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Original Article

Preventive effects of ibuprofen on periarticular heterotopic ossification after total hip arthroplasty: A randomized double-blind prospective study of treatment time

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Pages 111-115 | Received 28 Dec 1997, Accepted 26 Feb 1998, Published online: 08 Jul 2009

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Filippo Migliorini, Giovanni Asparago, Francesco Oliva, Francesco Cuozzo & Nicola Maffulli. (2022) A comprehensive update on the pharmacological management of heterotopic ossification following hip arthroplasty: a level I evidenced based expert opinion. Expert Opinion on Pharmacotherapy 23:10, pages 1195-1203.
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Sigbjørn Dimmen. (2011) Effects of cox inhibitors on bone and tendon healing. Acta Orthopaedica 82:sup342, pages 1-22.
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Robert J Macfarlane, Boon Han Ng, Zakareya Gamie, Mohamed A El Masry, Stylianos Velonis, Constantin Schizas & Eleftherios Tsiridis. (2008) Pharmacological treatment of heterotopic ossification following hip and acetabular surgery. Expert Opinion on Pharmacotherapy 9:5, pages 767-786.
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Per Aspenberg. (2002) Avoid cox inhibitors after skeletal surgery!. Acta Orthopaedica Scandinavica 73:5, pages 489-490.
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Finn B Christensen, Malene Laursen, John Gelineck, Ebbe S Hansen & Cody E Bünger. (2001) Posterolateral spinal fusion at unintended levels due to bone-graft migration: No effect on clinical outcome in 19/130 patients. Acta Orthopaedica Scandinavica 72:4, pages 354-358.
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Articles from other publishers (38)

