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Research Article

Hemoglobin–albumin cross-linking with disuccinimidyl suberate (DSS) and/or glutaraldehyde for blood substitutes

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Pages 13-17 | Received 23 Dec 2012, Accepted 23 Dec 2012, Published online: 23 Jan 2013

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Mengdi Wu, Kun Feng, Qiuhui Li, Huiya Ma, Hongli Zhu, Yudou Xie, Gaofei Yan, Chao Chen & Kunping Yan. (2018) Glutaraldehyde-polymerized hemoglobin and tempol (PolyHb-tempol) has superoxide dismutase activity that can attenuate oxidative stress on endothelial cells induced by superoxide anion. Artificial Cells, Nanomedicine, and Biotechnology 46:1, pages 47-55.
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Mariann-Kinga Arkosi, Augustin C. Mot, Iulia Lupan, Miruna Georgiana Ghinia Tegla & Radu Silaghi-Dumitrescu. (2023) Selective Attachment of Polyethylene Glycol to Hemerythrin for Potential Use in Blood Substitutes. The Protein Journal 42:4, pages 374-382.
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Nitin B. Charbe, Francisco Castillo, Murtaza M. Tambuwala, Parteek Prasher, Dinesh Kumar Chellappan, Aurora Carreño, Saurabh Satija, Sachin Kumar Singh, Monica Gulati, Kamal Dua, José Vicente González-Aramundiz & Flavia C. Zacconi. (2022) A new era in oxygen therapeutics? From perfluorocarbon systems to haemoglobin-based oxygen carriers. Blood Reviews 54, pages 100927.
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Anca D. Farcas, Vlad Al Toma, Ioana Roman, Bogdan Sevastre, Florina Scurtu & Radu Silaghi-Dumitrescu. (2020) Glutaraldehyde-Polymerized Hemoglobin: In Search of Improved Performance as Oxygen Carrier in Hemorrhage Models. Bioinorganic Chemistry and Applications 2020, pages 1-11.
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Alina Matei, Cristina Puscas, Iulia Patrascu, Maria Lehene, Julia Ziebro, Florina Scurtu, Monica Baia, Dan Porumb, Robert Totos & Radu Silaghi-Dumitrescu. (2020) Stability of Glutaraldehyde in Biocide Compositions. International Journal of Molecular Sciences 21:9, pages 3372.
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Barbara Steigenberger, Roland J. Pieters, Albert J. R. Heck & Richard A. Scheltema. (2019) PhoX: An IMAC-Enrichable Cross-Linking Reagent. ACS Central Science 5:9, pages 1514-1522.
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James DeCaprio & Thomas O. Kohl. (2019) Cross-Linking Antibodies to Beads with Disuccinimidyl Suberate (DSS). Cold Spring Harbor Protocols 2019:2, pages pdb.prot098632.
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Denisa Hathazi, Florina Scurtu, Cristina Bischin, Augustin Mot, Amr Attia, Jacob Kongsted & Radu Silaghi-Dumitrescu. (2018) The Reaction of Oxy Hemoglobin with Nitrite: Mechanism, Antioxidant-Modulated Effect, and Implications for Blood Substitute Evaluation. Molecules 23:2, pages 350.
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Vlad Al. Toma, Anca D. Farcas, Ioana Roman, Bogdan Sevastre, Denisa Hathazi, Florina Scurtu, Grigore Damian & Radu Silaghi-Dumitrescu. (2018) In vivo evaluation of hemerythrin-based oxygen carriers: Similarities with hemoglobin-based counterparts. International Journal of Biological Macromolecules 107, pages 1422-1427.
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Vlad Al. Toma, Anca D. Farcaș, Ioana Roman, Bogdan Sevastre, Denisa Hathazi, Florina Scurtu, Grigore Damian & Radu Silaghi-Dumitrescu. (2016) Comparative In Vivo Effects of Hemoglobin-Based Oxygen Carriers (HBOC) with Varying Prooxidant and Physiological Reactivity. PLOS ONE 11:4, pages e0153909.
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Seetharama A. Acharya, Marcos Intaglietta, Amy G. Tsai & Fantao Meng. 2013. Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics. Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics 185 234 .

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