2,922
Views
26
CrossRef citations to date
0
Altmetric
Research Article

Saponin-enriched sea cucumber extracts exhibit an antiobesity effect through inhibition of pancreatic lipase activity and upregulation of LXR-β signaling

, , , , , & show all
Pages 1312-1325 | Received 12 Nov 2014, Accepted 11 Jul 2015, Published online: 06 Oct 2015

References

  • Abedin MZ, Karim AA, Ahmed F, et al. (2013). Isolation and characterization of pepsin-solubilized collagen from the integument of sea cucumber (Stichopus vastus). J Sci Food Agric 93:1083–8.
  • Anderson RE, Bottino NR, Reiser R. (1967). Pancreatic lipase hydrolysis as a source of diglycerides for the stereospecific analysis of triglycerides. Lipids 2:440–2.
  • Ballinger A, Peikin SR. (2002). Orlistat: Its current status as an anti-obesity drug. Eur J Pharmacol 440:109–17.
  • Baranowski M. (2008). Biological role of liver X receptors. J Physiol Pharmacol 59:31–55.
  • Beyea MM, Heslop CL, Sawyez CG, et al. (2007). Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol. J Biol Chem 282:5207–16.
  • Bohlooli S, Jafari N, Jahed S. (2012). Cytotoxic effect of freeze-dried extract of Ecballium elaterium fruit on gastric adenocarcinoma (AGS) and esophageal squamous cell carcinoma (KYSE30) cell lines. J Gastrointest Cancer 43:579–83.
  • Birari RB, Bhutani KK. (2007). Pancreatic lipase inhibitors from natural sources: Unexplored potential. Drug Discov Today 12:879–89.
  • Crandall WV, Lowe ME. (2001). Colipase residues Glu64 and Arg65 are essential for normal lipase-mediated fat digestion in the presence of bile salt micelles. J Biol Chem 276:12505–12.
  • de la Garza AL, Milagro FI, Boque N, et al. (2011). Natural inhibitors of pancreatic lipase as new players in obesity treatment. Planta Med 77:773–85.
  • Deters AM, Lengsfeld C, Hensel A. (2005). Oligo- and polysaccharides exhibit a structure-dependent bioactivity on human keratinocytes in vitro. J Ethnopharmacol 102:391–9.
  • Drent ML, van der Veen EA. (1995). First clinical studies with orlistat: A short review. Obes Res 3:623S–5.
  • Folch J, Lees M, Sloane Stanley GH. (1957). A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226:497–509.
  • Gao Y, Islam MS, Tian J, et al. (2014). Inactivation of ATP citrate lyase by Cucurbitacin B: A bioactive compound from cucumber, inhibits prostate cancer growth. Cancer Lett 349:15–25.
  • Grove KA, Sae-tan S, Kennett MJ, et al. (2012). (−)-Epigallocatechin-3-gallate inhibits pancreatic lipase and reduces body weight gain in high fat-fed obese mice. Obesity (Silver Spring) 20:2311–13.
  • Han LK, Takaku T, Li J, et al. (1999). Anti-obesity action of oolong tea. Int J Obes Relat Metab Disord 23:98–105.
  • Han LK, Zheng YN, Yoshikawa M, et al. (2005). Anti-obesity effects of chikusetsusaponins isolated from Panax japonicus rhizomes. BMC Complement Altern Med 5:9.
  • Haslam DW, James WP. (2005). Obesity. Lancet 366:1197–209.
  • Hsieh CJ, Wang PW, Liu RT, et al. (2005). Orlistat for obesity: Benefits beyond weight loss. Diabetes Res Clin Pract 67:78–83.
  • Hu X, Li Z, Xue Y, et al. (2012). Dietary saponins of sea cucumber ameliorate obesity, hepatic steatosis, and glucose intolerance in high-fat diet-fed mice. J Med Food 15:909–16.
  • Jiang HL, Niu JJ, Zhang WF, et al. (2014). The role of central nervous system on hypoglycemia and the feasibility of the brain theory in traditional Chinese medicine on treatment of diabetes mellitus. J Integr Med 12:1–6.
