Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 28, Issue 4 (2013)

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Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 28, Issue 4 (2013)

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Research Article

Article
Inhibitory effect of cisplatin and [Pt(dach)Cl2] on the activity of phospholipase A2
Maja Radisavljević, Tina Kamčeva, Živadin D. Bugarčić & Marijana Petković
Pages: 651-660
Published online: 16 Mar 2012
AbstractforInhibitory effect of cisplatin and [Pt(dach)Cl2] on the activity of phospholipase A2 | Full Text | References | PDF (807.2 KB)
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Article
Inhibition of cysteine proteases by a natural biflavone: behavioral evaluation of fukugetin as papain and cruzain inhibitor
Diego Magno Assis, Vanessa Silva Gontijo, Ivan de Oliveira Pereira, Jorge Alexandre Nogueira Santos, Ihosvany Camps, Tanus Jorge Nagem, Javier Ellena, Mario Augusto Izidoro, Ivarne Luis dos Santos Tersariol, Nilana Meza Tenório de Barros, Antonio Carlos Doriguetto, Marcelo Henrique dos Santos & Maria Aparecida Juliano
Pages: 661-670
Published online: 02 Apr 2012
AbstractforInhibition of cysteine proteases by a natural biflavone: behavioral evaluation of fukugetin as papain and cruzain inhibitor | Full Text | References | PDF (1,018.2 KB)
  • 1632 Views
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Article
Synthesis and biological evaluation of 5-fluoroquinolone-3-carboxylic acids as potential HIV-1 integrase inhibitors
Qiu-Qin He, Xuan Zhang, Liu-Meng Yang, Yong-Tang Zheng & Fener Chen
Pages: 671-676
Published online: 02 Apr 2012
AbstractforSynthesis and biological evaluation of 5-fluoroquinolone-3-carboxylic acids as potential HIV-1 integrase inhibitors | Full Text | References | PDF (772.4 KB)
  • 581 Views
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Article
2,2′-dithienyl diselenide, an organoselenium compound, elicits antioxidant action and inhibits monoamine oxidase activity in vitro
Cristiani F. Bortolatto, Pietro M. Chagas, Ethel A. Wilhelm, Gilson Zeni & Cristina W. Nogueira
Pages: 677-684
Published online: 02 Apr 2012
Abstractfor2,2′-dithienyl diselenide, an organoselenium compound, elicits antioxidant action and inhibits monoamine oxidase activity in vitro | Full Text | References | PDF (704.5 KB)
  • 765 Views
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Article
Tyrosinase inhibitory activities of the compounds isolated from Neolitsea aciculata (Blume) Koidz.
Sang Suk Kim, Chang-Gu Hyun, Young Hun Choi & Nam Ho Lee
Pages: 685-689
Published online: 02 Apr 2012
AbstractforTyrosinase inhibitory activities of the compounds isolated from Neolitsea aciculata (Blume) Koidz. | Full Text | References | PDF (674.9 KB)
  • 1497 Views
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Article
Famotidine inhibits glycogen synthase kinase-3β: An investigation by docking simulation and experimental validation
Mohammad Mohammad, Ihab M. Al-Masri, Ala Issa, Mohamed A.S. Al-Ghussein, Mohammad Fararjeh, Hatim Alkhatib, Mutasem O. Taha & Yasser Bustanji
Pages: 690-694
Published online: 18 Apr 2012
AbstractforFamotidine inhibits glycogen synthase kinase-3β: An investigation by docking simulation and experimental validation | Full Text | References | PDF (735.1 KB)
  • 8281 Views
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Article
Direct antiproliferative effect of nonsteroidal 17β-hydroxysteroid dehydrogenase type 1 inhibitors in vitro
Ágnes Berényi, Martin Frotscher, Sandrine Marchais-Oberwinkler, Rolf W. Hartmann, Renáta Minorics, Imre Ocsovszki, George Falkay & István Zupkó
Pages: 695-703
Published online: 03 Apr 2012
AbstractforDirect antiproliferative effect of nonsteroidal 17β-hydroxysteroid dehydrogenase type 1 inhibitors in vitro | Full Text | References | PDF (753.3 KB) | Supplemental
  • 497 Views
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Article
Minor iridoids from Scutellaria albida ssp. albida. Inhibitory potencies on lipoxygenase, linoleic acid lipid peroxidation and antioxidant activity of iridoids from Scutellaria sp.
