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Research Article

Elevation of circulating HLA DR+ CD8+ T-cells and correlation with chromium and cobalt concentrations 6 years after metal-on-metal hip arthroplasty

A randomized trial

, , &
Pages 6-12 | Received 15 Mar 2010, Accepted 06 Sep 2010, Published online: 29 Dec 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Noora Honkasaari, Olli Lainiala, Outi Laine, Aleksi Reito & Antti Eskelinen. (2020) No association between blood count levels and whole-blood cobalt and chromium levels in 1,900 patients with metal-on-metal hip arthroplasty. Acta Orthopaedica 91:6, pages 711-716.
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Henrik Dahlstrand, André Stark, Marius C Wick, Lucas Anissian, Nils P Hailer & Rüdiger J Weiss. (2017) Comparison of metal ion concentrations and implant survival after total hip arthroplasty with metal-on-metal versus metal-on-polyethylene articulations. Acta Orthopaedica 88:5, pages 490-495.
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Jeannette Ø Penny, Jens–Erik Varmarken, Ole Ovesen, Christian Nielsen & Søren Overgaard. (2013) Metal ion levels and lymphocyte counts: ASR hip resurfacing prosthesis vs. standard THA. Acta Orthopaedica 84:2, pages 130-137.
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Articles from other publishers (21)

