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Research Article

A convenient synthesis and molecular modeling study of novel pyrazolo[3,4-d]pyrimidine and pyrazole derivatives as anti-tumor agents

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Pages 396-405 | Received 22 May 2014, Accepted 23 Jun 2014, Published online: 28 Jul 2014

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Prasad Sanjay Dhiwar, Gurubasavaraja Swamy Purawarga Matada, Rohit Pal, Ekta Singh, Abhishek Ghara, Lalmohan Maji, Sindhuja Sengupta & Ganesh Andhale. (2023) An assessment of EGFR and HER2 inhibitors with structure activity relationship of fused pyrimidine derivatives for breast cancer: a brief review. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-18.
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Asmaa A. Mandour, Ibrahim F. Nassar, Mohammed T. Abdel Aal, Mahmoud A. E. Shahin, Wael A. El-Sayed, Maghawry Hegazy, Amr Mohamed Yehia, Ahmed Ismail, Mohamed Hagras, Eslam B. Elkaeed, Hanan M. Refaat & Nasser S. M. Ismail. (2022) Synthesis, biological evaluation, and in silico studies of new CDK2 inhibitors based on pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold with apoptotic activity. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 1957-1973.
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Eman Mansour, Ahmed A. Abd-Rabou, Ibrahim F. Nassar & Safaa I. Elewa. (2022) Synthesis, Docking and Anticancer Evaluation of New Pyridine-3-Carbonitrile Derivatives. Polycyclic Aromatic Compounds 42:6, pages 3523-3544.
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Ibrahim F. Nassar, Ahmed F. El Farargy, Fathy M. Abdelrazek & Zeinab Hamza. (2020) Synthesis of new uracil derivatives and their sugar hydrazones with potent antimicrobial, antioxidant and anticancer activities. Nucleosides, Nucleotides & Nucleic Acids 39:7, pages 991-1010.
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Sharifah Bee Abd Hamid, Salam J. J. Titinchi, Hanna Abbo & Nader Ghaffari Khaligh. (2018) One-Pot Multicomponent Synthesis of Pyrazolo[3,4-d]pyrimidine-6-one Derivatives. Polycyclic Aromatic Compounds 38:2, pages 189-198.
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Ibrahim F. Nassar, Ahmed F. El Farargy, Fathy M. Abdelrazek & Nasser S.M. Ismail. (2017) Design, synthesis and anticancer evaluation of novel pyrazole, pyrazolo[3,4-d]pyrimidine and their glycoside derivatives. Nucleosides, Nucleotides & Nucleic Acids 36:4, pages 275-291.
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Articles from other publishers (13)

Adel Z. Nasr, Abeer Farahat, Mohamed A. Zein & El-Sayed M. Abdelrehim. (2022) Synthesis and Antimicrobial Activity of 1,3,4-Oxadiazoline, 1,3-Thiazolidine, and 1,2,4-Triazoline Double-Tailed Acyclo C-Nucleosides. ACS Omega 7:20, pages 16884-16894.
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Ibrahim F. Nassar, Mohammed T. Abdel Aal, Wael A. El-Sayed, Mahmoud A. E Shahin, Elsayed G. E. Elsakka, Mahmoud Mohamed Mokhtar, Maghawry Hegazy, Mohamed Hagras, Asmaa A. Mandour & Nasser S. M. Ismail. (2022) Discovery of pyrazolo[3,4- d ]pyrimidine and pyrazolo[4,3- e ][1,2,4]triazolo[1,5- c ]pyrimidine derivatives as novel CDK2 inhibitors: synthesis, biological and molecular modeling investigations . RSC Advances 12:23, pages 14865-14882.
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Thoraya A. Farghaly & Kamal M. Dawood. (2022) Inhibitory Activities of Pyrazolo-Oxazine Heterocyclic Derivatives. Mini-Reviews in Medicinal Chemistry 22:9, pages 1256-1267.
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Adel A.-H. Abdel-Rahman, Amira K. F. Shaban, Ibrahim F. Nassar, Dina S. EL-Kady, Nasser S. M. Ismail, Samy F. Mahmoud, Hanem M. Awad & Wael A. El-Sayed. (2021) Discovery of New Pyrazolopyridine, Furopyridine, and Pyridine Derivatives as CDK2 Inhibitors: Design, Synthesis, Docking Studies, and Anti-Proliferative Activity. Molecules 26:13, pages 3923.
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Kamal M. Dawood, Thoraya A. Farghaly & Mohamed A. Raslan. (2020) Heteroannulation Routes to Bioactive Pyrazolooxazines. Current Organic Chemistry 24:17, pages 1943-1975.
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W. H. Lashin, I. F. Nassar, A. F. El Farargy & A. O. Abdelhamid. (2020) Synthesis of New Furanone Derivatives with Potent Anticancer Activity. Russian Journal of Bioorganic Chemistry 46:6, pages 1074-1086.
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Safaa I. Elewa, Eman Mansour, Ibrahim F. Nassar & Amal A. I. Mekawey. (2020) Synthesis of Some New Pyrazoline-Based Thiazole Derivatives and Evaluation of Their Antimicrobial, Antifungal, and Anticancer Activities. Russian Journal of Bioorganic Chemistry 46:3, pages 382-392.
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Adeleke A. Adesola, Sizwe J. Zamisa & Bernard Omondi. (2019) Crystal structure of 4-(1-phenylimidazo[1,5- a ]pyridin-3-yl)benzoic acid (C 20 H 14 N 2 O 2 ) . Zeitschrift für Kristallographie - New Crystal Structures 234:6, pages 1157-1159.
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Adel A.H. Abdel Rahman, Ibrahim F. Nassar, Amira K.F. Shaban, Dina S. EL-Kady, Hanem M. Awad & Wael A. El Sayed. (2019) Synthesis, Docking Studies into CDK-2 and Anticancer Activity of New Derivatives Based Pyrimidine Scaffold and Their Derived Glycosides. Mini-Reviews in Medicinal Chemistry 19:13, pages 1093-1110.
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Ibrahim F. Nassar, Dina S. El kady, Hanem M. Awad & Wael A. El‐Sayed. (2019) Design, Synthesis, and Anticancer Activity of New Oxadiazolyl‐Linked and Thiazolyl‐Linked Benzimidazole Arylidines, Thioglycoside, and Acyclic Analogs. Journal of Heterocyclic Chemistry 56:3, pages 1086-1100.
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Ibrahim F. Nassar, Ahmed F. El Farargy & Fathy M. Abdelrazek. (2018) Synthesis and Anticancer Activity of Some New Fused Pyrazoles and Their Glycoside Derivatives. Journal of Heterocyclic Chemistry 55:7, pages 1709-1719.
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Felicia Phei Lin Lim, Nathan R. Halcovitch, Edward R.T. Tiekink & Anton V. Dolzhenko. (2018) A new microwave-assisted, three-component reaction of 5-aminopyrazole-4-carboxylates: Selective synthesis of substituted 5-aza-9-deaza-adenines. Tetrahedron 74:15, pages 1868-1879.
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Mohamed El Hafi, Mohammed Naas, Mohammed Loubidi, Jabrane Jouha, Youssef Ramli, Joel T. Mague, El Mokhtar Essassi & Gérald Guillaumet. (2017) Palladium-catalyzed regioselective direct C H arylation of pyrazolo[3,4- d ]pyrimidines. Comptes Rendus Chimie 20:9-10, pages 927-933.
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