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Original Article

Safety and efficacy of tocilizumab, an anti-IL-6-receptor monoclonal antibody, in patients with polyarticular-course juvenile idiopathic arthritis

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Pages 109-115 | Received 16 Dec 2010, Accepted 25 May 2011, Published online: 02 Jan 2014

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Read on this site (15)

Rolando Cimaz, Gabriella Maioli & Giulia Calabrese. (2020) Current and emerging biologics for the treatment of juvenile idiopathic arthritis. Expert Opinion on Biological Therapy 20:7, pages 725-740.
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Xiaoping Zhang, Ya-Chi Chen & Kimio Terao. (2017) Clinical pharmacology of tocilizumab for the treatment of polyarticular-course juvenile idiopathic arthritis. Expert Review of Clinical Pharmacology 10:5, pages 471-482.
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Tomohiro Kubota, Hiroyuki Imanaka, Syuji Takei, Tsuyoshi Yamatou, Yasuhito Nerome, Yuuichi Yamasaki, Yukiko Nonaka, Harumi Akaike, Tomoko Takezaki & Yosihumi Kawano. (2016) Disease activity score in 28 joints at 3 months after the initiation of biologic agent can be a predictive target for switching to the second biologic agent in patients with polyarticular juvenile idiopathic arthritis. Modern Rheumatology 26:3, pages 358-361.
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Özgül Muştu Koryürek & Göknur Kalkan. (2016) A new alternative therapy in dermatology: tocilizumab. Cutaneous and Ocular Toxicology 35:2, pages 145-152.
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Jessica L. Turnier & Hermine I. Brunner. (2016) Tocilizumab for treating juvenile idiopathic arthritis. Expert Opinion on Biological Therapy 16:4, pages 559-566.
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Gerd Horneff. (2015) Safety of biologic therapies for the treatment of juvenile idiopathic arthritis. Expert Opinion on Drug Safety 14:7, pages 1111-1126.
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Tomomi Tsuru, Kimio Terao, Miho Murakami, Takaji Matsutani, Midori Suzaki, Toshiaki Amamoto, Hitoshi Nakashima, Azusa Akiyama & Norihiro Nishimoto. (2014) Immune response to influenza vaccine and pneumococcal polysaccharide vaccine under IL-6 signal inhibition therapy with tocilizumab. Modern Rheumatology 24:3, pages 511-516.
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Troels Herlin. (2012) Tocilizumab for the treatment of systemic juvenile idiopathic arthritis. Expert Review of Clinical Immunology 8:6, pages 517-525.
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Daniel D Reiff, Matthew L Stoll & Randy Q Cron. (2021) Precision medicine in juvenile idiopathic arthritis—has the time arrived?. The Lancet Rheumatology 3:11, pages e808-e817.
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Ernest H. Choy, Fabrizio De Benedetti, Tsutomu Takeuchi, Misato Hashizume, Markus R. John & Tadamitsu Kishimoto. (2020) Translating IL-6 biology into effective treatments. Nature Reviews Rheumatology 16:6, pages 335-345.
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Martijn J H Doeleman, Erik M van Maarseveen & Joost F Swart. (2019) Immunogenicity of biologic agents in juvenile idiopathic arthritis: a systematic review and meta-analysis. Rheumatology 58:10, pages 1839-1849.
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Violetta Opoka-Winiarska, Zbigniew Żuber, Ekaterina Alexeeva, Vyacheslav Chasnyk, Irina Nikishina, Grażyna Dębowska & Elżbieta Smolewska. (2018) Long-term, interventional, open-label extension study evaluating the safety of tocilizumab treatment in patients with polyarticular-course juvenile idiopathic arthritis from Poland and Russia who completed the global, international CHERISH trial. Clinical Rheumatology 37:7, pages 1807-1816.
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Andrea Rubbert-Roth, Daniel E. Furst, Jan Michael Nebesky, Angela Jin & Erhan Berber. (2018) A Review of Recent Advances Using Tocilizumab in the Treatment of Rheumatic Diseases. Rheumatology and Therapy 5:1, pages 21-42.
