Advanced search
Publication Cover
Dialogues in Clinical Neuroscience Volume 8, 2006 - Issue 3
Submit an article Journal homepage
3,919
Views
165
CrossRef citations to date
0
Altmetric
Clinical Research

The role of serendipity in drug discovery

El papel de la casualidad en el descubrimiento de fármacos

Rôle du hasard dans la découverte médicamenteuse

Thomas A. BanEmeritus Professor of Psychiatry, Vanderbilt University, Nashville, Tenn, USACorrespondence[email protected]
Pages 335-344 | Published online: 01 Apr 2022

Citations (165)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (14)

Prashasti Sinha & Anil Kumar Yadav. (2023) Identification of 3, 4-dihydroxy complexes as potential antiviral via DFT, molecular docking, molecular dynamics and MM/PBSA against rabies and dengue receptors. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-17.
Read now
C. Brendan Montano, W. Clay Jackson, Denise Vanacore & Richard Weisler. (2023) Considerations when selecting an antidepressant: a narrative review for primary care providers treating adults with depression. Postgraduate Medicine 135:5, pages 449-465.
Read now
Gabriel C. Veríssimo, Mateus Sá M. Serafim, Thales Kronenberger, Rafaela S. Ferreira, Kathia M. Honorio & Vinícius G. Maltarollo. (2022) Designing drugs when there is low data availability: one-shot learning and other approaches to face the issues of a long-term concern. Expert Opinion on Drug Discovery 17:9, pages 929-947.
Read now
A. B. Bayoumy, N. K. H. de Boer, A. R. Ansari, F. Crouwel & C. J. J. Mulder. (2020) Unrealized potential of drug repositioning in Europe during COVID-19 and beyond: a physician’s perspective. Journal of Pharmaceutical Policy and Practice 13:1.
Read now
Togapur Pavan Kumar, Ambica V, Srivari Chandrasekhar & Prathama S. Mainkar. (2020) Rediscovering the discovered: the new paradigm in repurposing drugs. Indian Chemical Engineer 62:4, pages 359-366.
Read now
Robert Musiol. (2017) An overview of quinoline as a privileged scaffold in cancer drug discovery. Expert Opinion on Drug Discovery 12:6, pages 583-597.
Read now
Alonso Montoya, Robert Bruins, Martin A Katzman & Pierre Blier. (2016) The noradrenergic paradox: implications in the management of depression and anxiety. Neuropsychiatric Disease and Treatment 12, pages 541-557.
Read now
Stefano Fais. (2016) A nonmainstream approach against cancer. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 882-889.
Read now
Kalyan Immadisetty, Laura M Geffert, Christopher K Surratt & Jeffry D Madura. (2013) New design strategies for antidepressant drugs. Expert Opinion on Drug Discovery 8:11, pages 1399-1414.
Read now
Manuella Adrian. (2012) Can Failure Carefully Observed Become a Springboard to Success?. Substance Use & Misuse 47:13-14, pages 1384-1397.
Read now
Fabian López-Vallejo, Terry L Peppard, José L Medina-Franco & Karina Martínez-Mayorga. (2011) Computational methods for the discovery of mood disorder therapies. Expert Opinion on Drug Discovery 6:12, pages 1227-1245.
Read now
Alan A. Baumeister, Mike F. Hawkins & Francisco López-Muñoz. (2010) Toward Standardized Usage of the Word Serendipity in the Historiography of Psychopharmacology. Journal of the History of the Neurosciences 19:3, pages 253-270.
Read now
Zhengming Chen & Phil Skolnick. (2007) Triple uptake inhibitors: therapeutic potential in depression and beyond. Expert Opinion on Investigational Drugs 16:9, pages 1365-1377.
Read now
Michael J Minzenberg & Cameron S Carter. (2007) The quest for developing new treatments from imaging techniques: promises, problems and future potential. Expert Opinion on Drug Discovery 2:8, pages 1029-1033.
Read now

Articles from other publishers (151)

Vlad Ratziu & Frank Tacke. (2023) At the dawn of potent therapeutics for fatty liver disease – introducing the miniseries on promising pharmacological targets for NASH. Journal of Hepatology 79:2, pages 261-262.
Crossref
David C. Thompson & Samantha M. Copeland. (2023) Serendipity in research and development: The promise of putting into place patterns for paying attention. Drug Discovery Today 28:8, pages 103648.
Crossref
Eric J. Wang, Jay Karri, Nuj Tontisirin & Steven P. Cohen. (2023) Antimicrobial therapies for chronic pain (part 1): analgesic mechanisms. The Korean Journal of Pain 36:3, pages 281-298.
Crossref
Moksh Jain, Tristan Deleu, Jason Hartford, Cheng-Hao Liu, Alex Hernandez-Garcia & Yoshua Bengio. (2023) GFlowNets for AI-driven scientific discovery. Digital Discovery 2:3, pages 557-577.
