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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 28, 2013 - Issue 4
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Research Article

Synthesis, activity evaluation, and docking analysis of barbituric acid aryl hydrazone derivatives as RSK2 inhibitors

Mengzhu XueShanghai Key Laboratory of New Drug Design, Shanghai Key Laboratory of Chemical Biology, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, China
,
Minghao XuShanghai Key Laboratory of New Drug Design, Shanghai Key Laboratory of Chemical Biology, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, China
,
Weiqiang LuShanghai Key Laboratory of New Drug Design, Shanghai Key Laboratory of Chemical Biology, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, China
,
Jin HuangShanghai Key Laboratory of New Drug Design, Shanghai Key Laboratory of Chemical Biology, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, China
,
Honglin LiShanghai Key Laboratory of New Drug Design, Shanghai Key Laboratory of Chemical Biology, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, China
,
Yufang XuShanghai Key Laboratory of New Drug Design, Shanghai Key Laboratory of Chemical Biology, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, China
,
Xiaofeng LiuShanghai Key Laboratory of New Drug Design, Shanghai Key Laboratory of Chemical Biology, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, China
&
Zhenjiang ZhaoShanghai Key Laboratory of New Drug Design, Shanghai Key Laboratory of Chemical Biology, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai, China
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Pages 747-752 | Received 31 Dec 2011, Accepted 27 Mar 2012, Published online: 30 Apr 2012

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Xiaohong Zhu, Lu Zhou, Liangliang Zhong, Duoqian Dai, Meiyuan Hong, Rong You & Taijin Wang. (2017) Exploration of potential RSK2 inhibitors by pharmacophore modelling, structure-based 3D-QSAR, molecular docking study and molecular dynamics simulation. Molecular Simulation 43:7, pages 534-547.
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Articles from other publishers (4)

Andrea Baier, Anne Kokel, William Horton, Ewa Gizińska, Garima Pandey, Ryszard Szyszka, Béla Török & Marianna Török. (2021) Organofluorine Hydrazone Derivatives as Multifunctional Anti‐Alzheimer's Agents with CK2 Inhibitory and Antioxidant Features. ChemMedChem 16:12, pages 1927-1932.
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Priyanka Bhatt, Manoj Kumar & Anjali Jha. (2018) Design, Synthesis and Anticancer Evaluation of Oxa/Thiadiazolylhydrazones of Barbituric and Thiobarbituric Acid: A Collective In Vitro and In Silico Approach. ChemistrySelect 3:25, pages 7060-7065.
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Wei Zhou, Shiliang Li, Weiqiang Lu, Jun Yuan, Yufang Xu, Honglin Li, Jin Huang & Zhenjiang Zhao. (2016) Isoindole-1,3-dione derivatives as RSK2 inhibitors: synthesis, molecular docking simulation and SAR analysis. MedChemComm 7:2, pages 292-296.
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Jun Yuan, Ye Zhong, Shiliang Li, Xue Zhao, Guoqin Luan, Zhenjiang Zhao, Jin Huang, Honglin Li & Yufang Xu. (2013) Triazole and Benzotriazole Derivatives as Novel Inhibitors for p90 Ribosomal S6 Protein Kinase 2: Synthesis, Molecular Docking and SAR Analysis. Chinese Journal of Chemistry, pages n/a-n/a.
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