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Clinical Focus: Hypertension and Related Disorders

Original Research: Telmisartan plus Amlodipine in Patients with Moderate or Severe Hypertension: Results from a Subgroup Analysis of a Randomized, Placebo-Controlled, Parallel-Group, 4 × 4 Factorial Study

, MD, , MD, , MD, , MD, , RN, MBA & , MD
Pages 5-14 | Published online: 13 Mar 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (16)

Julian Segura & Luis Miguel Ruilope. (2013) A review of the benefits of early treatment initiation with single-pill combinations of telmisartan with amlodipine or hydrochlorothiazide. Vascular Health and Risk Management 9, pages 521-528.
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Scott S Billecke & Pamela A Marcovitz. (2013) Long-term safety and efficacy of telmisartan/amlodipine single pill combination in the treatment of hypertension. Vascular Health and Risk Management 9, pages 95-104.
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Jocelyn D Jones, Sylvia H Jackson & Charlie Colquitt. (2013) Azilsartan alone and in combination for the treatment of hypertension – clinical utility and patient considerations. Research Reports in Clinical Cardiology 4, pages 125-133.
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Henry A. Punzi, Björn Dahlöf, Dave Webster, Claudio R. Majul, Wille Oigman, Rafael Olvera, Mary Seeber, Maureen Kobe & Helmut Schumacher. (2013) The Effects of Telmisartan and Amlodipine in Treatment-Naïve and Previously Treated Hypertensive Patients: A Subanalysis from a 4 × 4 Factorial Design Study. Clinical and Experimental Hypertension 35:5, pages 330-340.
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Sripal Bangalore & Ludwin Ley. (2012) Improving treatment adherence to antihypertensive therapy: the role of single-pill combinations. Expert Opinion on Pharmacotherapy 13:3, pages 345-355.
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Julian Segura & Luis M Ruilope. (2011) Clinical utility of fixed-combination telmisartan–amlodipine in the treatment of hypertension. Integrated Blood Pressure Control 4, pages 27-34.
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Robert M. Guthrie, Björn Dahlöf, Kenneth A. Jamerson, Rafael Olvera, Mary Seeber, Helmut Schumacher & Wille Oigman. (2011) Efficacy and tolerability of telmisartan plus amlodipine in added-risk hypertensive patients. Current Medical Research and Opinion 27:10, pages 1995-2008.
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Joel M. Neutel. (2011) Long-Term Blood Pressure Control: What Can We Do?. Postgraduate Medicine 123:1, pages 88-93.
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Wille Oigman, Mario Fritsch Neves & Ronaldo AOC Gismondi. (2010) Combination of telmisartan plus amlodipine in the treatment of hypertension: review of results. Expert Review of Cardiovascular Therapy 8:11, pages 1509-1517.
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Biff F. Palmer & Andrew Z. Fenves. (2010) Optimizing Blood Pressure Control in Patients with Chronic Kidney Disease. Baylor University Medical Center Proceedings 23:3, pages 239-245.
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Steven G Chrysant. (2009) Amlodipine besylate/olmesartan medoximil fixed combination for the treatment of hypertension. Expert Review of Cardiovascular Therapy 7:8, pages 887-895.
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Eun-Seok Jeon, Sang Wook Lim, Seok-Yeon Kim, Hyoung-Mo Yang, Moo Hyun Kim, Moo-Yong Rhee, Seung Hwan Han, Jinho Shin, Kwang-il Kim, Jin-Ok Jeong, Ki Chul Sung, Geu Ru Hong, Hyung-Seop Kim, Kihwan Kwon, Tae-Soo Kang, Hae-Young Lee & Su-Eun Han. (2022) A randomized, double-blind, multicenter, phase III study on the efficacy and safety of a combination treatment involving fimasartan, amlodipine, rosuvastatin in patients with essential hypertension and dyslipidemia who fail to respond adequately to fimasartan monotherapy. Clinical Hypertension 28:1.
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Joo-Eun Kim & Young-Joon Park. (2022) QbD Consideration for Developing a Double-Layered Tablet into a Single-Layered Tablet with Telmisartan and Amlodipine. Pharmaceutics 14:2, pages 377.
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Zhiguo Wang & Baofeng YangZhiguo Wang & Baofeng Yang. 2022. Polypharmacology. Polypharmacology 323 342 .
Davor Vukadinović, Sean S. Scholz, Franz H. Messerli, Michael A. Weber, Bryan Williams, Michael Böhm & Felix Mahfoud. (2019) Peripheral edema and headache associated with amlodipine treatment. Journal of Hypertension 37:10, pages 2093-2103.
