Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 29, Issue 3 (2014)

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Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 29, Issue 3 (2014)

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Original Article

Article
Novel inhibitor of bacterial sphingomyelinase, SMY-540, developed based on three-dimensional structure analysis
Masataka Oda, Hiroshi Imagawa, Ryoko Kato, Kenta Yabiku, Tomomi Yoshikawa, Takayuki Takemoto, Hironobu Takahashi, Hirofumi Yamamoto, Mugio Nishizawa, Jun Sakurai & Masahiro Nagahama
Pages: 303-310
Published online: 14 Mar 2013
AbstractforNovel inhibitor of bacterial sphingomyelinase, SMY-540, developed based on three-dimensional structure analysis | Full Text | References | PDF (928 KB)
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Research Article

Article
Antioxidant activity of aminodiarylamines in the thieno[3,2-b]pyridine series: radical scavenging activity, lipid peroxidation inhibition and redox profile
Ricardo C. Calhelha, Daniela Peixoto, Miguel Vilas Boas, Maria-João R. P. Queiroz & Isabel C. F. R. Ferreira
Pages: 311-316
Published online: 12 Mar 2013
AbstractforAntioxidant activity of aminodiarylamines in the thieno[3,2-b]pyridine series: radical scavenging activity, lipid peroxidation inhibition and redox profile | Full Text | References | PDF (409.1 KB)
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Article
Predictive QSAR models development and validation for human ether-a-go-go related gene (hERG) blockers using newer tools
N. S. Hari Narayana Moorthy, Maria J. Ramos & Pedro A. Fernandes
Pages: 317-324
Published online: 08 Apr 2013
AbstractforPredictive QSAR models development and validation for human ether-a-go-go related gene (hERG) blockers using newer tools | Full Text | References | PDF (477.6 KB)
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Article
Discovery of Entamoeba histolytica hexokinase 1 inhibitors through homology modeling and virtual screening
María Leticia Saucedo-Mendiola, José Manuel Salas-Pacheco, Hugo Nájera, Arturo Rojo-Domínguez, Lilián Yépez-Mulia, Claudia Avitia-Domínguez & Alfredo Téllez-Valencia
Pages: 325-332
Published online: 27 Mar 2013
AbstractforDiscovery of Entamoeba histolytica hexokinase 1 inhibitors through homology modeling and virtual screening | Full Text | References | PDF (1.9 MB)
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Article
Discovery of a series of small molecules as potent histone deacetylase inhibitors
Lei Zhang, Xuejian Wang, Xiaoguang Li & Wenfang Xu
Pages: 333-337
Published online: 27 Mar 2013
AbstractforDiscovery of a series of small molecules as potent histone deacetylase inhibitors | Full Text | References | PDF (389.4 KB)
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Article
Design, synthesis and evaluation of 2-phenylisothiazolidin-3-one-1,1-dioxides as a new class of human protein kinase CK2 inhibitors
Maksym O. Chekanov, Olga V. Ostrynska, Anatoliy R. Synyugin, Volodymyr G. Bdzhola & Sergiy M. Yarmoluk
Pages: 338-343
Published online: 11 Apr 2013
AbstractforDesign, synthesis and evaluation of 2-phenylisothiazolidin-3-one-1,1-dioxides as a new class of human protein kinase CK2 inhibitors | Full Text | References | PDF (948.6 KB) | Supplemental
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Article
Indirect inactivation of tyrosinase in its action on 4-tert-butylphenol
Jose Luis Muñoz-Muñoz, María del Mar García-Molina, Francisco García-Molina, Ramón Varon, Pedro Antonio García-Ruiz, Jose Neptuno Rodríguez-López & Francisco García-Cánovas
Pages: 344-352
Published online: 11 Apr 2013
AbstractforIndirect inactivation of tyrosinase in its action on 4-tert-butylphenol | Full Text | References | PDF (651.5 KB)
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Article
Synthesis and characterization of a proton transfer salt between 2,6-pyridinedicarboxylic acid and 2-aminobenzothiazole, and its complexes and their inhibition studies on carbonic anhydrase isoenzymes
Halil İlkimen, Cengiz Yenikaya, Musa Sarı, Metin Bülbül, Ekrem Tunca & Hakan Dal
Pages: 353-361
Published online: 01 Jul 2013
AbstractforSynthesis and characterization of a proton transfer salt between 2,6-pyridinedicarboxylic acid and 2-aminobenzothiazole, and its complexes and their inhibition studies on carbonic anhydrase isoenzymes | Full Text | References | PDF (551.1 KB) | Supplemental
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Article
Synthesis and blood glucose lowering activity of some novel benzenesulfonylthiourea derivatives substituted with 4-aryl-1-oxophthalazin-2(1H)yl-ones
Shafiya Yaseen, Rafia Bashir, Syed Ovais, Pooja Rathore, Mohammed Samim & Kalim Javed
Pages: 362-366
Published online: 11 Apr 2013
AbstractforSynthesis and blood glucose lowering activity of some novel benzenesulfonylthiourea derivatives substituted with 4-aryl-1-oxophthalazin-2(1H)yl-ones | Full Text | References | PDF (186.1 KB) | Supplemental
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Article
Synthesis and biological evaluation of some novel tetrahydroquinolines as anticancer and antimicrobial agents
Hassan M. Faidallah, Alaa A. Saqer, Khalid A. Alamry, Khalid A. Khan & Abdullah M. Asiri
Pages: 367-378
Published online: 22 Apr 2013
AbstractforSynthesis and biological evaluation of some novel tetrahydroquinolines as anticancer and antimicrobial agents | Full Text | References | PDF (402.1 KB)
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Review Article

