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Archives of Physiology and Biochemistry
The Journal of Metabolic Diseases
Volume 117, 2011 - Issue 3
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Research Article

p66Shc, a multifaceted protein linking Erk signalling, glucose metabolism, and oxidative stress

Annalisa NatalicchioDepartment of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari School of Medicine, Bari, Italy
,
Federica TortosaDepartment of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari School of Medicine, Bari, Italy
,
Sebastio PerriniDepartment of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari School of Medicine, Bari, Italy
,
Luigi LaviolaDepartment of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari School of Medicine, Bari, Italy
&
Francesco GiorginoDepartment of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari School of Medicine, Bari, ItalyCorrespondence[email protected]
Pages 116-124 | Received 31 Jan 2011, Accepted 08 Feb 2011, Published online: 21 Apr 2011

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He-Dong Liu, Mao-Xian Ren, Yang Li, Ruo-Tian Zhang, Neng-Feng Ma, Tian-Lin Li, Wen-Kai Jiang, Zhi Zhou, Xue-Wei Yao, Zhi-Yi Liu & Min Yang. (2022) Melatonin alleviates hydrogen peroxide induced oxidative damage in MC3T3-E1 cells and promotes osteogenesis by activating SIRT1. Free Radical Research 56:1, pages 63-76.
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Kaitlyn Beyfuss & David A. Hood. (2018) A systematic review of p53 regulation of oxidative stress in skeletal muscle. Redox Report 23:1, pages 100-117.
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Shi-Kun Yang, Li Xiao, Jun Li, Fuyou Liu & Lin Sun. (2014) Oxidative stress, a common molecular pathway for kidney disease: Role of the redox enzyme p66Shc. Renal Failure 36:2, pages 313-320.
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Anna Leonardini & Angelo Avogaro. (2013) Abnormalities of the cardiac stem and progenitor cell compartment in experimental and human diabetes. Archives of Physiology and Biochemistry 119:4, pages 179-187.
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Articles from other publishers (25)