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Scott Martin Vouri, Joseph S. van Tuyl, Margaret A. Olsen, Hong Xian & Mario Schootman. (2018) An evaluation of a potential calcium channel blocker–lower-extremity edema–loop diuretic prescribing cascade. Journal of the American Pharmacists Association 58:5, pages 534-539.e4.
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T He, X Liu, Y Li, X Y Liu, Q Y Wu, M L Liu & H Yuan. (2016) High-dose calcium channel blocker (CCB) monotherapy vs combination therapy of standard-dose CCBs and angiotensin receptor blockers for hypertension: a meta-analysis. Journal of Human Hypertension 31:2, pages 79-88.
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Chang Gyu Park, Tae Hun Ahn, Eun Ju Cho, Won Kim, Hyung Seob Kim, Ju Yeong Yang, Jae Geun Ryu, Cheol Ho Kim, Min Soo Hyeon, Seung Je Tak, Se Jung Im, Jong Won Ha, Wook Beom Pyeon, Je Geon Jae, Gyu Rok Han, Jun Hyung Doh, Sang Wook Im & Myeong Muk Lee. (2016) Comparison of the Efficacy and Safety of Fixed-dose S-Amlodipine/Telmisartan and Telmisartan in Hypertensive Patients Inadequately Controlled with Telmisartan: A Randomized, Double-blind, Multicenter Study. Clinical Therapeutics 38:10, pages 2185-2194.
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Gurpreet Kaur Randhawa, Navyug Raj Singh, Jaswant Rai, Gobindnoor Kaur & Resham Kashyap. (2015) A Critical Analysis of Claims and Their Authenticity in Indian Drug Promotional Advertisements. Advances in Medicine 2015, pages 1-7.
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V N Shishkova. (2014) The mechanisms of developmentcardiovascular disease and type 2 diabetes: the role of insulin resistance, hyperinsulinemia and hypoadiponektinemia. Treatment and management. Systemic Hypertension 11:2, pages 48-53.
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Gianfranco Parati & Helmut Schumacher. (2013) Blood pressure variability over 24 h: prognostic implications and treatment perspectives. An assessment using the smoothness index with telmisartan–amlodipine monotherapy and combination. Hypertension Research 37:3, pages 187-193.
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Dingliang Zhu, Pingjin Gao, Werner Holtbruegge & Chenglei Huang. (2014) A randomized, double-blind study to evaluate the efficacy and safety of a single-pill combination of telmisartan 80 mg/amlodipine 5 mg versus amlodipine 5 mg in hypertensive Asian patients. Journal of International Medical Research 42:1, pages 52-66.
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Dingliang Zhu, Pingjin Gao, Nobutaka Yagi & Helmut Schumacher. (2014) Efficacy and Tolerability of Telmisartan Plus Amlodipine in Asian Patients Not Adequately Controlled on Either Monotherapy or on Low-Dose Combination Therapy. International Journal of Hypertension 2014, pages 1-11.
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S. Neldam, B. Dahlöf, W. Oigman & H. Schumacher. (2013) Early combination therapy with telmisartan plus amlodipine for rapid achievement of blood pressure goals. International Journal of Clinical Practice 67:9, pages 843-852.
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Joel M Neutel. (2013) Treatment algorithms for hypertension: a practical approach. Clinical Practice 10:3, pages 333-344.
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O. D. Ostroumova & T. F. Guseva. (2013) COMBINATION THERAPY OF ARTERIAL HYPERTENSION - OUR EXPECTATIONS. Eurasian heart journal:1, pages 19-30.
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Steen Neldam, Dingliang Zhu & Helmut Schumacher. (2013) Efficacy of Telmisartan Plus Amlodipine in Nonresponders to CCB Monotherapy. International Journal of Hypertension 2013, pages 1-8.
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Dingliang L. Zhu, Harold Bays, Pingjin Gao, Michaela Mattheus, Birgit Voelker & Luis M. Ruilope. (2012) Efficacy and Tolerability of Initial Therapy With Single-Pill Combination Telmisartan/Hydrochlorothiazide 80/25 mg in Patients With Grade 2 or 3 Hypertension: A Multinational, Randomized, Double-Blind, Active-Controlled Trial. Clinical Therapeutics 34:7, pages 1613-1624.
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Liyuan Ma, Wen Wang, Yong Zhao, Yuqing Zhang, Qing Deng, Mingbo Liu, Hui Sun, Jianchun Wang & Lisheng Liu. (2012) Combination of Amlodipine plus Angiotensin Receptor Blocker or Diuretics in High-Risk Hypertensive Patients. American Journal Cardiovascular Drugs 12:2, pages 137-142.
