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Review Articles

Strategies for the inhibition of gingipains for the potential treatment of periodontitis and associated systemic diseases

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Article: 24800 | Received 29 Apr 2014, Accepted 15 Jul 2014, Published online: 18 Aug 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Zhiyan He, Wei Jiang, Yiting Jiang, Jiachen Dong, Zhongchen Song, Jianrong Xu & Wei Zhou. (2022) Anti-biofilm activities of coumarin as quorum sensing inhibitor for Porphyromonas gingivalis. Journal of Oral Microbiology 14:1.
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Christine A. Seers, A. Sayeed M. Mahmud, N. Laila Huq, Keith J. Cross & Eric C. Reynolds. (2021) Porphyromonas gingivalis laboratory strains and clinical isolates exhibit different distribution of cell surface and secreted gingipains. Journal of Oral Microbiology 13:1.
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Krzysztof M. Zak, Mark J. Bostock, Irena Waligorska, Ida B. Thøgersen, Jan J. Enghild, Grzegorz M. Popowicz, Przemyslaw Grudnik, Jan Potempa & Miroslaw Ksiazek. (2021) Latency, thermal stability, and identification of an inhibitory compound of mirolysin, a secretory protease of the human periodontopathogen Tannerella forsythia. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 1267-1281.
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Yuqing Li, Karthik Krishnan & Margaret J. Duncan. (2018) Post-translational regulation of a Porphyromonas gingivalis regulator. Journal of Oral Microbiology 10:1.
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Articles from other publishers (41)

Toru Kariu, Nobushiro Hamada & Kesavalu Lakshmyya. (2023) Luteolin inhibits Porphyromonas gingivalis growth and alleviates alveolar bone destruction in experimental murine periodontitis . Bioscience, Biotechnology, and Biochemistry.
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Yuka Shiheido-Watanabe, Yasuhiro Maejima, Shun Nakagama, Qintao Fan, Natsuko Tamura & Tetsuo Sasano. (2023) Porphyromonas gingivalis, a periodontal pathogen, impairs post-infarcted myocardium by inhibiting autophagosome–lysosome fusion. International Journal of Oral Science 15:1.
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Giulia Degiacomi, Beatrice Gianibbi, Deborah Recchia, Giovanni Stelitano, Giuseppina Ivana Truglio, Paola Marra, Alessandro Stamilla, Vadim Makarov, Laurent Robert Chiarelli, Fabrizio Manetti & Maria Rosalia Pasca. (2023) CanB, a Druggable Cellular Target in Mycobacterium tuberculosis . ACS Omega 8:28, pages 25209-25220.
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Blanca Esther Blancas-Luciano, Jaime Zamora-Chimal, Pablo Gomes da Silva-de Rosenzweig, Mariana Ramos-Mares & Ana María Fernández-Presas. (2023) Macrophages immunomodulation induced by Porphyromonas gingivalis and oral antimicrobial peptides. Odontology.
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婧 高. (2023) Research Progress in Pathogenicity and Drug Therapy of Porphyromonas gingivalis. Advances in Clinical Medicine 13:02, pages 2155-2159.
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Harini Venkata Subbiah, Polani Ramesh Babu & Usha Subbiah. (2022) In silico targeting of red complex bacteria virulence factors of periodontitis with β-defensin 1. Journal of Genetic Engineering and Biotechnology 20:1.
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Marines du Teil Espina, Yanyan Fu, Demi van der Horst, Claudia Hirschfeld, Marina López-Álvarez, Lianne M. Mulder, Costanza Gscheider, Anna Haider Rubio, Minke Huitema, Dörte Becher, Peter Heeringa & Jan Maarten van Dijl. (2022) Coating and Corruption of Human Neutrophils by Bacterial Outer Membrane Vesicles. Microbiology Spectrum 10:5.
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Yoke Chan Chow, Hok Chai Yam, Baskaran Gunasekaran, Weng Yeen Lai, Weng Yue Wo, Tarun Agarwal, Yien Yien Ong, Siew Lee Cheong & Sheri-Ann Tan. (2022) Implications of Porphyromonas gingivalis peptidyl arginine deiminase and gingipain R in human health and diseases. Frontiers in Cellular and Infection Microbiology 12.
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Mark I. Ryder. (2022) The Link Between Periodontitis and Alzheimer’s Disease: Reality or Yet Another Association. Current Oral Health Reports 9:4, pages 157-166.
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Tetsuo Kobayashi, Satoshi Ito, Akira Murasawa, Hajime Ishikawa & Koichi Tabeta. (2022) The serum immunoglobulin G titres against Porphyromonas gingivalis as a predictor of clinical response to 1-year treatment with biological disease-modifying antirheumatic drugs in rheumatoid arthritis patients: A retrospective cohort study . Modern Rheumatology.
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Colman Moore, Yong Cheng, Natalia Tjokro, Brendan ZhangMatthew Kerr, Mohammed Hayati, Kai Chiao Joe Chang, Nisarg Shah, Casey Chen & Jesse V. Jokerst. (2022) A Photoacoustic‐Fluorescent Imaging Probe for Proteolytic Gingipains Expressed by Porphyromonas gingivalis . Angewandte Chemie International Edition 61:30.