  • Jung UJ, Lee MK, Park YB, et al. (2006). Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice. Int J Biochem Cell Biol 38:1134–45.
  • Lowe ME. (1997). Structure and function of pancreatic lipase and colipase. Annu Rev Nutr 17:141–58.
  • Luo L, Wu M, Xu L, et al. (2013). Comparison of physicochemical characteristics and anticoagulant activities of polysaccharides from three sea cucumbers. Mar Drugs 11:399–417.
  • Ma X, Kundu N, Collin PD, et al. (2012). Frondoside A inhibits breast cancer metastasis and antagonizes prostaglandin E receptors EP4 and EP2. Breast Cancer Res Treat 132:1001–8.
  • Masuko T, Minami A, Iwasaki N, et al. (2005). Carbohydrate analysis by a phenol-sulfuric acid method in microplate format. Anal Biochem 339:69–72.
  • Melnikova I, Wages D. (2006). Anti-obesity therapies. Nat Rev Drug Discov 5:369–70.
  • Oram JF. (2003). HDL apolipoproteins and ABCA1: Partners in the removal of excess cellular cholesterol. Arterioscler Thromb Vasc Biol 23:720–7.
  • Osbourn A, Goss RJ, Field RA. (2011). The saponins: Polar isoprenoids with important and diverse biological activities. Nat Prod Rep 28:1261–8.
  • Roh C, Jung U. (2012). Screening of crude plant extracts with anti-obesity activity. Int J Mol Sci 13:1710–19.
  • Slanc P, Doljak B, Kreft S, et al. (2009). Screening of selected food and medicinal plant extracts for pancreatic lipase inhibition. Phytother Res 23:874–7.
  • Sparrow CP, Baffic J, Lam MH, et al. (2002). A potent synthetic LXR agonist is more effective than cholesterol loading at inducing ABCA1 mRNA and stimulating cholesterol efflux. J Biol Chem 277:10021–7.
  • Terasaka N, Hiroshima A, Koieyama T, et al. (2003). T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice. FEBS Lett 536:6–11.
  • Thomson AB, De Pover A, Keelan M, et al. (1997). Inhibition of lipid absorption as an approach to the treatment of obesity. Methods Enzymol 286:3–44.
  • Tian X, Tang H, Lin H, et al. (2013). Saponins: The potential chemotherapeutic agents in pursuing new anti-glioblastoma drugs. Mini Rev Med Chem 13:1709–24.
  • Van Dyck S, Gerbaux P, Flammang P. (2010). Qualitative and quantitative saponin contents in five sea cucumbers from the Indian ocean. Mar Drugs 8:173–89.
  • Weisberg SP, McCann D, Desai M, et al. (2003). Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796–808.
  • Wijesinghe WA, Jeon YJ, Ramasamy P, et al. (2013). Anticancer activity and mediation of apoptosis in human HL-60 leukaemia cells by edible sea cucumber (Holothuria edulis) extract. Food Chem 139:326–31.
  • Zhang B, Xue C, Hu X, et al. (2012a). Dietary sea cucumber cerebroside alleviates orotic acid-induced excess hepatic adipopexis in rats. Lipids Health Dis 11:48.
  • Zhang Y, Fan S, Hu N, et al. (2012b). Rhein reduces fat weight in db/db mouse and prevents diet-induced obesity in C57Bl/6 mouse through the inhibition of PPARgamma signaling. PPAR Res 2012:374936.
  • Zhao HL, Kim YS. (2004). Determination of the kinetic properties of platycodin D for the inhibition of pancreatic lipase using a 1,2-diglyceride-based colorimetric assay. Arch Pharm Res 27:1048–52.
  • Zhao Q, Xue Y, Wang JF, et al. (2012). In vitro and in vivo anti-tumour activities of echinoside A and ds-echinoside A from Pearsonothuria graeffei. J Sci Food Agric 92:965–74.
  • Zheng Q, Koike K, Han LK, et al. (2004). New biologically active triterpenoid saponins from Scabiosa tschiliensis. J Nat Prod 67:604–13.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.