Chrysoula Gousiadou, Charlotte H. Gotfredsen, Marina Matsa, Dimitra Hadjipavlou-Litina & Helen Skaltsa
Pages: 704-710
Published online: 28 May 2012
AbstractforMinor iridoids from Scutellaria albida ssp. albida. Inhibitory potencies on lipoxygenase, linoleic acid lipid peroxidation and antioxidant activity of iridoids from Scutellaria sp. | Full Text | References | PDF (695 KB)
  • 918 Views
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Article
The effect of some antineoplastic agents on glutathione S-transferase from human erythrocytes
Mustafa Erat & Halis Şakiroğlu
Pages: 711-716
Published online: 18 Apr 2012
AbstractforThe effect of some antineoplastic agents on glutathione S-transferase from human erythrocytes | Full Text | References | PDF (670.7 KB)
  • 869 Views
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Article
Design, synthesis and biological evaluation of novel L-isoserine tripeptide derivatives as aminopeptidase N inhibitors
Huili Pan, Kanghui Yang, Jian Zhang, Yingying Xu, Yuqi Jiang, Yumei Yuan, Xiaopan Zhang & Wenfang Xu
Pages: 717-726
Published online: 30 Apr 2012
AbstractforDesign, synthesis and biological evaluation of novel L-isoserine tripeptide derivatives as aminopeptidase N inhibitors | Full Text | References | PDF (1.7 MB)
  • 723 Views
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Article
Interaction of superoxide dismutase with the glycine zipper regions of β-amyloid peptides: Is there an implication towards Alzheimer’s disease and oxidative stress?
F. Oyatsi & C.G. Whiteley
Pages: 727-733
Published online: 23 Apr 2012
AbstractforInteraction of superoxide dismutase with the glycine zipper regions of β-amyloid peptides: Is there an implication towards Alzheimer’s disease and oxidative stress? | Full Text | References | PDF (1,017.4 KB)
  • 564 Views
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Article
Effect of the o-methyl catechols apocynin, curcumin and vanillin on the cytotoxicity activity of tamoxifen
Lígia Santos Pedroso, Giovani Marino Fávero, Luciana Erzinger Alves de Camargo, Rubiana Mara Mainardes & Najeh Maissar Khalil
Pages: 734-740
Published online: 23 Apr 2012
AbstractforEffect of the o-methyl catechols apocynin, curcumin and vanillin on the cytotoxicity activity of tamoxifen | Full Text | References | PDF (693.2 KB)
  • 981 Views
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Article
The efficient expression of human fibroblast collagenase in Escherichia coli and the discovery of flavonoid inhibitors
Weiqiang Lu, Junsheng Zhu, Shien Zou, Xi Li & Jin Huang
Pages: 741-746
Published online: 23 Apr 2012
AbstractforThe efficient expression of human fibroblast collagenase in Escherichia coli and the discovery of flavonoid inhibitors | Full Text | References | PDF (681.4 KB)
  • 1441 Views
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Article
Synthesis, activity evaluation, and docking analysis of barbituric acid aryl hydrazone derivatives as RSK2 inhibitors
Mengzhu Xue, Minghao Xu, Weiqiang Lu, Jin Huang, Honglin Li, Yufang Xu, Xiaofeng Liu & Zhenjiang Zhao
Pages: 747-752
Published online: 30 Apr 2012
AbstractforSynthesis, activity evaluation, and docking analysis of barbituric acid aryl hydrazone derivatives as RSK2 inhibitors | Full Text | References | PDF (846 KB)
  • 1232 Views
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Article
A comparison of the reactivating efficacy of a novel bispyridinium oxime K203 with currently available oximes in VX agent-poisoned rats
Jiri Kassa, Jana Zdarova Karasova & Vendula Sepsova
Pages: 753-757
Published online: 30 Apr 2012
AbstractforA comparison of the reactivating efficacy of a novel bispyridinium oxime K203 with currently available oximes in VX agent-poisoned rats | Full Text | References | PDF (637.6 KB)
  • 407 Views
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Article