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Colman Moore, Yong Cheng, Natalia Tjokro, Brendan ZhangMatthew Kerr, Mohammed Hayati, Kai Chiao Joe Chang, Nisarg Shah, Casey Chen & Jesse V. Jokerst. (2022) A Photoacoustic‐Fluorescent Imaging Probe for Proteolytic Gingipains Expressed by Porphyromonas gingivalis . Angewandte Chemie 134:30.
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Marines du Teil Espina, Anna Haider Rubio, Yanyan Fu, Marina López-Álvarez, Giorgio Gabarrini & Jan Maarten van Dijl. (2022) Outer membrane vesicles of the oral pathogen Porphyromonas gingivalis promote aggregation and phagocytosis of Staphylococcus aureus. Frontiers in Oral Health 3.
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Izabela Ciaston, Joanna Budziaszek, Dorota Satala, Barbara Potempa, Andrew Fuchs, Maria Rapala-Kozik, Danuta Mizgalska, Ewelina Dobosz, Richard J. Lamont, Jan Potempa & Joanna Koziel. (2022) Proteolytic Activity-Independent Activation of the Immune Response by Gingipains from Porphyromonas gingivalis. mBio 13:3.
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Sheri-Ann Tan, Hok Chai Yam, Siew Lee Cheong, Yoke Chan Chow, Chui Yin Bok, Jia Min Ho, Pei Yin Lee & Baskaran Gunasekaran. (2022) Inhibition of Porphyromonas gingivalis peptidyl arginine deiminase, a virulence factor, by antioxidant-rich Cratoxylum cochinchinense: In vitro and in silico evaluation. Saudi Journal of Biological Sciences 29:4, pages 2573-2581.
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Mohammad Auwal Sa’ad, Ramasamy Kavitha, Shivkanya Fuloria, Neeraj Kumar Fuloria, Manickam Ravichandran & Pattabhiraman Lalitha. (2022) Synthesis, Characterization and Biological Evaluation of Novel Benzamidine Derivatives: Newer Antibiotics for Periodontitis Treatment. Antibiotics 11:2, pages 207.
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Thuraya Elgreu, Sean Lee, Sabrina Wen, Radwa Elghadafi, Thanarut Tangkham, Yun Ma, Bing Liu, Serge Dibart & Xiaoren Tang. (2021) The pathogenic mechanism of oral bacteria and treatment with inhibitors. Clinical and Experimental Dental Research 8:1, pages 439-448.
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Shenbakam P, Ravi J. Rao, Srikumar Prabhu, S. Srirangarajan & Vinaya Rudresh. (2021) Influence of antibacterial effects of tetracycline, laser, and photodynamic therapy on cell viability, cell damage, and virulence of Porphyromonas gingivalis.. Photodiagnosis and Photodynamic Therapy 36, pages 102617.
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Camille Zenobia, Karla-Luise Herpoldt & Marcelo Freire. (2021) Is the oral microbiome a source to enhance mucosal immunity against infectious diseases?. npj Vaccines 6:1.
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Ignacio Lunar Silva & Eric Cascales. (2021) Molecular Strategies Underlying Porphyromonas gingivalis Virulence. Journal of Molecular Biology 433:7, pages 166836.
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Aurélien Fouillen, Charline Mary, Katia Julissa Ponce, Pierre Moffatt & Antonio Nanci. (2021) A proline rich protein from the gingival seal around teeth exhibits antimicrobial properties against Porphyromonas gingivalis. Scientific Reports 11:1.
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Daniel P. Miller & David A. Scott. (2021) Inherently and Conditionally Essential Protein Catabolism Genes of Porphyromonas gingivalis. Trends in Microbiology 29:1, pages 54-64.
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Sara A. Eltigani, Mohamed M. Eltayeb, Tomohiro Bito, Tsuyoshi Ichiyanagi, Atsushi Ishihara & Jiro Arima. (2020) Argeloside I inhibits the pathogenicity of Porphyromonas gingivalis TDC60. Journal of Bioscience and Bioengineering 130:6, pages 644-649.
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Hye‐Kyung Jun, Sun‐Jin An, Hyun Young Kim & Bong‐Kyu Choi. (2020) Inflammatory response of uric acid produced by Porphyromonas gingivalis gingipains . Molecular Oral Microbiology 35:5, pages 222-230.
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Ursula Haditsch, Theresa Roth, Leo Rodriguez, Sandy Hancock, Thomas Cecere, Mai Nguyen, Shirin Arastu-Kapur, Sean Broce, Debasish Raha, Casey C. Lynch, Leslie J. Holsinger, Stephen S. Dominy & Florian Ermini. (2020) Alzheimer’s Disease-Like Neurodegeneration in Porphyromonas gingivalis Infected Neurons with Persistent Expression of Active Gingipains. Journal of Alzheimer's Disease 75:4, pages 1361-1376.