Dongmei Wu, Rohan M Bhalekar, Jordan S Marsh, David J Langton & Alan J Stewart. (2022) Periarticular metal hypersensitivity complications of hip bearings containing cobalt–chromium. EFORT Open Reviews 7:11, pages 758-771.
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Catherine B. Klein & Max Costa. 2022. Handbook on the Toxicology of Metals. Handbook on the Toxicology of Metals 615 637 .
Joseph J. Kavolus, Alexander L. Lazarides, Christina Moore, Thorsten M. Seyler, Samuel S. Wellman, David E. Attarian, Michael P. Bolognesi & Benjamin A. Alman. (2021) The Calpain Gene is Correlated With Metal-on-Metal Hip Replacement Failures. The Journal of Arthroplasty 36:1, pages 236-241.e3.
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Anders Brüggemann, Hans Mallmin, Mats Bengtsson & Nils P. Hailer. (2020) Safety of Use of Tantalum in Total Hip Arthroplasty. Journal of Bone and Joint Surgery 102:5, pages 368-374.
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Shuye Yang, Kai Zhang, Jianhao Jiang, Bonface James & Shang-You Yang. (2019) Particulate and ion forms of cobalt-chromium challenged preosteoblasts promote osteoclastogenesis and osteolysis in a murine model of prosthesis failure. Journal of Biomedical Materials Research Part A 107:1, pages 187-194.
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David C. Markel, Christopher Bergum, Jeffrey Flynn, Nancy Jackson, Therese Bou-Akl & Weiping Ren. (2018) Relationship of Blood Metal Ion Levels and Leukocyte Profiles in Patients With Articular Surface Replacement Metal-on-Metal Hip Replacement. Orthopedics 41:3.
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Zhe Du, Shujun Wang, Bing Yue, Ying Wang & You Wang. (2017) Effects of wear particles of polyether-ether-ketone and cobalt-chromium-molybdenum on CD4- and CD8-T-cell responses. Oncotarget 9:13, pages 11197-11208.
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Zhe Du, Shujun Wang & You Wang. (2018) Preferential CD8 rather than CD4 T-cell response to wear particles of polyether-ether-ketone and highly cross-linked polyethylene. RSC Advances 8:4, pages 1866-1874.
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B. G. Pijls, J. M. T. A. Meessen, J. W. Schoones, M. Fiocco, H. J. L. van der Heide, A. Sedrakyan & R. G. H. H. Nelissen. (2016) Increased Mortality in Metal-on-Metal versus Non-Metal-on-Metal Primary Total Hip Arthroplasty at 10 Years and Longer Follow-Up: A Systematic Review and Meta-Analysis. PLOS ONE 11:6, pages e0156051.
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Daniel M. Vasconcelos, Susana G. Santos, Meriem Lamghari & Mário A. Barbosa. (2016) The two faces of metal ions: From implants rejection to tissue repair/regeneration. Biomaterials 84, pages 262-275.
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P. A. Revell, G. S. Matharu, S. Mittal, P. B. Pynsent, C. D. Buckley & M. P. Revell. (2016) Increased expression of inducible co-stimulator on CD4+ T-cells in the peripheral blood and synovial fluid of patients with failed hip arthroplasties. Bone & Joint Research 5:2, pages 52-60.
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Shuye Yang, Kai Zhang, Fangfang Li, Jianhao Jiang, Tanghong Jia & Shang-You Yang. (2015) Biological responses of preosteoblasts to particulate and ion forms of Co-Cr alloy. Journal of Biomedical Materials Research Part A 103:11, pages 3564-3571.
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Aileen Clarke, Ruth Pulikottil-Jacob, Amy Grove, Karoline Freeman, Hema Mistry, Alexander Tsertsvadze, Martin Connock, Rachel Court, Ngianga-Bakwin Kandala, Matthew Costa, Gaurav Suri, David Metcalfe, Michael Crowther, Sarah Morrow, Samantha Johnson & Paul Sutcliffe. (2015) Total hip replacement and surface replacement for the treatment of pain and disability resulting from end-stage arthritis of the hip (review of technology appraisal guidance 2 and 44): systematic review and economic evaluation. Health Technology Assessment 19:10, pages 1-668.
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Catherine Klein & Max Costa. 2015. Handbook on the Toxicology of Metals. Handbook on the Toxicology of Metals 1091 1111 .
Paul H. Wooley. (2014) How Has the Introduction of New Bearing Surfaces Altered the Biological Reactions to Byproducts of Wear and Modularity?. Clinical Orthopaedics and Related Research® 472:12, pages 3699-3708.
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C.A. Engh, S.J. MacDonald, S. Sritulanondha, A. Korczak, D. Naudie & C. Engh. (2014) Metal Ion Levels After Metal-on-Metal Total Hip Arthroplasty. Journal of Bone and Joint Surgery 96:6, pages 448-455.
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Nils P. Hailer, Mats Bengtsson, Christina Lundberg & Jan Milbrink. (2013) High Metal Ion Levels After Use of the ASR™ Device Correlate With Development of Pseudotumors and T Cell Activation. Clinical Orthopaedics and Related Research® 472:3, pages 953-961.
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Albrecht Hartmann, Franziska Hannemann, Jörg Lützner, Andreas Seidler, Hans Drexler, Klaus-Peter Günther & Jochen Schmitt. (2013) Metal Ion Concentrations in Body Fluids after Implantation of Hip Replacements with Metal-on-Metal Bearing – Systematic Review of Clinical and Epidemiological Studies. PLoS ONE 8:8, pages e70359.
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Henri Migaud, Sophie Putman, Antoine Combes, Charles Berton, Donatien Bocquet, Laurent Vasseur & Julien Girard. (2012) Metal-on-Metal Bearing: Is This the End of the Line? We Do Not Think So. HSS Journal ® 8:3, pages 262-269.
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Kevin J. Bozic, James Browne, Chris J. Dangles, Paul A. Manner, Adolph J. YatesJrJr, Kristy L. Weber, Kevin M. Boyer, Paul Zemaitis, Anne Woznica, Charles M. Turkelson & Janet L. Wies. (2012) Modern Metal-on-Metal Hip Implants. Journal of the American Academy of Orthopaedic Surgeons 20:6, pages 402-406.
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Xinhua Qu, Xiaolu Huang & Kerong Dai. (2011) Metal-on-metal or metal-on-polyethylene for total hip arthroplasty: a meta-analysis of prospective randomized studies. Archives of Orthopaedic and Trauma Surgery 131:11, pages 1573-1583.
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