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Review Article

The role of zinc in the prevention of diabetic cardiomyopathy and nephropathy

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Pages 27-33 | Received 18 Jul 2012, Accepted 26 Sep 2012, Published online: 29 Nov 2012

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Betul Yazğan, Abdulkerim Kasim Baltaci, Rasim Mogulkoc & Mustafa Cihat Avunduk. (2020) Effects of zinc supplementation on metallothionein levels in ischemic renal tissue. Biotechnic & Histochemistry 95:4, pages 285-296.
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Yinmao Chi, Xiuli Zhang, Dan Liang, Yue Wang, Xiaoyi Cai, Jiqiu Dong, Lingzhi Li & Zhihong Chi. (2022) ZnT8 Exerts Anti-apoptosis of Kidney Tubular Epithelial Cell in Diabetic Kidney Disease Through TNFAIP3-NF-κB Signal Pathways. Biological Trace Element Research 201:5, pages 2442-2457.
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Adaku C. Ume, Tara-Yesomi Wenegieme, Danielle N. Adams, Sherry E. Adesina & Clintoria R. Williams. (2023) Zinc Deficiency: A Potential Hidden Driver of the Detrimental Cycle of Chronic Kidney Disease and Hypertension. Kidney360 4:3, pages 398-404.
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Mark F. McCarty, James J. DiNicolantonio & James H. O’Keefe. (2022) Nutraceutical Prevention of Diabetic Complications—Focus on Dicarbonyl and Oxidative Stress. Current Issues in Molecular Biology 44:9, pages 4314-4338.
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Toshiko Takao, Hiroyuki Yanagisawa, Machi Suka, Yoko Yoshida, Yukiko Onishi, Tazu Tahara, Takako Kikuchi, Akifumi Kushiyama, Motonobu Anai, Kazuyuki Takahashi, Sayaka Wakabayashi Sugawa, Hiroki Yamazaki, Shoji Kawazu, Yasuhiko Iwamoto, Mitsuhiko Noda & Masato Kasuga. (2021) Synergistic association of the copper/zinc ratio under inflammatory conditions with diabetic kidney disease in patients with type 2 diabetes: The Asahi Diabetes Complications Study. Journal of Diabetes Investigation 13:2, pages 299-307.
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Anshul Yadav, Kunal Mondal & Ankur Gupta. 2022. Metal Oxides for Biomedical and Biosensor Applications. Metal Oxides for Biomedical and Biosensor Applications 407 435 .
Lechu Yu, Yuanyuan Liu, Yichun Jin, Tinghao Liu, Wenhan Wang, Xuemian Lu & Chi Zhang. (2021) Zinc Supplementation Prevented Type 2 Diabetes-Induced Liver Injury Mediated by the Nrf2-MT Antioxidative Pathway. Journal of Diabetes Research 2021, pages 1-14.
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Mikhail Yu. Karganov, Irina B. Alchinova, Alexey A. Tinkov, Yulia S. Medvedeva, Marina A. Lebedeva, Olga P. Ajsuvakova, Margarita V. Polyakova, Margarita G. Skalnaya, Tatiana I. Burtseva, Svetlana V. Notova, Nadezhda N. Khlebnikova & Anatoly V. Skalny. (2020) Streptozotocin (STZ)-Induced Diabetes Affects Tissue Trace Element Content in Rats in a Dose-Dependent Manner. Biological Trace Element Research 198:2, pages 567-574.
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Chien-Yuan Pan, Fang-Yu Lin, Lung-Sen Kao, Chien-Chang Huang & Pei-Shan Liu. (2020) Zinc oxide nanoparticles modulate the gene expression of ZnT1 and ZIP8 to manipulate zinc homeostasis and stress-induced cytotoxicity in human neuroblastoma SH-SY5Y cells. PLOS ONE 15:9, pages e0232729.
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Nail Altunay & Konstantin P. Katin. (2020) Ultrasonic-assisted supramolecular solvent liquid-liquid microextraction for determination of manganese and zinc at trace levels in vegetables: Experimental and theoretical studies. Journal of Molecular Liquids 310, pages 113192.
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Kim San Tang. (2019) The current and future perspectives of zinc oxide nanoparticles in the treatment of diabetes mellitus. Life Sciences 239, pages 117011.
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Marlene Fabiola Escobedo-Monge, Guido Ayala-Macedo, Graciela Sakihara, Silvia Peralta, Ana Almaraz-Gómez, Enrique Barrado & J. M. Marugán-Miguelsanz. (2019) Effects of Zinc Supplementation on Nutritional Status in Children with Chronic Kidney Disease: A Randomized Trial. Nutrients 11:11, pages 2671.
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Fatemeh Khatami, Mohammad R. Mohajeri-Tehrani & Seyed M. Tavangar. (2019) The Importance of Precision Medicine in Type 2 Diabetes Mellitus (T2DM): From Pharmacogenetic and Pharmacoepigenetic Aspects. Endocrine, Metabolic & Immune Disorders - Drug Targets 19:6, pages 719-731.