Impacts of some antibiotics on human serum paraoxonase 1 activity
Esra Bayram Dilek, Ömer İrfan Küfrevioğlu & Şükrü Beydemir
Pages: 758-764
Published online: 16 May 2012
AbstractforImpacts of some antibiotics on human serum paraoxonase 1 activity | Full Text | References | PDF (813.7 KB)
  • 716 Views
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Article
Synthesis of purine homo-N-nucleosides modified with coumarins as free radicals scavengers*
Michael G. Kallitsakis, Dimitra J. Hadjipavlou-Litina & Konstantinos E. Litinas
Pages: 765-775
Published online: 16 May 2012
AbstractforSynthesis of purine homo-N-nucleosides modified with coumarins as free radicals scavengers* | Full Text | References | PDF (784.2 KB)
  • 692 Views
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Article
Conformation depends on 4D-QSAR analysis using EC–GA method: pharmacophore identification and bioactivity prediction of TIBOs as non-nucleoside reverse transcriptase inhibitors
Lalehan Akyüz & Emin Sarıpınar
Pages: 776-791
Published online: 16 May 2012
AbstractforConformation depends on 4D-QSAR analysis using EC–GA method: pharmacophore identification and bioactivity prediction of TIBOs as non-nucleoside reverse transcriptase inhibitors | Full Text | References | PDF (1.3 MB)
  • 539 Views
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Article
Synthesis and anticonvulsant activity evaluation of 6-substituted-[1,2,4]triazolo[3,4-a](tetrazolo[5,1-a])phthalazine derivatives
Ming Bian, Xian-Qing Deng, Guo-Hua Gong, Cheng-Xi Wei & Zhe-Shan Quan
Pages: 792-800
Published online: 20 Sep 2012
AbstractforSynthesis and anticonvulsant activity evaluation of 6-substituted-[1,2,4]triazolo[3,4-a](tetrazolo[5,1-a])phthalazine derivatives | Full Text | References | PDF (965.6 KB)
  • 1006 Views
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Article
The protective effect of docosahexaenoic acid on the bilirubin neurotoxicity
Cem Becerir, İlknur Kılıç, Özlem Şahin, Özmert Özdemir, Onur Tokgün, Bülent Özdemir & Hakan Akca
Pages: 801-807
Published online: 16 May 2012
AbstractforThe protective effect of docosahexaenoic acid on the bilirubin neurotoxicity | Full Text | References | PDF (736.6 KB)
  • 901 Views
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Article
Synthesis and theoretical calculations of carbazole substituted chalcone urea derivatives and studies their polyphenol oxidase enzyme activity
Arleta Rifati Nixha, Mustafa Arslan, Yusuf Atalay, Nahit Gençer, Adem Ergün & Oktay Arslan
Pages: 808-815
Published online: 18 Jul 2012
AbstractforSynthesis and theoretical calculations of carbazole substituted chalcone urea derivatives and studies their polyphenol oxidase enzyme activity | Full Text | References | PDF (984.3 KB)
  • 1353 Views
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Article
Synthesis and anticholinesterase activities of novel 1,3,4-thiadiazole based compounds
Alicja Skrzypek, Joanna Matysiak, Monika M. Karpińska & Andrzej Niewiadomy
Pages: 816-823
Published online: 28 May 2012
AbstractforSynthesis and anticholinesterase activities of novel 1,3,4-thiadiazole based compounds | Full Text | References | PDF (790.4 KB)
  • 1138 Views
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Article
Susceptibility of cord blood antioxidant enzymes glutathione reductase, glutathione peroxidase and glutathione S-transferase to different antibiotics: in vitro approach
Deniz Ekinci, Murat Cankaya, İlhami Gül & Taha Abdulkadir Coban
Pages: 824-829
Published online: 28 May 2012
AbstractforSusceptibility of cord blood antioxidant enzymes glutathione reductase, glutathione peroxidase and glutathione S-transferase to different antibiotics: in vitro approach | Full Text | References | PDF (671.4 KB)
  • 650 Views
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Article
