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Brief Reports

Massive acetylcysteine overdose associated with cerebral edema and seizures

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Pages 423-425 | Received 21 Mar 2011, Accepted 20 Apr 2011, Published online: 08 Jul 2011

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Kevin Burnham, Tianrui Yang, Haleigh Smith & Steven Knight. (2021) A review of alternative intravenous acetylcysteine regimens for acetaminophen overdose. Expert Review of Clinical Pharmacology 14:10, pages 1267-1278.
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James B. Leonard, Faisal S. Minhaj & Wendy Klein-Schwartz. (2021) An analysis of fatal iatrogenic therapeutic errors reported to United States poison centers. Clinical Toxicology 59:1, pages 53-60.
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Michael E. Mullins, Mark C. Yarema, Marco L. A. Sivilotti, Margaret Thompson, Michael C. Beuhler, D. Adam Algren & Christopher P. Holstege. (2020) Comment on “Transition to two-bag intravenous acetylcysteine for acetaminophen overdose”. Clinical Toxicology 58:5, pages 433-435.
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Michael E. Mullins, Mary Yu, Lauren O’Grady, Shariq Khan & Evan S. Schwarz. (2020) Adverse reactions in patients treated with the one-bag method of N-acetylcysteine for acetaminophen ingestion. Toxicology Communications 4:1, pages 49-54.
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Lars E. Schmidt, Ditlev N. Rasmussen, Tonny S. Petersen, Ines M. Macias-Perez, Leo Pavliv, Byron Kaelin, Richard C. Dart & Kim Dalhoff. (2018) Fewer adverse effects associated with a modified two-bag intravenous acetylcysteine protocol compared to traditional three-bag regimen in paracetamol overdose. Clinical Toxicology 56:11, pages 1128-1134.
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Alessandro Minarini, Silvia Ferrari, Martina Galletti, Nina Giambalvo, Daniela Perrone, Giulia Rioli & Gian Maria Galeazzi. (2017) N-acetylcysteine in the treatment of psychiatric disorders: current status and future prospects. Expert Opinion on Drug Metabolism & Toxicology 13:3, pages 279-292.
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Ghafar Ali Mahmoudi, Peyman Astaraki, Azita Zafar Mohtashami & Maryam Ahadi. (2015) N-acetylcysteine overdose after acetaminophen poisoning. International Medical Case Reports Journal 8, pages 65-69.
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M. L. A. Sivilotti, D. N. Juurlink, J. S. Garland, I. Lenga, R. Poley, L. N. Hanly & M. Thompson. (2013) Antidote removal during haemodialysis for massive acetaminophen overdose. Clinical Toxicology 51:9, pages 855-863.
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W Stephen Waring. (2012) Criteria for acetylcysteine treatment and clinical outcomes after paracetamol poisoning. Expert Review of Clinical Pharmacology 5:3, pages 311-318.
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Michael E. Mullins & Evan Schwarz. (2012) No need to change treatment of early presenting patients with acetaminophen overdose. Clinical Toxicology 50:1, pages 78-78.
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Michael C. Beuhler & Anna R. Dulaney. (2011) Further case details regarding IV N-Acetylcysteine overdoses. Clinical Toxicology 49:9, pages 878-878.
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Michael E. Mullins & Irena V Vitkovitsky. (2011) Hemolysis and Hemolytic Uremic Syndrome following Five-fold N-Acetylcysteine Overdose. Clinical Toxicology 49:8, pages 755-759.
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Articles from other publishers (20)

