Citations (49)
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Ken-ichi KIMURA, Yoshie ITAKURA, Reika GOTO, Masato TOJIMA, Nobumi EGAWA & Makoto YOSHIHAMA. (2007) Inhibition of 17α-Hydroxylase/C17,20-Lyase (CYP17) from Rat Testis by Green Tea Catechins and Black Tea Theaflavins. Bioscience, Biotechnology, and Biochemistry 71:9, pages 2325-2328.
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MARC LE BORGNE, PASCAL MARCHAND, MARIE-RENEE NOURRISSON, DENIS LOQUET, MARTINA PALZER, GUILLAUME LE BAUT & ROLF W. HARTMANN. (2007) Synthesis and biological evaluation of 3-(azolylmethyl)-1H-indoles and 3-(α-azolylbenzyl)-1H-indoles as selective aromatase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 22:5, pages 667-676.
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Marie-Pierre Lézé, Marc Le Borgne, Pascal Marchand, Denis Loquet, Manuela Kogler, Guillaume Le Baut, Anja Palusczak & Rolf W. Hartmann. (2004) 2- and 3-[(Aryl)(azolyl)methyl]indoles as Potential Non-steroidal Aromatase Inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 19:6, pages 549-557.
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Rolf W. Hartmann, Anja Palusczak, Fabrice Lacan, Giacomo Ricci & Renzo Ruzziconi. (2004) CYP 17 and CYP 19 Inhibitors. Evaluation of Fluorine Effects on the Inhibiting Activity of Regioselectively Fluorinated 1-(Naphthalen-2-ylmethyl)imidazoles. Journal of Enzyme Inhibition and Medicinal Chemistry 19:2, pages 145-155.
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Tilman U. Hutschenreuter, Peter B. Ehmer & Rolf W. Hartmann. (2004) Synthesis of Hydroxy Derivatives of Highly Potent Non-steroidal CYP 17 Inhibitors as Potential Metabolites and Evaluation of their Activity by a Non Cellular Assay using Recombinant Human Enzyme. Journal of Enzyme Inhibition and Medicinal Chemistry 19:1, pages 17-32.
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Hassan
Y. Aboul-Enein & Suhair Abu-Zaid. (2002) HPLC ENANTIOMERIC RESOLUTION OF NOVEL TETRALONE DERIVATIVES ON CELLULOSE AND AMYLOSE BASED CHIRAL STATIONARY PHASES UNDER NORMAL PHASE MODE. Journal of Liquid Chromatography & Related Technologies 25:7, pages 1077-1084.
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H John Smith, Paul J Nicholls, Claire Simons & Regis Le Lain. (2001) Inhibitors of steroidogenesis as agents for the treatment of hormone-dependent cancers. Expert Opinion on Therapeutic Patents 11:5, pages 789-824.
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Vincent C.O. Njar, Gertrud Grun & Rolf W. Hartmann. (1995) Evaluation of 6,7-Aziridinyl Steroids and Related Compounds as Inhibitors of Aromatase (P-450arom). Journal of Enzyme Inhibition 9:3, pages 195-202.
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Articles from other publishers (41)
Tomasz M. Wróbel, Flemming Steen Jørgensen, Amit V. Pandey, Angelika Grudzińska, Katyayani Sharma, Jibira Yakubu & Fredrik Björkling. (2023) Non-steroidal CYP17A1 Inhibitors: Discovery and Assessment. Journal of Medicinal Chemistry 66:10, pages 6542-6566.
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Irina I. Khan, Saida S. Karshieva, Darina V. Sokolova, Tatiana S. Spirina, Vladimir A. Zolottsev, Alexandra S. Latysheva, Natalia Y. Anisimova, Marina V. Komarova, Marina N. Yakunina, Tatiana A. Nitetskaya, Alexander Y. Misharin & Vadim S. Pokrovsky. (2021) Antiproliferative, proapoptotic, and tumor‐suppressing effects of the novel anticancer agent alsevirone in prostate cancer cells and xenografts. Archiv der Pharmazie 355:1.
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Muhammad Akram, Watcharee Waratchareeyakul, Joerg Haupenthal, Rolf W. Hartmann & Daniela Schuster. (2017) Pharmacophore Modeling and in Silico/in Vitro Screening for Human Cytochrome P450 11B1 and Cytochrome P450 11B2 Inhibitors. Frontiers in Chemistry 5.
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Najim A. Al-Masoudi, Nabeel A. Abdul-Rida, Rawaa A. Kadhim, Sebastian J. Krug, Matthias Engel & Bahjat A. Saeed. (2015) Synthesis and CYP17α hydroxylase inhibition activity of new 3α- and 3β-ester derivatives of pregnenolone and related ether analogues. Medicinal Chemistry Research 25:2, pages 310-321.
