossref
Michiel Peeters, Ana Alejandra Barrera Jiménez, Kensaku Matsunami, Fanny Stauffer, Ingmar Nopens & Thomas De Beer. (2023) Evaluation of the influence of material properties and process parameters on granule porosity in twin-screw wet granulation. International Journal of Pharmaceutics 641, pages 123010.
Crossref
Ana Alejandra Barrera Jiménez, Kensaku Matsunami, Michael Ghijs, Daan Van Hauwermeiren, Michiel Peeters, Fanny Stauffer, Thomas De Beer & Ingmar Nopens. (2023) Model development and calibration of two-dimensional population balance model for twin-screw wet granulation based on particle size distribution and porosity. Powder Technology 419, pages 118334.
Crossref
Vinod V. Kenekar, Suhas B. Ghugare & Veena Patil-Shinde. (2023) Multi-objective optimization of high-shear wet granulation process for better granule properties and fluidized bed drying characteristics. Powder Technology, pages 118373.
Crossref
Mizuki Yamada, Agata Ishikawa, Shun Muramatsu, Takayuki Furuishi, Yoshinori Onuki, Kaori Fukuzawa & Etsuo Yonemochi. (2022) Study of Orally Disintegrating Tablets Using Erythritol as an Excipient Produced by Moisture-Activated Dry Granulation (MADG). Pharmaceuticals 15:8, pages 1004.
Crossref
Bader Bouzar & Yannick Mamindy-Pajany. (2022) Manufacture and characterization of carbonated lightweight aggregates from waste paper fly ash. Powder Technology 406, pages 117583.
Crossref
Stefan Bellinghausen, Emmanuela Gavi, Laura Jerke, Dana Barrasso, Agba D. Salman & James D. Litster. (2022) Model-driven design using population balance modelling for high-shear wet granulation. Powder Technology 396, pages 578-595.
Crossref
Zheng Wang, Junjie Cao, Wanting Li, Yawen Wang, Gan Luo, Yanjiang Qiao, Yanling Zhang & Bing Xu. (2021) Using a material database and data fusion method to accelerate the process model development of high shear wet granulation. Scientific Reports 11:1.
Crossref
Indu Muthancheri, Anik Chaturbedi, Angelique Bétard & Rohit Ramachandran. (2021) A compartment based population balance model for the prediction of steady and induction granule growth behavior in high shear wet granulation. Advanced Powder Technology 32:6, pages 2085-2096.
Crossref
Binbin Liu, Jiamiao Wang, Jia Zeng, Lijie Zhao, Youjie Wang, Yi Feng & Ruofei Du. (2021) A review of high shear wet granulation for better process understanding, control and product development. Powder Technology 381, pages 204-223.
Crossref
Ji Yeon Kim, Myung Hee Chun & Du Hyung Choi. (2021) Control Strategy for Process Development of High-Shear Wet Granulation and Roller Compaction to Prepare a Combination Drug Using Integrated Quality by Design. Pharmaceutics 13:1, pages 80.
Crossref
Ryo Omata, Yusuke Hattori, Tetsuo Sasaki, Tomoaki Sakamoto & Makoto Otsuka. (2020) Elucidation of the Molecular Mechanism of Wet Granulation for Pharmaceutical Standard Formulations in a High-Speed Shear Mixer Using Near-Infrared Spectroscopy. Pharmaceuticals 13:9, pages 226.
Crossref
Keita Koyanagi, Akinori Ueno, Yusuke Hattori, Tetsuo Sasaki, Tomoaki Sakamoto & Makoto Otsuka. (2020) Analysis of granulation mechanism in a high-shear wet granulation method using near-infrared spectroscopy and stirring power consumption. Colloid and Polymer Science 298:8, pages 977-987.
Crossref
Lalith Kotamarthy, Nirupaplava Metta & Rohit Ramachandran. (2020) Understanding the Effect of Granulation and Milling Process Parameters on the Quality Attributes of Milled Granules. Processes 8:6, pages 683.
Crossref
Indu Muthancheri & Rohit Ramachandran. (2020) Mechanistic understanding of granule growth behavior in bi-component wet granulation processes with wettability differentials. Powder Technology 367, pages 841-859.
Crossref
A.A. Barba, A. Dalmoro, S. Bochicchio, V. De Simone, D. Caccavo, M. Iannone & G. Lamberti. (2020) Engineering approaches for drug delivery systems production and characterization. International Journal of Pharmaceutics 581, pages 119267.
