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Original Research Articles

Effects of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-oestradiol on ovarian function in comparison to a monophasic combined oral contraceptive containing drospirenone and ethinylestradiol

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Pages 314-325 | Published online: 09 Aug 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (18)

Suzanne Reed, Carol Koro, Julia DiBello, Kerstin Becker, Anja Bauerfeind, Christian Franke & Klaas Heinemann. (2021) Prospective controlled cohort study on the safety of a monophasic oral contraceptive containing nomegestrol acetate (2.5mg) and 17β-oestradiol (1.5mg) (PRO-E2 study): risk of venous and arterial thromboembolism. The European Journal of Contraception & Reproductive Health Care 26:6, pages 439-446.
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Carlo Bastianelli, Manuela Farris, Elena Rosato, Ivo Brosens & Giuseppe Benagiano. (2018) Pharmacodynamics of combined estrogen-progestin oral contraceptives 3. Inhibition of ovulation. Expert Review of Clinical Pharmacology 11:11, pages 1085-1098.
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Iñaki Lete & Oihane Lapuente. (2016) Contraceptive options for women with premenstrual dysphoric disorder: current insights and a narrative review. Open Access Journal of Contraception 7, pages 117-125.
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Hannat Akintomide & Sabeena Panicker. (2015) Nomegestrol acetate/17-beta estradiol: a review of efficacy, safety, and patient acceptability. Open Access Journal of Contraception 6, pages 77-86.
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Anita L Nelson. (2015) An update on new orally administered contraceptives for women. Expert Opinion on Pharmacotherapy 16:18, pages 2759-2772.
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Ingrid J.M. Duijkers, Christine Klipping, Yvette Zimmerman, Nicole Appels, Maud Jost, Catherine Maillard, Marie Mawet, Jean-Michel Foidart & Herjan J. T. Coelingh Bennink. (2015) Inhibition of ovulation by administration of estetrol in combination with drospirenone or levonorgestrel: Results of a phase II dose-finding pilot study. The European Journal of Contraception & Reproductive Health Care 20:6, pages 476-489.
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Han Witjes, Mitchell D. Creinin, Inger Sundström-Poromaa, Allison Martin Nguyen & Tjeerd Korver. (2015) Comparative analysis of the effects of nomegestrol acetate/17 β-estradiol and drospirenone/ethinylestradiol on premenstrual and menstrual symptoms and dysmenorrhea. The European Journal of Contraception & Reproductive Health Care 20:4, pages 296-307.
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Anne Burke. (2013) Nomegestrol acetate-17b-estradiol for oral contraception. Patient Preference and Adherence 7, pages 607-619.
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Jeffrey T Jensen, Johannes Bitzer & Marco Serrani. (2013) Comparison of the pharmacologic and clinical profiles of new combined oral contraceptives containing estradiol. Open Access Journal of Contraception 4, pages 39-50.
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Yvette Zimmerman, Herjan J. T. Coelingh Bennink, Wout Wouters, Frieda Ebes & Bart C. J. M. Fauser. (2013) The pharmacokinetics and pharmacodynamics of dehydroepiandrosterone during use of an ethinylestradiol- and drospirenone-containing oral contraceptive. The European Journal of Contraception & Reproductive Health Care 18:6, pages 489-500.
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Nathalie Chabbert-Buffet, Jan Gerris, Christian Jamin, Stefano Lello, Inaki Lete, Paloma Lobo, Rossella E. Nappi & Axelle Pintiaux. (2013) Toward a new concept of “natural balance” in oral estroprogestin contraception. Gynecological Endocrinology 29:10, pages 891-896.
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Yvette Zimmerman, Wout Wouters & Herjan J. T. Coelingh Bennink. (2013) The bioequivalence of the contraceptive steroids ethinylestradiol and drospirenone is not affected by co-administration of dehydroepiandrosterone. The European Journal of Contraception & Reproductive Health Care 18:3, pages 206-214.
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Franca Fruzzetti, Florence Trémollieres & Johannes Bitzer. (2012) An overview of the development of combined oral contraceptives containing estradiol: focus on estradiol valerate/dienogest. Gynecological Endocrinology 28:5, pages 400-408.
