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Original Articles: Clinical

Study of motor asymmetry in ALS indicates an effect of limb dominance on onset and spread of weakness, and an important role for upper motor neurons

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Pages 481-487 | Received 08 Nov 2013, Accepted 17 Mar 2014, Published online: 09 May 2014

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Pamela A. McCombe, Fleur C Garton, Matthew Katz, Naomi R Wray & Robert D Henderson. (2020) What do we know about the variability in survival of patients with amyotrophic lateral sclerosis?. Expert Review of Neurotherapeutics 20:9, pages 921-941.
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Susana Pinto, Marta Gromicho & Mamede de Carvalho. (2019) Assessing upper limb function with ALSFRS-R in amyotrophic lateral sclerosis patients. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 20:5-6, pages 445-448.
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Yuzhou Wang, Xiaodi Li, Wenming Chen, Zhanhang Wang, Yan Xu, Jingpan Luo, Hanbo Lin & Guijun Sun. (2017) Detecting neuronal dysfunction of hand motor cortex in ALS: A MRSI study. Somatosensory & Motor Research 34:1, pages 15-20.
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Matthew S. Devine, Emma Ballard, Peter O’Rourke, Matthew C. Kiernan, Pamela A. Mccombe & Robert D. Henderson. (2016) Targeted assessment of lower motor neuron burden is associated with survival in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 17:3-4, pages 184-190.
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Giammarco Milella, Stefano Zoccolella, Daniele Urso, Salvatore Nigro, Ludovica Tamburrino, Valentina Gnoni, Marco Filardi & Giancarlo Logroscino. (2023) Different patterns of spreading direction and motor neurons involvement in a cohort of limb‐onset amyotrophic lateral sclerosis patients from Southern Italy: Potential implication on disease course or progression?. Brain and Behavior 13:6.
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André Truffert, Eglė Sukockienė, Annaïck Desmaison, Miglė Ališauskienė, Ruxandra Iancu Ferfoglia & Nathalie Guy. (2023) Combined tendon reflex and motor evoked potential recordings in amyotrophic lateral sclerosis. Clinical Neurophysiology 147, pages 88-98.
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Harold H. G. Tan, Henk‐Jan Westeneng, Abram D. Nitert, Kevin van Veenhuijzen, Jil M. Meier, Hannelore K. van der Burgh, Martine J. E. van Zandvoort, Michael A. van Es, Jan H. Veldink & Leonard H. van den Berg. (2022) MRI Clustering Reveals Three ALS Subtypes With Unique Neurodegeneration Patterns . Annals of Neurology 92:6, pages 1030-1045.
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Abram D Nitert, Harold HG Tan, Renée Walhout, Nienke L Knijnenburg, Michael A van Es, Jan H Veldink, Jeroen Hendrikse, Henk-Jan Westeneng & Leonard H van den Berg. (2022) Sensitivity of brain MRI and neurological examination for detection of upper motor neurone degeneration in amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery & Psychiatry 93:1, pages 82-92.
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Steve Vucic, Nathan Pavey, Mouna Haidar, Bradley J. Turner & Matthew C. Kiernan. (2021) Cortical hyperexcitability: Diagnostic and pathogenic biomarker of ALS. Neuroscience Letters 759, pages 136039.
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Noah Lubben, Elizabeth Ensink, Gerhard A Coetzee & Viviane Labrie. (2021) The enigma and implications of brain hemispheric asymmetry in neurodegenerative diseases. Brain Communications 3:3.
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Dariusz Zapała, Paulina Iwanowicz, Piotr Francuz & Paweł Augustynowicz. (2021) Handedness effects on motor imagery during kinesthetic and visual-motor conditions. Scientific Reports 11:1.
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Stefano Zoccolella, Alessandro Introna, Giammarco Milella, Antonella Mastronardi, Giovanni Iliceto, Eustachio D'Errico, Angela Fraddosio & Isabella Laura Simone. (2021) Subclinical upper motor neuron involvement at the diagnosis may predict disease progression in a cohort of lower motor neuron syndromes from Southern Italy. Journal of the Neurological Sciences 425, pages 117392.
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Mehdi A. J. Bos, Mana Higashihara, Nimeshan Geevasinga, Parvathi Menon, Matthew C. Kiernan & Steve Vucic. (2020) Pathophysiological associations of transcallosal dysfunction in ALS. European Journal of Neurology 28:4, pages 1172-1180.
