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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 26, 2011 - Issue 1
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Research Article

Analysis of highly potent amidine containing inhibitors of serine proteases and their N-hydroxylated prodrugs (amidoximes)

Joscha KotthausDepartment of Pharmaceutical and Medicinal Chemistry, Pharmaceutical Institute, Christian-Albrechts-University of Kiel, Gutenbergstr, Kiel, Germany
,
Torsten SteinmetzerInstitute of Pharmaceutical Chemistry, Philipps University Marburg, Marburg, Germany
,
Andreas van de LochtThe Medicines Company, Deutscher Platz, Leipzig, Germany
&
Bernd ClementDepartment of Pharmaceutical and Medicinal Chemistry, Pharmaceutical Institute, Christian-Albrechts-University of Kiel, Gutenbergstr, Kiel, GermanyCorrespondence[email protected]
Pages 115-122 | Received 14 Jan 2010, Accepted 23 Feb 2010, Published online: 28 Jun 2010

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Kevin R. Lynch, S. Brandon Thorpe & Webster L. Santos. (2016) Sphingosine kinase inhibitors: a review of patent literature (2006-2015). Expert Opinion on Therapeutic Patents 26:12, pages 1409-1416.
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Danilo Froriep, Bernd Clement, Florian Bittner, Ralf R. Mendel, Debora Reichmann, Wolfgang Schmalix & Antje Havemeyer. (2013) Activation of the anti-cancer agent upamostat by the mARC enzyme system. Xenobiotica 43:9, pages 780-784.
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Articles from other publishers (14)

Jianglong Wu, Zhongjie Wang, Chenyu Wang, Yan Wang, Hongjun Li, Hui Luo, Hao Li, Fuqiang Wang, Dianjun Li & Jinhui Yang. (2023) Research Progress on the Synthesis of Nitrogen-Containing Compounds with Cyanamide as a Building Block. Chinese Journal of Organic Chemistry 43:2, pages 436.
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Fattaneh Mohammadpour & Arash Ghaderi. (2022) Synthesis of N-sulfonylamidines via three-component reaction of proline, aldehydes, and sulfonyl azides under metal-free conditions. Monatshefte für Chemie - Chemical Monthly 153:5-6, pages 487-494.
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Jan Samsonowicz-Górski, Paweł Kowalczyk, Dominik Koszelewski, Anna Brodzka, Mateusz Szymczak, Karol Kramkowski & Ryszard Ostaszewski. (2021) The Synthesis and Evaluation of Amidoximes as Cytotoxic Agents on Model Bacterial E. coli Strains. Materials 14:24, pages 7577.
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Ekaterina V. Bogdanova, Marina Yu. Stogniy, Kyrill Yu. Suponitsky, Igor B. Sivaev & Vladimir I. Bregadze. (2021) Synthesis of Boronated Amidines by Addition of Amines to Nitrilium Derivative of Cobalt Bis(Dicarbollide). Molecules 26:21, pages 6544.
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Yanhong Bu, Hong Wu, Ran Deng & Yan Wang. (2021) Therapeutic Potential of SphK1 Inhibitors Based on Abnormal Expression of SphK1 in Inflammatory Immune Related-Diseases. Frontiers in Pharmacology 12.
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G. Stuart Cockerill, Richard M. AngellAlexandre BedernjakIrina ChuckowreeIan FraserJose Gascon-SimorteMorgan S. A. Gilman, James A. D. GoodRachel HarlandSara M. Johnson, John H Ludes-Meyers, Edward LittlerJames LumleyGraham LunnNeil MathewsJason S. McLellan, Michael ParadowskiMark E. Peeples, Claire ScottDereck TaitGeraldine TaylorMichelle ThomElaine ThomasCarol Villalonga BarberSimon E. Ward, Daniel Watterson, Gareth WilliamsPaul Young & Kenneth Powell. (2021) Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion. Journal of Medicinal Chemistry 64:7, pages 3658-3676.
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Cristina Maccallini, Lisa Marinelli, Patrick Indorf, Ivana Cacciatore, Marialuigia Fantacuzzi, Bernd Clement, Antonio Di Stefano & Rosa Amoroso. (2020) A Novel Prodrug of a nNOS Inhibitor with Improved Pharmacokinetic Potential. ChemMedChem 15:22, pages 2157-2163.
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Salman Shojaei, Zarrin Ghasemi & Aziz Shahrisa. (2017) Three-component synthesis of N-sulfonylformamidines in the presence of magnetic cellulose supported N-heterocyclic carbene-copper complex, as an efficient heterogeneous nanocatalyst. Tetrahedron Letters 58:42, pages 3957-3965.
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Jonas Rydfjord, Bobo Skillinghaug, Peter Brandt, Luke R. Odell & Mats Larhed. (2017) Route to 3-Amidino Indoles via Pd(II)-Catalyzed C–H Bond Activation. Organic Letters 19:15, pages 4066-4069.
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Shiao Y. Chow & Luke R. Odell. (2017) Synthesis of N-Sulfonyl Amidines and Acyl Sulfonyl Ureas from Sulfonyl Azides, Carbon Monoxide, and Amides. The Journal of Organic Chemistry 82:5, pages 2515-2522.
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Boris Vabre, Yves Canac, Christine Lepetit, Carine Duhayon, Remi Chauvin & Davit Zargarian. (2015) Charge Effects in PCP Pincer Complexes of Ni II bearing Phosphinite and Imidazol(i)ophosphine Coordinating Jaws: From Synthesis to Catalysis through Bonding Analysis . Chemistry - A European Journal 21:48, pages 17403-17414.
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Jonas Rydfjord, Fredrik Svensson, Alejandro Trejos, Per J. R. Sjöberg, Christian Sköld, Jonas Sävmarker, Luke R. Odell & Mats Larhed. (2013) Decarboxylative Palladium(II)‐Catalyzed Synthesis of Aryl Amidines from Aryl Carboxylic Acids: Development and Mechanistic Investigation. Chemistry – A European Journal 19:41, pages 13803-13810.
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Jonas Sävmarker, Jonas Rydfjord, Johan Gising, Luke R. Odell & Mats Larhed. (2012) Direct Palladium(II)-Catalyzed Synthesis of Arylamidines from Aryltrifluoroborates. Organic Letters 14:9, pages 2394-2397.
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Joscha Kotthaus, Helen Hungeling, Christiane Reeh, Jürke Kotthaus, Dennis Schade, Silvia Wein, Siegfried Wolffram & Bernd Clement. (2011) Synthesis and biological evaluation of l-valine-amidoximeesters as double prodrugs of amidines. Bioorganic & Medicinal Chemistry 19:6, pages 1907-1914.
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