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Original Article

Carbetocin for the prevention of postpartum hemorrhage: a systematic review and meta-analysis of randomized controlled trials

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Pages 400-407 | Received 29 Sep 2014, Accepted 22 Dec 2014, Published online: 12 Jan 2015

Keep up to date with the latest research on this topic with citation updates for this article.

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Erkan Kalafat, Ali Gokce, Pat O’Brien, Can Benlioglu, Acar Koc, Onur Karaaslan & Asma Khalil. (2021) Efficacy of carbetocin in the prevention of postpartum hemorrhage: a systematic review and Bayesian meta-analysis of randomized trials. The Journal of Maternal-Fetal & Neonatal Medicine 34:14, pages 2303-2316.
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Zakia M. Ibrahim, Waleed A. Sayed Ahmed, Eman M. Abd El-Hamid, Omima T. Taha & Amira M. Elbahie. (2020) Carbetocin versus oxytocin for prevention of postpartum hemorrhage in hypertensive women undergoing elective cesarean section. Hypertension in Pregnancy 39:3, pages 319-325.
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Laura Sotillo, Maria De la Calle, Fernando Magdaleno & Jose Luis Bartha. (2020) Efficacy of carbetocin for preventing postpartum bleeding after cesarean section in twin pregnancy. The Journal of Maternal-Fetal & Neonatal Medicine 33:2, pages 267-271.
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Yasmin Luni, Aditya Borakati, Arti Matah, Katie Skeats & Padma Eedarapalli. (2017) A prospective cohort study evaluating the cost-effectiveness of carbetocin for prevention of postpartum haemorrhage in caesarean sections. Journal of Obstetrics and Gynaecology 37:5, pages 601-604.
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Articles from other publishers (26)

