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The World Journal of Biological Psychiatry Volume 14, 2013 - Issue 2
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Research Article

The KCNH2 gene is associated with neurocognition and the risk of schizophrenia

Ryota HashimotoMolecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Kanazawa University and Hamamatsu University School of Medicine, Osaka, Japan;Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan;CREST (Core Research for Evolutionary Science and Technology) of JST (Japan Science and Technology Agency), Saitama, JapanCorrespondence[email protected]
,
Kazutaka OhiDepartment of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan;CREST (Core Research for Evolutionary Science and Technology) of JST (Japan Science and Technology Agency), Saitama, Japan
,
Yuka YasudaDepartment of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan;CREST (Core Research for Evolutionary Science and Technology) of JST (Japan Science and Technology Agency), Saitama, Japan
,
Motoyuki FukumotoDepartment of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan;CREST (Core Research for Evolutionary Science and Technology) of JST (Japan Science and Technology Agency), Saitama, Japan
,
Hidenaga YamamoriDepartment of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan;CREST (Core Research for Evolutionary Science and Technology) of JST (Japan Science and Technology Agency), Saitama, Japan;Department of Molecular Neuropsychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
,
Kouzin KaminoDepartment of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan;Shoraiso National Hospital, Yamatokoriyama, Nara, Japan
,
Takashi MoriharaDepartment of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
,
Masao IwaseDepartment of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
,
Hiroaki KazuiDepartment of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
&
Masatoshi TakedaMolecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Kanazawa University and Hamamatsu University School of Medicine, Osaka, Japan;Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
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Pages 114-120 | Received 22 Feb 2011, Accepted 07 Jul 2011, Published online: 22 Sep 2011