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Ulla M. Ågren, Marjatta Anttila, Kristiina Mäenpää-Liukko, Maija-Liisa Rantala, Hilkka Rautiainen, Werner F. Sommer & Ellen Mommers. (2011) Effects of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-oestradiol in comparison to one containing levonorgestrel and ethinylestradiol on markers of endocrine function. The European Journal of Contraception & Reproductive Health Care 16:6, pages 458-467.
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Diana Mansour, Carole Verhoeven, Werner Sommer, Edith Weisberg, Surasak Taneepanichskul, Gian Benedetto Melis, Inger Sundström-Poromaa & Tjeerd Korver. (2011) Efficacy and tolerability of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-oestradiol in a 24/4 regimen, in comparison to an oral contraceptive containing ethinylestradiol and drospirenone in a 21/7 regimen. The European Journal of Contraception & Reproductive Health Care 16:6, pages 430-443.
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Ulla M. Ågren, Marjatta Anttila, Kristiina Mäenpää-Liukko, Maija-Liisa Rantala, Hilkka Rautiainen, Werner F. Sommer & Ellen Mommers. (2011) Effects of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-oestradiol compared with one containing levonorgestrel and ethinylestradiol on haemostasis, lipids and carbohydrate metabolism. The European Journal of Contraception & Reproductive Health Care 16:6, pages 444-457.
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Lee P Shulman & Jessica W Kiley. (2011) Oral contraception: from birth control to pregnancy prevention with noncontraceptive benefits. Expert Review of Obstetrics & Gynecology 6:5, pages 539-550.
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Luis Bahamondes, Maria Valeria Bahamondes, Arlete Maria dos Santos Fernandes & Ilza Monteiro. (2011) Emerging female contraceptives. Expert Opinion on Emerging Drugs 16:2, pages 373-387.
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Articles from other publishers (26)

Annina Haverinen, Kaisu Luiro, Marika H Kangasniemi, Terhi T Piltonen, Steinar Hustad, Oskari Heikinheimo & Juha S Tapanainen. (2022) Estradiol Valerate vs Ethinylestradiol in Combined Oral Contraceptives: Effects on the Pituitary-Ovarian Axis. The Journal of Clinical Endocrinology & Metabolism 107:7, pages e3008-e3017.
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. (2019) FSRH Guideline (January 2019, amended October 2023) Combined Hormonal Contraception. BMJ Sexual & Reproductive Health 45:Suppl 1, pages 1-93.
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Giuseppe Benagiano, Carlo Bastianelli, Manuela Farris & Ivo Brosens. 2018. Reproductive Medicine for Clinical Practice. Reproductive Medicine for Clinical Practice 133 147 .
Salvatore CarusoStefano CianciMaria CariolaValentina FavaSalvatore Di PasquaAntonio Cianci. (2017) Improvement of Low Sexual Desire Due to Antiandrogenic Combined Oral Contraceptives After Switching to an Oral Contraceptive Containing 17 β -Estradiol . Journal of Women's Health 26:7, pages 728-734.
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Diana Mansour, Carolyn Westhoff, Uma Kher & Tjeerd Korver. (2017) Pooled analysis of two randomized, open-label studies comparing the effects of nomegestrol acetate/17?-estradiol and drospirenone/ethinyl estradiol on bleeding patterns in healthy women. Contraception 95:4, pages 390-397.
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Diana L. Blithe. (2016) Pipeline for contraceptive development. Fertility and Sterility 106:6, pages 1295-1302.
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Y. Zimmerman, J.-M. Foidart, A. Pintiaux, J.-M. Minon, B.C.J.M. Fauser, K. Cobey & H.J.T. Coelingh Bennink. (2015) Restoring testosterone levels by adding dehydroepiandrosterone to a drospirenone containing combined oral contraceptive: I. Endocrine effects. Contraception 91:2, pages 127-133.
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Lino Del Pup, Massimiliano Berretta, Raffaele Di Francia, Carla Cavaliere, Marilena Di Napoli, Gaetano Facchini, Francesco Fiorica, Mario Mileto & Adolf E. Schindler. (2014) Nomegestrol acetate/estradiol hormonal oral contraceptive and breast cancer risk. Anti-Cancer Drugs 25:7, pages 745-750.
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Y. Zimmerman, M. J. C. Eijkemans, H. J. T. Coelingh Bennink, M. A. Blankenstein & B. C. J. M. Fauser. (2013) The effect of combined oral contraception on testosterone levels in healthy women: a systematic review and meta-analysis. Human Reproduction Update 20:1, pages 76-105.
