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Clinical Toxicology Volume 51, 2013 - Issue 7
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Critical Care

Hump-nosed pit viper (Hypnale hypnale) envenoming causes mild coagulopathy with incomplete clotting factor consumption

K. MaduwageSchool of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia;Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, NSW, Australia;South Asian Clinical Toxicology Research Collaboration (SACTRC), Faculty of Medicine, University of Peradeniya, Sri Lanka
,
F. E. ScorgieHunter Haematology Research Group, Calvary Mater Newcastle, Newcastle, NSW, Australia
,
A. SilvaSouth Asian Clinical Toxicology Research Collaboration (SACTRC), Faculty of Medicine, University of Peradeniya, Sri Lanka;Department of Parasitology, Faculty of Medicine and Allied Sciences, Rajarata University, Anuradhapura, Sri Lanka
,
S. ShahmySouth Asian Clinical Toxicology Research Collaboration (SACTRC), Faculty of Medicine, University of Peradeniya, Sri Lanka
,
F. MohamedSouth Asian Clinical Toxicology Research Collaboration (SACTRC), Faculty of Medicine, University of Peradeniya, Sri Lanka
,
C. AbeysinghePolonnaruwa General Hospital, North Central Province, Polonnaruwa, Sri Lanka
,
H. KarunathilakePolonnaruwa General Hospital, North Central Province, Polonnaruwa, Sri Lanka
,
L. F. LinczSchool of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia;Hunter Haematology Research Group, Calvary Mater Newcastle, Newcastle, NSW, Australia
,
C. A. GnanathasanDepartment of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka
&
G. K. IsbisterSchool of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia;Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, NSW, Australia;South Asian Clinical Toxicology Research Collaboration (SACTRC), Faculty of Medicine, University of Peradeniya, Sri LankaCorrespondence[email protected]
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Pages 527-531 | Received 31 Jan 2013, Accepted 28 May 2013, Published online: 23 Jul 2013

