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COPD: Journal of Chronic Obstructive Pulmonary Disease Volume 10, 2013 - Issue 2
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ORIGINAL RESEARCH

High-Dose N-Acetylcysteine in the Prevention of COPD Exacerbations: Rationale and Design of the PANTHEON Study

Jin-Ping ZhengState Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical College, Guangzhou, ChinaCorrespondence[email protected] [email protected]
,
Fu-Qiang WenHuaxi Hospital, Sichuan University, Chengdu, China
,
Chun-Xue BaiZhongshan Hospital, Fudan University, Shanghai, China
,
Huan-Ying WanRui Jin Hospital Shanghai Jiao Tong University School of Medicine
,
Jian KangFirst Affiliated Hospital of China Medical University, Shenyang, China
,
Ping ChenShenyang PLA General Hospital, Shenyang, China
,
Wan-Zhen YaoPeking University Third Hospital, Beijing, China
,
Li-Jun MaHenan Provincial People's Hospital, Zhengzhou, China
,
Qi-kui XiaPublic Health University of Fudan University, Shanghai, China
,
Yi GaoState Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical College, Guangzhou, China
&
Nan-Shan ZhongState Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical College, Guangzhou, ChinaCorrespondence[email protected] [email protected]
, on behalf of the PANTHEON study committee show all
Pages 164-171 | Published online: 12 Oct 2012

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Pierachille Santus, Angelo Corsico, Paolo Solidoro, Fulvio Braido, Fabiano Di Marco & Nicola Scichilone. (2014) Oxidative Stress and Respiratory System: Pharmacological and Clinical Reappraisal of N-Acetylcysteine. COPD: Journal of Chronic Obstructive Pulmonary Disease 11:6, pages 705-717.
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Yanfei Shen, Wanru Cai, Shu Lei & Zhongheng Zhang. (2014) Effect of High/Low Dose N-Acetylcysteine on Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis. COPD: Journal of Chronic Obstructive Pulmonary Disease 11:3, pages 351-358.
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Articles from other publishers (14)

Ankit Singh, Harsh J Shah, Jacky Pariyani, Kalyani V Shinde & Paarth Kumar. (2023) A Comparative Study to Assess Efficacy and Safety of NAC Combination and NAC in Patients of Productive Cough with Acute Bronchitis. Indian Journal of Respiratory Care 12:3, pages 254-258.
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O. O. Kotova, D. A. Gassan, I. Yu. Sugaylo, D. E. Naumov, Y. G. Gorchakova & E. G. Sheludko. (2023) Oxidative stress in peripheral blood leukocytes of patients with chronic obstructive pulmonary disease. Bulletin Physiology and Pathology of Respiration:87, pages 62-70.
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Ai Luo, Xuemei Liu, Qiongqiong Hu, Mei Yang, Hongli Jiang & Wei Liu. (2022) Efficacy of N -acetylcysteine on idiopathic or postinfective non-cystic fibrosis bronchiectasis: a systematic review and meta-analysis protocol . BMJ Open 12:3, pages e053625.
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Hirofumi Kiyokawa, Yuma Hoshino, Kazuhiro Sakaguchi, Shigeo Muro & Junji Yodoi. (2021) Redox Regulation in Aging Lungs and Therapeutic Implications of Antioxidants in COPD. Antioxidants 10:9, pages 1429.
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N. Jung, W.-J. Mayet, P.R. Mertens, J. Meyer (federführend)O.-A. Müller, M. Pfeifer, P. Schellinger, N. Weiss & C.-M. Wendtner. 2020. Rationelle Diagnostik und Therapie in der Inneren Medizin. Rationelle Diagnostik und Therapie in der Inneren Medizin C-1 C22-4 .
Qian Qi, Yirepanjaing Ailiyaer, Ruijuan Liu, Yan Zhang, Caiyu Li, Mingtao Liu, Xiuxiu Wang, Lijun Jing & Yu Li. (2019) Effect of N-acetylcysteine on exacerbations of bronchiectasis (BENE): a randomized controlled trial. Respiratory Research 20:1.
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Huihui Ti, Yang Zhou, Xue Liang, Runfeng Li, Ke Ding & Xin Zhao. (2019) Targeted Treatments for Chronic Obstructive Pulmonary Disease (COPD) Using Low-Molecular-Weight Drugs (LMWDs). Journal of Medicinal Chemistry 62:13, pages 5944-5978.
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Phillippa Poole, Kavin Sathananthan & Rebecca Fortescue. (2019) Mucolytic agents versus placebo for chronic bronchitis or chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews 2020:3.
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Alberto Papi, Jinping Zheng, Gerard J. Criner, Leonardo M. Fabbri & Peter M.A. Calverley. (2019) Impact of smoking status and concomitant medications on the effect of high-dose N-acetylcysteine on chronic obstructive pulmonary disease exacerbations: A post-hoc analysis of the PANTHEON study. Respiratory Medicine 147, pages 37-43.
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Kaushal Fowdar, Huan Chen, Zhiyi He, Jiujin Zhang, Xiaoning Zhong, Jianquan Zhang, Meihua Li & Jing Bai. (2017) The effect of N-acetylcysteine on exacerbations of chronic obstructive pulmonary disease: A meta-analysis and systematic review. Heart & Lung 46:2, pages 120-128.
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Phillippa Poole, Jimmy Chong & Christopher J Cates. (2015) Mucolytic agents versus placebo for chronic bronchitis or chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews.
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A. Klemmer, T. Greulich, A. R. Koczulla & C. F. Vogelmeier. (2014) Die chronisch-obstruktive Lungenerkrankung (COPD). CME 11:12, pages 52-61.
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A. Klemmer, T. Greulich, A.R. Koczulla & C.F. Vogelmeier. (2014) Die chronisch-obstruktive Lungenerkrankung (COPD)Chronic obstructive pulmonary disease (COPD). Der Internist 55:4, pages 401-414.
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Jin-Ping Zheng, Fu-Qiang Wen, Chun-Xue Bai, Huan-Ying Wan, Jian Kang, Ping Chen, Wan-Zhen Yao, Li-Jun Ma, Xia Li, Luca Raiteri, Marco Sardina, Yi Gao, Bai-Song Wang & Nan-Shan Zhong. (2014) Twice daily N-acetylcysteine 600 mg for exacerbations of chronic obstructive pulmonary disease (PANTHEON): a randomised, double-blind placebo-controlled trial. The Lancet Respiratory Medicine 2:3, pages 187-194.
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