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Research Article

Local treatment of cancellous bone grafts with BMP-7 and zoledronate increases both the bone formation rate and bone density

A bone chamber study in rats

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Pages 228-233 | Received 12 Apr 2010, Accepted 02 Oct 2010, Published online: 24 Mar 2011

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Per Bosemark, Hanna Isaksson, Michelle M McDonald, David G Little & Magnus Tägil. (2013) Augmentation of autologous bone graft by a combination of bone morphogenic protein and bisphosphonate increased both callus volume and strength. Acta Orthopaedica 84:1, pages 106-111.
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Nikola Stokovic, Natalia Ivanjko, Igor Erjavec, Anita Breski, Mihaela Peric & Slobodan Vukicevic. (2021) Zoledronate Bound to Ceramics Increases Ectopic Bone Volume Induced by rhBMP6 Delivered in Autologous Blood Coagulum in Rats. Biomedicines 9:10, pages 1487.
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Tomo Hamada, Hidenori Matsubara, Toshifumi Hikichi, Kanu Shimokawa & Hiroyuki Tsuchiya. (2021) Rat model of an autologous cancellous bone graft. Scientific Reports 11:1.
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Marwa Y. Shaheen, Amani M. Basudan, Abdurahman A. Niazy, Jeroen J. J. P. van den Beucken, John A. Jansen & Hamdan S. Alghamdi. (2021) Effect of Systemic Zoledronic Acid Dosing Regimens on Bone Regeneration in Osteoporotic Rats. Applied Sciences 11:4, pages 1906.
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Franziska Lademann, Lorenz C. Hofbauer & Martina Rauner. (2020) The Bone Morphogenetic Protein Pathway: The Osteoclastic Perspective. Frontiers in Cell and Developmental Biology 8.
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Karolina Papera Valente, Alexandre Brolo & Afzal Suleman. (2020) From Dermal Patch to Implants—Applications of Biocomposites in Living Tissues. Molecules 25:3, pages 507.
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Christoph A. Lahr, Ferdinand Wagner, Abbas Shafiee, Maximilian Rudert, Dietmar W. Hutmacher & Boris Michael Holzapfel. (2019) Recombinant Human Bone Morphogenetic Protein 7 Exerts Osteo-Catabolic Effects on Bone Grafts That Outweigh Its Osteo-Anabolic Capacity. Calcified Tissue International 105:3, pages 331-340.
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Peter Frederik HorstmannDeepak Bushan RainaHanna IsakssonWerner HettwerLars LidgrenMichael Mørk PetersenMagnus Tägil. (2017) Composite Biomaterial as a Carrier for Bone-Active Substances for Metaphyseal Tibial Bone Defect Reconstruction in Rats . Tissue Engineering Part A 23:23-24, pages 1403-1412.
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Jorgen Baas, Marianne Vestermark, Thomas Jensen, Joan Bechtold, Kjeld Soballe & Thomas Jakobsen. (2017) Topical bisphosphonate augments fixation of bone-grafted hydroxyapatite coated implants, BMP-2 causes resorption-based decrease in bone. Bone 97, pages 76-82.
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Arun Kumar Teotia, Deepak Bushan Raina, Chandan Singh, Neeraj Sinha, Hanna Isaksson, Magnus Tägil, Lars Lidgren & Ashok Kumar. (2017) Nano-Hydroxyapatite Bone Substitute Functionalized with Bone Active Molecules for Enhanced Cranial Bone Regeneration. ACS Applied Materials & Interfaces 9:8, pages 6816-6828.
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Kenji Mamoto, Yoichi Ohta, Koichi Ichikawa, Yuuki Imai, Yukihide Minoda, Kunio Takaoka & Hiroaki Nakamura. (2017) CO-ADMINISTRATION OF SYSTEMIC ZOLEDRONATE PROMOTES OSTEOGENESIS INDUCED BY A LOCAL CO-DELIVERY OF RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2 AND β-TRICALCIUM PHOSPHATE IN THE BONE MARROW OF THE RABBIT FEMUR. Journal of Musculoskeletal Research 19:03, pages 1650015.
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Deepak Bushan Raina, Hanna Isaksson, Arun Kumar Teotia, Lars Lidgren, Magnus Tägil & Ashok Kumar. (2016) Biocomposite macroporous cryogels as potential carrier scaffolds for bone active agents augmenting bone regeneration. Journal of Controlled Release 235, pages 365-378.