Crossref
Nanna Reiter, Charlotte U. Andersen, Karen L. Thomsen, Christian A. Wamberg, Tonny S. Petersen & Kim Dalhoff. (2023) Risk of prolonged sedation with the use of chlordiazepoxide in alcohol withdrawal treatment. Adverse Drug Reaction Bulletin 340:1, pages 1319-1322.
Crossref
David Irving Hermann Maier, Barend Christiaan Buurman Bezuidenhoudt & Charlene Marais. (2023) Strategies in the synthesis of dibenzo[ b,f ]heteropines . Beilstein Journal of Organic Chemistry 19, pages 700-718.
Crossref
Shraddha M. Dalwadi, Andrew Hunt, Mark D. Bonnen & Yohannes T. Ghebre. (2023) Computational approaches for drug repurposing in oncology: untapped opportunity for high value innovation. Frontiers in Oncology 13.
Crossref
Bo Jin, Xuechao Pang, Qingce Zang, Man Ga, Jing Xu, Zhigang Luo, Ruiping Zhang, Jiangong Shi, Jiuming He & Zeper Abliz. (2023) Spatiotemporally resolved metabolomics and isotope tracing reveal CNS drug targets. Acta Pharmaceutica Sinica B 13:4, pages 1699-1710.
Crossref
Jose de Leon. (2023) Reflections on the Lack of Consideration of Ethnic Ancestry to Stratify Clozapine Dosing. Psychiatry Investigation 20:3, pages 183-195.
Crossref
Matteo Pavan & Stefano Moro. (2023) Lessons Learnt from COVID-19: Computational Strategies for Facing Present and Future Pandemics. International Journal of Molecular Sciences 24:5, pages 4401.
Crossref
Silvia Menin, Matteo Pavan, Veronica Salmaso, Mattia Sturlese & Stefano Moro. (2023) Thermal Titration Molecular Dynamics (TTMD): Not Your Usual Post-Docking Refinement. International Journal of Molecular Sciences 24:4, pages 3596.
Crossref
Emily C. Parke & Anya Plutynski. (2023) Going big by going small: Trade-offs in microbiome explanations of cancer. Studies in History and Philosophy of Science 97, pages 101-110.
Crossref
Erwin B MontgomeryJr.Jr. & Olivier Darbin. 2023. Nonlinear Dynamics of Parkinson's Disease and the Basal Ganglia-Thalamic-cortical System. Nonlinear Dynamics of Parkinson's Disease and the Basal Ganglia-Thalamic-cortical System 1 75 .
Mainak Chatterjee & Kunal Roy. 2023. Cheminformatics, QSAR and Machine Learning Applications for Novel Drug Development. Cheminformatics, QSAR and Machine Learning Applications for Novel Drug Development 3 38 .
Rohan Palanki & Sourav K. Bose. 2023. Translational Surgery. Translational Surgery 35 41 .
Valentin K. Gribkoff & Leonard K. Kaczmarek. 2023. Drug Development in Psychiatry. Drug Development in Psychiatry 255 285 .
Alexandre Magalhães. (2022) Serendipidade na investigação científica. Revista de Ciência Elementar 10:4.
Crossref
Stefano Fais. (2022) Scientific Discoveries Supporting Theories in Science: From Thinking to Practice. International Journal of Molecular Sciences 23:23, pages 15025.
Crossref
Dan J. Stein, Steven J. Shoptaw, Daniel V. Vigo, Crick Lund, Pim Cuijpers, Jason Bantjes, Norman Sartorius & Mario Maj. (2022) Psychiatric diagnosis and treatment in the 21st century: paradigm shifts versus incremental integration. World Psychiatry 21:3, pages 393-414.
Crossref
Mubashir Aziz, Syeda Abida Ejaz, Seema Zargar, Naveed Akhtar, Abdullahi Tunde Aborode, Tanveer A. Wani, Gaber El-Saber Batiha, Farhan Siddique, Mohammed Alqarni & Ashraf Akintayo Akintola. (2022) Deep Learning and Structure-Based Virtual Screening for Drug Discovery against NEK7: A Novel Target for the Treatment of Cancer. Molecules 27:13, pages 4098.
Crossref
Gabriel Taricani Kubota. (2022) It is time anti-CGRP monoclonal antibodies be considered first-line prophylaxis for migraine. Arquivos de Neuro-Psiquiatria 80:5 suppl 1, pages 218-226.
Crossref
Inbar Kobal & Yuval Ramot. (2022) Januskinaseinhibitoren in der Therapie der Alopecia areataJanus kinase inhibitors for the treatment of alopecia areata. Der Hautarzt 73:5, pages 336-343.
Crossref
Joseph Zohar & Daniel Minkin Levy. (2022) Neuroscience-based nomenclature of psychotropics: Progress report. European Neuropsychopharmacology 57, pages 36-38.
Crossref
Nutan Rao, Riddhi Kini, Drashti Maniyar & Rishika Amin. (2022) Journey from Serendipity to Biologics. Pharmaceutical Chemistry Journal 55:12, pages 1329-1337.