Crossref
Hiroshi Takasaki, Atsushi Sakurai, Takuma Katayama, Yuka Matsuura, Naoko Ohyagi, Masashi Mizoguchi, Junichi Takano, Koichi Wada, Koh Matsui, Takuya Nagato, Agata Ishikawa & Etsuo Yonemochi. (2019) Importance of free water in controlling granule and tablet properties in a novel granulation method, green fluidized bed granulation (GFBG). International Journal of Pharmaceutics 570, pages 118647.
Crossref
Sherif I.F. Badawy, Ajit S. Narang, Keirnan R. LaMarche, Ganeshkumar A. Subramanian & Sailesh A. Varia. 2019. Handbook of Pharmaceutical Wet Granulation. Handbook of Pharmaceutical Wet Granulation 89 118 .
Ajit S. Narang & Sherif I.F. Badawy. 2019. Handbook of Pharmaceutical Wet Granulation. Handbook of Pharmaceutical Wet Granulation 825 840 .
Sherif I.F. Badawy, Ajit S. Narang, Keirnan R. LaMarche, Ganeshkumar A. Subramanian, Sailesh A. Varia, Judy Lin, Tim Stevens & Pankaj A. Shah. 2019. Handbook of Pharmaceutical Wet Granulation. Handbook of Pharmaceutical Wet Granulation 665 702 .
Preetanshu Pandey & Sherif I.F. Badawy. 2019. Handbook of Pharmaceutical Wet Granulation. Handbook of Pharmaceutical Wet Granulation 615 650 .
Rajan Verma, Maneesha Patil & Carlos O. Paz. 2019. Handbook of Pharmaceutical Wet Granulation. Handbook of Pharmaceutical Wet Granulation 203 259 .
Wei Meng, Sarang Oka, Xue Liu, Thamer Omer, Rohit Ramachandran & Fernando J. Muzzio. (2017) Effects of Process and Design Parameters on Granule Size Distribution in a Continuous High Shear Granulation Process. Journal of Pharmaceutical Innovation 12:4, pages 283-295.
Crossref
P. Suresh, I. Sreedhar, R. Vaidhiswaran & A. Venugopal. (2017) A comprehensive review on process and engineering aspects of pharmaceutical wet granulation. Chemical Engineering Journal 328, pages 785-815.
Crossref
Laís Maia Rodrigues, Ricardo Francisco Pires & Davi Leonardo de Souza. (2017) Study of Granulated Gypsum Hardness Coming from the Granulation Process in Rotating Disk. Materials Science Forum 899, pages 160-166.
Crossref
Anik Chaturbedi, Chandra Kanth Bandi, Dheeraj Reddy, Preetanshu Pandey, Ajit Narang, Dilbir Bindra, Li Tao, Junshu Zhao, Jinjiang Li, Munir Hussain & Rohit Ramachandran. (2017) Compartment based population balance model development of a high shear wet granulation process via dry and wet binder addition. Chemical Engineering Research and Design 123, pages 187-200.
Crossref
F. Shikata, S. Kimura, Y. Hattori & M. Otsuka. (2017) Real-time monitoring of granule properties during high shear wet granulation by near-infrared spectroscopy with a chemometrics approach. RSC Advances 7:61, pages 38307-38317.
Crossref
S. Badawy & P. Pandey. 2017. Developing Solid Oral Dosage Forms. Developing Solid Oral Dosage Forms 749 776 .
A. Chaudhury, D. Barrasso, D.A. Pohlman, J.D. Litster & R. Ramachandran. 2017. Predictive Modeling of Pharmaceutical Unit Operations. Predictive Modeling of Pharmaceutical Unit Operations 99 135 .
P. Pandey, R. Bharadwaj & X. Chen. 2017. Predictive Modeling of Pharmaceutical Unit Operations. Predictive Modeling of Pharmaceutical Unit Operations 1 13 .
Rohit P. Dugar, Bhavin Y. Gajera & Rutesh H. Dave. (2016) Fusion Method for Solubility and Dissolution Rate Enhancement of Ibuprofen Using Block Copolymer Poloxamer 407. AAPS PharmSciTech 17:6, pages 1428-1440.
