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The World Journal of Biological Psychiatry Volume 14, 2013 - Issue 8
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Research Article

A pilot genome wide association and gene expression array study of suicide with and without major depression

Hanga GalfalvyDivision of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, and Department of Psychiatry, Columbia University, New York, NY, USA
,
Gil ZalsmanDivision of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, and Department of Psychiatry, Columbia University, New York, NY, USA;Geha Mental Health Center and Department of Psychiatry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
,
Yung-Yu HuangDivision of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, and Department of Psychiatry, Columbia University, New York, NY, USA
,
Lauren MurphyDivision of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, and Department of Psychiatry, Columbia University, New York, NY, USA
,
Gorazd RosoklijaDivision of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, and Department of Psychiatry, Columbia University, New York, NY, USA;Macedonian Academy of Sciences and Arts, Skopje, R. Macedonia
,
Andrew J. DworkDivision of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, and Department of Psychiatry, Columbia University, New York, NY, USA;Pathology and Cell Biology Division, Columbia University, New York, NY, USA
,
Fatima HaghighiDivision of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, and Department of Psychiatry, Columbia University, New York, NY, USA
,
Victoria ArangoDivision of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, and Department of Psychiatry, Columbia University, New York, NY, USA
&
J. John MannDivision of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, and Department of Psychiatry, Columbia University, New York, NY, USACorrespondence[email protected]
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Pages 574-582 | Received 03 Mar 2011, Accepted 26 May 2011, Published online: 07 Nov 2011

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Martina Focardi, Barbara Gualco, Vilma Pinchi, Norelli Gian-Aristide, Regina Rensi, Elisabetta Pelo, Ilaria Carboni & Ugo Ricci. (2022) Genetic analysis of suicide: a sample study in Tuscany (Central Italy). Forensic Sciences Research 7:4, pages 790-797.
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Articles from other publishers (53)

Daniela Navarro, Marta Marín-Mayor, Ani Gasparyan, María Salud García-Gutiérrez, Gabriel Rubio & Jorge Manzanares. (2023) Molecular Changes Associated with Suicide. International Journal of Molecular Sciences 24:23, pages 16726.
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Qiong Sha, Zhen Fu, Martha L. Escobar Galvis, Zach Madaj, Mark D. Underwood, Jennifer A. Steiner, Andrew Dwork, Norman Simpson, Hanga Galfalvy, Gorazd Rozoklija, Eric D. Achtyes, J. John Mann & Lena Brundin. (2023) Integrative transcriptome- and DNA methylation analysis of brain tissue from the temporal pole in suicide decedents and their controls. Molecular Psychiatry.
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Thelma Beatriz González-Castro, Alma Delia Genis-Mendoza, María Lilia López-Narváez, Isela Esther Juárez-Rojop, Miguel Angel Ramos-Méndez, Carlos Alfonso Tovilla-Zárate & Humberto Nicolini. (2023) Gene Expression Analysis in Postmortem Brains from Individuals Who Died by Suicide: A Systematic Review. Brain Sciences 13:6, pages 906.
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Xenia Gonda, Peter Dome, Gianluca Serafini & Maurizio Pompili. (2023) How to save a life: From neurobiological underpinnings to psychopharmacotherapies in the prevention of suicide. Pharmacology & Therapeutics 244, pages 108390.
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Gil Zalsman. (2023) How else can inflammation kill you?. European Neuropsychopharmacology 67, pages 1-3.
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Rabah Tamimou, Serge Lumbroso, Kevin Mouzat & Jorge Lopez-Castroman. (2022) Genetic variations related to inflammation in suicidal ideation and behavior: A systematic review. Frontiers in Psychiatry 13.
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Salahudeen Mirza, Anna R. Docherty, Amanda Bakian, Hilary Coon, Jair C. Soares, Consuelo Walss‐Bass & Gabriel R. Fries. (2022) Genetics and epigenetics of self‐injurious thoughts and behaviors: Systematic review of the suicide literature and methodological considerations. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 189:7-8, pages 221-246.
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Katarina Kouter & Alja Videtic Paska. (2021) ‘Omics’ of suicidal behaviour: A path to personalised psychiatry. World Journal of Psychiatry 11:10, pages 774-790.
