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Original Articles

Approaches to vitamin B12 deficiency

Early treatment may prevent devastating complications

, MD & , PhD
Pages 99-105 | Published online: 30 Jun 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Dick Nelson, Ning Xu & Joyce Carlson. (2012) Semi-automated quantification of methylmalonic acid in human serum by LC-MS/MS. Scandinavian Journal of Clinical and Laboratory Investigation 72:6, pages 441-446.
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Steven F Werder. (2010) Cobalamin deficiency, hyperhomocysteinemia, and dementia. Neuropsychiatric Disease and Treatment 6, pages 159-195.
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Sangeeta Borkataky, Ritu Jain, Ruchika Gupta, Sompal Singh, Gopal Krishan, Kusum Gupta & Madhur Kudesia. (2009) Role of platelet volume indices in the differential diagnosis of thrombocytopenia: a simple and inexpensive method. Hematology 14:3, pages 182-186.
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Kevin R Scott & Anna M Barrett. (2007) Dementia syndromes: evaluation and treatment. Expert Review of Neurotherapeutics 7:4, pages 407-422.
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Anna M. Barrett. (2005) Is it Alzheimer's disease or something else?. Postgraduate Medicine 117:5, pages 47-53.
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Articles from other publishers (37)

Onur Yıldız & Hacer Erdem Tilki. (2023) Visual Evoked Potentials in Patients With Vitamin B12 Deficiency. Journal of Clinical Neurophysiology 40:6, pages 535-540.
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Živa Lavriša, Hristo Hristov, Maša Hribar, Katja Žmitek, Anita Kušar, Barbara Koroušić Seljak, Matej Gregorič, Urška Blaznik, Nadan Gregorič, Katja Zaletel, Adrijana Oblak, Joško Osredkar & Igor Pravst. (2022) Dietary Intake and Status of Vitamin B12 in Slovenian Population. Nutrients 14:2, pages 334.
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Zhe‐Xuan Bao, Xiao‐Wen Yang & Dong‐Dong Fang. (2020) Lingual Linear Lesions: A Clinical Sign Strongly Suggestive of Severe Vitamin B 12 Deficiency . Nutrition in Clinical Practice 36:5, pages 1041-1048.
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T. S. Dharmarajan & Srinivas Guptha Gunturu. 2021. Geriatric Gastroenterology. Geriatric Gastroenterology 597 629 .
Teresa Sanz-Cuesta, Esperanza Escortell-Mayor, Isabel Cura-Gonzalez, Jesus Martin-Fernandez, Rosario Riesgo-Fuertes, Sofía Garrido-Elustondo, Jose Enrique Mariño-Suárez, Mar Álvarez-Villalba, Tomás Gómez-Gascón, Inmaculada González-García, Paloma González-Escobar, Concepción Vargas-Machuca Cabañero, Mar Noguerol-Álvarez, Francisca García de Blas-González, Raquel Baños-Morras, Concepción Díaz-Laso, Nuria Caballero-Ramírez, Alicia Herrero de-Dios, Rosa Fernández-García, Jesús Herrero-Hernández, Belen Pose-García, María Luisa Sevillano-Palmero, Carmen Mateo-Ruiz, Beatriz Medina-Bustillo & Monica Aguilar-Jiménez. (2020) Oral versus intramuscular administration of vitamin B12 for vitamin B12 deficiency in primary care: a pragmatic, randomised, non-inferiority clinical trial (OB12). BMJ Open 10:8, pages e033687.
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Araceli Jarquin Campos, Lorenz Risch, Urs Nydegger, Jacobo Wiesner, Maclovia Vazquez Van Dyck, Harald Renz, Zeno Stanga & Martin Risch. (2020) Diagnostic Accuracy of Holotranscobalamin, Vitamin B12, Methylmalonic Acid, and Homocysteine in Detecting B12 Deficiency in a Large, Mixed Patient Population. Disease Markers 2020, pages 1-11.
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T. S. Dharmarajan & Srinivas G. Gunturu. 2020. Geriatric Gastroenterology. Geriatric Gastroenterology 1 33 .
Duygu Nurdan AVCI & Canan ERSOY. (2019) Evaluation of the effects of diabetes mellitus and metformin usage on serum vitamin B12 levels in cobalamin deficient subjects. Turkish Journal of Internal Medicine 1:1, pages 15-20.