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Shigeomi TAKEDA, Masahiko KOIKE, Naoki IWATA, Mitsuro KANDA, Michitaka FUJIWARA & Yasuhiro KODERA. (2018) A Case of Esophageal Cancer Occurred in a Patient with Multicentric Castleman's Disease Treated by Using Tocilizumab—Report of a Case—トシリズマブ投与中のCastleman病患者に発生した食道癌の1例. Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 79:5, pages 995-999.
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Rolando Cimaz, Achille Marino & Alberto Martini. (2017) How I treat juvenile idiopathic arthritis: A state of the art review. Autoimmunity Reviews 16:10, pages 1008-1015.
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Kei Ishibashi, Tobias Haber, Ines Breuksch, Susanne Gebhard, Takashi Sugino, Hitoshi Kubo, Junya Hata, Tomoyuki Koguchi, Michihiro Yabe, Masao Kataoka, Soichiro Ogawa, Hiroyuki Hiraki, Tomohiko Yanagida, Nobuhiro Haga, Joachim W. Thüroff, Dirk Prawitt, Walburgis Brenner & Yoshiyuki Kojima. (2017) Overriding TKI resistance of renal cell carcinoma by combination therapy with IL-6 receptor blockade. Oncotarget 8:33, pages 55230-55245.
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Darong Kim, Hee Yeon Won, Eun Sook Hwang, Young-Kook Kim & Hea-Young Park Choo. (2017) Synthesis of benzoxazole derivatives as interleukin-6 antagonists. Bioorganic & Medicinal Chemistry 25:12, pages 3127-3134.
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Toshio Tanaka & Masashi Narazaki. (2017) Interleukin-6 Inhibition in Inflammatory Diseases: Results Achieved and Tasks to Accomplish. Journal of Scleroderma and Related Disorders 2:2_suppl, pages S20-S28.
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Ya-Qun Zhou, Zheng Liu, Zhi-Heng Liu, Shu-Ping Chen, Man Li, Allahverdi Shahveranov, Da-Wei Ye & Yu-Ke Tian. (2016) Interleukin-6: an emerging regulator of pathological pain. Journal of Neuroinflammation 13:1.
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Gabriella Giancane, Alessandro Consolaro, Stefano Lanni, Sergio Davì, Benedetta Schiappapietra & Angelo Ravelli. (2016) Juvenile Idiopathic Arthritis: Diagnosis and Treatment. Rheumatology and Therapy 3:2, pages 187-207.
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Mikhail M Kostik, Margarita F Dubko, Vera V Masalova, Ludmila S Snegireva, Tatyana L Kornishina, Irina A Chikova, Eugenia A Isupova, Ekaterina M Kuchinskaya, Natalia I Glebova, Natalia V Buchinskaya, Olga V Kalashnikova & Vyacheslav G Chasnyk. (2015) Successful treatment with tocilizumab every 4 weeks of a low disease activity group who achieve a drug-free remission in patients with systemic-onset juvenile idiopathic arthritis. Pediatric Rheumatology 13:1.
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Yusuke Tozawa, Shouji Fujita, Shuji Abe, Koichi Kitamura & Ichiro Kobayashi. (2015) Radiological improvement by tocilizumab in polyarticular juvenile idiopathic arthritis. Pediatrics International 57:2, pages 307-310.
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C. Le Stradic, C. Galeotti & I. Koné-Paut. (2014) Traitement par tocilizumab : expérience d’un centre de rhumatologie pédiatrique. Archives de Pédiatrie 21:12, pages 1299-1304.
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Parvin Ataie-Kachoie, Mohammad H Pourgholami, Des R Richardson & David L Morris. (2014) Gene of the month: Interleukin 6 (IL-6). Journal of Clinical Pathology 67:11, pages 932-937.
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Ruth Davies & Ernest Choy. (2014) Clinical experience of IL-6 blockade in rheumatic diseases—Implications on IL-6 biology and disease pathogenesis. Seminars in Immunology 26:1, pages 97-104.
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Nora Honke, Kim Ohl, Anastasia Wiener, Jeff Bierwagen, Joachim Peitz, Stefano Di Fiore, Rainer Fischer, Norbert Wagner, Stefan Wüller & Klaus Tenbrock. (2014) The p38-Mediated Rapid Down-Regulation of Cell Surface gp130 Expression Impairs Interleukin-6 Signaling in the Synovial Fluid of Juvenile Idiopathic Arthritis Patients. Arthritis & Rheumatology 66:2, pages 470-478.
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Shumpei Yokota, Toshio Tanaka & Tadamitsu Kishimoto. (2012) Efficacy, safety and tolerability of tocilizumab in patients with systemic juvenile idiopathic arthritis. Therapeutic Advances in Musculoskeletal Disease 4:6, pages 387-397.
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