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Research Article

A pilot genome wide association and gene expression array study of suicide with and without major depression

, , , , , , , & show all
Pages 574-582 | Received 03 Mar 2011, Accepted 26 May 2011, Published online: 07 Nov 2011

References

  • Brent DA, Bridge J, Johnson BA, Connolly J. 1996. Suicidal behavior runs in families. A controlled family study of adolescent suicide victims. Arch Gen Psychiatry 53:1145–1152.
  • Bunney WE, Bunney BG, Vawter MP, Tomita H, Li J, Evans SJ, et al. 2003. Microarray technology: a review of new strategies to discover candidate vulnerability genes in psychiatric disorders. Am J Psychiatry 160:657–666.
  • Godar S, Ince TA, Bell GW, Feldser D, Donaher JL, Bergh J, et al. 2008. Growth-inhibitory and tumor-suppressive functions of p53 depend on its repression of CD44 expression. Cell 134:62–73.
  • Hao M, Akrami K, Wei K, De Diego C, Che N, Ku JH, et al. 2008. Muscleblind-like 2 (Mbnl2) -deficient mice as a model for myotonic dystrophy. Dev Dyn 237:403–410.
  • Hayer S, Steiner G, Gortz B, Reiter E, Tohidast-Akrad M, Amling M, et al. 2005. CD44 is a determinant of inflammatory bone loss. J Exp Med 201:903–914.
  • Hochberg Y, Benjamini Y. 1990. More powerful procedures for multiple significance testing. Stat Med 9:811–818.
  • Huang YY, Grailhe R, Arango V, Hen R, Mann JJ. 1999. Relationship of psychopathology to the human serotonin1B genotype and receptor binding kinetics in postmortem brain tissue. Neuropsychopharmacology 21:238–246.
  • Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U, Speed TP. 2003. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4:249–264.
  • Kasper S, Hamon M. 2009. Beyond the monoaminergic hypothesis: agomelatine, a new antidepressant with an innovative mechanism of action. World J Biol Psychiatry 10:117–126.
  • Kelly TM, Mann JJ. 1996. Validity of DSM-III-R diagnosis by psychological autopsy: a comparison with clinician ante-mortem diagnosis. Acta Psychiatr Scand 94:337–343.
  • Kennedy GC, Matsuzaki H, Dong S, Liu WM, Huang J, Liu G, et al. 2003. Large-scale genotyping of complex DNA. Nat Biotechnol 21:1233–1237.
  • Laje G, Allen AS, Akula N, Manji H, John RA, McMahon FJ. 2009. Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients. Pharmacogenet Genomics 19:666–674.
  • Lipshutz RJ, Fodor SP, Gingeras TR, Lockhart DJ. 1999. High density synthetic oligonucleotide arrays. Nat Genet 21:20–24.
  • Maes M, Yirmyia R, Noraberg J, Brene S, Hibbeln J, Perini G, et al. 2009. The inflammatory andneurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression. Metab Brain Dis 24:27–53.
  • Malhotra AK, Goldman D. 1999. Benefits and pitfalls encountered in psychiatric genetic association studies. Biol Psychiatry 45:544–550.
  • Mann JJ. 2002. A current perspective of suicide and attempted suicide. Ann Intern Med 136:302–311.
  • Mann JJ. 2003. Neurobiology of suicidal behaviour. Nat Rev Neurosci 4:819–828.
  • Mann JJ, Currier D. 2006. Effects of genes and stress on the neurobiology of depression. Int Rev Neurobiol 73:153–189.
  • Mann JJ, Waternaux C, Haas GL, Malone KM. 1999. Toward a clinical model of suicidal behavior in psychiatric patients. Am J Psychiatry 156:181–189.
  • Mann JJ, Bortinger J, Oquendo MA, Currier D, Li S, Brent DA. 2005. Family history of suicidal behavior and mood disorders in probands with mood disorders. Am J Psychiatry 162: 1672–1679.