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Najim A. Al-Masoudi, Kuthiar M. Mahdi, Nabeel A. Abdul-Rida, Bahjat A. Saeed & Mathias Engel. (2015) A new pregnenolone analogues as privileged scaffolds in inhibition of CYP17 hydroxylase enzyme. Synthesis and in silico molecular docking study. Steroids 100, pages 52-59.
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Nikoletta Szabó, Jovana Ajduković, Evgenija Djurendić, Marija Sakač, Imre Ignáth, János Gardi, Gábor Mahmoud, Olivera Klisurić, Suzana Jovanović-Šanta, Katarina Penov Gaši & Mihály Szécsi. (2015)
Determination of 17α-hydroxylase-C
17,20
-lyase (P450
17α
) enzyme activities and their inhibition by selected steroidal picolyl and picolinylidene compounds
. Acta Biologica Hungarica 66:1, pages 41-51.
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Tomohiro Kaku, Takenori Hitaka, Akio Ojida, Nobuyuki Matsunaga, Mari Adachi, Toshimasa Tanaka, Takahito Hara, Masuo Yamaoka, Masami Kusaka, Teruaki Okuda, Satoru Asahi, Shuichi Furuya & Akihiro Tasaka. (2011) Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer. Bioorganic & Medicinal Chemistry 19:21, pages 6383-6399.
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Tomohiro Kaku, Saori Tsujimoto, Nobuyuki Matsunaga, Toshimasa Tanaka, Takahito Hara, Masuo Yamaoka, Masami Kusaka & Akihiro Tasaka. (2011) 17,20-Lyase inhibitors. Part 3: Design, synthesis, and structure–activity relationships of biphenylylmethylimidazole derivatives as novel 17,20-lyase inhibitors. Bioorganic & Medicinal Chemistry 19:7, pages 2428-2442.
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Tomohiro Kaku, Nobuyuki Matsunaga, Akio Ojida, Toshimasa Tanaka, Takahito Hara, Masuo Yamaoka, Masami Kusaka & Akihiro Tasaka. (2011) 17,20-Lyase inhibitors. Part 4: Design, synthesis and structure–activity relationships of naphthylmethylimidazole derivatives as novel 17,20-lyase inhibitors. Bioorganic & Medicinal Chemistry 19:5, pages 1751-1770.
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Ulrike E. Hille, Qingzhong Hu, Mariano A.E. Pinto-Bazurco Mendieta, Marc Bartels, Carsten A. Vock, Thomas Lauterbach & Rolf W. Hartmann. (2009) Steroidogenic cytochrome P450 (CYP) enzymes as drug targets: Combining substructures of known CYP inhibitors leads to compounds with different inhibitory profile. Comptes Rendus Chimie 12:10-11, pages 1117-1126.
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Alison HM Reid, Gerhardt Attard, Elaine Barrie & Johann S de Bono. (2008) CYP17 inhibition as a hormonal strategy for prostate cancer. Nature Clinical Practice Urology 5:11, pages 610-620.
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Mariano A. E. Pinto‐Bazurco Mendieta, Matthias Negri, Qingzhong Hu, Ulrike E. Hille, Carsten Jagusch, Kerstin Jahn‐Hoffmann, Ursula Müller‐Vieira, Dirk Schmidt, Thomas Lauterbach & Rolf W. Hartmann. (2008) CYP17 Inhibitors. Annulations of Additional Rings in Methylene Imidazole Substituted Biphenyls: Synthesis, Biological Evaluation and Molecular Modelling. Archiv der Pharmazie 341:10, pages 597-609.
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Mariano A. E. Pinto-Bazurco Mendieta, Matthias Negri, Carsten Jagusch, Ursula Müller-Vieira, Thomas Lauterbach & Rolf W. Hartmann. (2008) Synthesis, Biological Evaluation, and Molecular Modeling of Abiraterone Analogues: Novel CYP17 Inhibitors for the Treatment of Prostate Cancer. Journal of Medicinal Chemistry 51:16, pages 5009-5018.
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Mariano A.E. Pinto-Bazurco Mendieta, Matthias Negri, Carsten Jagusch, Ulrike E. Hille, Ursula Müller-Vieira, Dirk Schmidt, Klaus Hansen & Rolf W. Hartmann. (2008) Synthesis, biological evaluation and molecular modelling studies of novel ACD- and ABD-ring steroidomimetics as inhibitors of CYP17. Bioorganic & Medicinal Chemistry Letters 18:1, pages 267-273.