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Christine Marques, Thibaut Burg, Jelena Scekic-Zahirovic, Mathieu Fischer & Caroline Rouaux. (2021) Upper and Lower Motor Neuron Degenerations Are Somatotopically Related and Temporally Ordered in the Sod1 Mouse Model of Amyotrophic Lateral Sclerosis. Brain Sciences 11:3, pages 369.
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Yingsheng Xu, Junyi Chen, Shuo Zhang & Dongsheng Fan. (2021) Upper Motor Neuron Signs in the Cervical Region of Patients With Flail Arm Syndrome. Frontiers in Neurology 12.
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Rebekah M. Ahmed, Frederik Steyn & Luc Dupuis. 2021. The Human Hypothalamus - Middle and Posterior Region. The Human Hypothalamus - Middle and Posterior Region 327 338 .
Ashwag R. Alruwaili, Kerstin Pannek, Robert D. Henderson, Marcus Gray, Nyoman D. Kurniawan & Pamela A. McCombe. (2020) Serial MRI studies over 12 months using manual and atlas-based region of interest in patients with amyotrophic lateral sclerosis. BMC Medical Imaging 20:1.
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Viral Upadhyay, Matthew Katz, Matthew Kiernan & Robert Henderson. (2020) Review of the revised amyotrophic lateral sclerosis diagnostic criteria. Clinical Neurophysiology 131:8, pages 1767-1768.
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Ashwag R. Alruwaili, Kerstin Pannek, Robert D. Henderson, Marcus Gray, Nyoman D. Kurniawan & Pamela A. McCombe. (2019) Tract integrity in amyotrophic lateral sclerosis: 6–month evaluation using MR diffusion tensor imaging. BMC Medical Imaging 19:1.
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Pilar Rojas, Rosa de Hoz, Ana Ramírez, Antonio Ferreras, Elena Salobrar-Garcia, José Muñoz-Blanco, José Urcelay-Segura, Juan Salazar & José Ramírez. (2019) Changes in Retinal OCT and Their Correlations with Neurological Disability in Early ALS Patients, a Follow-Up Study. Brain Sciences 9:12, pages 337.
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Roaya Khalaf, Sarah Martin, Cathy Ellis, Rachel Burman, Jemeen Sreedharan, Christopher Shaw, P Nigel Leigh, Martin R Turner & Ammar Al-Chalabi. (2019) Relative preservation of triceps over biceps strength in upper limb-onset ALS: the ‘split elbow’. Journal of Neurology, Neurosurgery & Psychiatry 90:7, pages 730-733.
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Mehdi A. J. van den Bos, Nimeshan Geevasinga, Mana Higashihara, Parvathi Menon & Steve Vucic. (2019) Pathophysiology and Diagnosis of ALS: Insights from Advances in Neurophysiological Techniques. International Journal of Molecular Sciences 20:11, pages 2818.
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Robert D Henderson, Fleur C Garton, Matthew C Kiernan, Martin R Turner & Andrew Eisen. (2019) Human cerebral evolution and the clinical syndrome of amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery & Psychiatry 90:5, pages 570-575.
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Parvathi Menon, Matthew C. Kiernan & Steve Vucic. (2018) Cortical excitability varies across different muscles. Journal of Neurophysiology 120:3, pages 1397-1403.
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Carmel Armon. (2018) From Snow to Hill to ALS: An epidemiological odyssey in search of ALS causation. Journal of the Neurological Sciences 391, pages 134-140.
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Matthew J. Fogarty. (2018) Driven to decay: Excitability and synaptic abnormalities in amyotrophic lateral sclerosis. Brain Research Bulletin 140, pages 318-333.
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Ana Filipa Geraldo, João Pereira, Pedro Nunes, Sofia Reimão, Rita Sousa, Miguel Castelo-Branco, Susana Pinto, Jorge Guedes Campos & Mamede de Carvalho. (2018) Beyond fractional anisotropy in amyotrophic lateral sclerosis: the value of mean, axial, and radial diffusivity and its correlation with electrophysiological conductivity changes. Neuroradiology 60:5, pages 505-515.
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N. G. Simon, W. Huynh, S. Vucic, K. Talbot & M. C. Kiernan. (2015) Motor neuron disease: current management and future prospects. Internal Medicine Journal 45:10, pages 1005-1013.
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Pierre-François Pradat, Edor Kabashi & Claude Desnuelle. (2015) Deciphering spreading mechanisms in amyotrophic lateral sclerosis. Current Opinion in Neurology 28:5, pages 455-461.
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Matthew S. Devine, Kerstin Pannek, Alan Coulthard, Pamela A. McCombe, Stephen E. Rose & Robert D. Henderson. (2015) Exposing asymmetric gray matter vulnerability in amyotrophic lateral sclerosis. NeuroImage: Clinical 7, pages 782-787.
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