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GZA Soliman. (2019) Serum/Urine Zn Level of Egyptian Type II Diabetic Patients and Its relation with Glycemic Control (HbA1c). Journal of Biology and Medicine 3:1, pages 044-047.
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Tingwen Ge, Youxi Yu, Jiuwei Cui & Lu Cai. (2019) The adaptive immune role of metallothioneins in the pathogenesis of diabetic cardiomyopathy: good or bad. American Journal of Physiology-Heart and Circulatory Physiology 317:2, pages H264-H275.
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Aamir Bashir, Md Azharuddin, Ishfaq Rashid, Krishna Murti & Krishna Pandey. (2019) Predictors of cardiomyopathy in patients with type-2 diabetes mellitus with and without cardiovascular complications: A cross-sectional study. Diabetes Research and Clinical Practice 154, pages 90-100.
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Kristien Daenen, Asmin Andries, Djalila Mekahli, Ann Van Schepdael, François Jouret & Bert Bammens. (2018) Oxidative stress in chronic kidney disease. Pediatric Nephrology 34:6, pages 975-991.
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Meihua Piao, Ya Liu, Ting Yu & Ying Lu. (2018) Dietary zinc reduces endoplasmic reticulum stress and autophagy to protect against diabetic renal damage in streptozotocin-induced diabetic rats. International Journal of Diabetes in Developing Countries 39:2, pages 340-345.
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Fumitsugu Yoshikawa, Tetsu Nakajima, Masaharu Hanada, Kazuo Hirata, Tohru Masuyama & Ryuichi Aikawa. (2019) Beneficial effect of polaprezinc on cardiac function post-myocardial infarction. Medicine 98:10, pages e14637.
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Agnès Sallé. (2018) Le diabète, facteur de dénutrition et de carences en micronutriments ?. Nutrition Clinique et Métabolisme 32:1, pages 8-21.
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Ayodele Olufemi Morakinyo, Titilola Aderonke Samuel & Daniel Abiodun Adekunbi. (2018) Magnesium upregulates insulin receptor and glucose transporter-4 in streptozotocin-nicotinamide-induced type-2 diabetic rats. Endocrine Regulations 52:1, pages 6-16.
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Robertina Giacconi, Lu Cai, Laura Costarelli, Maurizio Cardelli, Marco Malavolta, Francesco Piacenza & Mauro Provinciali. (2017) Implications of impaired zinc homeostasis in diabetic cardiomyopathy and nephropathy. BioFactors 43:6, pages 770-784.
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Serhan Ozyıldırım, Abdulkerim Kasim Baltaci, Engin Sahna & Rasim Mogulkoc. (2016) Effects of Chronic and Acute Zinc Supplementation on Myocardial Ischemia-Reperfusion Injury in Rats. Biological Trace Element Research 178:1, pages 64-70.
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Martina Raudenska, Veronika Dvorakova, Lukas Pacal, Katarina Chalasova, Monika Kratochvilova, Jaromir Gumulec, Branislav Ruttkay-Nedecky, Ondrej Zitka, Katerina Kankova, Vojtech Adam & Michal Masarik. (2017) Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease. Journal of Biochemical and Molecular Toxicology 31:6, pages e21891.
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Mark McCarty. (2017) Supplementation with Phycocyanobilin, Citrulline, Taurine, and Supranutritional Doses of Folic Acid and Biotin—Potential for Preventing or Slowing the Progression of Diabetic Complications. Healthcare 5:1, pages 15.
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Mirandy S. LiSherry E. Adesina, Carla L. EllisJennifer L. Gooch, Robert S. Hoover & Clintoria R. Williams. (2017) NADPH oxidase-2 mediates zinc deficiency-induced oxidative stress and kidney damage. American Journal of Physiology-Cell Physiology 312:1, pages C47-C55.
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A. Cancarini, J. Fostinelli, L. Napoli, M.E. Gilberti, P. Apostoli & F. Semeraro. (2017) Trace elements and diabetes: Assessment of levels in tears and serum. Experimental Eye Research 154, pages 47-52.
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Krishna Prahlad Maremanda, Sabbir Khan & G. B. Jena. (2016) Role of Zinc Supplementation in Testicular and Epididymal Damages in Diabetic Rat: Involvement of Nrf2, SOD1, and GPX5. Biological Trace Element Research 173:2, pages 452-464.
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Amr M. AbbasHussein F. Sakr. (2016) Effect of magnesium sulfate and thyroxine on inflammatory markers in a rat model of hypothyroidism. Canadian Journal of Physiology and Pharmacology 94:4, pages 426-432.
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Mussie Sium, Patrick Kareru, Joseph Keriko, Berhane Girmay, Ghebrehiwet Medhanie & Semere Debretsion. (2016) Profile of Trace Elements in Selected Medicinal Plants Used for the Treatment of Diabetes in Eritrea. The Scientific World Journal 2016, pages 1-7.
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Yonggang Wang, Xiao Miao, Jian Sun & Lu Cai. 2016. Molecular Nutrition and Diabetes. Molecular Nutrition and Diabetes 65 72 .