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Line K. M. Lybech, Marco Calabró, Silvana Briuglia, Antonio Drago & Concetta Crisafulli. (2021) Suicide Related Phenotypes in a Bipolar Sample: Genetic Underpinnings. Genes 12:10, pages 1482.
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Bhaskar Roy & Yogesh Dwivedi. (2021) Modeling endophenotypes of suicidal behavior in animals. Neuroscience & Biobehavioral Reviews 128, pages 819-827.
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Ruqayya Afridi, Sihwan Seol, Hyo Jung Kang & Kyoungho Suk. (2021) Brain-immune interactions in neuropsychiatric disorders: Lessons from transcriptome studies for molecular targeting. Biochemical Pharmacology 188, pages 114532.
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Naijun Yuan, Kairui Tang, Xiaoli Da, Hua Gan, Liangliang He, Xiaojuan Li, Qingyu Ma & Jiaxu Chen. (2021) Integrating Clinical and Genomic Analyses of Hippocampal-Prefrontal Circuit Disorder in Depression. Frontiers in Genetics 11.
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V. A. Rozanov, G. E. Mazo & N. A. Kulemin. (2020) Genome-Wide Association Studies in Suicidology: A Review of Recent Achievements. Russian Journal of Genetics 56:7, pages 769-785.
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Nathália G. Souza-Silva, Eduardo S. Nicolau, Kate Hoy, Ziarih Hawi, Mark A. Bellgrove, Débora M. Miranda, Marco A. Romano-Silva & Paul B. Fitzgerald. (2020) A genetic profile of refractory individuals with major depressive disorder and their responsiveness to transcranial magnetic stimulation. Brain Stimulation 13:4, pages 1091-1093.
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Stefania Policicchio, Sam Washer, Joana Viana, Artemis Iatrou, Joe Burrage, Eilis Hannon, Gustavo Turecki, Zachary Kaminsky, Jonathan Mill, Emma L. Dempster & Therese M. Murphy. (2020) Genome-wide DNA methylation meta-analysis in the brains of suicide completers. Translational Psychiatry 10:1.
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Gustavo Turecki, David A. Brent, David Gunnell, Rory C. O’Connor, Maria A. Oquendo, Jane Pirkis & Barbara H. Stanley. (2019) Suicide and suicide risk. Nature Reviews Disease Primers 5:1.
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Matthew E. Glover, Chelsea R. McCoy, Elizabeth A. Shupe, Keaton A. Unroe, Nateka L. Jackson & Sarah M. Clinton. (2019) Perinatal exposure to the SSRI paroxetine alters the methylome landscape of the developing dentate gyrus . European Journal of Neuroscience 50:2, pages 1843-1870.
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Thelma B. González‐Castro, Carlos A. Tovilla‐Zárate, Alma D. Genis‐Mendoza, Isela E. Juárez‐Rojop, Humberto Nicolini, María L. López‐Narváez & José J. Martínez‐Magaña. (2019) Identification of gene ontology and pathways implicated in suicide behavior: Systematic review and enrichment analysis of GWAS studies. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 180:5, pages 320-329.
Crossref
Alex W. Wang, Dimitrios Avramopoulos, Adriana Lori, Jennifer Mulle, Karen Conneely, Abigail Powers, Erica Duncan, Lynn Almli, Nicholas Massa, John McGrath, Ann C. Schwartz, Fernando S. Goes, Lei Weng, Ruihua Wang, Robert Yolken, Ingo Ruczinski, Charles F. Gillespie, Tanja Jovanovic, Kerry Ressler, Ann E. Pulver & Brad D. Pearce. (2019) Genome-wide association study in two populations to determine genetic variants associated with Toxoplasma gondii infection and relationship to schizophrenia risk. Progress in Neuro-Psychopharmacology and Biological Psychiatry 92, pages 133-147.
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Crossref
Rezvan Noroozi, Mir Davood Omrani, Seyed Abdulmajid Ayatollahi, Arezou Sayad, Athar Ata, Hamid Fallah, Mohammad Taheri & Soudeh Ghafouri-Fard. (2018) Interleukin (IL)-8 polymorphisms contribute in suicide behavior. Cytokine 111, pages 28-32.