Ari B. Filip & Michael E. Mullins. (2022) Fomepizole should be used more liberally in paracetamol overdose. British Journal of Clinical Pharmacology 89:2, pages 594-598.
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Jephte Y. Akakpo, Anup Ramachandran, Steven C. Curry, Barry H. Rumack & Hartmut Jaeschke. (2022) Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose. Archives of Toxicology 96:2, pages 453-465.
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Reza Asadzadeh, Zahra Khalighi, Nahid Mamizadeh, Marzieh Hadavi, Abas Ghaysouri & Aliashraf Mozafari. (2021) Acute Renal Failure and Hemolytic Uremic Syndrome in Overdose With N-acetyl Cysteine After Acetaminophen Poisoning. Nephro-Urology Monthly 13:3.
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Gunn-Guang Liou, Cheng-Chi Hsieh, Yi-Ju Lee, Pin-Hung Li, Ming-Shiun Tsai, Chi-Ting Li & Sue-Hong Wang. (2021) N-Acetyl Cysteine Overdose Inducing Hepatic Steatosis and Systemic Inflammation in Both Propacetamol-Induced Hepatotoxic and Normal Mice. Antioxidants 10:3, pages 442.
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Carmen Griñan-Lison, Jose L. Blaya-Cánovas, Araceli López-Tejada, Marta Ávalos-Moreno, Alba Navarro-Ocón, Francisca E. Cara, Adrián González-González, Jose A. Lorente, Juan A. Marchal & Sergio Granados-Principal. (2021) Antioxidants for the Treatment of Breast Cancer: Are We There Yet?. Antioxidants 10:2, pages 205.
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Kristen M. Audley & Jamie M. Rosini. (2020) Increased Intravenous N-Acetylcysteine Dosing Following Massive Acetaminophen Ingestion: A Case Report. Journal of Emergency Nursing 46:3, pages 359-363.
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Angela Jackson & Mark Little. (2019) Electronic intravenous N‐acetyl cysteine ordering tool: A retrospective review. Emergency Medicine Australasia 32:2, pages 267-270.
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Lauren O'Grady, Michael E. Mullins & Evan S. Schwarz. (2017) A comment on ‘An assessment of the variation in the concentrations of acetylcysteine in infusions for the treatment of paracetamol overdose’. British Journal of Clinical Pharmacology 83:12, pages 2833-2834.
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George P. Bailey, David M. Wood, John R. H. Archer, Edmund Rab, Robert J. Flanagan & Paul I. Dargan. (2016) An assessment of the variation in the concentration of acetylcysteine in infusions for the treatment of paracetamol overdose. British Journal of Clinical Pharmacology 83:2, pages 393-399.
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Eric Villeneuve & Sophie Gosselin. 2017. Critical Care Toxicology. Critical Care Toxicology 2879 2888 .
Jan Grendar & Elijah Dixon. (2016) Response to Letter to the Editor on “Effect of N-acetylcysteine on liver recovery after resection. A randomized clinical trial”. Journal of Surgical Oncology 114:6, pages 774-774.
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Eric Villeneuve & Sophie Gosselin. 2016. Critical Care Toxicology. Critical Care Toxicology 1 10 .
SH Zyoud, SW Al-Jabi, WM Sweileh, R Awang & WS Waring. (2015) Global research productivity of N -acetylcysteine use in paracetamol overdose . Human & Experimental Toxicology 34:10, pages 1006-1016.
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Shawn M. Varney, Jennie A. Buchanan, Jamie Kokko & Kennon Heard. (2014) Acetylcysteine for Acetaminophen Overdose in Patients Who Weigh >100 Kg. American Journal of Therapeutics 21:3, pages 159-163.
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Salvatore Grosso & Ursula Geronzi. 2014. Perinatal and Prenatal Disorders. Perinatal and Prenatal Disorders 371 394 .
Shona McIntyre, David McD Taylor & Shaun Greene. (2013) Introduction of an N-acetylcysteine weight-based dosing chart reduces prescription errors in the treatment of paracetamol poisoning. Emergency Medicine Australasia 25:1, pages 28-35.
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Byeong Jo ChunJeong Mi MoonSeung Ho Kim. (2013) Antidote for acetaminophen poisoning: N -acetylcysteine . Journal of the Korean Medical Association 56:12, pages 1067.
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W. Stephen Waring. (2012) Novel acetylcysteine regimens for treatment of paracetamol overdose. Therapeutic Advances in Drug Safety 3:6, pages 305-315.
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Steven M. Selbst & Kevin Osterhoudt. (2012) Pediatric Emergency Medicine. Pediatric Emergency Care 28:12, pages 1402-1405.
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Michael J. Hodgman & Alexander R. Garrard. (2012) A Review of Acetaminophen Poisoning. Critical Care Clinics 28:4, pages 499-516.
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