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Makoto Kinoshita, Shusuke Numata, Atsushi Tajima, Shinji Shimodera, Issei Imoto & Tetsuro Ohmori. (2013) Plasma total homocysteine is associated with DNA methylation in patients with schizophrenia. Epigenetics 8:6, pages 584-590.
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Sonia Hasan, Francis Delicata, Leonardo Guasti, Claudia Duranti, Fatemah Mousalem Haidar, Annarosa Arcangeli, Paola Imbrici, Mauro Pessia, Mario Valentino & Maria Cristina D’Adamo. (2022) Locus Coeruleus Neurons’ Firing Pattern Is Regulated by ERG Voltage-Gated K+ Channels. International Journal of Molecular Sciences 23:23, pages 15334.
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Alexander Refisch, Shoko Komatsuzaki, Martin Ungelenk, Andy Schumann, Ha-Yeun Chung, Susann S. Schilling, Wibke Jantzen, Sabine Schröder, Markus M. Nöthen, Thomas W. Mühleisen, Christian A. Hübner & Karl-Jürgen Bär. (2022) Analysis of CACNA1C and KCNH2 Risk Variants on Cardiac Autonomic Function in Patients with Schizophrenia. Genes 13:11, pages 2132.
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Maria Guardiola-Ripoll, Carmen Almodóvar-Payá, Alba Lubeiro, Raymond Salvador, Pilar Salgado-Pineda, Jesús J Gomar, Amalia Guerrero-Pedraza, Salvador Sarró, Teresa Maristany, Inés Fernández-Linsenbarth, Marta Hernández-García, Sergi Papiol, Vicente Molina, Edith Pomarol-Clotet & Mar Fatjó-Vilas. (2022) New insights of the role of the KCNH2 gene in schizophrenia: An fMRI case-control study. European Neuropsychopharmacology 60, pages 38-47.
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Hiroko Kashiwagi, Junya Matsumoto, Kenichiro Miura, Koji Takeda, Yuji Yamada, Michiko Fujimoto, Yuka Yasuda, Hidenaga Yamamori, Manabu Ikeda, Naotsugu Hirabayashi & Ryota Hashimoto. (2022) Neurocognitive features, personality traits, and social function in patients with schizophrenia with a history of violence. Journal of Psychiatric Research 147, pages 50-58.
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Haiyan Cao, Yongjie Zhou, Tao Li, Cong Yao, Weiliang Yang, Siying Kong, Yanyan Wang, Baoping Yu, Qingyan Jiao, Yun Sun, Xiaoju Jia, Yuting Wang, Zhonggang Wang, Xiangyang Zhang & Jie Li. (2021) The Prevalence, Risk Factors and Clinical Correlates of QTc Prolongation in Chinese Hospitalized Patients With Chronic Schizophrenia. Frontiers in Psychiatry 12.
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Abbas F. Almulla, Shatha R. Moustafa, Arafat H. Al-Dujaili, Hussein K. Al-Hakeim & Michael Maes. (2021) Lowered serum cesium levels in schizophrenia: association with immune-inflammatory biomarkers and cognitive impairments. Brazilian Journal of Psychiatry 43:2, pages 131-137.
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Alba Lubeiro, Mar Fatjó-Vilas, Maria Guardiola, Carmen Almodóvar, Javier Gomez-Pilar, Benjamin Cea-Cañas, Jesús Poza, Aitor Palomino, Marta Gómez-García, Jone Zugasti & Vicente Molina. (2019) Analysis of KCNH2 and CACNA1C schizophrenia risk genes on EEG functional network modulation during an auditory odd-ball task. European Archives of Psychiatry and Clinical Neuroscience 270:4, pages 433-442.
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Xueping Wang, Yi Su, Hao Yan, Zhuo Huang, Yu Huang & Weihua Yue. (2019) Association Study of KCNH7 Polymorphisms and Individual Responses to Risperidone Treatment in Schizophrenia. Frontiers in Psychiatry 10.
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Edward D Cui & Ben W Strowbridge. (2019) Selective attenuation of Ether-a-go-go related K+ currents by endogenous acetylcholine reduces spike-frequency adaptation and network correlation. eLife 8.
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Monica Bomba, Lucio Tremolizzo, Fabiola Corbetta, Franco Nicosia, Francesca Lanfranconi, Gianni Poggioli, Karine Goulene, Marco Stramba-Badiale, Elisa Conti, Francesca Neri & Renata Nacinovich. (2017) QT interval and dispersion in drug-free anorexia nervosa adolescents: a case control study. European Child & Adolescent Psychiatry 27:7, pages 861-866.
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Edward D. Cui & Ben W. Strowbridge. (2018) Modulation of Ether-à-Go-Go Related Gene (ERG) Current Governs Intrinsic Persistent Activity in Rodent Neocortical Pyramidal Cells. The Journal of Neuroscience 38:2, pages 423-440.
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Hong Joon Lee, Jin-Sung Choi, Bok Hee Choi & Sang June Hahn. (2018) Effects of norquetiapine, the active metabolite of quetiapine, on cloned hERG potassium channels. Neuroscience Letters 664, pages 66-73.
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Júlia Šatková & Markéta Bébarová. (2017) Functional impact of hERG: from physiological role to target of anticancer therapy. Vnitřní lékařství 63:2, pages 114-123.
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G V Carr, J Chen, F Yang, M Ren, P Yuan, Q Tian, A Bebensee, G Y Zhang, J Du, P Glineburg, R Xun, O Akhile, D Akuma, J Pickel, J C Barrow, F Papaleo & D R Weinberger. (2016) KCNH2-3.1 expression impairs cognition and alters neuronal function in a model of molecular pathology associated with schizophrenia. Molecular Psychiatry 21:11, pages 1517-1526.
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Merlin G. Butler, Austen B. McGuire, Humaira Masoud & Ann M. Manzardo. (2016) Currently recognized genes for schizophrenia: High-resolution chromosome ideogram representation. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 171:2, pages 181-202.
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Nicholas E. Calcaterra, Daniel J. Hoeppner, Huijun Wei, Andrew E. Jaffe, Brady J. Maher & James C. Barrow. (2016) Schizophrenia-Associated hERG channel Kv11.1-3.1 Exhibits a Unique Trafficking Deficit that is Rescued Through Proteasome Inhibition for High Throughput Screening. Scientific Reports 6:1.
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Susanne Henningsson, Anna Zettergren, Daniel Hovey, Lina Jonsson, Joakim Svärd, Diana S. Cortes, Jonas Melke, Natalie C. Ebner, Petri Laukka, Håkan Fischer & Lars Westberg. (2015) Association between polymorphisms in NOS3 and KCNH2 and social memory. Frontiers in Neuroscience 9.
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Kazutaka Ohi, Ryota Hashimoto, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Satomi Umeda-Yano & Masatoshi Takeda. 2015. Neurodegenerative Disorders as Systemic Diseases. Neurodegenerative Disorders as Systemic Diseases 135 155 .
R Hashimoto, M Ikeda, F Yamashita, K Ohi, H Yamamori, Y Yasuda, M Fujimoto, M Fukunaga, K Nemoto, T Takahashi, M Tochigi, T Onitsuka, H Yamasue, K Matsuo, T Iidaka, N Iwata, M Suzuki, M Takeda, K Kasai & N Ozaki. (2014) Common variants at 1p36 are associated with superior frontal gyrus volume. Translational Psychiatry 4:10, pages e472-e472.
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Kumiko Fujii, Yuji Ozeki, Hiroaki Okayasu, Yumiko Takano, Takahiro Shinozaki, Hiroaki Hori, Masami Orui, Minoru Horie, Hiroshi Kunugi & Kazutaka Shimoda. (2014) QT Is Longer in Drug-Free Patients with Schizophrenia Compared with Age-Matched Healthy Subjects. PLoS ONE 9:6, pages e98555.
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Fa-Zhong He, Howard L. McLeod & Wei Zhang. (2013) Current pharmacogenomic studies on hERG potassium channels. Trends in Molecular Medicine 19:4, pages 227-238.
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Hongkai Wang, Chengren Li, Hanzhi Wang, Feng Mei, Zhi Liu, Hai-Ying Shen & Lan Xiao. (2013) Cuprizone-induced demyelination in mice: age-related vulnerability and exploratory behavior deficit. Neuroscience Bulletin 29:2, pages 251-259.
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