Crossref
Jiang Li, Akane Yoshikawa & Herbert Y. Meltzer. (2017) Replication of rs300774, a genetic biomarker near ACP1, associated with suicide attempts in patients with schizophrenia: Relation to brain cholesterol biosynthesis. Journal of Psychiatric Research 94, pages 54-61.
Crossref
P-E Lutz, N Mechawar & G Turecki. (2017) Neuropathology of suicide: recent findings and future directions. Molecular Psychiatry 22:10, pages 1395-1412.
Crossref
S P Pantazatos, Y-Y Huang, G B Rosoklija, A J Dwork, V Arango & J J Mann. (2016) Whole-transcriptome brain expression and exon-usage profiling in major depression and suicide: evidence for altered glial, endothelial and ATPase activity. Molecular Psychiatry 22:5, pages 760-773.
Crossref
Birgit Ludwig, Bhaskar Roy, Qingzhong Wang, Badari Birur & Yogesh Dwivedi. (2017) The Life Span Model of Suicide and Its Neurobiological Foundation. Frontiers in Neuroscience 11.
Crossref
Dominique F. Maciejewski, Miguel E. Renteria, Abdel Abdellaoui, Sarah E. Medland, Lauren R. Few, Scott D. Gordon, Pamela A.F. Madden, Grant Montgomery, Timothy J. Trull, Andrew C. Heath, Dixie J. Statham, Nicholas G. Martin, Brendan P. Zietsch & Karin J.H. Verweij. (2016) The Association of Genetic Predisposition to Depressive Symptoms with Non-suicidal and Suicidal Self-Injuries. Behavior Genetics 47:1, pages 3-10.
Crossref
Marcus Sokolowski, Jerzy Wasserman & Danuta Wasserman. (2016) Rare CNVs in Suicide Attempt include Schizophrenia-Associated Loci and Neurodevelopmental Genes: A Pilot Genome-Wide and Family-Based Study. PLOS ONE 11:12, pages e0168531.
Crossref
R. Barzilay, F. Ventorp, H. Segal-Gavish, I. Aharony, A. Bieber, S. Dar, M. Vescan, R. Globus, A. Weizman, D. Naor, J. Lipton, S. Janelidze, L. Brundin & D. Offen. (2016) CD44 Deficiency Is Associated with Increased Susceptibility to Stress-Induced Anxiety-like Behavior in Mice. Journal of Molecular Neuroscience 60:4, pages 548-558.
Crossref
M Sokolowski, J Wasserman & D Wasserman. (2015) Polygenic associations of neurodevelopmental genes in suicide attempt. Molecular Psychiatry 21:10, pages 1381-1390.
Crossref
Bojan Mirkovic, Claudine Laurent, Marc-Antoine Podlipski, Thierry Frebourg, David Cohen & Priscille Gerardin. (2016) Genetic Association Studies of Suicidal Behavior: A Review of the Past 10 Years, Progress, Limitations, and Future Directions. Frontiers in Psychiatry 7.
Crossref
F. Ventorp, R. Barzilay, S. Erhardt, M. Samuelsson, L. Träskman-Bendz, S. Janelidze, A. Weizman, D. Offen & L. Brundin. (2016) The CD44 ligand hyaluronic acid is elevated in the cerebrospinal fluid of suicide attempters and is associated with increased blood–brain barrier permeability. Journal of Affective Disorders 193, pages 349-354.
Crossref
Aigul Zainullina, Adelina Valiullina & Elza Khusnutdinova. 2016. Behavioural Genetics for Education. Behavioural Genetics for Education 205 230 .
Xenia Gonda, Zoltan Rihmer & Peter Dome. 2016. Melatonin, Neuroprotective Agents and Antidepressant Therapy. Melatonin, Neuroprotective Agents and Antidepressant Therapy 501 522 .
Frank Bellivier & Sebastien Guillaume. 2016. Understanding Suicide. Understanding Suicide 303 311 .