Crossref
Irini Doytchinova. (2022) Drug Design—Past, Present, Future. Molecules 27:5, pages 1496.
Crossref
Vishal B Siramshetty, Ivan Grishagin, Ðắc-Trung Nguyễn, Tyler Peryea, Yulia Skovpen, Oleg Stroganov, Daniel Katzel, Timothy Sheils, Ajit Jadhav, Ewy A Mathé & Noel T Southall. (2022) NCATS Inxight Drugs: a comprehensive and curated portal for translational research. Nucleic Acids Research 50:D1, pages D1307-D1316.
Crossref
Dan J. Stein. 2022. Comprehensive Clinical Psychology. Comprehensive Clinical Psychology 97 104 .
Sakshi Piplani, Puneet Singh, David A. Winkler & Nikolai Petrovsky. 2022. Frontiers of COVID-19. Frontiers of COVID-19 471 486 .
Vlad P. Glăveanu. 2022. The Art of Serendipity. The Art of Serendipity 23 39 .
Mohamed Haider, Amr Elsherbeny, Valeria Pittalà, Antonino N. Fallica, Maha Ali Alghamdi & Khaled Greish. (2021) The Potential Role of Sildenafil in Cancer Management through EPR Augmentation. Journal of Personalized Medicine 11:6, pages 585.
Crossref
José T. Moreira-Filho, Arthur C. Silva, Rafael F. Dantas, Barbara F. Gomes, Lauro R. Souza Neto, Jose Brandao-Neto, Raymond J. Owens, Nicholas Furnham, Bruno J. Neves, Floriano P. Silva-Junior & Carolina H. Andrade. (2021) Schistosomiasis Drug Discovery in the Era of Automation and Artificial Intelligence. Frontiers in Immunology 12.
Crossref
Pierpaolo Andriani & Renata Kaminska. (2021) Exploring the dynamics of novelty production through exaptation: a historical analysis of coal tar-based innovations. Research Policy 50:2, pages 104171.
Crossref
Robert Suchting, Vaishali Tirumalaraju, Rida Gareeb, Taya Bockmann, Constanza de Dios, Jacob Aickareth, Omar Pinjari, Jair C. Soares, Phil J. Cowen & Sudhakar Selvaraj. (2021) Revisiting monoamine oxidase inhibitors for the treatment of depressive disorders: A systematic review and network meta-analysis. Journal of Affective Disorders 282, pages 1153-1160.
Crossref
Zongliang Chang, Weibing Qin, Huili Zheng, Kathleen Schegg, Lu Han, Xiaohua Liu, Yue Wang, Zhuqing Wang, Hayden McSwiggin, Hongying Peng, Shuiqiao Yuan, Jiabao Wu, Yongxia Wang, Shenghui Zhu, Yanjia Jiang, Hua Nie, Yuan Tang, Yu Zhou, Michael J. M. Hitchcock, Yunge Tang & Wei Yan. (2021) Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates. Nature Communications 12:1.
Crossref
Pedro N. Batalha, Luana S.M. Forezi, Carolina G.S. Lima, Fernanda P. Pauli, Fernanda C.S. Boechat, Maria Cecília B.V. de Souza, Anna C. Cunha, Vitor F. Ferreira & Fernando de C. da Silva. (2021) Drug repurposing for the treatment of COVID-19: Pharmacological aspects and synthetic approaches. Bioorganic Chemistry 106, pages 104488.
Crossref
Martin Wehling. 2021. Principles of Translational Science in Medicine. Principles of Translational Science in Medicine 115 122 .
Ramarao Poduri. 2021. Drug Discovery and Development. Drug Discovery and Development 1 10 .
Elke Schüßler & Benjamin Schiemer. 2021. Handbuch Innovationsforschung. Handbuch Innovationsforschung 395 410 .
Arjan Blokland. 2021. Modern CNS Drug Discovery. Modern CNS Drug Discovery 25 33 .
Norbert Schwarz. (2020) Theory and Effects in Consumer Psychology. Journal of Consumer Psychology 31:1, pages 209-213.
Crossref
Benjamin E. Jewett, Merry N. Miller, Libby A. Ligon, Zachary Carter, Ibrahim Mohammad & Gregory A. Ordway. (2020) Rapid and temporary improvement of depression and anxiety observed following niraparib administration: a case report. BMC Psychiatry 20:1.
Crossref
Daohong Chen & Eric Yining Qi. (2020) Innovative highlights of clinical drug trial design. Translational Research 224, pages 71-77.
Crossref
Chong Sun, Wenwen Zhao, Xumei Wang, Yinxiang Sun & Xiuping Chen. (2020) A pharmacological review of dicoumarol: An old natural anticoagulant agent. Pharmacological Research 160, pages 105193.
Crossref
B. Drukarch, G.E. Jacobs & M.M.M. Wilhelmus. (2020) Solving the crisis in psychopharmacological research: Cellular-membrane(s) pharmacology to the rescue?. Biomedicine & Pharmacotherapy 130, pages 110545.
