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Research Article

Antidiabetic potential of phycocyanin: Effects on KKAy mice

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Pages 539-544 | Received 22 May 2012, Accepted 04 Nov 2012, Published online: 01 Feb 2013

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Yu Ou, Zhiheng Ren, Jianhui Wang & Xuegan Yang. (2016) Phycocyanin ameliorates alloxan-induced diabetes mellitus in mice: Involved in insulin signaling pathway and GK expression. Chemico-Biological Interactions 247, pages 49-54.
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Yingnv Gao, Gaoyong Liao, Chenxi Xiang, Xuegan Yang, Xiaodong Cheng & Yu Ou. (2016) Effects of phycocyanin on INS-1 pancreatic β-cell mediated by PI3K/Akt/FoxO1 signaling pathway. International Journal of Biological Macromolecules 83, pages 185-194.
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Germán Chamorro-Cevallos. (2016) Methods for Extraction, Isolation and Purification of C-phycocyanin: 50 years of research in review. International Journal of Food and Nutritional Science 3:3, pages 1-10.
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Chitralekha Nag Dasgupta. 2015. Algal Biorefinery: An Integrated Approach. Algal Biorefinery: An Integrated Approach 253 276 .
Gergana Gacheva & Liliana Gigova. (2014) Biological activity of microalgae can be enhanced by manipulating the cultivation temperature and irradiance. Open Life Sciences 9:12, pages 1168-1181.
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Greta Faccio, Michael M. Kämpf, Chiara Piatti, Linda Thöny-Meyer & Michael Richter. (2014) Tyrosinase-catalyzed site-specific immobilization of engineered C-phycocyanin to surface. Scientific Reports 4:1.
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Elena Gardeva, Reneta Toshkova, Liliya Yossifova, Kaledona Minkova, Natalia Ivanova & Liliana Gigova. (2014) Antitumor activity of C-phycocyanin from Arthronema africanum (Cyanophyceae). Brazilian Archives of Biology and Technology 57:5, pages 675-684.
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