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Frédéric Leroux, Tilman U. Hutschenreuter, Céline Charrière, Rosario Scopelliti & Rolf W. Hartmann. (2003)
N
‐(4‐Biphenylmethyl)imidazoles as Potential Therapeutics for the Treatment of Prostate Cancer: Metabolic Robustness Due to Fluorine Substitution?
. Helvetica Chimica Acta 86:7, pages 2671-2686.
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Pascal Marchand, Marc Le Borgne, Martina Palzer, Guillaume Le Baut & Rolf W. Hartmann. (2003) Preparation and pharmacological profile of 7-(?-Azolylbenzyl)-1H-indoles and indolines as new aromatase inhibitors. Bioorganic & Medicinal Chemistry Letters 13:9, pages 1553-1555.
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Samer Haidar, Peter B. Ehmer, Stephan Barassin, Christine Batzl-Hartmann & Rolf W. Hartmann. (2003) Effects of novel 17?-hydroxylase/C17, 20-lyase (P450 17, CYP 17) inhibitors on androgen biosynthesis in vitro and in vivo. The Journal of Steroid Biochemistry and Molecular Biology 84:5, pages 555-562.
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Rolf W. Hartmann, Ursula Müller & Peter B. Ehmer. (2003) Discovery of selective CYP11B2 (aldosterone synthase) inhibitors for the therapy of congestive heart failure and myocardial fibrosis. European Journal of Medicinal Chemistry 38:4, pages 363-366.
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Samer Haidar & Rolf W. Hartmann. (2003) C16 and C17 Substituted Derivatives of Pregnenolone and Progesterone as Inhibitors of 17α‐Hydroxylase‐C17, 20‐lyase: Synthesis and Biological Evaluation. Archiv der Pharmazie 335:11-12, pages 526-534.
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Joseph P Burkhart, Philip M Weintraub, Cynthia A Gates, Robert J Resvick, Roy J Vaz, Dirk Friedrich, Michael R Angelastro, Philippe Bey & Norton P Peet. (2002) Novel Steroidal Vinyl Fluorides as Inhibitors of Steroid C17(20) Lyase. Bioorganic & Medicinal Chemistry 10:4, pages 929-934.
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Rolf W. Hartmann, Peter B. Ehmer, Samer Haidar, Markus Hector, Joachim Jose, Christian D. P. Klein, Stefanie B. Seidel, Tom F. Sergejew, Bertil G. Wachall, Gerald A. Wächter & Yan Zhuang. (2002) Inhibition of CYP 17, a New Strategy for the Treatment of Prostate Cancer. Archiv der Pharmazie 335:4, pages 119-128.
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Samer Haidar, Peter B. Ehmer & Rolf W. Hartmann. (2001) Novel steroidal pyrimidyl inhibitors of P450 17 (17α-hydroxylase/C17-20-lyase). Archiv der Pharmazie 334:12, pages 373-374.
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Hassan Y. Aboul-Enein & Imran Ali. (2001) Enantiomeric resolution of some substituted tetralone derivatives on amylose tris(3,5-dimethyl phenylcarbamate) chiral stationary phase in reversed phase mode. Journal of Separation Science 24:10-11, pages 831-834.
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Hassan Y. Aboul-Enein & Imran Ali. (2001) A Comparative Study of the Enantiomeric Resolution of Several Tetralone Derivatives on Macrocyclic Antibiotic Chiral Stationary Phases Using HPLC under Normal Phase Mode. Archiv der Pharmazie 334:7, pages 258-260.
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Samer Haidar, Christian D.P. Klein & Rolf W. Hartmann. (2001) Synthesis and Evaluation of Steroidal Hydroxamic Acids as Inhibitors of P450 17 (17α-Hydroxylase/C17-20-Lyase). Archiv der Pharmazie 334:4, pages 138-140.
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Peter B. Ehmer, Joachim Jose & Rolf W. Hartmann. (2000) Development of a simple and rapid assay for the evaluation of inhibitors of human 17α-hydroxylase-C17,20-lyase (P450cl7) by coexpression of P450cl7 with NADPH-cytochrome-P450-reductase in Escherichia coli. The Journal of Steroid Biochemistry and Molecular Biology 75:1, pages 57-63.
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Yan Zhuang, Bertil G. Wachall & Rolf W. Hartmann. (2000) Novel imidazolyl and triazolyl substituted biphenyl compounds: synthesis and evaluation as nonsteroidal inhibitors of human 17α-hydroxylase-C17, 20-Lyase (P450 17). Bioorganic & Medicinal Chemistry 8:6, pages 1245-1252.