Crossref
Scott D Nelson, Colin G Walsh, Casey A Olsen, Andrew J McLaughlin, Joseph R LeGrand, Nick Schutz & Thomas A Lasko. (2020) Demystifying artificial intelligence in pharmacy. American Journal of Health-System Pharmacy 77:19, pages 1556-1570.
Crossref
Simon J.F. Macdonald & Richard J.D. Hatley. (2020) Sprinkling the pixie dust: reflections on innovation and innovators in medicinal chemistry and drug discovery. Drug Discovery Today 25:3, pages 599-609.
Crossref
Felipe R. S. Santos, Damiana A. F. Nunes, William G. Lima, Danilo Davyt, Luciana L. Santos, Alex G. Taranto & Jaqueline M. S. Ferreira. (2019) Identification of Zika Virus NS2B-NS3 Protease Inhibitors by Structure-Based Virtual Screening and Drug Repurposing Approaches. Journal of Chemical Information and Modeling 60:2, pages 731-737.
Crossref
Evan D. Bander, Gary Kocharian, Benjamin Liechty, Apostolos J. Tsiouris & Theodore H. Schwartz. (2019) Spontaneous regression of a clival chordoma. Case report. Acta Neurochirurgica 162:2, pages 433-436.
Crossref
Rodrigo Pérez-Esparza, Luis Fabián Kobayashi-Romero, Ana María García Mendoza, Reyna Minerva Lamas-Aguilar, Melissa Vargas Sosa, Melissa Encarnación-Martínez, Luz Andrea González-Manríquez, Silvia Alejandra Eternod-Rodríguez, Fernanda Maltos-Gómez, Karen Marisel Vargas-Valencia & Alan Fonseca Pérez-Amador. (2020) Ketamina, un nuevo agente terapéutico para la depresión. Revista de la Facultad de Medicina 63:1, pages 6-13.
Crossref
Larisa Đurić, Maja Milanović, Nataša Milošević & Nataša Milić. (2020) New pharmaceuticals: The importance of serendipity. Medicinski casopis 54:4, pages 143-148.
Crossref
Samaneh Nemati, Teddy J. Akiki, Jeremy Roscoe, Yumeng Ju, Christopher L. Averill, Samar Fouda, Arpan Dutta, Shane McKie, John H. Krystal, J.F. William Deakin, Lynnette A. Averill & Chadi G. Abdallah. (2020) A Unique Brain Connectome Fingerprint Predates and Predicts Response to Antidepressants. iScience 23:1, pages 100800.
Crossref
Shu-Wei Yang, Jianping Pan, Yuriko Root, Giovanna Scapin, Li Xiao & Jing Su. (2020) Serendipitous discovery of aryl boronic acids as β-lactamase inhibitors. Bioorganic & Medicinal Chemistry Letters 30:2, pages 126795.
Crossref
Gerd Rosenkranz. 2019. Exploratory Subgroup Analyses in Clinical Research. Exploratory Subgroup Analyses in Clinical Research 197 215 .
Kosuke Kato, Shin Ito & Kazuhiko Itaya. (2019) Can Accidental Discoveries be Managed? Exploring Key Factors Impacting Idea Generation in R&D Sites in Japan. International Journal of Innovation and Technology Management 16:06.
Crossref
Rimpy Bhatia, Kulbir Kadyan, Meenakshi Duhan, Meena Devi, Rahul Singh, Ramesh C. Kamboj & Parvin Kumar. (2019) A Serendipitous Synthesis: SiO 2 ‐HNO 3 Mediated Oxidative Aromatization and Regioselective Nitration of 1,3,5‐Trisubstituted‐4,5‐Dihydro‐1 H ‐Pyrazoles . ChemistrySelect 4:35, pages 10417-10424.
Crossref
Roger E. Meyer. (2019) Learning From History to Shape Destiny. Journal of Clinical Psychopharmacology 39:5, pages 423-425.
Crossref
Assia Belhassan, Hanane Zaki, Mohamed Benlyas, Tahar Lakhlifi & Mohammed Bouachrine. (2019) Study of novel triazolo-benzodiazepine analogues as antidepressants targeting by molecular docking and ADMET properties prediction. Heliyon 5:9, pages e02446.
Crossref
Barnaby D. Dunn, Heather O'Mahen, Kim Wright & Gary Brown. (2019) A commentary on research rigour in clinical psychological science: How to avoid throwing out the innovation baby with the research credibility bath water in the depression field. Behaviour Research and Therapy 120, pages 103417.
Crossref
A. Filipa de Almeida, Rui Moreira & Tiago Rodrigues. (2019) Synthetic organic chemistry driven by artificial intelligence. Nature Reviews Chemistry 3:10, pages 589-604.
Crossref
Victor Cui, Waverly W. Ding & Yoshio Yanadori. (2019) Exploration versus exploitation in technology firms: The role of compensation structure for R&D workforce. Research Policy 48:6, pages 1534-1549.