L. Sentilhes, T. Schmitz, H. Madar, H. Bouchghoul, F. Fuchs, C. Garabédian, D. Korb, K. Nouette-Gaulain, O. Pécheux, N. Sananès, J. Sibiude, M.-V. Sénat & F. Goffinet. (2023) La technique de la césarienne : recommandations pour la pratique clinique du Collège national des gynécologues obstétriciens français. Gynécologie Obstétrique Fertilité & Sénologie  51:1, pages 7-34.
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Haiyan Sun, Lei Xu, Yu Li & Shurong Zhao. (2022) Effectiveness and safety of carboxytocin versus oxytocin in preventing postpartum hemorrhage: A systematic review and meta‐analysis. Journal of Obstetrics and Gynaecology Research 48:4, pages 889-901.
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Shaymaa Al Zubaidi & Taghreed Alhaidari. (2022) Heat stable carbetocin vs. oxytocin for the prevention of post-partum hemorrhage in emergency caesarean delivery: a randomized controlled trial. Journal of Perinatal Medicine 50:2, pages 150-156.
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H. Madar, J. Lansac & L. Sentilhes. 2022. Pratique de L'accouchement. Pratique de L'accouchement 281 302 .
Ramazan BÜLBÜL, Mehmet Murat IŞIKALAN & Ali ACAR. (2020) SEZARYEN DOĞUM SONRASINDA POSTPARTUM HEMORAJİNİN ÖNLENMESİNDE UYGULANAN KARBETOSİN VE OKSİTOSİNİN ETKİNLİĞİNİN KARŞILAŞTIRILMASIComparison of the Efficacy of Carbetocin and Oxytocın to Prevent Postpartum Hemorrhage After Cesarean Delivery. Kırıkkale Üniversitesi Tıp Fakültesi Dergisi 22:3, pages 386-392.
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Jamaica Roanne Briones, Pattarawalai Talungchit, Montarat Thavorncharoensap & Usa Chaikledkaew. (2020) Economic evaluation of carbetocin as prophylaxis for postpartum hemorrhage in the Philippines. BMC Health Services Research 20:1.
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Desire N. Onwochei, Adetokunbo Owolabi, Preet Mohinder Singh & David T. Monks. (2020) Carbetocin compared with oxytocin in non-elective Cesarean delivery: a systematic review, meta-analysis, and trial sequential analysis of randomized-controlled trialsComparaison de la carbétocine à l’ocytocine pour un accouchement par césarienne non planifié : revue systématique, méta-analyse et analyse séquentielle des études randomisées contrôlées. Canadian Journal of Anesthesia/Journal canadien d'anesthésie 67:11, pages 1524-1534.
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Е. Н. Носенко. (2020) Modern uterotonics: vitally required and dangerous... Literature review. REPRODUCTIVE ENDOCRINOLOGY:52, pages 8-17.
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Kihyug Kwon, Dohyung Kim, Hyunmin Jo, Ji Eun Park & Kyung Ok Kim. (2020) Hemodynamic effects of carbetocin administered as an intravenous bolus or infusion during cesarean delivery. Anesthesia and Pain Medicine 15:2, pages 167-172.
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D.N. Onwochei, J. Van Ross, PM. Singh, A. Salter & D.T. Monks. (2019) Carbetocin reduces the need for additional uterotonics in elective caesarean delivery: a systematic review, meta-analysis and trial sequential analysis of randomised controlled trials. International Journal of Obstetric Anesthesia 40, pages 14-23.
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Jemma Wohling, Nicole Edge, David Pena-Leal, Rui Wang, Ben Willem Mol & Gustaaf Dekker. (2019) Clinical and financial evaluation of carbetocin as postpartum haemorrhage prophylaxis at caesarean section: A retrospective cohort study. Australian and New Zealand Journal of Obstetrics and Gynaecology 59:4, pages 501-507.
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A. G. Babloyan, S. G. Tsakhilova, N. Yu. Sakvarelidze, P. P. Pyhut, A. S. Zykova, A. A. Morgoeva & D. R. Khadzhimba. (2019) Prevention of obstetric bleeding in high risk groups. Modern treatment tactics. Problemy reproduktsii 25:5, pages 100.
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Yuko Masuzawa, Yaeko Kataoka, Kana Fujii & Satomi Inoue. (2018) Prophylactic management of postpartum haemorrhage in the third stage of labour: an overview of systematic reviews. Systematic Reviews 7:1.
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Paweena Amornpetchakul, Tripop Lertbunnaphong, Dittakarn Boriboonhiransarn, Jarunee Leetheeragul, Ratree Sirisomboon & Ratchada Jiraprasertwong. (2018) Intravenous carbetocin versus intravenous oxytocin for preventing atonic postpartum hemorrhage after normal vaginal delivery in high-risk singleton pregnancies: a triple-blind randomized controlled trial. Archives of Gynecology and Obstetrics 298:2, pages 319-327.
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D. Mannaerts, L. Van der Veeken, H. Coppejans & Y. Jacquemyn. (2018) Adverse Effects of Carbetocin versus Oxytocin in the Prevention of Postpartum Haemorrhage after Caesarean Section: A Randomized Controlled Trial. Journal of Pregnancy 2018, pages 1-6.
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L. Bernaud-Bourrelier, U. Ishaque & R. Gabriel. (2017) Alumbramiento normal, alumbramiento dirigido, hemorragias posparto. EMC - Ginecología-Obstetricia 53:4, pages 1-14.
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D.N. Onwochei & D.T. Monks. (2017) The role of carbetocin in the prevention and management of postpartum haemorrhage. International Journal of Obstetric Anesthesia 32, pages 90-91.
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Aquiles Rodrigo Henríquez-Trujillo, Ruth Alicia Lucio-Romero & Kerlly Bermúdez-Gallegos. (2017) Analysis of the cost–effectiveness of carbetocin for the prevention of hemorrhage following cesarean delivery in Ecuador. Journal of Comparative Effectiveness Research 6:6, pages 529-536.
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Kok-Min Seow, Kuo-Hu Chen, Peng-Hui Wang, Yu-Hung Lin & Jiann-Loung Hwang. (2017) Carbetocin versus oxytocin for prevention of postpartum hemorrhage in infertile women with twin pregnancy undergoing elective cesarean delivery. Taiwanese Journal of Obstetrics and Gynecology 56:3, pages 273-275.
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Nicole S. Carlson. (2017) Current Resources for Evidence-Based Practice, January/February 2017. Journal of Obstetric, Gynecologic & Neonatal Nursing 46:1, pages 91-99.
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Chih-Yao Chen, Yi-Ning Su, Tzu-Hung Lin, Yi Chang, Huann-Cheng Horng, Peng-Hui Wang, Chang-Ching Yeh, Wen-Hsun Chang & Hsin-Yi Huang. (2016) Carbetocin in prevention of postpartum hemorrhage: Experience in a tertiary medical center of Taiwan. Taiwanese Journal of Obstetrics and Gynecology 55:6, pages 804-809.
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L.S. Meshykhi, M.R. Nel & D.N. Lucas. (2016) The role of carbetocin in the prevention and management of postpartum haemorrhage. International Journal of Obstetric Anesthesia 28, pages 61-69.
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Ez-Zoubir Amri & Didier F. Pisani. (2016) Control of bone and fat mass by oxytocin. Hormone Molecular Biology and Clinical Investigation 28:2, pages 95-104.
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V.P. Kovacheva, M.A. Soens & L.C. Tsen. (2016) A Randomized, Double-blinded Trial of a “Rule of Threes” Algorithm Versus Continuous Infusion of Oxytocin During Elective Cesarean Delivery. Obstetric Anesthesia Digest 36:2, pages 61-63.
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