Synthesis and antimicrobial activity of some new hydrazone-bridged thiazole-pyrrole derivatives
Leyla Yurttaş, Yusuf Özkay, Zafer Asim Kaplancıklı, Yağmur Tunalı & Hülya Karaca
Pages: 830-835
Published online: 31 May 2012
AbstractforSynthesis and antimicrobial activity of some new hydrazone-bridged thiazole-pyrrole derivatives | Full Text | References | PDF (730.1 KB)
  • 1956 Views
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Article
Purification and characterization of OXA-23 from Acinetobacter baumannii
Sinem Torol & Murat Kasap
Pages: 836-842
Published online: 31 May 2012
AbstractforPurification and characterization of OXA-23 from Acinetobacter baumannii | Full Text | References | PDF (869.6 KB)
  • 1412 Views
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Article
New 5-(nitroheteroaryl)-1,3,4-thiadiazols containing acyclic amines at C-2: synthesis and SAR study for their antileishmanial activity
Azar Tahghighi, Saeed Emami, Sepide Razmi, Farzane Rezazade Marznaki, Sussan Kabudanian Ardestani, Siavoush Dastmalchi, Farzad Kobarfard, Abbas Shafiee & Alireza Foroumadi
Pages: 843-852
Published online: 31 May 2012
AbstractforNew 5-(nitroheteroaryl)-1,3,4-thiadiazols containing acyclic amines at C-2: synthesis and SAR study for their antileishmanial activity | Full Text | References | PDF (1.7 MB)
  • 669 Views
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Article
Synthesis of a new class of antimicrobial agents incorporating the indolin-2-one moiety
Nadia G. Kandile, Howida T. Zaky, Yassmin G. Saleh & Nashwa A. Ahmed
Pages: 853-862
Published online: 31 May 2012
AbstractforSynthesis of a new class of antimicrobial agents incorporating the indolin-2-one moiety | Full Text | References | PDF (1.3 MB)
  • 803 Views
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Article
The Pharmacological effects of novel 5-fluoro-N-(9,10-dihydro-9,10-dioxoanthracen-8-yl)-1H-indole-2-carboxamide derivatives on plasma lipid profile of Triton-WR-1339-induced Wistar rats
Ghassan Shattat, Tariq Al-Qirim, Ghassan Abu Sheikha, Yusuf Al-Hiari, Kamal Sweidan, Rania Al-Qirim, Suhair Hikmat, Lama Hamadneh & Sameer Al-kouz
Pages: 863-869
Published online: 31 May 2012
AbstractforThe Pharmacological effects of novel 5-fluoro-N-(9,10-dihydro-9,10-dioxoanthracen-8-yl)-1H-indole-2-carboxamide derivatives on plasma lipid profile of Triton-WR-1339-induced Wistar rats | Full Text | References | PDF (820.7 KB)
  • 767 Views
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Article
Synthesis, antielastase, antioxidant and radical scavenging activities of 4-(aza substituted) methylene substituted dihydroxy coumarines
Bahar Bilgin Sokmen, Gulsah Aydin, Arzu Gumus, Seref Karadeniz, Halil Ibrahim Ugras, Refiye Yanardag & Umit Cakır
Pages: 870-875
Published online: 18 Jul 2012
AbstractforSynthesis, antielastase, antioxidant and radical scavenging activities of 4-(aza substituted) methylene substituted dihydroxy coumarines | Full Text | References | PDF (644.3 KB) | Supplemental
  • 770 Views
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Short Communications

A new depsidone of Lobaria pulmonaria with acetylcholinesterase inhibition activity
Boris Pejin, Giuseppina Tommonaro, Carmine Iodice, Vele Tesevic, Vlatka Vajs & Salvatore De Rosa
Pages: 876-878
Published online: 18 Apr 2012
AbstractforA new depsidone of Lobaria pulmonaria with acetylcholinesterase inhibition activity | Full Text | References | PDF (605.6 KB)
  • 1164 Views
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The integrated Michaelis-Menten rate equation: déjà vu or vu jàdé?
Marko Goličnik
Pages: 879-893
Published online: 28 May 2012
AbstractforThe integrated Michaelis-Menten rate equation: déjà vu or vu jàdé? | Full Text | References | PDF (659.4 KB)
  • 6461 Views
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