  • Matsuzaki H, Dong S, Loi H, Di X, Liu G, Law J, et al. 2004. Genotyping over 100,000 SNPs on a pair of oligonucleotide arrays. Nat Methods 1:109–111.
  • McGuffin P, Riley B, Plomin R. 2001. Genomics and behavior. Toward behavioral genomics. Science 291:1232–1249.
  • Mendlovic S, Doron A, Eilat E. 1997. Short note: can depressive patients exploit the immune system for suicide?. Med Hypotheses 49:445–446.
  • Mendlovic S, Mozes E, Eilat E, Doron A, Lereya J, Zakuth V, Spirer Z. 1999. Immune activation in non-treated suicidal major depression. Immunol Lett 67:105–108.
  • Nassberger L, Traskman-Bendz L. 1993. Increased soluble interleukin-2 receptor concentrations in suicide attempters. Acta Psychiatr Scand 88:48–52.
  • Perlis RH, Huang J, Purcell S, Fava M, Rush AJ, Sullivan PF, et al. 2010. Genome-wide association study of suicide attempts in mood disorder patients. Am J Psychiatry 167:1499–1507.
  • Postolache TT, Stiller JW, Herrell R, Goldstein MA, Shreeram SS, Zebrak R, et al. 2005. Tree pollen peaks are associated with increased nonviolent suicide in women. Mol Psychiatry 10:232–235.
  • Postolache TT, Lapidus M, Sander ER, Langenberg P, Hamilton RG, Soriano JJ, et al. 2007. Changes in allergy symptoms and depression scores are positively correlated in patients with recurrent mood disorders exposed to seasonal peaks in aeroallergens. Sci World J 7:1968–1977.
  • Postolache TT, Mortensen PB, Tonelli LH, Jiao X, Frangakis C, Soriano JJ, Qin P. 2010. Seasonal spring peaks of suicide in victims with and without prior history of hospitalization for mood disorders. J Affect Disord 121:88–93.
  • Rothenhausler HB, Stepan A, Kapfhammer HP. 2006. Soluble interleukin 2 receptor levels, temperament and character in formerly depressed suicide attempters compared with normal controls. Suicide Life Threat Behav 36:455–466.
  • Roy A. 1983. Family history of suicide. Arch Gen Psychiatry 40:971–974.
  • Roy A, Segal NL, Centerwall BS, Robinette CD. 1991. Suicide in twins. Arch Gen Psychiatry 48:29–32.
  • Rujescu D, Giegling I. 2010. The genetics of neurosystems in mental ill-health and suicidality: Beyond serotonin. Eur Psychiatry 25:272–274.
  • Rujescu D, Thalmeier A, Moller HJ, Bronisch T, Giegling I. 2007. Molecular genetic findings in suicidal behavior: what is beyond the serotonergic system?. Arch Suicide Res 11: 17–40.
  • Sequeira A, Klempan T, Canetti L, ffrench-Mullen J, Benkelfat C, Rouleau GA, Turecki G. 2007. Patterns of gene expression in the limbic system of suicides with and without major depression. Mol Psychiatry 12:640–655.
  • Thalmeier A, Dickmann M, Giegling I, Schneider B, Hartmann M, Maurer K, et al. 2008. Gene expression profiling of post-mortem orbitofrontal cortex in violent suicide victims. Int J Neuropsychopharmacol 11:217–228.
  • Tonelli LH, Holmes A, Postolache TT. 2008. Intranasal immune challenge induces sex-dependent depressive-like behavior and cytokine expression in the brain. Neuropsychopharmacology 33:1038–1048.
  • Verhoeven K, Coen K, De Vriendt E, Jacobs A, Van GV, Smouts I, et al. 2004. SPTLC1 mutation in twin sisters with hereditary sensory neuropathy type I. Neurology 62:1001–1002.
  • Zubenko GS, Maher BS, Hughes HB III, Zubenko WN, Scott SJ, Marazita ML. 2004. Genome-wide linkage survey for genetic loci that affect the risk of suicide attempts in families with recurrent, early-onset, major depression. Am J Med Genet B Neuropsychiatr Genet 129B:47–54.

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