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Paper from the 20th Summerschool in Immunotoxicology, Beaune, France, Sept. 26–28, 2011

After TGN1412: Recent developments in cytokine release assays

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Pages 75-82 | Received 29 May 2012, Accepted 10 Jul 2012, Published online: 11 Sep 2012

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Rafael A. Ponce. 2014. Molecular Immunotoxicology. Molecular Immunotoxicology 159 188 .
Alexander Batista-Duharte, Deivys Portuondo, O Pérez & Iracilda Zeppone Carlos. (2014) Systemic immunotoxicity reactions induced by adjuvanted vaccines. International Immunopharmacology 20:1, pages 170-180.
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Crossref
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Suzanne J. Suchard, Patricia M. Davis, Selena Kansal, Dawn K. Stetsko, Ruth Brosius, James Tamura, Lumelle Schneeweis, James Bryson, Theodora Salcedo, Haiqing Wang, Zheng Yang, Catherine A. Fleener, Olga Ignatovich, Christopher Plummer, Steven Grant & Steven G. Nadler. (2013) A Monovalent Anti-Human CD28 Domain Antibody Antagonist: Preclinical Efficacy and Safety. The Journal of Immunology 191:9, pages 4599-4610.
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Crossref
Christina Ball, Bernard Fox, Simon Hufton, Giles Sharp, Stephen Poole, Richard Stebbings, David Eastwood, Lucy Findlay, Paul W. H. I. Parren, Robin Thorpe, Adrian Bristow & Susan J. Thorpe. (2012) Antibody C Region Influences TGN1412-like Functional Activity In Vitro. The Journal of Immunology 189:12, pages 5831-5840.
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