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Yılmaz SEZGİN. (2019) Vitamin B12 Yetersizliğine YaklaşımApproach to Vitamin B12 Deficiency. Konuralp Tıp Dergisi 11:3, pages 482-488.
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Anthony Kouri, Mina Tanios, Joseph S. Herron, Maxwell Cooper & Mustafa Khan. (2018) Mimickers of Cervical Spondylotic Myelopathy. JBJS Reviews 6:10, pages e9-e9.
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Nages Nagaratnam, Kujan Nagaratnam & Gary CheukNages Nagaratnam, Kujan Nagaratnam & Gary Cheuk. 2018. Geriatric Diseases. Geriatric Diseases 229 238 .
Nages Nagaratnam, Kujan Nagaratnam & Gary CheukNages Nagaratnam, Kujan Nagaratnam & Gary Cheuk. 2017. Geriatric Diseases. Geriatric Diseases 1 10 .
Nages Nagaratnam, Kujan Nagaratnam & Gary CheukNages Nagaratnam, Kujan Nagaratnam & Gary Cheuk. 2016. Diseases in the Elderly. Diseases in the Elderly 95 116 .
Azize Esra Gürsoy, Mehmet Kolukısa, Gülsen Babacan-Yıldız & Arif Çelebi. (2013) Subacute Combined Degeneration of the Spinal Cord due to Different Etiologies and Improvement of MRI Findings. Case Reports in Neurological Medicine 2013, pages 1-5.
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Teresa Sanz-Cuesta, Paloma González-Escobar, Rosario Riesgo-Fuertes, Sofía Garrido-Elustondo, Isabel del Cura-González, Jesús Martín-Fernández, Esperanza Escortell-Mayor, Francisco Rodríguez-Salvanés, Marta García-Solano, Rocío González-González, María Ángeles Martín-de la Sierra-San Agustín, Carmen Olmedo-Lucerón, María Luisa Sevillano Palmero, Carmen Mateo-Ruiz, Beatriz Medina-Bustillo, Antonio Valdivia-Pérez, Francisca García-de Blas-González, José Enrique Mariño-Suárez, Ricardo Rodríguez-Barrientos, Gloria Ariza-Cardiel, Luisa María Cabello-Ballesteros, Elena Polentinos-Castro, Milagros Rico-Blázquez, Ma Teresa Rodríguez-Monje, Sonia Soto-Díaz, Susana Martín-Iglesias, Ramón Rodríguez-González, Irene Bretón-Lesmes, María Vicente-Herrero, Jesús Sánchez-Díaz, Tomás Gómez-Gascón, Mercedes Drake-Canela & Ángel Asúnsolo-del Barco. (2012) Oral versus intramuscular administration of vitamin B12 for the treatment of patients with vitamin B12 deficiency: a pragmatic, randomised, multicentre, non-inferiority clinical trial undertaken in the primary healthcare setting (Project OB12). BMC Public Health 12:1.
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Isabel Herrero Medina, Julio Francisco Rubio Piquero, M. Luisa Fernández Gómez & José Miguel Castillo Alonso. (2012) ¿Cómo tratamos a nuestros pacientes con déficit de vitamina B12?. Atención Primaria 44:4, pages e18-e19.
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T. S. Dharmarajan, T. S. Dharmarajan, T. S. Dharmarajan, T. S. Dharmarajan & Srinivas Guptha Gunturu. 2012. Geriatric Gastroenterology. Geriatric Gastroenterology 161 176 .
Elizabeth A. Hahn & Ross Andel. (2011) Nonpharmacological Therapies for Behavioral and Cognitive Symptoms of Mild Cognitive Impairment. Journal of Aging and Health 23:8, pages 1223-1245.
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Camila Bitu Moreno Braga, Helio Vannucchi, Cristiana Maria Murbach Freire, J?lio S?rgio Marchini, Alceu Afonso Jord?o J?nior & Selma Freire de Carvalho da Cunha. (2011) Serum Vitamins in Adult Patients With Short Bowel Syndrome Receiving Intermittent Parenteral Nutrition. Journal of Parenteral and Enteral Nutrition 35:4, pages 493-498.
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Valerie K. Sabol, Barbara Resnick, Elizabeth Galik, Ann Gruber-Baldini, Patricia Gonce Morton & Gregory E. Hicks. (2010) Anemia and its impact on function in nursing home residents: What do we know?. Journal of the American Academy of Nurse Practitioners 22:1, pages 3-16.
