2,859
Views
25
CrossRef citations to date
0
Altmetric
Original Article

Metformin inhibits proliferation and proinflammatory cytokines of human keratinocytes in vitro via mTOR-signaling pathway

, , &
Pages 1173-1178 | Received 24 Feb 2015, Accepted 28 May 2015, Published online: 21 Aug 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Huan Lin, Haiyong Ao, Guanghua Guo & Mingzhuo Liu. (2023) The Role and Mechanism of Metformin in Inflammatory Diseases. Journal of Inflammation Research 16, pages 5545-5564.
Read now
Shaomin Zhi, Jun Li, Xiao Kong, Xuemei Xie, Qiangli Zhang & Guoxiang Fang. (2021) Insulin-like growth factor 2 mRNA binding protein 2 regulates proliferation, migration, and angiogenesis of keratinocytes by modulating heparanase stability. Bioengineered 12:2, pages 11267-11276.
Read now
Kiana Jenabikordi, Behzad Sharif Makhmal Zadeh & Anahita Rezaie. (2021) Co-encapsulation of metformin and ginger into the liposomes: in vitro characterization and in vivo anti-psoriasis evaluation. Drug Development and Industrial Pharmacy 47:9, pages 1447-1458.
Read now

Articles from other publishers (22)

Andreea Petrasca, Roisin Hambly, Niamh Kearney, Conor M Smith, Emily K Pender, Julie Mac Mahon, Aoife M O’Rourke, Mohamed Ismaiel, Patrick A Boland, Jose P Almeida, Czara Kennedy, Alexandra Zaborowski, Siun Murphy, Desmond Winter, Brian Kirby & Jean M Fletcher. (2023) Metformin has anti-inflammatory effects and induces immunometabolic reprogramming via multiple mechanisms in hidradenitis suppurativa. British Journal of Dermatology 189:6, pages 730-740.
Crossref
Hee-Geun Jo, Hyehwa Kim, Eunhye Baek, Donghun Lee & Ji Hye Hwang. (2023) Efficacy and Key Materials of East Asian Herbal Medicine Combined with Conventional Medicine on Inflammatory Skin Lesion in Patients with Psoriasis Vulgaris: A Meta-Analysis, Integrated Data Mining, and Network Pharmacology. Pharmaceuticals 16:8, pages 1160.
Crossref
Tithi Roy, Samuel T. Boateng, Mohammad B. Uddin, Sergette Banang-Mbeumi, Rajesh K. Yadav, Chelsea R. Bock, Joy T. Folahan, Xavier Siwe-Noundou, Anthony L. Walker, Judy A. King, Claudia Buerger, Shile Huang & Jean Christopher Chamcheu. (2023) The PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds. Cells 12:12, pages 1671.
Crossref
Roisin Hambly, Niamh Kearney, Rosalind Hughes, Jean M. Fletcher & Brian Kirby. (2023) Metformin Treatment of Hidradenitis Suppurativa: Effect on Metabolic Parameters, Inflammation, Cardiovascular Risk Biomarkers, and Immune Mediators. International Journal of Molecular Sciences 24:8, pages 6969.
Crossref
Guanyi Liu, Dingyang Li, Liwei Zhang, Qiuping Xu, Dexuan Zhuang, Panpan Liu, Ling Hu, Huiting Deng, Jianfeng Sun, Shuangshuang Wang, Bin Zheng, Jing Guo & Xunwei Wu. (2022) Phenformin Down-Regulates c-Myc Expression to Suppress the Expression of Pro-Inflammatory Cytokines in Keratinocytes. Cells 11:15, pages 2429.
Crossref
Jessica Shiu, Lihua Zhang, Griffin Lentsch, Jessica L. Flesher, Suoqin Jin, Christopher Polleys, Seong Jin Jo, Craig Mizzoni, Pezhman Mobasher, Jasmine Kwan, Francisca Rius-Diaz, Bruce J. Tromberg, Irene Georgakoudi, Qing Nie, Mihaela Balu & Anand K. Ganesan. (2022) Multimodal analyses of vitiligo skin identifies tissue characteristics of stable disease. JCI Insight 7:13.
Crossref
Huynh Thi Xuan Tam, Luong Nguyen Dac Thuy, Ngo Minh Vinh, Tran Ngoc Anh & Bui Thi Van. (2022) The Combined Use of Metformin and Methotrexate in Psoriasis Patients with Metabolic Syndrome. Dermatology Research and Practice 2022, pages 1-7.
Crossref
