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Research Article

Saponin-enriched sea cucumber extracts exhibit an antiobesity effect through inhibition of pancreatic lipase activity and upregulation of LXR-β signaling

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Pages 1312-1325 | Received 12 Nov 2014, Accepted 11 Jul 2015, Published online: 06 Oct 2015

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Ruilin Li, Zihan Xue, Yanan Jia, Yajie Wang, Shuqin Li, Jingna Zhou, Junyu Liu, Min Zhang, Chengwei He & Haixia Chen. (2021) Polysaccharides from mulberry (Morus alba L.) leaf prevents obesity by inhibiting pancreatic lipase in high-fat diet induced mice. International Journal of Biological Macromolecules 192, pages 452-460.
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Rong Li, Jing Meng, Haohao Shi, Chengcheng Wang, Zhaojie Li, Changhu Xue, Yuming Wang & Tiantian Zhang. (2021) Dietary Supplementation with Sea Cucumber Saponins and Exercise Can Significantly Suppress Adipose Accumulation in Mice Fed with High-Fat Diet. Journal of Ocean University of China 20:3, pages 629-640.
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Alan Ramalho, Nadine Leblanc, Marie-Gil Fortin, André Marette, André Tchernof & Hélène Jacques. (2020) Characterization of a Coproduct from the Sea Cucumber Cucumaria frondosa and Its Effects on Visceral Adipocyte Size in Male Wistar Rats. Marine Drugs 18:11, pages 530.
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Mohd Rehan, Shafiullah & Sameer A. Mir. (2020) Structural diversity, natural sources, and pharmacological potential of plant-based saponins with special focus on anticancer activity: a review. Medicinal Chemistry Research 29:10, pages 1707-1722.
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Binsong Han, Yaqiong Jian, Xubin Xia, Wei Hu, Lina Zhang & Peng Zhou. (2020) Studying the effects of sea cucumber ovum powder on nonalcoholic fatty liver disease by proteomics techniques in a rat model. Food & Function 11:7, pages 6139-6147.
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Leticia Olivera-Castillo, George Grant, Nuvia Kantún-Moreno, Hirian A. Barrera-Pérez, Jorge Montero, Miguel A. Olvera-Novoa, Leydi M. Carrillo-Cocom, Juan J. Acevedo, Cesar Puerto-Castillo, Victor May Solís, Juan A. Pérez-Vega, Judit Gil-Zamorano, Enrique Hernández-Garibay, María A. Fernández-Herrera, Mayra Pérez-Tapia, Oscar Medina-Contreras, Jairo R. Villanueva-Toledo, Rossanna Rodriguez-Canul & Alberto Dávalos. (2020) A Glycosaminoglycan-Rich Fraction from Sea Cucumber Isostichopus badionotus Has Potent Anti-Inflammatory Properties In Vitro and In Vivo. Nutrients 12:6, pages 1698.
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Ansharullah, Tamrin, A B Patadjai & Asranuddin. (2020) Powder production of sea cucumber (Holothuria scabra): effect of processing methods on the antioxidant activities and physico-chemical characteristics. IOP Conference Series: Earth and Environmental Science 443:1, pages 012024.
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Nahla E. Omran, Hoda K. Salem, Samia H. Eissa, Amal M. Kabbash, Manar A. Kandeil & Mohamed A. Salem. (2019) Chemotaxonomic study of the most abundant Egyptian sea-cucumbers using ultra-performance liquid chromatography (UPLC) coupled to high-resolution mass spectrometry (HRMS). Chemoecology 30:1, pages 35-48.
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A. Shadi & A. Oujifard. (2018) Antibacterial, cytotoxic and hemolytic activity of Holothuria parva sea cucumber from north Persian Gulf. International Journal of Environmental Science and Technology 16:10, pages 5937-5944.
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Kawita Chumphoochai, Pawanrat Chalorak, Worawit Suphamungmee, Prasert Sobhon & Krai Meemon. (2019) Saponin‐enriched extracts from body wall and Cuvierian tubule of Holothuria leucospilota reduce fat accumulation and suppress lipogenesis in Caenorhabditis elegans . Journal of the Science of Food and Agriculture 99:8, pages 4158-4166.
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Cheng Xu, Rui Zhang & Zhiyou Wen. (2018) Bioactive compounds and biological functions of sea cucumbers as potential functional foods. Journal of Functional Foods 49, pages 73-84.
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Lin Ding, Tian-Tian Zhang, Hong-Xia Che, Ling-Yu Zhang, Chang-Hu Xue, Yao-Guang Chang & Yu-Ming Wang. (2018) Saponins of sea cucumber attenuate atherosclerosis in ApoE−/− mice via lipid-lowering and anti-inflammatory properties. Journal of Functional Foods 48, pages 490-497.
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Ying-Cai Zhao, Chang-Hu Xue, Tian-Tian Zhang & Yu-Ming Wang. (2018) Saponins from Sea Cucumber and Their Biological Activities. Journal of Agricultural and Food Chemistry 66:28, pages 7222-7237.
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Ratih Pangestuti & Zainal Arifin. (2018) Medicinal and health benefit effects of functional sea cucumbers. Journal of Traditional and Complementary Medicine 8:3, pages 341-351.
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Qi-an Han, Kaifeng Li, Xiuping Dong, Yongkang Luo & Beiwei Zhu. (2018) Function of Thelenota ananas saponin desulfated holothurin A in modulating cholesterol metabolism. Scientific Reports 8:1.
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Yuri Khotimchenko. (2018) Pharmacological Potential of Sea Cucumbers. International Journal of Molecular Sciences 19:5, pages 1342.
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Surendiran Gangadaran & Sukhinder Kaur Cheema. (2017) A high fat diet enriched with sea cucumber gut powder provides cardio-protective and anti-obesity effects in C57BL/6 mice. Food Research International 99, pages 799-806.
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Lu Peng, Xing-Shan Zhao & Dacheng Peng. (2017) Anti-obesity Effect of a Novel Potent Synthetic Steroidal Liver X Receptor α (LXRα)-selective Agonist in Male ob/ob C57BL/6 Mice. International Journal of Pharmacology 13:6, pages 636-642.
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