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Journal of Neurovirology Volume 3, 1997 - Issue 2
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Original Article

Human immunodeficiency virus type 1 Tat protein induces death by apoptosis in primary human neuron cultures

Deborah R New Departments of Neurobiology and Anatomy, University of Rochester Medical Center, 601 Elmwood Ave., Rochester, New York, 14642, USA; Dental Research, University of Rochester Medical Center, 601 Elmwood Ave., Rochester, New York, 14642, USA
,
Meihui Ma Department of Medical Microbiology, University of Manitoba, 523-730 William Ave., Winnipeg, Manitoba, R3E OW3, Canada
,
Leon G Epstein Departments of Neurology, University of Rochester Medical Center, 601 Elmwood Ave., Rochester, New York, 14642, USA; Departments of Pediatrics, University of Rochester Medical Center, 601 Elmwood Ave., Rochester, New York, 14642, USA; Departments of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Ave., Rochester, New York, 14642, USA
,
Avindra Nath Department of Medical Microbiology, University of Manitoba, 523-730 William Ave., Winnipeg, Manitoba, R3E OW3, Canada; Internal Medicine (Section of Neurology), University of Manitoba, 523-730 William Ave., Winnipeg, Manitoba, R3E OW3, Canada
&
Harris A Gelbard Departments of Neurology, University of Rochester Medical Center, 601 Elmwood Ave., Rochester, New York, 14642, USA; Departments of Pediatrics, University of Rochester Medical Center, 601 Elmwood Ave., Rochester, New York, 14642, USA; Departments of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Ave., Rochester, New York, 14642, USA
Pages 168-173 | Received 18 Sep 1996, Accepted 05 Dec 1996, Published online: 10 Jul 2009

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Joy E Hazleton, Joan W Berman & Eliseo A Eugenin. (2010) Novel mechanisms of central nervous system damage in HIV infection. HIV/AIDS - Research and Palliative Care 2, pages 39-49.
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Fuwang Peng, Navneet Dhillon, Shannon Callen, Honghong Yao, Sirosh Bokhari, Xuhui Zhu, Hicham H Baydoun & Shilpa Buch. (2008) Platelet-derived growth factor protects neurons against gp120-mediated toxicity. Journal of Neurovirology 14:1, pages 62-72.
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Eugen Brailoiu, G Cristina Brailoiu, Giuseppe Mameli, Antonina Dolei, Bassel E Sawaya & Nae J Dun. (2006) Acute exposure to ethanol potentiates human immunodeficiency virus type 1 Tat–induced Ca2+ overload and neuronal death in cultured rat cortical neurons. Journal of Neurovirology 12:1, pages 17-24.
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Rick B Meeker, Jeramiah C Boles, Kevin R Robertson & Colin D Hall. (2005) Cerebrospinal fluid from human immunodeficiency virus–infected individuals facilitates neurotoxicity by suppressing intracellular calcium recovery. Journal of Neurovirology 11:2, pages 144-156.
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Adeline Nukuna, Howard E Gendelman, Jenae Limoges, Jennifer Rasmussen, Larisa Poluektova, Anuja Ghorpade & Yuri Persidsky. (2004) Levels of human immunodeficiency virus type 1 (HIV-1) replication in macrophages determines the severity of murine HIV-1 encephalitis. Journal of Neurovirology 10:sup1, pages 82-90.
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EMMANUEL G. RÉGULIER, KRYZSZTOF REISS, KAMEL KHALILI, SHOHREH AMINI, JAY RAPPAPORT, JEAN-FRANÇOIS ZAGURY & PETER D. KATSIKIS. (2004) T-CELL AND NEURONAL APOPTOSIS IN HIV INFECTION: IMPLICATIONS FOR THERAPEUTIC INTERVENTION. International Reviews of Immunology 23:1-2, pages 25-59.
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Naveed Ahmed Khan, Francescopaolo Di Cello, Avi Nath & Kwang Sik Kim. (2003) Human Immunodeficiency Virus Type 1 Tat-Mediated Cytotoxicity of Human Brain Microvascular Endothelial Cells. Journal of Neurovirology 9:6, pages 584-593.
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Aleida Pérez, Albert W Probert, Kevin KW Wang, Lamia Sharmeen. (2001) Evaluation of HIV-1 Tat induced neurotoxicity in rat cortical cell culture. Journal of Neurovirology 7:1, pages 1-10.
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Lance Hudson, Jiankai Liu, Avindra Nath, Melina Jones, Ravi Raghavan, Opendra Narayan, David Male & Ian Everall. (2000) Detection of the human immunodeficiency virus regulatory protein tat in CNS tissues. Journal of Neurovirology 6:2, pages 145-155.
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Rick B Meeker, Kevin Robertson, Tammy Barry & Colin Hall. (1999) Neurotoxicity of CSF from HIV-infected humans. Journal of Neurovirology 5:5, pages 507-518.
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Scott E Woodman, Etty N Benveniste, Avindra Nath & Joan W Berman. (1999) Human immunodeficiency virus type 1 TAT protein induces adhesion molecule expression in astrocytes. Journal of Neurovirology 5:6, pages 678-684.
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Bin Shi, Jay Raina, Alfredo Lorenzo, Jorge Busciglio & Dana Gabuzda. (1998) Neuronal apoptosis induced by HIV-1 Tat protein and TNF-α: potentiation of neurotoxicity mediated by oxidative stress and implications for HIV-1 dementia. Journal of Neurovirology 4:3, pages 281-290.
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