J. John Mann & Dianne Currier. 2016. The Medical Basis of Psychiatry. The Medical Basis of Psychiatry 687 706 .
Hanga Galfalvy, Fatemeh Haghighi, Colin Hodgkinson, David Goldman, Maria A. Oquendo, Ainsley Burke, Yung-yu Huang, Ina Giegling, Dan Rujescu, Alexandre Bureau, Gustavo Turecki & J. John Mann. (2015) A genome-wide association study of suicidal behavior. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 168:7, pages 557-563.
Crossref
M Sokolowski, J Wasserman & D Wasserman. (2014) An overview of the neurobiology of suicidal behaviors as one meta-system. Molecular Psychiatry 20:1, pages 56-71.
Crossref
Krassimira A. Garbett, Andrea Vereczkei, Sára Kálmán, Jacquelyn A. Brown, Warren D. Taylor, Gábor Faludi, Željka Korade, Richard C. Shelton & Károly Mirnics. (2015) Coordinated Messenger RNA/MicroRNA Changes in Fibroblasts of Patients with Major Depression. Biological Psychiatry 77:3, pages 256-265.
Crossref
E Beurel & R S Jope. (2014) Inflammation and lithium: clues to mechanisms contributing to suicide-linked traits. Translational Psychiatry 4:12, pages e488-e488.
Crossref
Gustavo Turecki. (2014) The molecular bases of the suicidal brain. Nature Reviews Neuroscience 15:12, pages 802-816.
Crossref
Marcus Sokolowski, Jerzy Wasserman & Danuta Wasserman. (2014) Genome-wide association studies of suicidal behaviors: A review. European Neuropsychopharmacology 24:10, pages 1567-1577.
Crossref
Izabela Chojnicka, Sylwia Fudalej, Anna Walczak, Krystyna Wasilewska, Marcin Fudalej, Piotr Stawiński, Katarzyna Strawa, Aleksandra Pawlak, Marcin Wojnar, Paweł Krajewski & Rafał Płoski. (2014) Inverse Association between Obesity Predisposing FTO Genotype and Completed Suicide. PLoS ONE 9:9, pages e108900.
Crossref
. 2014. A Concise Guide to Understanding Suicide. A Concise Guide to Understanding Suicide 277 356 .
Niamh Mullins, Nader Perroud, Rudolf Uher, Amy W. Butler, Sarah Cohen-Woods, Margarita Rivera, Karim Malki, Jack Euesden, Robert A. Power, Katherine E. Tansey, Lisa Jones, Ian Jones, Nick Craddock, Michael J. Owen, Ania Korszun, Michael Gill, Ole Mors, Martin Preisig, Wolfgang Maier, Marcella Rietschel, John P. Rice, Bertram Müller-Myhsok, Elisabeth B. Binder, Susanne Lucae, Marcus Ising, Ian W. Craig, Anne E. Farmer, Peter McGuffin, Gerome Breen & Cathryn M. Lewis. (2014) Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: A genome-wide association and polygenic scoring study. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 165:5, pages 428-437.
Crossref
Kees van Heeringen & J John Mann. (2014) The neurobiology of suicide. The Lancet Psychiatry 1:1, pages 63-72.
Crossref
H Le-Niculescu, D F Levey, M Ayalew, L Palmer, L M Gavrin, N Jain, E Winiger, S Bhosrekar, G Shankar, M Radel, E Bellanger, H Duckworth, K Olesek, J Vergo, R Schweitzer, M Yard, A Ballew, A Shekhar, G E Sandusky, N J Schork, S M Kurian, D R Salomon & A B NiculescuIIIIII. (2013) Discovery and validation of blood biomarkers for suicidality. Molecular Psychiatry 18:12, pages 1249-1264.
Crossref
Otto Benkert & Hanns HippiusOtto Benkert & Hanns Hippius. 2013. Kompendium der Psychiatrischen Pharmakotherapie. Kompendium der Psychiatrischen Pharmakotherapie 595 632 .
Dimitry A. Chistiakov, Zurab I. Kekelidze & Vladimir P. Chekhonin. (2012) Endophenotypes as a measure of suicidality. Journal of Applied Genetics 53:4, pages 389-413.
Crossref

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