Crossref
Crist N. Filer, Anne G. Laseter & Emma J. Shelton. (2019) Spiperone: Tritium labelling at high specific activity. Applied Radiation and Isotopes 147, pages 211-214.
Crossref
Tom H. Johnston, Alix M.B. Lacoste, Naomi P. Visanji, Anthony E. Lang, Susan H. Fox & Jonathan M. Brotchie. (2019) Repurposing drugs to treat l-DOPA-induced dyskinesia in Parkinson's disease. Neuropharmacology 147, pages 11-27.
Crossref
Berend Olivier. (2019) Waar blijven de nieuwe psychofarmaca?. Neuropraxis 23:1, pages 7-14.
Crossref
Debra Boyd-Kimball, Katelyn Gonczy, Benjamin Lewis, Thomas Mason, Nicole Siliko & Jacob Wolfe. (2018) Classics in Chemical Neuroscience: Chlorpromazine. ACS Chemical Neuroscience 10:1, pages 79-88.
Crossref
. 2019. Wind-Borne Illness from Coastal Seas. Wind-Borne Illness from Coastal Seas 385 525 .
Elke Schüßler & Benjamin Schiemer. 2019. Handbuch Innovationsforschung. Handbuch Innovationsforschung 1 16 .
Gabriel Ibarra, Jose D. Herazo-Maya & Naftali Kaminski. 2019. Idiopathic Pulmonary Fibrosis. Idiopathic Pulmonary Fibrosis 207 239 .
Brian Smith, Alyse Ley, Katherine Krive & Jed Magen. 2019. School Psychopharmacology. School Psychopharmacology 69 82 .
Arie Kaffman, Jordon D. White, Lan Wei, Frances K. Johnson & John H. Krystal. 2019. Psychiatric Disorders. Psychiatric Disorders 3 22 .
Sean J. Belouin & Jack E. Henningfield. (2018) Psychedelics: Where we are now, why we got here, what we must do. Neuropharmacology 142, pages 7-19.
Crossref
Sandra J. Engle, Laura Blaha & Robin J. Kleiman. (2018) Best Practices for Translational Disease Modeling Using Human iPSC-Derived Neurons. Neuron 100:4, pages 783-797.
Crossref
Chadi G. Abdallah, Gerard Sanacora, Ronald S. Duman & John H. Krystal. (2018) The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation?. Pharmacology & Therapeutics 190, pages 148-158.
Crossref
Thomas Stoeger, Martin Gerlach, Richard I. Morimoto & Luís A. Nunes Amaral. (2018) Large-scale investigation of the reasons why potentially important genes are ignored. PLOS Biology 16:9, pages e2006643.
Crossref
Stephen A. Gallo & Scott R. Glisson. (2018) External Tests of Peer Review Validity Via Impact Measures. Frontiers in Research Metrics and Analytics 3.
Crossref
Derek P. Claxton & Eric Gouaux. (2018) Expression and purification of a functional heteromeric GABAA receptor for structural studies. PLOS ONE 13:7, pages e0201210.
Crossref
Alessandra Ventura, Aaron Vassall, Eve Robinson, Renata Filler, Douglas Hanlon, Katrina Meeth, Harib Ezaldein, Michael Girardi, Olga Sobolev, Marcus W. Bosenberg & Richard L. Edelson. (2018) Extracorporeal Photochemotherapy Drives Monocyte-to-Dendritic Cell Maturation to Induce Anticancer Immunity. Cancer Research 78:14, pages 4045-4058.
Crossref
Alexia V. Williams & Brian C. Trainor. (2018) The impact of sex as a biological variable in the search for novel antidepressants. Frontiers in Neuroendocrinology 50, pages 107-117.
Crossref
Dılgeş Baskın, Yasin Çetinkaya & Metin Balci. (2018) Synthesis of dipyrrolo-diazepine derivatives via intramolecular alkyne cyclization. Tetrahedron 74:30, pages 4062-4070.
Crossref
Anand K Deva. (2018) Commentary on: Breast Erythema in a Patient With Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Case Report Discussing Cutaneous Manifestations. Aesthetic Surgery Journal 38:3, pages NP53-NP55.
Crossref
Jose de Leon. (2018) Young Researchers and Young Clinicians Should Not Pay Much Attention to the Journal Impact Factor When Selecting a Journal for Publishing Articles. Journal of Clinical Psychopharmacology 38:1, pages 86-87.
Crossref
Ronald Kaminsky. (2018) Where Is the Breakthrough Innovation for Parasite Control?. Trends in Parasitology 34:2, pages 99-101.
Crossref
James Schuler, Matthew Hudson, Diane Schwartz & Ram Samudrala. (2017) A Systematic Review of Computational Drug Discovery, Development, and Repurposing for Ebola Virus Disease Treatment. Molecules 22:10, pages 1777.
Crossref
Di Guo, Xinyu Hua & Kun Jiang. (2017) Agency and strategic contracts: Theory and evidence from R&D agreements in the pharmaceutical industry. International Journal of Industrial Organization 54, pages 37-64.