Review Article
Sulfa and trimethoprim-like drugs – antimetabolites acting as carbonic anhydrase, dihydropteroate synthase and dihydrofolate reductase inhibitors
Clemente Capasso & Claudiu T. Supuran
Pages: 379-387
Published online: 29 Apr 2013
AbstractforSulfa and trimethoprim-like drugs – antimetabolites acting as carbonic anhydrase, dihydropteroate synthase and dihydrofolate reductase inhibitors | Full Text | References | PDF (868.2 KB)
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Review Article
Production of an alkaline protease using Bacillus pumilus D3 without inactivation by SDS, its characterization and purification
Burçin Özçelik, Pınar Aytar, Serap Gedikli, Ezgi Yardımcı, Figen Çalışkan & Ahmet Çabuk
Pages: 388-396
Published online: 02 May 2013
AbstractforProduction of an alkaline protease using Bacillus pumilus D3 without inactivation by SDS, its characterization and purification | Full Text | References | PDF (570.5 KB)
  • 1757 Views
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Research Article

Article
Comparative inhibition of tetrameric carbonyl reductase activity in pig heart cytosol by alkyl 4-pyridyl ketones
Hideaki Shimada, Takahiro Tanigawa, Kazunori Matayoshi, Kazufumi Katakura, Ken Babazono, Hiroyuki Takayama, Tsuyoshi Murahashi, Hiroyuki Akita, Toshiyuki Higuchi, Masashi Eto & Yorishige Imamura
Pages: 397-400
Published online: 08 May 2013
AbstractforComparative inhibition of tetrameric carbonyl reductase activity in pig heart cytosol by alkyl 4-pyridyl ketones | Full Text | References | PDF (221.9 KB)
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Short Communication

Article
Design, synthesis and antistaphylococcal activity of marine pyrrole alkaloid derivatives
Rajesh A. Rane, Niteshkumar U. Sahu, Chetan P. Shah & Nishant K. Shah
Pages: 401-407
Published online: 10 May 2013
AbstractforDesign, synthesis and antistaphylococcal activity of marine pyrrole alkaloid derivatives | Full Text | References | PDF (467.3 KB)
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Original Article

Article
Design, synthesis and biological evaluation of novel inosine 5′-monophosphate dehydrogenase (IMPDH) inhibitors
Torsten Dunkern, Sunil Chavan, Digambar Bankar, Anuja Patil, Pritee Kulkarni, Prashant S. Kharkar, Arati Prabhu, Heike Goebel, Edith Rolser, Waltraud Burckhard-Boer, Premkumar Arumugam & Mahindra T. Makhija
Pages: 408-419
Published online: 10 May 2013
AbstractforDesign, synthesis and biological evaluation of novel inosine 5′-monophosphate dehydrogenase (IMPDH) inhibitors | Full Text | References | PDF (2.9 MB)
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Research Article

Article
Synthesis of new N,N′-bis[1-aryl-3-(piperidine-1-yl)propylidene]hydrazine dihydrochlorides and evaluation of their cytotoxicity against human hepatoma and breast cancer cells
Kaan Kucukoglu, H. Inci Gul, Rengul Cetin-Atalay, Yosra Baratli, Anne-Laure Charles, Murat Sukuroglu, Mustafa Gul & Bernard Geny
Pages: 420-426
Published online: 16 Jul 2013
AbstractforSynthesis of new N,N′-bis[1-aryl-3-(piperidine-1-yl)propylidene]hydrazine dihydrochlorides and evaluation of their cytotoxicity against human hepatoma and breast cancer cells | Full Text | References | PDF (327.7 KB)
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Review Article

Review Article
4,5-Dihydro-1H-pyrazole: an indispensable scaffold
Jimi Marin Alex & Raj Kumar
Pages: 427-442
Published online: 01 Jul 2013
Abstractfor4,5-Dihydro-1H-pyrazole: an indispensable scaffold | Full Text | References | PDF (2.5 MB)
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Research Article

Article
Synthesis and hypoglycemic activity of some new theophylline derivatives
Ahmed M. Alafeefy, Saleh I Alqasoumi, Sami G. Abdel hamid, Kamal E. H. El-Tahir, Menshawy Mohamed, Mohamed E. Zain & Amani S. Awaad
Pages: 443-448
Published online: 23 May 2013
AbstractforSynthesis and hypoglycemic activity of some new theophylline derivatives | Full Text | References | PDF (211.7 KB)
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Original Article

Article
3D-QSAR CoMFA studies on sulfonamide inhibitors of the Rv3588c β-carbonic anhydrase from Mycobacterium tuberculosis and design of not yet synthesized new molecules
Shalini Singh & Claudiu T. Supuran
Pages: 449-455
Published online: 01 Jul 2013
Abstractfor3D-QSAR CoMFA studies on sulfonamide inhibitors of the Rv3588c β-carbonic anhydrase from Mycobacterium tuberculosis and design of not yet synthesized new molecules | Full Text | References | PDF (942.1 KB)
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