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Ana M. Cortizo, Graciela Ruderman, Flavia N. Mazzini, M. Silvina Molinuevo & Ines G. Mogilner. (2016) Novel Vanadium-Loaded Ordered Collagen Scaffold Promotes Osteochondral Differentiation of Bone Marrow Progenitor Cells. International Journal of Biomaterials 2016, pages 1-11.
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Per Bosemark, Christina Perdikouri, Mea Pelkonen, Hanna Isaksson & Magnus Tägil. (2015) The masquelet induced membrane technique with BMP and a synthetic scaffold can heal a rat femoral critical size defect. Journal of Orthopaedic Research 33:4, pages 488-495.
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N. M. C. Mathijssen, P. Buma & G. Hannink. (2013) Combining bisphosphonates with allograft bone for implant fixation. Cell and Tissue Banking 15:3, pages 329-336.
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Alexander Wurm, Michael Nogler, Christoph G. Ammann & D?bora C. Cora?a-Huber. (2014) Effect of storage temperature and antibiotic impregnation on the quantity of bone morphogenetic protein seven in human bone grafts. International Orthopaedics 38:7, pages 1513-1517.
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Ciara M. Murphy, Aaron Schindeler, John P. Gleeson, Nicole Y.C. Yu, Laurence C. Cantrill, Kathy Mikulec, Lauren Peacock, Fergal J. O’Brien & David G. Little. (2014) A collagen–hydroxyapatite scaffold allows for binding and co-delivery of recombinant bone morphogenetic proteins and bisphosphonates. Acta Biomaterialia 10:5, pages 2250-2258.
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Per Bosemark, Hanna Isaksson & Magnus Tägil. (2014) Influence of systemic bisphosphonate treatment on mechanical properties of BMP-induced calluses in a rat fracture model: Comparison of three-point bending and twisting test. Journal of Orthopaedic Research 32:5, pages 721-726.
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Wenlong Gou, Xin Wang, Jiang Peng, Qiang Lu, Yu Wang, Aiyuan Wang, Quanyi Guo, Xupeng Gao, Wenjing Xu & Shibi Lu. (2014) Controlled Delivery of Zoledronate Improved Bone Formation Locally In Vivo. PLoS ONE 9:3, pages e91317.
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Mette Sørensen, Jeppe Barckman, Joan E. Bechtold, Kjeld Søballe & Jørgen Baas. (2013) Preclinical Evaluation of Zoledronate to Maintain Bone Allograft and Improve Implant Fixation in Revision Joint Replacement. The Journal of Bone & Joint Surgery 95:20, pages 1862-1868.
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Neashan Mathavan, Per Bosemark, Hanna Isaksson & Magnus T?gil. (2013) Investigating the synergistic efficacy of BMP-7 and zoledronate on bone allografts using an open rat osteotomy model. Bone 56:2, pages 440-448.
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Bonnie K. Culpepper, Paul P. Bonvallet, Michael S. Reddy, Selvarangan Ponnazhagan & Susan L. Bellis. (2013) Polyglutamate directed coupling of bioactive peptides for the delivery of osteoinductive signals on allograft bone. Biomaterials 34:5, pages 1506-1513.
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Ola Belfrage, Hanna Isaksson & Magnus Tägil. (2012) Local treatment of a bone graft by soaking in zoledronic acid inhibits bone resorption and bone formation. A bone chamber study in rats. BMC Musculoskeletal Disorders 13:1.
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Vivianne Chappuis, Laura Gamer, Karen Cox, Jonathan W. Lowery, Dieter D. Bosshardt & Vicki Rosen. (2012) Periosteal BMP2 activity drives bone graft healing. Bone 51:4, pages 800-809.
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Jerald E Dumas, Pamela B BrownBaer, Edna M Prieto, Teja Guda, Robert G Hale, Joseph C Wenke & Scott A Guelcher. (2012) Injectable reactive biocomposites for bone healing in critical-size rabbit calvarial defects. Biomedical Materials 7:2, pages 024112.
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Serge Ferrari, Ego Seeman, Philippe Clézardin, David Karasik, David G Little & Toshio Matsumoto. (2011) Clinical and basic research papers – August 2011. IBMS BoneKEy 8:8, pages 352-361.
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