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Pharmaceutical Biology Volume 54, 2016 - Issue 9
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Research Article

Pharmacokinetic study of harmane and its 10 metabolites in rat after intravenous and oral administration by UPLC-ESI-MS/MS

Shuping LiThe MOE Key Laboratory for Standardization of Chinese Medicines, The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China; ;Department of Pharmacy, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China;
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Liang TengThe MOE Key Laboratory for Standardization of Chinese Medicines, The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China; ;Department of Pharmacy, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China;
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Wei LiuThe MOE Key Laboratory for Standardization of Chinese Medicines, The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China;
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Xuemei ChengThe MOE Key Laboratory for Standardization of Chinese Medicines, The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China; ;Shanghai R&D Centre for Standardization of Chinese Medicines, Shanghai, China
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Bo JiangThe MOE Key Laboratory for Standardization of Chinese Medicines, The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China;
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Zhengtao WangThe MOE Key Laboratory for Standardization of Chinese Medicines, The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China; ;Shanghai R&D Centre for Standardization of Chinese Medicines, Shanghai, China
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Chang-hong WangThe MOE Key Laboratory for Standardization of Chinese Medicines, The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China; ;Shanghai R&D Centre for Standardization of Chinese Medicines, Shanghai, ChinaCorrespondence[email protected]
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Pages 1768-1781 | Received 19 Apr 2015, Accepted 28 Nov 2015, Published online: 05 Jan 2016

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Nigar Yilmaz, Yasemin Ustundag, Seyda Kivrak, Serdar Kahvecioglu, Huseyin Celik, Ibrahim Kivrak & Kağan Huysal. (2016) Serum indoleamine 2,3 dioxygenase and tryptophan and kynurenine ratio using the UPLC-MS/MS method, in patients undergoing peritoneal dialysis, hemodialysis, and kidney transplantation. Renal Failure 38:8, pages 1300-1309.
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Articles from other publishers (12)

Bao Tan Nguyen, Nguyen Thi Hai Yen, Ninh Khac Thanh Tung, Gil-Saeng Jeong, Jong Seong Kang, Nguyen Phuoc Long & Hyung Min Kim. (2023) Lipid class-dependent alterations of Caenorhabditis elegans under harmane exposure. Journal of Pharmaceutical and Biomedical Analysis 231, pages 115401.
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Rania Aro, Amandine Nachtergael, Laurence Ris, Mario Manto & Pierre Duez. (2023) Essential tremor: A three-dimensional neurosphere in vitro model to assess the neurotoxicity of harmane. Journal of Traditional Chinese Medical Sciences 10:1, pages 19-34.
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Toluwase Hezekiah Fatoki, Stanley Chukwuejim, Omodele Ibraheem, Christiana Abiodun Oke, Blessing Anuoluwapo Ejimadu, Isaiah Oluwamayomikun Olaoye, Oluwabukola Islamiat Oyegbenro, Taiwo Hannah Salami, Romilola Jumoke Basorun, Oluwafisayomi Taiwo Oluwadare & Yetunde Zainab Salawudeen. (2022) Harmine and 7,8-dihydroxyflavone synergistically suitable for amyotrophic lateral sclerosis management: An in silico study. Research Results in Pharmacology 8:3, pages 49-61.
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Ning Cao, Shuping Li, Aimin Xu, Manlin Li, Xiaoguang Zou, Zunji Ke, Gang Deng, Xuemei Cheng & Changhong Wang. (2022) Dynamic Changes of Endogenic or Exogenic β-Carboline Alkaloid Harmine in Different Mammals and Human in vivo at Developmental and Physiological States. Frontiers in Aging Neuroscience 13.
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Faisal Omar, Abu Montakim Tareq, Ali M. Alqahtani, Kuldeep Dhama, Mohammed Abu Sayeed, Talha Bin Emran & Jesus Simal-Gandara. (2021) Plant-Based Indole Alkaloids: A Comprehensive Overview from a Pharmacological Perspective. Molecules 26:8, pages 2297.
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Andrew C. Harris, Peter Muelken & Mark G. LeSage. (2020) β-Carbolines found in cigarette smoke elevate intracranial self-stimulation thresholds in rats. Pharmacology Biochemistry and Behavior 198, pages 173041.
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Renata Zawirska-Wojtasiak, Agnieszka Fedoruk-Wyszomirska, Paulina Piechowska, Sylwia Mildner-Szkudlarz, Joanna Bajerska, Elżbieta Wojtowicz, Krzysztof Przygoński, Dorota Gurda, Wiktoria Kubicka & Eliza Wyszko. (2020) β-Carbolines in Experiments on Laboratory Animals. International Journal of Molecular Sciences 21:15, pages 5245.
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Bruno Lima Giacobbo, Janine Doorduin, Rodrigo Moraga-Amaro, Luiza Reali Nazario, Anna Schildt, Elke Bromberg, Rudi A.J.O. Dierckx & Erik F.J. de Vries. (2020) Chronic harmine treatment has a delayed effect on mobility in control and socially defeated rats. Psychopharmacology 237:6, pages 1595-1606.
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Paulina Piechowska, Renata Zawirska-Wojtasiak & Sylwia Mildner-Szkudlarz. (2019) Bioactive β-Carbolines in Food: A Review. Nutrients 11:4, pages 814.
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Yunpeng Zhang, Shuping Li, Youxu Wang, Gang Deng, Ning Cao, Chao Wu, Wenzheng Ding, Yuwen Wang, Xuemei Cheng & Changhong Wang. (2019) Potential Pharmacokinetic Drug–Drug Interaction Between Harmine, a Cholinesterase Inhibitor, and Memantine, a Non-Competitive N-Methyl-d-Aspartate Receptor Antagonist. Molecules 24:7, pages 1430.
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Chang Liu, Rong-Rong Cheng, Li Yang, Zhong-Chen Song & Zheng-Tao Wang. (2019) Inhibition of CYP450 enzymes by quassinoids from Picrasma quassioides leaves. Phytochemistry Letters 30, pages 138-142.
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Shuping Li, Xuemei Cheng & Changhong Wang. (2017) A review on traditional uses, phytochemistry, pharmacology, pharmacokinetics and toxicology of the genus Peganum. Journal of Ethnopharmacology 203, pages 127-162.
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