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R. M. M. K. Namal Rathnayaka, P. E. Anusha Nishanthi Ranathunga & S. A. M. Kularatne. (2023) Long-term health manifestations of hump-nosed pit viper (Genus: Hypnale) bites. Clinical Toxicology 61:9, pages 680-686.
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Eranga S. Wijewickrama, Lalindra V. Gooneratne, Ariaranee Gnanathasan, Indika Gawarammana, Mangala Gunatilake & Geoffrey K. Isbister. (2021) Severe acute kidney injury following Sri Lankan Hypnale spp. envenoming is associated with thrombotic microangiopathy. Clinical Toxicology 59:4, pages 296-302.
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Anjana Silva, E. Michael Sedgwick, Prasanna Weerawansa, Senaka Pilapitiya, Vajira Weerasinghe, Nicholas Buckley, Sisira Siribaddana & Geoffrey K. Isbister. (2019) Sub-clinical neuromuscular dysfunction after envenoming by Merrem’s hump-nosed pit viper (Hypnale hypnale). Toxicology Communications 3:1, pages 23-28.
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Ranjith B. Adhikari, Ashoka Dangolla, Indika B. Gawarammana, D. D. N. De Silva, A. D. Premarathna & Indira D. Silva. (2018) Epidemiology of snakebite in dogs in Sri Lanka. Toxicology Communications 2:1, pages 107-112.
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R. M. M. K. Namal Rathnayaka, P. E. A. Nishanthi Ranathunga, S. A. M. Kularatne & Sanath Jayasinghe. (2022) Acute ischemic stroke: a rare complication of hump-nosed pit viper (Hypnale spp.) bite: a case report. Journal of Medical Case Reports 16:1.
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Freston M. Sirur, Jayaraj M. Balakrishnan & Vrinda Lath. (2022) Hump-Nosed Pit Viper Envenomation in Western Coastal India: A Case Series. Wilderness & Environmental Medicine 33:4, pages 399-405.
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R.M.M.K. Namal Rathnayaka, P.E. Anusha Nishanthi Ranathunga & S.A.M. Kularatne. (2021) Kounis Syndrome Following Hypnale zara (Hump-Nosed Pit Viper) Bite in Sri Lanka. Wilderness & Environmental Medicine 32:2, pages 210-216.
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Bolar Sadananda Naik. (2021) Hypnale Coagulopathy: Snake Envenomation of a Different Kind . Journal of the Royal College of Physicians of Edinburgh 51:1, pages 31-36.
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E.W.R.A. Witharana, A. Gnanathasan, A.S. Dissanayake, S.K.J. Wijesinghe, S.C.L. Kadahetti & R.M.J.K. Rajapaksha. (2021) Hump-nosed pit viper (Hypnale hypnale and Hypnale zara) envenoming in Deniyaya, Sri Lanka: Epidemiological and clinical features from a prospective observational study. Toxicon 189, pages 19-23.
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Siju V. Abraham, Bezalel Hakkeem, Deo Mathew, Aboobacker Mohamed Rafi, Aruvi Poomali, Joe Thomas & C.K. Kassyap. (2020) Hematotoxic Snakebite Victim with Trauma: The Role of Guided Transfusion, Rotational Thromboelastometry, and Tranexamic Acid. Wilderness & Environmental Medicine 31:4, pages 470-481.
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Eun Jung Park, Sangchun Choi, Hyuk-Hoon Kim & Yoon Seok Jung. (2020) Novel Treatment Strategy for Patients with Venom-Induced Consumptive Coagulopathy from a Pit Viper Bite. Toxins 12:5, pages 295.
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Jordan Debono, Mettine H.A. Bos, Francisco Coimbra, Lilin Ge, Nathaniel Frank, Hang Fai Kwok & Bryan G. Fry. (2019) Basal but divergent: Clinical implications of differential coagulotoxicity in a clade of Asian vipers. Toxicology in Vitro 58, pages 195-206.
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Harendra Kumara, Nimal Seneviratne, Dilini S. Jayaratne, Sisira Siribaddana, Geoffrey K. Isbister & Anjana Silva. (2019) Severe coagulopathy in Merrem's hump-nosed pit viper (Hypnale hypnale) envenoming unresponsive to fresh frozen plasma: A case report. Toxicon 163, pages 19-22.
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G.K. Isbister, S. Jayamanne, F. Mohamed, A.H. Dawson, K. Maduwage, I. Gawarammana, D.G. Lalloo, H.J. de Silva, F.E. Scorgie, L.F. Lincz & N.A. Buckley. (2017) A randomized controlled trial of fresh frozen plasma for coagulopathy in Russell's viper (Daboia russelii) envenoming. Journal of Thrombosis and Haemostasis 15:4, pages 645-654.
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Mauren Villalta, Andrés Sánchez, María Herrera, Mariángela Vargas, Álvaro Segura, Maykel Cerdas, Ricardo Estrada, Indika Gawarammana, Dan E. Keyler, Kimberly McWhorter, Roy Malleappah, Alberto Alape-Girón, Guillermo León & José María Gutiérrez. (2016) Development of a new polyspecific antivenom for snakebite envenoming in Sri Lanka: Analysis of its preclinical efficacy as compared to a currently available antivenom. Toxicon 122, pages 152-159.
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Kalana P. Maduwage, Fiona E. Scorgie, Lisa F. Lincz, Margaret A. O'Leary & Geoffrey K. Isbister. (2016) Procoagulant snake venoms have differential effects in animal plasmas: Implications for antivenom testing in animal models. Thrombosis Research 137, pages 174-177.
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Geoffrey K. Isbister, Kalana Maduwage, Fiona E. Scorgie, Seyed Shahmy, Fahim Mohamed, Chandana Abeysinghe, Harendra Karunathilake, Margaret A. O’Leary, Christeine A. Gnanathasan & Lisa F. Lincz. (2015) Venom Concentrations and Clotting Factor Levels in a Prospective Cohort of Russell’s Viper Bites with Coagulopathy. PLOS Neglected Tropical Diseases 9:8, pages e0003968.
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Kalana Maduwage, Margaret A. O'Leary, Fiona E. Scorgie, Seyed Shahmy, Fahim Mohamed, Chandana Abeysinghe, Harindra Karunathilake, Lisa F. Lincz, Christeine A. Gnanathasan & Geoffrey K. Isbister. (2014) Detection of Venom after Antivenom Is Not Associated with Persistent Coagulopathy in a Prospective Cohort of Russell's Viper (Daboia russelii) Envenomings. PLoS Neglected Tropical Diseases 8:12, pages e3304.
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G.K. Isbister, K. Maduwage & C.B. Page. (2014) Antivenom cross neutralisation in a suspected Asian pit viper envenoming causing severe coagulopathy. Toxicon 90, pages 286-290.
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Kalana Maduwage & Geoffrey K. Isbister. (2014) Current Treatment for Venom-Induced Consumption Coagulopathy Resulting from Snakebite. PLoS Neglected Tropical Diseases 8:10, pages e3220.
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Kalana Maduwage, Margaret A. O'Leary & Geoffrey K. Isbister. (2014) Diagnosis of snake envenomation using a simple phospholipase A2 assay. Scientific Reports 4:1.
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Mitrakrishnan Shivanthan, Jevon Yudhishdran, Rayno Navinan & Senaka Rajapakse. (2014) Hump-nosed viper bite: an important but under-recognized cause of systemic envenoming. Journal of Venomous Animals and Toxins including Tropical Diseases 20:1, pages 24.
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