Crossref
Lee P Shulman. (2013) Changing convention in combination oral contraceptives: estradiol and nomegestrol acetate in a monophasic 24/4 regimen. Journal of Family Planning and Reproductive Health Care 39:3, pages 211-216.
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Frank Z. Stanczyk, David F. Archer & Bhagu R. Bhavnani. (2013) Ethinyl estradiol and 17β-estradiol in combined oral contraceptives: pharmacokinetics, pharmacodynamics and risk assessment. Contraception 87:6, pages 706-727.
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Jan Endrikat, Susanne Parke, Dietmar Trummer, Marco Serrani, Ingrid Duijkers & Christine Klipping. (2013) Pituitary, ovarian and additional contraceptive effects of an estradiol-based combined oral contraceptive: results of a randomized, open-label study. Contraception 87:2, pages 227-234.
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Mireille G.F. Gerrits, Peter G. Schnabel, Teun M. Post & Pierre A.M. Peeters. (2013) Pharmacokinetic profile of nomegestrol acetate and 17?-estradiol after multiple and single dosing in healthy women. Contraception 87:2, pages 193-200.
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Katherine A. Lyseng-Williamson, Lily P. H. Yang & Greg L. Plosker. (2012) Nomegestrol acetate/estradiol: a guide to its use in oral contraception. Drugs & Therapy Perspectives 29:1, pages 1-6.
Crossref
TERJE SØRDAL, PAUL GROB & CAROLE VERHOEVEN. (2012) Effects on bone mineral density of a monophasic combined oral contraceptive containing nomegestrol acetate/17β‐estradiol in comparison to levonorgestrel/ethinylestradiol. Acta Obstetricia et Gynecologica Scandinavica 91:11, pages 1279-1285.
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Lily P.H. Yang & Greg L. Plosker. (2012) Nomegestrol Acetate/Estradiol. Drugs 72:14, pages 1917-1928.
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Carolyn Westhoff, Andrew M. Kaunitz, Tjeerd Korver, Werner Sommer, Luis Bahamondes, Philip Darney & Carole Verhoeven. (2012) Efficacy, Safety, and Tolerability of a Monophasic Oral Contraceptive Containing Nomegestrol Acetate and 17β-Estradiol. Obstetrics & Gynecology 119:5, pages 989-999.
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Xiangyan Ruan, Harald Seeger & Alfred O. Mueck. (2012) The pharmacology of nomegestrol acetate. Maturitas 71:4, pages 345-353.
Crossref
F. Trémollieres. (2012) Contraception orale estro-progestative : quelle différence entre éthinylestradiol et estradiol ?. Gynécologie Obstétrique & Fertilité 40:2, pages 109-115.
Crossref
Harry A van Diepen. (2012) Preclinical pharmacological profile of nomegestrol acetate, a synthetic 19-nor-progesterone derivative. Reproductive Biology and Endocrinology 10:1, pages 85.
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Do Won Hahn, John L. McGuire & Joachim Kuhnke. 2003. Ullmann's Encyclopedia of Industrial Chemistry. Ullmann's Encyclopedia of Industrial Chemistry.
Johannes Bitzer & James A. Simon. (2011) Current issues and available options in combined hormonal contraception. Contraception 84:4, pages 342-356.
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Lee P. Shulman. (2011) The state of hormonal contraception today: benefits and risks of hormonal contraceptives: combined estrogen and progestin contraceptives. American Journal of Obstetrics and Gynecology 205:4, pages S9-S13.
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Jeffrey T. Jensen. (2011) The future of contraception: innovations in contraceptive agents: tomorrow's hormonal contraceptive agents and their clinical implications. American Journal of Obstetrics and Gynecology 205:4, pages S21-S25.
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S. Christin-Maitre, D. Serfaty, N. Chabbert-Buffet, E. Ochsenbein, D. Chassard & J.- L. Thomas. (2011) Comparison of a 24-day and a 21-day pill regimen for the novel combined oral contraceptive, nomegestrol acetate and 17 -estradiol (NOMAC/E2): a double-blind, randomized study. Human Reproduction 26:6, pages 1338-1347.
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Alfred O. Mueck & Regine Sitruk-Ware. (2011) Nomegestrol acetate, a novel progestogen for oral contraception. Steroids 76:6, pages 531-539.
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