Crossref
Ariel Adamski, Dariusz Kruszka, Zbigniew Dutkiewicz, Maciej Kubicki, Adam Gorczyński & Violetta Patroniak. (2017) Novel family of fused tricyclic [1,4]diazepines: Design, synthesis, crystal structures and molecular docking studies. Tetrahedron 73:24, pages 3377-3386.
Crossref
Thomas Schaubroeck & Thomas Gibon. (2017) Outlining reasons to apply hybrid LCA—a reply to “rethinking system boundary in LCA” by Yi Yang (2017). The International Journal of Life Cycle Assessment 22:6, pages 1012-1013.
Crossref
Robert A. McArthur. (2017) Aligning physiology with psychology: Translational neuroscience in neuropsychiatric drug discovery. Neuroscience & Biobehavioral Reviews 76, pages 4-21.
Crossref
Lutz Bornmann. (2016) Measuring impact in research evaluations: a thorough discussion of methods for, effects of and problems with impact measurements. Higher Education 73:5, pages 775-787.
Crossref
Pierpaolo Andriani, Ayfer Ali & Mariano Mastrogiorgio. (2017) Measuring Exaptation and Its Impact on Innovation, Search, and Problem Solving. Organization Science 28:2, pages 320-338.
Crossref
Pierpaolo Andriani. (2017) Exaptation, serendipity and aging. Mechanisms of Ageing and Development 163, pages 30-35.
Crossref
Timothy R Powell, Tytus Murphy, Sang H Lee, Jack Price, Sandrine Thuret & Gerome Breen. (2017) Transcriptomic profiling of human hippocampal progenitor cells treated with antidepressants and its application in drug repositioning. Journal of Psychopharmacology 31:3, pages 338-345.
Crossref
John R. Ciallella & Andrew G. Reaume. (2017) In vivo phenotypic screening: clinical proof of concept for a drug repositioning approach. Drug Discovery Today: Technologies 23, pages 45-52.
Crossref
Brandon Stamper, Waseem Gul, Murrell Godfrey, Shahbaz W. Gul & Mahmoud A. ElSohly. (2016) LC–MS-MS Method for Analysis of Benzodiazepines in Wastewater During Football Games IV. Journal of Analytical Toxicology.
Crossref
Guy Bar‐Klein, Rebecca Klee, Claudia Brandt, Marion Bankstahl, Pablo Bascuñana, Kathrin Töllner, Hotjensa Dalipaj, Jens P. Bankstahl, Alon Friedman & Wolfgang Löscher. (2016) Isoflurane prevents acquired epilepsy in rat models of temporal lobe epilepsy. Annals of Neurology 80:6, pages 896-908.
Crossref
Robert H. Howland. (2016) Methylene Blue: The Long and Winding Road From Stain to Brain: Part 2. Journal of Psychosocial Nursing and Mental Health Services 54:10, pages 21-26.
Crossref
Hassan Al-Ali. (2016) The evolution of drug discovery: from phenotypes to targets, and back. MedChemComm 7:5, pages 788-798.
Crossref
Michael J. Joyner. (2016) Precision Medicine, Cardiovascular Disease and Hunting Elephants. Progress in Cardiovascular Diseases 58:6, pages 651-660.
Crossref
Guido K. W. Frank & Megan E. Shott. (2016) The Role of Psychotropic Medications in the Management of Anorexia Nervosa: Rationale, Evidence and Future Prospects. CNS Drugs 30:5, pages 419-442.
Crossref
Ying Chen, JD Elenee Argentinis & Griff Weber. (2016) IBM Watson: How Cognitive Computing Can Be Applied to Big Data Challenges in Life Sciences Research. Clinical Therapeutics 38:4, pages 688-701.
Crossref
Doru Georg Margineanu. (2016) Neuropharmacology beyond reductionism – A likely prospect. Biosystems 141, pages 1-9.
Crossref
Hugh MacPhersonRichard HammerschlagRemy R. CoeytauxRobert T. DavisRichard E. HarrisJiang-Ti KongHelene M. LangevinLixing LaoRyan J. MilleyVitaly NapadowRosa N. SchnyerElisabet Stener-VictorinClaudia M. WittPeter M. Wayne. (2016) Unanticipated Insights into Biomedicine from the Study of Acupuncture. The Journal of Alternative and Complementary Medicine 22:2, pages 101-107.
Crossref
Jessica D. Tenenbaum. (2016) Translational Bioinformatics: Past, Present, and Future. Genomics, Proteomics & Bioinformatics 14:1, pages 31-41.
Crossref
Sun Hongmao. 2016. A Practical Guide to Rational Drug Design. A Practical Guide to Rational Drug Design 61 108 .
Jose Valdes, Douglas L. Boggs, Angela A. Boggs & Jose A. Rey. 2016. Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents. Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents 471 495 .
