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Toxicology Mechanisms and Methods Volume 24, 2014 - Issue 4
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Research Article

SAR genotoxicity and tumorigenicity predictions for 2-MI and 4-MI using multiple SAR software

Kavya A. KrishnaPreclinical Candidate Evaluation Department, Supernus Pharmaceuticals Inc. Rockville, MDUSA
,
Saryu GoelPreclinical Candidate Evaluation Department, Supernus Pharmaceuticals Inc. Rockville, MDUSA
&
Gopala KrishnaPreclinical Candidate Evaluation Department, Supernus Pharmaceuticals Inc. Rockville, MDUSACorrespondence[email protected]
Pages 284-293 | Received 18 Nov 2013, Accepted 07 Jan 2014, Published online: 27 Jan 2014

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Angela S. Howard & Neepa Choksi. (2020) Evaluation of two in silico programs for predicting mutagenicity and carcinogenicity potential for 4-methylimidazole (4-MeI) and known metabolites. Toxicology Mechanisms and Methods 30:4, pages 246-256.
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Rima Celik & Mehmet Topaktas. (2018) Genotoxic effects of 4-methylimidazole on human peripheral lymphocytes in vitro. Drug and Chemical Toxicology 41:1, pages 27-32.
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Articles from other publishers (6)

Octavia-Laura Moldovan, Alexandra Sandulea, Ioana-Andreea Lungu, Șerban Andrei Gâz & Aura Rusu. (2023) Identification of Some Glutamic Acid Derivatives with Biological Potential by Computational Methods. Molecules 28:10, pages 4123.
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Susan J. Borghoff, Seneca E. Fitch, Michael B. Black, Patrick D. McMullen, Melvin E. Andersen & Grace A. Chappell. (2021) A systematic approach to evaluate plausible modes of actions for mouse lung tumors in mice exposed to 4-methylimidozole. Regulatory Toxicology and Pharmacology 124, pages 104977.
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David Brusick, Marilyn J. Aardema, William T. Allaben, David J. Kirkland, Gary Williams, G. Craig Llewellyn, Julia M. Parker & Marisa O. Rihner. (2020) A weight of evidence assessment of the genotoxic potential of 4-methylimidazole as a possible mode of action for the formation of lung tumors in exposed mice. Food and Chemical Toxicology 145, pages 111652.
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Gopala Krishna, Priya A. Krishna, Saryu Goel & Kavya A. Krishna. 2019. Biomarkers in Toxicology. Biomarkers in Toxicology 143 161 .
Ana Paula  Peron. (2017) Cytogenotoxicity of Shakes Added with Synthetic Micro Ingredients. MOJ Biology and Medicine 1:6.
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Takeshi Morita & Chikako Uneyama. (2016) Genotoxicity assessment of 4-methylimidazole: regulatory perspectives. Genes and Environment 38:1.
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