SeyedehFatemeh Mousavi, Mohammad Amin Khazeei Tabari, Alireza Bagheri, Noosha Samieefar, Negar Shaterian & Roya Kelishadi. (2022) The Role of p66Shc in Diabetes: A Comprehensive Review from Bench to Bedside. Journal of Diabetes Research 2022, pages 1-15.
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Yanli Liu, Xia Gong, Juan Wang, Yongxiang Wang, Yong Zhang, Tao Li, Juan Yan, Min Zhou & Benzhong Zhang. (2022) Investigation of nickel sulfate‐induced cytotoxicity and underlying toxicological mechanisms in human umbilical vein endothelial cells through oxidative stress, inflammation, apoptosis, and MAPK signaling pathways . Environmental Toxicology 37:8, pages 2058-2071.
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Landon Haslem, Jennifer M. Hays & Franklin A. Hays. (2022) p66Shc in Cardiovascular Pathology. Cells 11:11, pages 1855.
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Bradley Miller, Kevin Regner & Andrey Sorokin. (2022) p66Shc signaling does not contribute to tubular damage induced by renal ischemia-reperfusion injury in rat. Biochemical and Biophysical Research Communications 603, pages 69-74.
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Claudia Molinaro, Luca Salerno, Fabiola Marino, Mariangela Scalise, Nadia Salerno, Loredana Pagano, Antonella De Angelis, Eleonora Cianflone, Daniele Torella & Konrad Urbanek. (2022) Unraveling and Targeting Myocardial Regeneration Deficit in Diabetes. Antioxidants 11:2, pages 208.
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Yang Yang, Ying Luan, Qi Feng, Xing Chen, Bo Qin, Kai-Di Ren & Yi Luan. (2022) Epigenetics and Beyond: Targeting Histone Methylation to Treat Type 2 Diabetes Mellitus. Frontiers in Pharmacology 12.
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Chaoxing Ren, Xiaowei Zhou, Xiaowen Bao, Jie Zhang, Jun Tang, Zhiming Zhu, Nan Zhang, Yu Bai, Youli Xi, Qi Zhang & Bo Ma. (2021) Dioscorea zingiberensis ameliorates diabetic nephropathy by inhibiting NLRP3 inflammasome and curbing the expression of p66Shc in high-fat diet/streptozotocin-induced diabetic mice . Journal of Pharmacy and Pharmacology 73:9, pages 1218-1229.
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Marlies Corine LudikhuizeMaría José Rodríguez Colman. (2021) Metabolic Regulation of Stem Cells and Differentiation: A Forkhead Box O Transcription Factor Perspective. Antioxidants & Redox Signaling 34:13, pages 1004-1024.
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Stefano Ciciliot & Gian Fadini. (2019) Modulation of Obesity and Insulin Resistance by the Redox Enzyme and Adaptor Protein p66Shc. International Journal of Molecular Sciences 20:4, pages 985.
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Mohammad Hosein Farzaei, Devesh Tewari, Saeideh Momtaz, Sandro Argüelles & Seyed Mohammad Nabavi. (2018) Targeting ERK signaling pathway by polyphenols as novel therapeutic strategy for neurodegeneration. Food and Chemical Toxicology 120, pages 183-195.
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Kevin D. Wright, Alexander Staruschenko & Andrey Sorokin. (2018) Role of adaptor protein p66Shc in renal pathologies. American Journal of Physiology-Renal Physiology 314:2, pages F143-F153.
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Maria Angela Incalza, Rossella D'Oria, Annalisa Natalicchio, Sebastio Perrini, Luigi Laviola & Francesco Giorgino. (2018) Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases. Vascular Pharmacology 100, pages 1-19.
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Dustin K Reed, Anthony Carter, Mehul Dixit & Istvan Arany. (2017) p66shc-mediated toxicity of high-dose α-tocopherol in renal proximal tubule cells. Journal of Physiology and Biochemistry 73:2, pages 267-273.
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Owen G. Davies, Yang Liu, Darren J. Player, Neil R. W. Martin, Liam M. Grover & Mark P. Lewis. (2017) Defining the Balance between Regeneration and Pathological Ossification in Skeletal Muscle Following Traumatic Injury. Frontiers in Physiology 8.
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Julien Wils, Julie Favre & Jérémy Bellien. (2017) Modulating putative endothelial progenitor cells for the treatment of endothelial dysfunction and cardiovascular complications in diabetes. Pharmacology & Therapeutics 170, pages 98-115.
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Lucía Pronsato & Lorena Milanesi. (2016) Effect of testosterone on the regulation of p53 and p66Shc during oxidative stress damage in C2C12 cells. Steroids 106, pages 41-54.
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Ian James Martins. (2016) Anti-Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations. Advances in Aging Research 05:01, pages 9-26.
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Annalisa Natalicchio, Federica Tortosa, Rossella Labarbuta, Giuseppina Biondi, Nicola Marrano, Emanuele Carchia, Anna Leonardini, Angelo Cignarelli, Marco Bugliani, Piero Marchetti, Gian Paolo Fadini, Marco Giorgio, Angelo Avogaro, Sebastio Perrini, Luigi Laviola & Francesco Giorgino. (2015) The p66Shc redox adaptor protein is induced by saturated fatty acids and mediates lipotoxicity-induced apoptosis in pancreatic beta cells. Diabetologia 58:6, pages 1260-1271.
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Magdalena Lebiedzinska-Arciszewska, Monika Oparka, Ignacio Vega-Naredo, Agnieszka Karkucinska-Wieckowska, Paolo Pinton, Jerzy Duszynski & Mariusz R. Wieckowski. (2015) The interplay between p66Shc, reactive oxygen species and cancer cell metabolism. European Journal of Clinical Investigation 45, pages 25-31.
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Rafael S. LindosoFederica CollinoStefania BrunoDayana S. AraujoJulliana F. Sant'AnnaCiro TettaPaolo ProveroPeter J. QuesenberryAdalberto VieyraMarcelo Einicker-LamasGiovanni Camussi. (2014) Extracellular Vesicles Released from Mesenchymal Stromal Cells Modulate miRNA in Renal Tubular Cells and Inhibit ATP Depletion Injury. Stem Cells and Development 23:15, pages 1809-1819.
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Dean H. Betts, Nathan T. Bain & Pavneesh Madan. (2014) The p66Shc Adaptor Protein Controls Oxidative Stress Response in Early Bovine Embryos. PLoS ONE 9:1, pages e86978.
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Guo-Lin Zhang, De-Zai Dai, Can Zhang & Yin Dai. (2013) Apocynin and raisanberine alleviate intermittent hypoxia induced abnormal StAR and 3β-HSD and low testosterone by suppressing endoplasmic reticulum stress and activated p66Shc in rat testes. Reproductive Toxicology 36, pages 60-70.
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Yu-Si Cheng, Xiao-Dong Cong, De-Zai Dai, Yun Zhang & Yin Dai. (2013) Argirein alleviates corpus cavernosum dysfunction by suppressing pro-inflammatory factors p66Shc and ER stress chaperone Bip in diabetic rats. Journal of Pharmacy and Pharmacology 65:1, pages 94-101.
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Melanie K. B. Wills & Nina Jones. (2012) Teaching an old dogma new tricks: twenty years of Shc adaptor signalling. Biochemical Journal 447:1, pages 1-16.
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Zoe Redshaw & Paul T. Loughna. (2012) Oxygen concentration modulates the differentiation of muscle stem cells toward myogenic and adipogenic fates. Differentiation 84:2, pages 193-202.
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