Shekhar Neema, Sunmeet Sandhu, Ankan Gupta, Soumya Jagadeesan & Biju Vasudevan. (2021) Unconventional treatment options in psoriasis: A review. Indian Journal of Dermatology, Venereology and Leprology 88, pages 137-143.
Crossref
Ana Maria Alexandra Stanescu, Anca Angela Simionescu, Mira Florea & Camelia Cristina Diaconu. (2021) Is Metformin a Possible Beneficial Treatment for Psoriasis? A Scoping Review. Journal of Personalized Medicine 11:4, pages 251.
Crossref
Ching‐Chi Chi, Chin‐Yu Lee, Chia‐Yu Liu, Shu‐Hui Wang, Felice Tien O’Donnell & Tao‐Hsin Tung. (2020) Effects of antidiabetic drugs on psoriasis: A meta‐analysis. European Journal of Clinical Investigation 51:2.
Crossref
K.R. van Straalen, S. Schneider‐Burrus & E.P. Prens. (2018) Current and future treatment of hidradenitis suppurativa. British Journal of Dermatology 183:6.
Crossref
Ji-Eun Chang & Min Sik Choi. (2020) A Molecular Perspective on the Potential Benefits of Metformin for the Treatment of Inflammatory Skin Disorders. International Journal of Molecular Sciences 21:23, pages 8960.
Crossref
Lingxiao Chen, Haiming Chen, Yue Lu, Ling Han, Shenfei Wang, Meiting Liu, Xiong Li, Jing Zhao, Chuanjian Lu & Shaoping Li. (2020) Decoding active components in a formulation of multiple herbs for treatment of psoriasis based on three cell lines fishing and liquid chromatography-mass spectrometry analysis. Journal of Pharmaceutical and Biomedical Analysis 186, pages 113331.
Crossref
Samantha R. Goldburg, Bruce E. Strober & Michael J. Payette. (2020) Hidradenitis suppurativa. Journal of the American Academy of Dermatology 82:5, pages 1061-1082.
Crossref
Gaku Tsuji, Akiko Hashimoto-Hachiya, Vu Hai Yen, Masaki Takemura, Ayako Yumine, Kazuhisa Furue, Masutaka Furue & Takeshi Nakahara. (2020) Metformin inhibits IL-1β secretion via impairment of NLRP3 inflammasome in keratinocytes: implications for preventing the development of psoriasis. Cell Death Discovery 6:1.
Crossref
Minjung Chae, Eui Dong Son, Il-Hong Bae, Eun-Gyung Cho, Hyoung-June Kim & Ji-Yong Jung. (2020) UVB-dependent inhibition of lipin-1 protects against proinflammatory responses in human keratinocytes. Experimental & Molecular Medicine 52:2, pages 293-307.
Crossref
Pugazhenthan Thangaraju, ShobanBabu Varthya & Sajitha Venkatesan. (2020) Target/therapies for chronic recurrent erythema nodosum leprosum. Indian Journal of Pharmacology 52:3, pages 222.
Crossref
Liu Zhu, Chao Li, Qiang Liu, Weiting Xu & Xiang Zhou. (2019) Molecular biomarkers in cardiac hypertrophy. Journal of Cellular and Molecular Medicine 23:3, pages 1671-1677.
Crossref
B.C. Melnik, S.M. John, W. Chen & G. Plewig. (2018) T helper 17 cell/regulatory T-cell imbalance in hidradenitis suppurativa/acne inversa: the link to hair follicle dissection, obesity, smoking and autoimmune comorbidities. British Journal of Dermatology.
Crossref
Xiaoyan Wang, Ronghua Li, Xintong Zhao, Xiaojing Yu & Qing Sun. (2018) Metformin Promotes HaCaT Cell Apoptosis through Generation of Reactive Oxygen Species via Raf-1-ERK1/2-Nrf2 Inactivation. Inflammation 41:3, pages 948-958.
Crossref
Richard GA Faragher, Anne McArdle, Alison Willows & Elizabeth L. Ostler. (2017) Senescence in the aging process. F1000Research 6, pages 1219.
Crossref
Yi Xiao, Guowei Zhou, Danrong Jing, zhenwei Tang, Cong Peng, Yehong Kuang, Wu Zhu, Xiang Chen, hong Liu & Minxue Shen. (2022) AMPK Activation, A Target of Metformin, is Associated with the Risk of Psoriasis and its Comorbidities in the UK Biobank: A Mendelian Randomization Study. SSRN Electronic Journal.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.