Orla Hardiman, Julie A. Kelly, Thomas H. Bak, Marwa Elamin, Dragos L. Mihaila, Pamela J. Shaw, Hiroshi Mitsumoto & Jeremy M. Shefner. 2016. Neurodegenerative Disorders. Neurodegenerative Disorders 289 303 .
Horrick Sharma, Soumava Santra & Aloke Dutta. (2015) Triple reuptake inhibitors as potential next-generation antidepressants: a new hope?. Future Medicinal Chemistry 7:17, pages 2385-2406.
Crossref
Bibiana I. Ferreira, Richard Hill & Wolfgang Link. (2015) Special Review. The Cancer Journal 21:6, pages 441-447.
Crossref
Guido K. W. Frank. (2015) Recent Advances in Neuroimaging to Model Eating Disorder Neurobiology. Current Psychiatry Reports 17:4.
Crossref
Régis Bordet. (2015) Addiction, Experimental Models and Neurobiological Mechanisms. Therapies 70:2, pages 141-146.
Crossref
Régis Bordet. (2015) Addiction, modèles expérimentaux et mécanismes neurobiologiques. Therapies 70:2, pages 133-139.
Crossref
Barbara Zarzycka, Tom Seijkens, Sander B. Nabuurs, Tina Ritschel, Jochen Grommes, Oliver Soehnlein, Roy Schrijver, Claudia M. van Tiel, Tilman M. Hackeng, Christian Weber, Fabian Giehler, Arnd Kieser, Esther Lutgens, Gert Vriend & Gerry A. F. Nicolaes. (2015) Discovery of Small Molecule CD40–TRAF6 Inhibitors. Journal of Chemical Information and Modeling 55:2, pages 294-307.
Crossref
Dan Siskind, Stephen Parker, Samantha Loi, Jeffrey C Looi, Matthew D Macfarlane, Sally Merry, Geoff Smith & Steve Kisely. (2014) How to survive in research: advice for the novice investigator. Australasian Psychiatry 23:1, pages 22-24.
Crossref
Robert T. Clemen. (2015) Creating Value: Data Exploration, Multiple Objectives, and Real Options. Creating Value: Data Exploration, Multiple Objectives, and Real Options.
Martin Wehling. 2015. Principles of Translational Science in Medicine. Principles of Translational Science in Medicine 107 113 .
Trygve Nissen & Rolf Wynn. (2014) The clinical case report: a review of its merits and limitations. BMC Research Notes 7:1.
Crossref
Pierpaolo Andriani & Giuseppe Carignani. (2014) Modular exaptation: A missing link in the synthesis of artificial form. Research Policy 43:9, pages 1608-1620.
Crossref
G Kronenberg, K Gertz, A Heinz & M Endres. (2014) Of mice and men: modelling post‐stroke depression experimentally. British Journal of Pharmacology 171:20, pages 4673-4689.
Crossref
Doru Georg Margineanu. (2014) Systems biology, complexity, and the impact on antiepileptic drug discovery. Epilepsy & Behavior 38, pages 131-142.
Crossref
Arun K. Ghosh & Sandra GemmaArun K. Ghosh & Sandra Gemma. 2014. Structure‐Based Design of Drugs and Other Bioactive Molecules. Structure‐Based Design of Drugs and Other Bioactive Molecules 1 18 .
Stefano Fais. (2014) “I Have a Dream”. Journal of Circulating Biomarkers 3, pages 5.
Crossref
Jose D. Herazo-Maya & Naftali Kaminski. 2014. Idiopathic Pulmonary Fibrosis. Idiopathic Pulmonary Fibrosis 379 402 .
Emad F. Eskander, Ahmed A. Abd-Rabou & Hanaa H. Ahmed. (2013) The Impact of Digestive and Colon Drugs on the Human Hormones Profile. Indian Journal of Clinical Biochemistry 28:4, pages 413-417.
Crossref
M. Prasath, S. Muthu & R. Arun Balaji. (2013) Vibrational spectroscopy investigation using ab initio and DFT vibrational analysis of 7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine-4-oxide. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 113, pages 224-235.
Crossref
Dieneke Hubbeling. (2013) Causal hypotheses are useful in medicine, also more limited ones – a response to R obyn B luhm on ‘capacities in psychiatry’ . Journal of Evaluation in Clinical Practice 19:3, pages 562-563.
Crossref
Y.C. Wu, R.A. Hill, A. Gogos & M. van den Buuse. (2013) Sex differences and the role of estrogen in animal models of schizophrenia: Interaction with BDNF. Neuroscience 239, pages 67-83.
Crossref
Stephan Rigol, Lothar Beyer, Lothar Hennig, Joachim Sieler & Athanassios Giannis. (2013) Hünlich Base: (Re)Discovery, Synthesis, and Structure Elucidation after a Century. Organic Letters 15:6, pages 1418-1420.
Crossref
Xavier Jalencas & Jordi Mestres. (2013) On the origins of drug polypharmacology. MedChemComm 4:1, pages 80-87.