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Bertil G. Wachall, Markus Hector, Yan Zhuang & Rolf W. Hartmann. (1999) Imidazole substituted biphenyls: A new class of highly potent and in vivo active inhibitors of P450 17 as potential therapeutics for treatment of prostate cancer. Bioorganic & Medicinal Chemistry 7:9, pages 1913-1924.
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Dmitry N. Grigoryev, Katsuya Kato, Vincent C.O. Njar, Brian J. Long, Yang-Zhi Ling, Xin Wang, James Mohler & Angela M.H. Brodie. (1999) Cytochrome P450c17-ExpressingEscherichia colias a First-Step Screening System for 17α-Hydroxylase- C17,20-lyase Inhibitors. Analytical Biochemistry 267:2, pages 319-330.
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Pierrick Auvray, Safa Moslemi, Pascal Sourdaine, Sébastien Galopin, Gilles-Eric Séralini, Cécile Enguehard, Patrick Dallemagne, Ronan Bureau, Pascal Sonnet & Sylvain Rault. (1998) Evidence for new non-steroidal human aromatase inhibitors and comparison with equine aromatase inhibition for an understanding of the mammalian active site. European Journal of Medicinal Chemistry 33:6, pages 451-462.
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Geoffrey D. Brown. (1998) The biosynthesis of steroids and triterpenoids. Natural Product Reports 15:6, pages 653.
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Michael Jarman, H. John Smith, Paul J. Nicholls & Claire Simons. (1998) Inhibitors of enzymes of androgen biosynthesis: cytochrome P45017α and 5α-steroid reductase. Natural Product Reports 15:5, pages 495.
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Yan Zhuang, Josef Zapp & Rolf W. Hartmann. (2006)
Synthesis of
Z
‐ and
E
‐1‐Methyl‐2‐(1‐hydroximinoethyl)‐6‐methoxy‐3,4‐dihydronaphthalene and Evaluation as Inhibitors of 17α‐Hydroxylase‐C17,20‐Lyase (P450 17)
. Archiv der Pharmazie 330:11, pages 359-361.
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Dorothea Ledergerber, Martin Frotscher & Rolf W. Hartmann. (2006)
Novel Highly Active Thromboxane A
2
Synthase Inhibitors Devoid of Carboxylic Groups
. Archiv der Pharmazie 330:1-2, pages 1-5.
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Vincent C.O. Njar, Gregory T. Klus & Angela M.H. Brodie. (1996) Nucleophilic vinylic “addition-elimination” substitution reaction of 3β-acetoxy-17-chloro-16-formylandrosta-5,16-diene: A novel and general route to 17-substituted steroids. Part 1 - synthesis of novel 17-azolyl-Δ16 steroids; inhibitors of 17α-hydroxylase/17, 20-lyase (17α-lyase). Bioorganic & Medicinal Chemistry Letters 6:22, pages 2777-2782.
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Vincent C.O. Njar, Markus Hector & Rolf W. Hartmann. (1996) 20-Amino and 20,21-aziridinyl pregnene steroids: Development of potent inhibitors of 17?-hydroxylase/C17,20-lyase (P450 17). Bioorganic & Medicinal Chemistry 4:9, pages 1447-1453.
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Thomas F. Sergejew & Rolf W. Hartmann. (1996) Effect of a diphenylethylenediamine platinum complex on steroidogenesis in rats. The Journal of Steroid Biochemistry and Molecular Biology 58:2, pages 243-248.
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Rolf W. Hartmann, Martin Frotscher, Dorothea Ledergerber, Gerald A. Wächter, Gertrud L. Grün & Tom F. Sergejew. (2006)
Synthesis and Evaluation of Azole‐Substituted Tetrahydronaphthalenes as Inhibitors of P450 arom, P450 17, and P450 TxA
2
. Archiv der Pharmazie 329:5, pages 251-261.
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Rolf W. Hartmann, Gerald A. Wächter, Tom Sergejew, Rieka Würtz & Jörg Düerkop. (2006)
4,5‐Dihydro‐3‐(2‐pyrazinyl)naphtho[1,2‐
c
]pyrazole: A Potent and Selective Inhibitor of Steroid‐17α‐Hydroxylase‐C17,20‐Lyase (P450 17)
. Archiv der Pharmazie 328:7-8, pages 573-575.
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M. Frotscher, G. W?chter & R.W. Hartmann. (1994) FC24 imidazolyl- and 1,2,4-triazolyl-substituted benzocyclohexenes as potent and selective inhibitors of cytochrome P-450 enzymes. European Journal of Pharmaceutical Sciences 2:1-2, pages 106.
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Rolf W. Hartmann. (1994) Selective inhibition of steriodogenic P450 enzymes: current status and future perspectives. European Journal of Pharmaceutical Sciences 2:1-2, pages 15-16.
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