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Charmaine H. Mziray-Andrew & Timothy A. Sentongo. (2009) Nutritional Deficiencies in Intestinal Failure. Pediatric Clinics of North America 56:5, pages 1185-1200.
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Leane Hoey, JJ Strain & Helene McNulty. (2009) Studies of biomarker responses to intervention with vitamin B-12: a systematic review of randomized controlled trials. The American Journal of Clinical Nutrition 89:6, pages 1981S-1996S.
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Timothy A Sentongo, Ruba Azzam & Joel Charrow. (2009) Vitamin B12 Status, Methylmalonic Acidemia, and Bacterial Overgrowth in Short Bowel Syndrome. Journal of Pediatric Gastroenterology & Nutrition 48:4, pages 495-497.
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Marina E. Solovieva, Valery V. Solovyev, Andrei A. Kudryavtsev, Yuliya A. Trizna & Vladimir S. Akatov. (2008) Vitamin B12b enhances the cytotoxicity of dithiothreitol. Free Radical Biology and Medicine 44:10, pages 1846-1856.
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T.S. Dharmarajan, Madhusudhana R. Kanagala, Padmavathi Murakonda, Ahna S. Lebelt & Edward P. Norkus. (2008) Do Acid-Lowering Agents Affect Vitamin B12 Status in Older Adults?. Journal of the American Medical Directors Association 9:3, pages 162-167.
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Jordi Casals Fransí & Jordi Matamoros Iraola. (2008) Anemia en el anciano. FMC - Formación Médica Continuada en Atención Primaria 15:3, pages 122-131.
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Jürgen Finke, Hartmut Bertz, Anna-Katharina Kaskel, Jürgen Heinz, A.K. Thomas, Dietmar P. Berger, Rupert Engelhardt & Oliver Schmah. 2008. Concise Manual of Hematology and Oncology. Concise Manual of Hematology and Oncology 327 399 .
M. E. Solov’eva, V. V. Solov’ev, A. A. Faskhutdinova, A. A. Kudryavtsev & V. S. Akatov. (2007) Prooxidant and cytotoxic action of N-acetylcysteine and glutathione in combinations with vitamin B12b. Cell and Tissue Biology 1:1, pages 40-49.
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Velibor Čabarkapa, Zoran Stošić, Radmila Žeravica, Branislava Ilinčić & Ana Filipović. (2007) The Importance of Holotranscobalamin Measurement. Journal of Medical Biochemistry 26:3.
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KR Dholakia. (2005) Vitamin B12 deficiency and gastric histopathology in older patients. World Journal of Gastroenterology 11:45, pages 7078.
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Raffick A.R Bowen, Betty Y.L Wong & David E.C Cole. (2004) Population-based differences in frequency of the transcobalamin II Pro259Arg polymorphism. Clinical Biochemistry 37:2, pages 128-133.
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Marc W. Sütterlin, Stefanie S. Bussen, Lorenz Rieger, Johannes Dietl & Thomas Steck. (2003) Serum folate and Vitamin B12 levels in women using modern oral contraceptives (OC) containing 20 μg ethinyl estradiol. European Journal of Obstetrics & Gynecology and Reproductive Biology 107:1, pages 57-61.
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Giridhar U. Adiga & Thiruvinvamalai S. Dharmarajan. (2003) Vitamin B12 and Methyl Malonic Acid: Do We Have All the Answers?. Journal of the American Geriatrics Society 51:2, pages 279-280.
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J.E. Mariño Suárez, I. Monedero Recuero & C. Peláez Laguno. (2003) Deficiencia de vitamina B12 y tratamiento por vía oral. Una opción tan eficaz como (todavía) poco utilizada. Atención Primaria 32:6, pages 382-387.
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J. Mariño Suárez, J. López Idígoras, C. Peláez Laguno & I. Monedero Recuero. (2003) Tratamiento oral de la deficiencia de vitamina B12: ¿ignoramos la evidencia?. Atención Primaria 31:7, pages 458.
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Elizabeth Cyran. (2002) Vitamin B12 Deficiency: Recognition and Management. Primary Care Case Reviews 5:2, pages 53-60.
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Sean J. Pittock, Troy A. Payne & C. Michel Harper. (2002) Reversible Myelopathy in a 34-Year-Old Man With Vitamin B12 Deficiency. Mayo Clinic Proceedings 77:3, pages 291-294.
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