Crossref
Hiroshi Takasaki, Etsuo Yonemochi, Masanori Ito, Koichi Wada & Katsuhide Terada. (2016) The effect of water activity on granule characteristics and tablet properties produced by moisture activated dry granulation (MADG). Powder Technology 294, pages 113-118.
Crossref
Xianglong Cui, Bing Xu, Xin Wang, Fei Sun, Xinyuan Shi & Yanjiang Qiao. (2016) Using quality by design and quality risk management principles to aid the development of a high shear wet granulation process. Using quality by design and quality risk management principles to aid the development of a high shear wet granulation process.
Ajit S. Narang, Valery Sheverev, Tim Freeman, Douglas Both, Vadim Stepaniuk, Michael Delancy, Doug Millington-Smith, Kevin Macias & Ganeshkumar Subramanian. (2016) Process Analytical Technology for High Shear Wet Granulation: Wet Mass Consistency Reported by In-Line Drag Flow Force Sensor Is Consistent With Powder Rheology Measured by At-Line FT4 Powder Rheometer®. Journal of Pharmaceutical Sciences 105:1, pages 182-187.
Crossref
Sherif I.F. Badawy, Ajit S. Narang, Keirnan R. LaMarche, Ganeshkumar A. Subramanian, Sailesh A. Varia, Judy Lin, Tim Stevens & Pankaj A. Shah. (2016) Integrated Application of Quality-by-Design Principles to Drug Product Development: A Case Study of Brivanib Alaninate Film–Coated Tablets. Journal of Pharmaceutical Sciences 105:1, pages 168-181.
Crossref
Anwesha Chaudhury, Maitraye Sen, Dana Barrasso & Rohit Ramachandran. 2016. Process Simulation and Data Modeling in Solid Oral Drug Development and Manufacture. Process Simulation and Data Modeling in Solid Oral Drug Development and Manufacture 43 83 .
David Smrčka, Jiří Dohnal & František Štěpánek. (2015) Effect of process scale-up on the dissolution of granules with a high content of active pharmaceutical ingredient. Powder Technology 285, pages 88-95.
Crossref
Jing Tao, Preetanshu Pandey, Dilbir S. Bindra, Julia Z. Gao & Ajit S. Narang. (2015) Evaluating Scale-Up Rules of a High-Shear Wet Granulation Process. Journal of Pharmaceutical Sciences 104:7, pages 2323-2333.
Crossref
Anwesha Chaudhury, Marco Euclide Armenante & Rohit Ramachandran. (2015) Compartment based population balance modeling of a high shear wet granulation process using data analytics. Chemical Engineering Research and Design 95, pages 211-228.
Crossref
Dana Barrasso & Rohit Ramachandran. (2015) Multi-scale modeling of granulation processes: Bi-directional coupling of PBM with DEM via collision frequencies. Chemical Engineering Research and Design 93, pages 304-317.
Crossref
Sarang Oka, Ondřej Kašpar, Viola Tokárová, Koushik Sowrirajan, Huiquan Wu, Mansoor Khan, Fernando Muzzio, František Štěpánek & Rohit Ramachandran. (2015) A quantitative study of the effect of process parameters on key granule characteristics in a high shear wet granulation process involving a two component pharmaceutical blend. Advanced Powder Technology 26:1, pages 315-322.
Crossref
Keirnan LaMarche, David Buckley, Ruiling Hartley, Feng Qian & Sherif Badawy. (2014) Assessing materials' tablet compaction properties using the Drucker–Prager Cap model. Powder Technology 267, pages 208-220.
Crossref
Yujing Liu, Dagobert Scharf, Thomas Graule & Frank J. Clemens. (2014) Granulation processing parameters on the mechanical properties of diatomite-based porous granulates. Powder Technology 263, pages 159-167.
Crossref
Anwesha Chaudhury, Dana Barrasso, Preetanshu Pandey, Huiquan Wu & Rohit Ramachandran. (2014) Population Balance Model Development, Validation, and Prediction of CQAs of a High-Shear Wet Granulation Process: Towards QbD in Drug Product Pharmaceutical Manufacturing. Journal of Pharmaceutical Innovation 9:1, pages 53-64.
Crossref
Catharine A. Kastner, George P.E. Brownbridge, Sebastian Mosbach & Markus Kraft. (2013) Impact of powder characteristics on a particle granulation model. Chemical Engineering Science 97, pages 282-295.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.