References
- Abdou AG, Hanout HM. (2008). Evaluation of survivin and NF-kappaB in psoriasis, an immunohistochemical study. J Cutan Pathol 35:445–51
- Ben Sahra I, Regazzetti C, Robert G, et al. (2011). Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1. Cancer Res 71:4366–72
- Boukamp P, Petrussevska RT, Breitkreutz D, et al. (1988). Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol 106:761–71
- Brauchli YB, Jick SS, Curtin F, et al. (2008). Association between use of thiazolidinediones or other oral antidiabetics and psoriasis: A population based case–control study. J Am Acad Dermatol 58:421–9
- Buerger C, Malisiewicz B, Eiser A, et al. (2013). mTOR and its downstream signalling components are activated in psoriatic skin. Br J Dermatol 169:156–9
- Choi YK, Park KG. (2013). Metabolic roles of AMPK and metformin in cancer cells. Mol Cells 36:279–87
- Frigerio E, Colombo MD, Franchi C. (2007). Severe psoriasis treated with a new macrolide: Everolimus. Br J Dermatol 156:372–4
- Huang T, Lin X, Meng X. (2014). Phosphoinositide-3 kinase/protein kinase-B/mammalian target of rapamycin pathway in psoriasis pathogenesis. A potential therapeutic target? Acta Derm Venereol 94:371–9.
- Kahn BB, Alquier T, Caning D, et al. (2005). AMP activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 1:15–25
- Karar J, Maity A. (2011). PI3K/AKT/mTOR Pathway in angiogenesis. Front Mol Neurosci 2011;4:51. doi: 10.3389/fnmol.2011.00051
- Kirsch AH, Riegelbauer V, Tagwerker A, et al. (2012). The mTOR-inhibitor rapamycin mediates proteinuria in nephrotoxic serum nephritis by activating the innate immune response. Am J Physiol Renal Physiol 303:569–75
- Leone A, Di Gennaro E, Bruzzese F, et al. (2014). New perspective for an old antidiabetic drug: Metformin as anticancer agent. Cancer Treat Res 159:355–76
- Li W, Ma W, Zhong H, et al. (2014). Metformin inhibits proliferation of human keratinocytes through a mechanism associated with activation of the MAPK signaling pathway. Exp Ther Med 7:389–92
- Mitra A, Raychaudhuri SK, Raychaudhuri SP. (2012). IL-22 induced cell proliferation is regulated by PI3K/Akt/mTOR signaling cascade. Cytokine 60:38–42
- Nestle FO, Kaplan DH, Barker J. (2009). Psoriasis. N Engl J Med 361:496–509
- Ormerod AD, Shah SA, Copeland P, et al. (2005). Treatment of psoriasis with topical sirolimus: Preclinical development and a randomized, double-blind trial. Br J Dermatol 152:758–64
- Pollak M. (2010). Metformin and other biguanides in oncology: Advancing the research agenda. Cancer Prev Res (Phila) 3:1060–5
- Reitamo S, Spuls P, Sassolas B, et al. Sirolimu European Psoriasis Study Group. (2001) Efficacy of sirolimus (rapamycin) administered concomitantly with a subtherapeutic dose of cyclosporin in the treatment of severe psoriasis: A randomized controlled trial. Br J Dermatol 145:438–45
- Soliman GA. (2013). The role of mechanistic target of rapamycin (mTOR) complexes signaling in the immune responses. Nutrients 5:2231–57
- Stein M, Bernd A, Ramirez-Bosca A, et al. (1997). Measurement of anti-inflammatory effects of glucocorticoids on human keratinocytes in vitro. Comparison of normal human keratinocytes with the keratinocyte cell line HaCaT. Arzneimittelforschung 47:1266–70
- Storozhuk Y, Hopmans SN, Sanli T, et al. (2013). Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK. Br J Cancer 108:2021–32
- Taubes G. (2012). Cancer research. Cancer prevention with a diabetes pill? Science. 335:29
- Wang XW, Zhang YJ. (2014). Targeting mTOR network in colorectal cancer therapy. World J Gastroenterolb 20:4178–88
- Wei KC, Lai PC. (2015). Combination of everolimus and tacrolimus: A potentially effective regimen for recalcitrant psoriasis. Dermatol Ther 28:25–7
- Weichhart T, Säemann MD. (2008). The PI3K/Akt/mTOR pathway in innate immune cells: Emerging therapeutic applications. Ann Rheum Dis 67:iii70–4
- Wu CY, Shieh JJ, Shen JL, et al. (2015). Association between antidiabetic drugs and psoriasis risk in diabetic patients: Results from a nationwide nested case-control study in Taiwan. J Am Acad Dermatol 72:123–30
- Zhang J, Ma WY. (2014). Nerve growth factor regulates the expression of vascular endothelial growth factor in human HaCaT keratinocytes via PI3K/mTOR pathway. Genet Mol Res 13:9324–35