Jens Schneider, Nicola Maffulli, Jörg Eschweiler, Andreas Bell, Frank Hildebrand & Filippo Migliorini. (2023) Efficacy of ibuprofen and indomethacin as prophylaxis of heterotopic ossification: a comparative study. Scientific Reports 13:1.
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Filippo Migliorini, Andrea Pintore, Alice Baroncini, Torsten Pastor, Frank Hildebrand & Nicola Maffulli. (2022) Selective versus non-selective NSAIDs as prophylaxis for heterotopic ossification following hip arthroplasty: a meta-analysis. Journal of Orthopaedics and Traumatology 23:1.
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Jacob Shapira, Mitchell J Yelton, Jeffery W Chen, Philip J Rosinsky, David R Maldonado, Mitchell Meghpara, Ajay C Lall & Benjamin G Domb. (2021) Efficacy of NSAIDs versus radiotherapy for heterotopic ossification prophylaxis following total hip arthroplasty in high-risk patients: a systematic review and meta-analysis. HIP International 32:5, pages 576-590.
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Muhammad Ali Tariq, Bilal Ahmed, Shehryar Shaikh, Hamza Amin & Syed Uzair Ali. (2022) Eficácia do ibuprofeno após artroplastia total de quadril para prevenção de ossificação heterotópica: Revisão sistemática e meta-análise. Revista Brasileira de Ortopedia.
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Filippo Migliorini, Andromahi Trivellas, Jörg Eschweiler, Arne Driessen, Markus Tingart & Nicola Maffulli. (2020) NSAIDs for Prophylaxis for Heterotopic Ossification After Total Hip Arthroplasty: A Bayesian Network Meta-analysis. Calcified Tissue International 108:2, pages 196-206.
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Liyang Cai, Zhan Wang, Xiangli Luo, Wei She & Hui Zhang. (2019) Optimal strategies for the prevention of heterotopic ossification after total hip arthroplasty: A network meta-analysis. International Journal of Surgery 62, pages 74-85.
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M. JoiceG. I. VasileiadisD. F. Amanatullah. (2018) Non-steroidal anti-inflammatory drugs for heterotopic ossification prophylaxis after total hip arthroplasty. The Bone & Joint Journal 100-B:7, pages 915-922.
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Ján Kuchálik, Anders Magnuson, Anders Lundin & Anil Gupta. (2017) Local infiltration analgesia: a 2-year follow-up of patients undergoing total hip arthroplasty. Journal of Anesthesia 31:6, pages 837-845.
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Sugantha Ganapathy, James L. Howard & Rakesh V. Sondekoppam. 2017. Complications of Regional Anesthesia. Complications of Regional Anesthesia 381 398 .
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Jeffrey A. Rihn, Kristen Radcliff, John Hipp, Alexander R. Vaccaro, Alan S. Hilibrand, David G. Anderson & Todd J. Albert. (2015) Radiographic Variables That May Predict Clinical Outcomes in Cervical Disk Replacement Surgery. Journal of Spinal Disorders & Techniques 28:3, pages 106-113.
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Ikram Nizam, Lawrence Kohan, Clarice Field & Dennis Kerr. (2015) Do Nonsteroidal Anti-Inflammatory Drugs Cause Endoprosthetic Loosening? Mid- to Long-Term Follow-Up of 100 Total Hip Arthroplasties after Local NSAID Infiltration. BioMed Research International 2015, pages 1-5.
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Oliver Tannous, Alec C. Stall, Cullen Griffith, Christopher T. Donaldson, Rudolph J. Castellani & Vincent D. Pellegrini. (2013) Heterotopic Bone Formation About the Hip Undergoes Endochondral Ossification: A Rabbit Model. Clinical Orthopaedics and Related Research? 471:5, pages 1584-1592.
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Marlene Fransen & Bruce Neal. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
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Mark J Haran, Tushar Bhuta & Bon San B Lee. (2010) Pharmacological interventions for treating acute heterotopic ossification. Cochrane Database of Systematic Reviews.
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Do?an Bek, Burak Beksa?Alejandro Gonz?lez Della Valle, Thomas P. Sculco & Eduardo A. Salvati. (2009) Aspirin Decreases the Prevalence and Severity of Heterotopic Ossification After 1-Stage Bilateral Total Hip Arthroplasty for Osteoarthrosis. The Journal of Arthroplasty 24:2, pages 226-232.
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N. Medina-Gálvez, M.D. García-Manzanares, T. Pedraz-Penalva, D. Tornero-Jiménez, M. Sunyer-Catllà & R. González-Martínez. (2008) Actualización sobre el diagnóstico y tratamiento de la osificación heterotópica. Rehabilitación 42:1, pages 34-43.
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Akif Ince, Ulf Sauer, Nicole Wollmerstedt & Christian Hendrich. (2007) No Migration of Acetabular Cups after Prophylaxis for Heterotopic Ossification. Clinical Orthopaedics & Related Research 461, pages 125-129.
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M. Saudan, P. Saudan, T. Perneger, N. Riand, A. KellerP. Hoffmeyer. (2007) Celecoxib versus ibuprofen in the prevention of heterotopic ossification following total hip replacement . The Journal of Bone and Joint Surgery. British volume 89-B:2, pages 155-159.
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Mustasim N. Rumi, Gurvinder S. Deol, Jason A. Bergandi, Kishor P. Singapuri & Vincent D. PellegriniJr.Jr.. (2005) Optimal Timing of Preoperative Radiation for Prophylaxis Against Heterotopic Ossification. The Journal of Bone & Joint Surgery 87:2, pages 366-373.
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MUSTASIM N. RUMI, GURVINDER S. DEOL, JASON A. BERGANDI, KISHOR P. SINGAPURI & VINCENT D. PELLEGRINI. (2005) OPTIMAL TIMING OF PREOPERATIVE RADIATION FOR PROPHYLAXIS AGAINST HETEROTOPIC OSSIFICATION. The Journal of Bone and Joint Surgery-American Volume 87:2, pages 366-373.
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L. Vastel, N. Rosencher, H. Siney & J.-P. Courpied. (2005) Comparaison célécoxib versus kétoprofène pour la prévention des ossifications péri-prothétiques de hanche. Revue de Chirurgie Orthopédique et Réparatrice de l'Appareil Moteur 91:1, pages 64-69.
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Mark J Haran, Tushar Bhuta & Bon San Bonne Lee. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Olena Virchenko, Björn Skoglund & Per Aspenberg. (2016) Parecoxib Impairs Early Tendon Repair but Improves Later Remodeling. The American Journal of Sports Medicine 32:7, pages 1743-1747.
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Laurence E. Dahners & Brian H. Mullis. (2004) Effects of Nonsteroidal Anti-Inflammatory Drugs on Bone Formation and Soft-Tissue Healing. Journal of the American Academy of Orthopaedic Surgeons 12:3, pages 139-143.
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Marlene Fransen. (2004) Preventing chronic ectopic bone-related pain and disability after hip replacement surgery with perioperative ibuprofen. A multicenter, randomized, double-blind, placebo-controlled trial (HIPAID). Controlled Clinical Trials 25:2, pages 223-233.
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Robert Legenstein, Peter B?sch & Alfred Ungersb?ck. (2003) Indomethacin versus meloxicam for prevention of heterotopic ossification after total hip arthroplasty. Archives of Orthopaedic and Trauma Surgery 123:2-3, pages 91-94.
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J. Nowak, E. Stålberg & S. Larsson. (2016) Good Reduction of Paresthesia and Pain after Excision of Excessive Callus Formation in Patients with Malunited Clavicular Fractures. Scandinavian Journal of Surgery 91:4, pages 369-373.
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M.B. Howard, W.J.M. Bruce, W. Walsh & J.A. Goldberg. (2016) Total Hip Arthroplasty for Arthrodesed Hips. Journal of Orthopaedic Surgery 10:1, pages 29-33.
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Wade T. Gofton & Graham J.W. King. (2001) Heterotopic ossification following elbow arthroscopy. Arthroscopy: The Journal of Arthroscopic & Related Surgery 17:1, pages 1-5.
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Stefan Sell, Thomas Schleh, Martin Handel, Jutta Scheiderbauer, Gerd Becker & Michael Bamberg. (2000) Heterotopic ossification after total hip replacement. Orthopaedics and Traumatology 8:4, pages 302-313.
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GREGORY P. ZAGAJA & WILLIAM J. CROMIE. (1999) HETEROTOPIC BONE FORMATION IN ASSOCIATION WITH PELVIC FRACTURE AND URETHRAL DISRUPTION. The Journal of Urology, pages 1950-1953.
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GREGORY P. ZAGAJA & WILLIAM J. CROMIE. (1999) HETEROTOPIC BONE FORMATION IN ASSOCIATION WITH PELVIC FRACTURE AND URETHRAL DISRUPTION. The Journal of Urology 161:6, pages 1950-1953.
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Olle S. Nilsson & Per-Erik Persson. (1999) Heterotopic bone formation after joint replacement. Current Opinion in Rheumatology 11:2, pages 127-131.
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