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Ellen Karla Nobre dos Santos-Lima, Kizzes Araújo Paiva Andrade Cardoso, Patrícia Mares de Miranda, Paulo Cirino de Carvalho-Filho, Thaise Passos Rocha, Lília Ferreira de Moura-Costa, Teresa Olczak, Michelle Miranda Lopes Falcão, Isaac Suzart Gomes-Filho, Roberto Meyer, Márcia Tosta Xavier & Soraya Castro Trindade. (2020) Novel synthetic peptide derived from Porphyromonas gingivalis Lys-gingipain detects IgG-mediated host response in periodontitis. Anaerobe 61, pages 102140.
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Chikoo Cherian, J. Jannet Vennila & Leena Sharan. (2019) Marine bromophenols as an effective inhibitor of virulent proteins (peptidyl arginine deiminase, gingipain R and hemagglutinin A) in Porphyromas gingivalis. Archives of Oral Biology 100, pages 119-128.
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Kübra Bunte, Andreas Hensel & Thomas Beikler. (2019) Polyphenols in the prevention and treatment of periodontal disease: A systematic review of in vivo, ex vivo and in vitro studies. Fitoterapia 132, pages 30-39.
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Sa V. Nguyen, Minh T.H. Nguyen, Binh C. Tran, Minh T.Q. Ho, Kouji Umeda & Shofiqur Rahman. (2018) Evaluation of lozenges containing egg yolk antibody against Porphyromonas gingivalis gingipains as an adjunct to conventional non-surgical therapy in periodontitis patients: A randomized controlled clinical trial . Journal of Periodontology 89:11, pages 1334-1339.
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Anders Johansson & Gunnar Dahlén. 2018. Pathogenesis of Periodontal Diseases. Pathogenesis of Periodontal Diseases 31 49 .
Meng-Hsuan Ho, Richard J. Lamont & Hua Xie. (2017) A novel peptidic inhibitor derived from Streptococcus cristatus ArcA attenuates virulence potential of Porphyromonas gingivalis. Scientific Reports 7:1.
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Anna M. Lasica, Miroslaw Ksiazek, Mariusz Madej & Jan Potempa. (2017) The Type IX Secretion System (T9SS): Highlights and Recent Insights into Its Structure and Function. Frontiers in Cellular and Infection Microbiology 7.
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Izabela Glowczyk, Alicia Wong, Barbara Potempa, Olena Babyak, Maciej Lech, Richard J. Lamont, Jan Potempa & Joanna Koziel. (2017) Inactive Gingipains from P. gingivalis Selectively Skews T Cells toward a Th17 Phenotype in an IL-6 Dependent Manner. Frontiers in Cellular and Infection Microbiology 7.
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B. Bechinger & S.-U. Gorr. (2016) Antimicrobial Peptides: Mechanisms of Action and Resistance. Journal of Dental Research 96:3, pages 254-260.
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Starlynn C. Clarke, Phillip A. Dumesic, Christina M. Homer, Anthony J. O’Donoghue, Florencia La Greca, Lenka Pallova, Pavel Majer, Hiten D. Madhani & Charles S. Craik. (2016) Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence. PLOS Pathogens 12:12, pages e1006051.
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Wei Zhou, Xuan Zhang, Cai-Lian Zhu, Zhi-Yan He, Jing-Ping Liang & Zhong-Chen Song. (2016) Melatonin Receptor Agonists as the “Perioceutics” Agents for Periodontal Disease through Modulation of Porphyromonas gingivalis Virulence and Inflammatory Response. PLOS ONE 11:11, pages e0166442.
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Magdalena Widziolek, Tomasz K. Prajsnar, Simon Tazzyman, Graham P. Stafford, Jan Potempa & Craig Murdoch. (2016) Zebrafish as a new model to study effects of periodontal pathogens on cardiovascular diseases. Scientific Reports 6:1.
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Karolina Plaza, Magdalena Kalinska, Oliwia Bochenska, Ulf Meyer-Hoffert, Zhihong Wu, Jan Fischer, Katherine Falkowski, Laura Sasiadek, Ewa Bielecka, Barbara Potempa, Andrzej Kozik, Jan Potempa & Tomasz Kantyka. (2016) Gingipains of Porphyromonas gingivalis Affect the Stability and Function of Serine Protease Inhibitor of Kazal-type 6 (SPINK6), a Tissue Inhibitor of Human Kallikreins. Journal of Biological Chemistry 291:36, pages 18753-18764.
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Aleksandar Dakic, Adrien Boillot, Cyrille Colliot, Maria-Clotilde Carra, Sébastien Czernichow & Philippe Bouchard. (2016) Detection of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans after Systemic Administration of Amoxicillin Plus Metronidazole as an Adjunct to Non-surgical Periodontal Therapy: A Systematic Review and Meta-Analysis. Frontiers in Microbiology 7.
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Nima Mahboobi & Seyed Moayed Alavian. (2014) Oral Conditions Might Cause Severe Outcomes in Patients With Viral Hepatitis Infection. Hepatitis Monthly 14:12.
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