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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 29, 2014 - Issue 3
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Original Article

Design, synthesis and biological evaluation of novel inosine 5′-monophosphate dehydrogenase (IMPDH) inhibitors

Torsten DunkernGlobal Discovery, Nycomed: a Takeda Company, Nycomed GmbH KonstanzGermany
,
Sunil ChavanGlobal Discovery, Nycomed: a Takeda Company MumbaiIndia
,
Digambar BankarGlobal Discovery, Nycomed: a Takeda Company MumbaiIndia
,
Anuja PatilGlobal Discovery, Nycomed: a Takeda Company MumbaiIndia
,
Pritee KulkarniGlobal Discovery, Nycomed: a Takeda Company MumbaiIndia
,
Prashant S. KharkarGlobal Discovery, Nycomed: a Takeda Company MumbaiIndia
,
Arati PrabhuGlobal Discovery, Nycomed: a Takeda Company MumbaiIndia
,
Heike GoebelGlobal Discovery, Nycomed: a Takeda Company, Nycomed GmbH KonstanzGermany
,
Edith RolserGlobal Discovery, Nycomed: a Takeda Company, Nycomed GmbH KonstanzGermany
,
Waltraud Burckhard-BoerGlobal Discovery, Nycomed: a Takeda Company, Nycomed GmbH KonstanzGermany
,
Premkumar ArumugamGVK Biosciences Private Limited, IDA Nacharam HyderabadIndia
&
Mahindra T. MakhijaGlobal Discovery, Nycomed: a Takeda Company MumbaiIndiaCorrespondence[email protected]
 show all
Pages 408-419 | Received 24 Mar 2013, Accepted 24 Mar 2013, Published online: 10 May 2013

Citations (9)

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Read on this site (1)

Chetan P. Shah & Prashant S. Kharkar. (2018) Newer human inosine 5′-monophosphate dehydrogenase 2 (hIMPDH2) inhibitors as potential anticancer agents. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 972-977.
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Articles from other publishers (8)

Wanyan Wang, Yu Wu, Si Chen, Xi Liu, Jiacheng He, Shuyi Wang, Weiqiang Lu, Yong Tang & Jin Huang. (2020) Shikonin is a novel and selective IMPDH2 inhibitor that target triple‐negative breast cancer . Phytotherapy Research 35:1, pages 463-476.
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Chetan P. Shah, Gayathri Purushothaman, Vijay Thiruvenkatam, Sivapriya Kirubakaran, Kapil Juvale & Prashant S. Kharkar. (2019) Design, synthesis and biological evaluation of Helicobacter pylori inosine 5′-monophosphate dehydrogenase (HpIMPDH) inhibitors. Further optimization of selectivity towards HpIMPDH over human IMPDH2. Bioorganic Chemistry 87, pages 753-764.
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Saigal Saigal, Sarfaraz Khan, Habibur Rahman, Shafiullah Shafiullah & Md. Musawwer Khan. (2019) Nitroketene N , S -acetals: synergistic building blocks for the synthesis of heterocycles . RSC Advances 9:25, pages 14477-14502.
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Niteshkumar U. Sahu, Gayathri Purushothaman, Vijay Thiruvenkatam & Prashant S. Kharkar. (2019) Design, synthesis, and biological evaluation of Helicobacter pylori inosine 5′-monophosphate dehydrogenase ( Hp IMPDH) inhibitors . Drug Development Research 80:1, pages 125-132.
Crossref
Chetan P. Shah & Prashant S. Kharkar. (2018) Discovery of novel human inosine 5′-monophosphate dehydrogenase 2 (hIMPDH2) inhibitors as potential anticancer agents. European Journal of Medicinal Chemistry 158, pages 286-301.
Crossref
Niteshkumar U. Sahu, Vinayak Singh, Davide M. Ferraris, Menico Rizzi & Prashant S. Kharkar. (2018) Hit discovery of Mycobacterium tuberculosis inosine 5′-monophosphate dehydrogenase, GuaB2, inhibitors. Bioorganic & Medicinal Chemistry Letters 28:10, pages 1714-1718.
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Li-Xi LiaoXiao-Min SongLi-Chao WangHai-Ning LvJin-Feng ChenDan Liu, Ge FuMing-Bo ZhaoYong JiangKe-Wu ZengPeng-Fei Tu. (2017) Highly selective inhibition of IMPDH2 provides the basis of antineuroinflammation therapy. Proceedings of the National Academy of Sciences 114:29.
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Chetan P Shah & Prashant S Kharkar. (2015) Inosine 5′-monophosphate dehydrogenase inhibitors as antimicrobial agents: recent progress and future perspectives. Future Medicinal Chemistry 7:11, pages 1415-1429.
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