Márta Sárközy, Gergő Szűcs, Márton Pipicz, Ágnes Zvara, Katalin Éder, Veronika Fekete, Csilla Szűcs, Judit Bárkányi, Csaba Csonka, László G. Puskás, Csaba Kónya, Péter Ferdinandy & Tamás Csont. (2015) The effect of a preparation of minerals, vitamins and trace elements on the cardiac gene expression pattern in male diabetic rats. Cardiovascular Diabetology 14:1.
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Atieh Makhlough, Marjan Makhlough, Mohammad Shokrzadeh, Mozhdeh Mohammadian, Omid Sedighi & Mansooreh Faghihan. (2015) Comparing the Levels of Trace Elements in Patients With Diabetic Nephropathy and Healthy Individuals. Nephro-Urology Monthly 7:4.
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Mark F. McCarty & James J. DiNicolantonio. (2015) The protection conferred by chelation therapy in post-MI diabetics might be replicated by high-dose zinc supplementation. Medical Hypotheses 84:5, pages 451-455.
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Tingting Liang, Quan Zhang, Weixia Sun, Ying Xin, Zhiguo Zhang, Yi Tan, Shanshan Zhou, Chi Zhang, Lu Cai, Xuemian Lu & Mingliang Cheng. (2015) Zinc treatment prevents type 1 diabetes-induced hepatic oxidative damage, endoplasmic reticulum stress, and cell death, and even prevents possible steatohepatitis in the OVE26 mouse model: Important role of metallothionein. Toxicology Letters 233:2, pages 114-124.
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Chaobin Liu, Xiaoyu He, Xinru Hong, Fenhong Kang, Suqing Chen, Qing Wang, Xiaoqiu Chen, Dian Hu & Qinghua Sun. (2014) Suppression of Placental Metallothionein 1 and Zinc Transporter 1 mRNA Expressions Contributes to Fetal Heart Malformations Caused by Maternal Zinc Deficiency. Cardiovascular Toxicology 14:4, pages 329-338.
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Quan Liu, Shudong Wang & Lu Cai. (2014) Diabetic cardiomyopathy and its mechanisms: Role of oxidative stress and damage. Journal of Diabetes Investigation 5:6, pages 623-634.
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Cennet Ragbetli, Semiha Dede, Pinar Tanritanir, İbrahim Hakki Yoruk & Murat Cetin Ragbetli. (2014) Determination of Micronutrients and Oxidative Stress Status in the Blood of STZ-Induced Experimental Diabetic Rat Models. Cell Biochemistry and Biophysics 70:2, pages 933-938.
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Nephertiti Efeovbokhan, Syamal K. Bhattacharya, Robert A. Ahokas, Yao Sun, Ramareddy V. Guntaka, Ivan C. Gerling & Karl T. Weber. (2014) Zinc and the Prooxidant Heart Failure Phenotype. Journal of Cardiovascular Pharmacology 64:4, pages 393-400.
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Mohammad Reza Parvizi, Mohsen Parviz, Seyed Mohammad Tavangar, Nepton Soltani, Mehri Kadkhodaee, Behjat Seifi, Yaser Azizi & Mansoor Keshavarz. (2014) Protective effect of magnesium on renal function in STZ-induced diabetic rats. Journal of Diabetes & Metabolic Disorders 13:1.
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Husam Dabbagh-Bazarbachi, Gael Clergeaud, Isabel M. Quesada, Mayreli Ortiz, Ciara K. O’Sullivan & Juan B. Fernández-Larrea. (2014) Zinc Ionophore Activity of Quercetin and Epigallocatechin-gallate: From Hepa 1-6 Cells to a Liposome Model. Journal of Agricultural and Food Chemistry 62:32, pages 8085-8093.
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Weitao Cong, Ting Zhao, Zhongxin Zhu, Binbin Huang, Weide Ma, Yuehui Wang, Yi Tan, Subrata Chakrabarti, Xiaokun Li, Litai Jin & Lu Cai. (2014) Metallothionein prevents cardiac pathological changes in diabetes by modulating nitration and inactivation of cardiac ATP synthase. The Journal of Nutritional Biochemistry 25:4, pages 463-474.
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Joseph Fomusi Ndisang, Alfredo Vannacci & Sharad Rastogi. (2014) Oxidative Stress and Inflammation in Obesity, Diabetes, Hypertension, and Related Cardiometabolic Complications. Oxidative Medicine and Cellular Longevity 2014, pages 1-3.
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Zhelong Xu & Juan Zhou. (2013) Zinc and myocardial ischemia/reperfusion injury. BioMetals 26:6, pages 863-878.
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Mario Arciello, Manuele Gori & Clara Balsano. (2013) Mitochondrial Dysfunctions and Altered Metals Homeostasis: New Weapons to Counteract HCV-Related Oxidative Stress. Oxidative Medicine and Cellular Longevity 2013, pages 1-10.
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Jiancheng Xu, Qi Zhou, Gilbert Liu, Yi Tan & Lu Cai. (2013) Analysis of Serum and Urinal Copper and Zinc in Chinese Northeast Population with the Prediabetes or Diabetes with and without Complications. Oxidative Medicine and Cellular Longevity 2013, pages 1-11.
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