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Hospital Practice Volume 37, 2009 - Issue 1
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Original Articles

Patients Presenting with Severe Hypotonic Hyponatremia: Etiological Factors, Assessment, and Outcomes

Thuy VuDepartment of Medicine, University of Melbourne Austin Health, Heidelberg, Victoria, Australia;Department of Endocrinology, Austin and Repatriation Hospital, Heidelberg, Victoria, AustraliaCorrespondence[email protected]
, MBBS,
Rosemary WongDepartment of Endocrinology, Western Hospital, Footscray, Victoria, Australia
, MBBS, FRACP, PhD,
P. Shane HamblinDepartment of Endocrinology, Western Hospital, Footscray, Victoria, Australia
, MBBS, FRACP, PhD,
Jeffrey ZajacDepartment of Medicine, University of Melbourne Austin Health, Heidelberg, Victoria, Australia;Department of Endocrinology, Austin and Repatriation Hospital, Heidelberg, Victoria, Australia
, MBBS, FRACP, PhD &
Mathis GrossmannDepartment of Medicine, University of Melbourne Austin Health, Heidelberg, Victoria, Australia;Department of Endocrinology, Austin and Repatriation Hospital, Heidelberg, Victoria, Australia
, MD, FRACP, PhD
Pages 128-136 | Published online: 24 Jun 2015

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Yaasir Mamoojee & Rasha Mukhtar. (2016) Challenges in the acute management of profound hyponatremia presenting with severe symptoms. Hospital Practice 44:4, pages 227-231.
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Steven B. Deitelzweig & Linda McCormick. (2011) Hyponatremia in Hospitalized Patients: The Potential Role of Tolvaptan. Hospital Practice 39:3, pages 87-98.
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Articles from other publishers (36)