Crossref
Gerhard Klebe. 2013. Drug Design. Drug Design 23 36 .
Ross J. BaldessariniRoss J. Baldessarini. 2013. Chemotherapy in Psychiatry. Chemotherapy in Psychiatry 1 29 .
Mark A. Geyer, Berend Olivier, Marian Joëls & René S. Kahn. (2012) From antipsychotic to anti-schizophrenia drugs: role of animal models. Trends in Pharmacological Sciences 33:10, pages 515-521.
Crossref
Rajarshi Guha, Dac‐Trung Nguyen, Noel Southall & Ajit Jadhav. (2012) Dealing with the Data Deluge: Handling the Multitude of Chemical Biology Data Sources. Current Protocols in Chemical Biology 4:3, pages 193-209.
Crossref
I. Taneli Helenius & J.‐R. Joanna Yeh. (2012) Small zebrafish in a big chemical pond. Journal of Cellular Biochemistry 113:7, pages 2208-2216.
Crossref
Jason Rihel & Alexander F. Schier. (2012) Behavioral screening for neuroactive drugs in zebrafish. Developmental Neurobiology 72:3, pages 373-385.
Crossref
Neil R. Smalheiser. (2012) Literature-based discovery: Beyond the ABCs. Journal of the American Society for Information Science and Technology 63:2, pages 218-224.
Crossref
E. Ben-Menachem. (2011) Mechanism of action of vigabatrin: correcting misperceptions. Acta Neurologica Scandinavica 124, pages 5-15.
Crossref
Jonas Boström, Niklas Falk & Christian Tyrchan. (2011) Exploiting personalized information for reagent selection in drug design. Drug Discovery Today 16:5-6, pages 181-187.
Crossref
Jaak Panksepp, Thomas Fuchs & Paolo Iacobucci. (2011) The basic neuroscience of emotional experiences in mammals: The case of subcortical FEAR circuitry and implications for clinical anxiety. Applied Animal Behaviour Science 129:1, pages 1-17.
Crossref
Gérard TillesGérard Tilles. 2011. Dermatologie des XIXe et XXe siècles Mutations et controverses. Dermatologie des XIXe et XXe siècles Mutations et controverses 201 224 .
Michael J. Minzenberg. 2012. Brain Imaging in Behavioral Neuroscience. Brain Imaging in Behavioral Neuroscience 365 388 .
Robert H. Howland. (2010) Serendipity and Psychopharmacology. Journal of Psychosocial Nursing and Mental Health Services 48:10, pages 9-12.
Crossref
Erik H. F. Wong, Frank Yocca, Mark A. Smith & Chi-Ming Lee. (2010) Challenges and opportunities for drug discovery in psychiatric disorders: the drug hunters' perspective. The International Journal of Neuropsychopharmacology 13:09, pages 1269-1284.
Crossref
Darwin J. Prockop, Daniel J. Kota, Nikolay Bazhanov & Roxanne L. Reger. (2010) Evolving paradigms for repair of tissues by adult stem/progenitor cells (MSCs). Journal of Cellular and Molecular Medicine 14:9, pages 2190-2199.
Crossref
James G. Pfaus. (2009) REVIEWS: Pathways of Sexual Desire. The Journal of Sexual Medicine 6:6, pages 1506-1533.
Crossref
Gerhard Klebe. 2009. Wirkstoffdesign. Wirkstoffdesign 23 31 .
Robert H. Belmaker. (2014) The Future of Depression Psychopharmacology. CNS Spectrums 13:8, pages 682-687.
Crossref
K. Ask, A. Moeller, J. Gauldie, T.H. Farncombe, R. Labiris & M.R.J. Kolb. (2008) The use of small animal imaging in respiratory disease drug discovery. Drug Discovery Today: Therapeutic Strategies 5:2, pages 81-85.
Crossref
Carlos A. ZarateJrJr & Husseini K. Manji. (2008) Bipolar disorder: candidate drug targets. Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine 75:3, pages 226-247.
Crossref
A. Ennaceur, S. Michalikova, R. van Rensburg & P.L. Chazot. (2008) Are benzodiazepines really anxiolytic?. Behavioural Brain Research 188:1, pages 136-153.
Crossref
Marc K. Hellerstein. (2008) A critique of the molecular target-based drug discovery paradigm based on principles of metabolic control: Advantages of pathway-based discovery. Metabolic Engineering 10:1, pages 1-9.
Crossref
Hans Gerhard Vogel. 2008. Drug Discovery and Evaluation. Drug Discovery and Evaluation 1 45 .
Amar Bhide, Srikant Datar & Katherine Stebbins. (2021) SSRIs and Non-SSRIs (through 1999): Case Histories of Significant Medical Advances. SSRN Electronic Journal.
Crossref
Ruth Maria Stock, Eric A. von Hippel, Christian Holthaus & Nils Lennart Gillert. (2017) Problem Solving Without Problem Formulation: Documenting Need-Solution Pairs in a Laboratory Setting. SSRN Electronic Journal.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.