Takahiro Kinoshita, Eric Mlodzinski, Qian Xiao, Raphael Sherak, Nathan H. Raines & Leo A. Celi. (2023) Effects of correction rate for severe hyponatremia in the intensive care unit on patient outcomes. Journal of Critical Care 77, pages 154325.
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Ahmet Murt & Kamyar Kalantar-Zadeh. (2023) Treating hyponatremia fast but modestly: counterbalancing risks and the fear of osmotic demyelination syndrome. Clinical Kidney Journal.
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Richard H. Sterns, Helbert Rondon-Berrios, Horacio J. Adrogué, Tomas Berl, Volker Burst, David M. Cohen, Mirjam Christ-Crain, Martin Cuesta, Guy Decaux, Michael Emmett, Aoife Garrahy, Fabrice Gankam-Kengne, John K. Hix, Ewout J. Hoorn, Kamel S. Kamel, Nicolaos E. Madias, Alessandro Peri, Julie Refardt, Mitchell H. Rosner, Mark Sherlock, Stephen M. Silver, Alain Soupart, Chris J. Thompson & Joseph G. Verbalis. (2023) Treatment Guidelines for Hyponatremia. Clinical Journal of the American Society of Nephrology.
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Annabelle M. Warren, Mathis Grossmann, Rudolf Hoermann, Jeffrey D. Zajac & Nicholas Russell. (2022) Tolvaptan versus fluid restriction in acutely hospitalised patients with moderate-profound hyponatraemia (TVFR-HypoNa): design and implementation of an open-label randomised trial. Trials 23:1.
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Hirofumi Sumi, Naohiko Imai & Yugo Shibagaki. (2022) Incidence and risk factors of overcorrection in patients presenting with severe hyponatremia to the emergency department. Clinical and Experimental Nephrology 26:11, pages 1086-1091.
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Ercan Turkmen, Ahmet Karatas & Mahmut Altindal. (2022) Factors affecting prognosis of the patients with severe hyponatremia. Nefrología (English Edition) 42:2, pages 196-202.
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Ercan Turkmen, Ahmet Karatas & Mahmut Altindal. (2022) Factors affecting prognosis of the patients with severe hyponatremia. Nefrología 42:2, pages 196-202.
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I. Puig, M. Alvarez, M. Lozano & G. Lucente. (2021) A case of late-onset osmotic demyelination syndrome. Neurología (English Edition) 36:8, pages 640-641.
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I. Puig, M. Alvarez, M. Lozano & G. Lucente. (2021) Un caso de síndrome de desmielinización osmótica de inicio tardío. Neurología 36:8, pages 640-641.
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Akihiko Sugimoto, Hiroyuki Akebo, Ryuichi Sada, Yukio Tsugihashi, Saki Minoda, Hirofumi Miyake, Hiroyasu Ishimaru & Kazuhiro Hatta. (2020) Successful treatment of severe chronic hyponatremia complicated by bacterial pneumonia with continuous infusion of low-dose vasopressin: A case report低用量バソプレシン持続静脈内投与が有効であった感染合併重症慢性低ナトリウム血症. Tenri Medical Bulletin 23:1, pages 14-20.
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Jorge Gabriel Ruiz-Sánchez, Diego Meneses, Cristina Álvarez-Escolá, Martin Cuesta, Alfonso Luis Calle-Pascual & Isabelle Runkle. (2020) The Effect of the Dose of Isotonic Saline on the Correction of Serum Sodium in the Treatment of Hypovolemic Hyponatremia. Journal of Clinical Medicine 9:11, pages 3567.
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Wenhui Huang & Robert Hawkins. (2020) Timing of repeat plasma sodium as a risk factor for eventual sodium overcorrection in patients with severe hyponatremia. European Journal of Internal Medicine 76, pages 132-133.
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Lenar Yessayan & Ryan E. Krahn. 2020. Evidence-Based Critical Care. Evidence-Based Critical Care 381 387 .
Andrew G. Burton & Kate Hopper. (2019) Hyponatremia in dogs and cats. Journal of Veterinary Emergency and Critical Care 29:5, pages 461-471.
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Juan Carlos Ayus & Michael L. Moritz. (2019) Misconceptions and Barriers to the Use of Hypertonic Saline to Treat Hyponatremic Encephalopathy. Frontiers in Medicine 6.
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Shirou Xiao, Yalin Liu, Kai Li, Baohui Lou, Kunpeng Chen & Zhigang Chang. (2019) Successful treatment of an 86‐year‐old patient with severe hyponatremia leading to central and extrapontine myelinolysis: A case report. AGING MEDICINE 2:1, pages 56-59.
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Kathryn Berkman, Kate Haigh, Ling Li, Jack Lockett, Goce Dimeski, Anthony Russell & Warrick J. Inder. (2018) Investigation and management of moderate to severe inpatient hyponatraemia in an Australian tertiary hospital. BMC Endocrine Disorders 18:1.
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Jason C. George, Waleed Zafar, Ion Dan Bucaloiu & Alex R. Chang. (2018) Risk Factors and Outcomes of Rapid Correction of Severe Hyponatremia. Clinical Journal of the American Society of Nephrology 13:7, pages 984-992.
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Richard H. Sterns. (2018) Treatment of Severe Hyponatremia. Clinical Journal of the American Society of Nephrology 13:4, pages 641-649.
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Michael Woodward, Peter Gonski, Mathis Grossmann, John Obeid, Ron Scholes & Duncan J. Topliss. (2018) Diagnosis and management of hyponatraemia in the older patient. Internal Medicine Journal 48, pages 5-12.
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Sae Aratani, Masahiko Hara, Masahiko Nagahama, Fumika Taki, Miyuki Futatsuyama, Shuichi Tsuruoka & Yasuhiro Komatsu. (2017) A low initial serum sodium level is associated with an increased risk of overcorrection in patients with chronic profound hyponatremia: a retrospective cohort analysis. BMC Nephrology 18:1.
Crossref
Christian Overgaard-Steensen & Troels Ring. 2017. Evidence-Based Critical Care. Evidence-Based Critical Care 401 409 .
Thierry Krummel, Eric Prinz, Marie-Astrid Metten, Claire Borni-Duval, Dorothée Bazin-Kara, Emmanuelle Charlin, Jean-Marc Lessinger & Thierry Hannedouche. (2016) Prognosis of patients with severe hyponatraemia is related not only to hyponatraemia but also to comorbidities and to medical management: results of an observational retrospective study. BMC Nephrology 17:1.
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Mary Ansley BuffingtonKenneth Abreo. (2015) Hyponatremia. Journal of Intensive Care Medicine 31:4, pages 223-236.
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Philip S. Mehler & Kristine Walsh. (2016) Electrolyte and acid-base abnormalities associated with purging behaviors. International Journal of Eating Disorders 49:3, pages 311-318.
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Vildan Tasdemir, Ali Kemal Oguz, Irmak Sayın & Ihsan Ergun. (2015) Hyponatremia in the outpatient setting: clinical characteristics, risk factors, and outcome. International Urology and Nephrology 47:12, pages 1977-1983.
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Pierce Geoghegan, Andrew M. Harrison, Charat Thongprayoon, Rahul Kashyap, Adil Ahmed, Yue Dong, Alejandro A. Rabinstein, Kianoush B. Kashani & Ognjen Gajic. (2015) Sodium Correction Practice and Clinical Outcomes in Profound Hyponatremia. Mayo Clinic Proceedings 90:10, pages 1348-1355.
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Joseph G. Verbalis, Steven R. Goldsmith, Arthur Greenberg, Cynthia Korzelius, Robert W. Schrier, Richard H. Sterns & Christopher J. Thompson. (2013) Diagnosis, Evaluation, and Treatment of Hyponatremia: Expert Panel Recommendations. The American Journal of Medicine 126:10, pages S1-S42.
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Richard H. Sterns, John K. Hix & Stephen M. Silver. (2013) Management of Hyponatremia in the ICU. Chest 144:2, pages 672-679.
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George Liamis & Moses Elisaf. 2013. Hyponatremia. Hyponatremia 111 126 .
Richard H. Sterns, Stephen M. Silver & John K. Hix. 2013. Hyponatremia. Hyponatremia 221 250 .
Paul Gaglio, Kwaku Marfo & Joseph ChiodoIIIIII. (2012) Hyponatremia in Cirrhosis and End-Stage Liver Disease: Treatment with the Vasopressin V2-Receptor Antagonist Tolvaptan. Digestive Diseases and Sciences 57:11, pages 2774-2785.
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Mohamed Osama Hegazi. (2012) Effect of Hypokalemia on the Clinical Impact of Hyponatremia. The Journal of Clinical Hypertension 14:9, pages 656-656.
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Christian Overgaard-Steensen & Troels Ring. (2012) Clinical review: Practical approach to hyponatraemia and hypernatraemia in critically ill patients. Critical Care 17:1, pages 206.
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John K. Hix, Stephen Silver & Richard H. Sterns. (2011) Diuretic-Associated Hyponatremia. Seminars in Nephrology 31:6, pages 553-566.
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Arun Chawla, Richard H. Sterns, Sagar U. Nigwekar & Joseph D. Cappuccio. (2011) Mortality and Serum Sodium. Clinical Journal of the American Society of Nephrology 6:5, pages 960-965.
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