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Joel M. Neutel, Giusepe Mancia, Henry R. Black, Bjorn Dahlöf, Holly Defeo, Ludwin Ley & Richard Vinisko. (2012) Single‐Pill Combination of Telmisartan/Amlodipine in Patients With Severe Hypertension: Results From the TEAMSTA Severe HTN Study. The Journal of Clinical Hypertension 14:4, pages 206-215.
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Arya M. Sharma, George Bakris, Joel M. Neutel, Thomas W. Littlejohn, Maureen Kobe, Naitee Ting & Ludwin Ley. (2012) Single-Pill Combination of Telmisartan/Amlodipine Versus Amlodipine Monotherapy in Diabetic Hypertensive Patients: An 8-Week Randomized, Parallel-Group, Double-Blind Trial. Clinical Therapeutics 34:3, pages 537-551.
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Steen Neldam, Colin Edwards, Margreet Lang & Russell Jones. (2012) Long-Term Tolerability and Efficacy of Single-Pill Combinations of Telmisartan 40–80 mg Plus Amlodipine 5 or 10 mg in Patients Whose Blood Pressure Was Not Initially Controlled by Amlodipine 5–10 mg: Open-Label, Long-Term Follow-Ups of the TEAMSTA-5 and TEAMSTA-10 Studies. Current Therapeutic Research 73:1-2, pages 65-84.
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Samir G Mallat. (2012) What is a preferred angiotensin II receptor blocker-based combination therapy for blood pressure control in hypertensive patients with diabetic and non-diabetic renal impairment?. Cardiovascular Diabetology 11:1, pages 32.
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Carmen Suárez. (2011) Single-Pill Telmisartan and Amlodipine. Drugs 71:17, pages 2295-2305.
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Howard S Weintraub & Amy Rudolph. (2011) Combination Therapy for Managing Difficult-to-Treat Patients With Stage 2 Hypertension: Focus on Valsartan-Based Combinations. American Journal of Therapeutics 18:6, pages e227-e243.
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Steen Neldam, Margreet Lang & Russell Jones. (2011) Telmisartan and Amlodipine Single-Pill Combinations vs Amlodipine Monotherapy for Superior Blood Pressure Lowering and Improved Tolerability in Patients With Uncontrolled Hypertension: Results of the TEAMSTA-5 Study. The Journal of Clinical Hypertension 13:7, pages 459-466.
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Harikrishna Makani, Sripal Bangalore, Jorge Romero, Nay Htyte, Ronaldo S Berrios, Hetal Makwana & Franz H Messerli. (2011) Peripheral edema associated with calcium channel blockers: incidence and withdrawal rate – a meta-analysis of randomized trials. Journal of Hypertension 29:7, pages 1270-1280.
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Steen NeldamRobert M Guthrie. (2011) Telmisartan/hydrochlorothiazide single-pill combination in the treatment of hypertension in elderly patients. Aging Health 7:2, pages 249-264.
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W Wang, L Ma, Y Zhang, Q Deng, M Liu & L Liu. (2010) The combination of amlodipine and angiotensin receptor blocker or diuretics in high-risk hypertensive patients: rationale, design and baseline characteristics. Journal of Human Hypertension 25:4, pages 271-277.
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Wei Liu, Wei Wang, Shu-Wei Song, Xiao-Fei Gu, Xiu-Juan Ma, Feng-Yun Su, Hao Zhang, Ai-Jun Liu & Ding-Feng Su. (2011) Synergism of Telmisartan and Amlodipine on Blood Pressure Reduction and Cardiorenal Protection in Hypertensive Rats. Journal of Cardiovascular Pharmacology 57:3, pages 308-316.
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Harikrishna Makani, Sripal Bangalore, Jorge Romero, Omar Wever-Pinzon & Franz H. Messerli. (2011) Effect of Renin-Angiotensin System Blockade on Calcium Channel Blocker-Associated Peripheral Edema. The American Journal of Medicine 124:2, pages 128-135.
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Marit D. Moen. (2010) Telmisartan/Amlodipine. American Journal Cardiovascular Drugs 10:6, pages 401-412.
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Steven G. Chrysant. (2010) The Role of Angiotensin Receptor Blocker and Calcium Channel Blocker Combination Therapy in Treating Hypertension. American Journal Cardiovascular Drugs 10:5, pages 315-320.
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Jung-Jin Lee, Chang-Yong Shin, Hong-Joon Park, Wei-Yun Zhang, Yohan Kim, In-Su Kim, Kyu-Hyun Lee & Chang-Seon Myung. (2010) Drug synergism of antihypertensive action in combination of telmisartan with lercanidipine in spontaneous hypertensive rats. Archives of Pharmacal Research 33:9, pages 1411-1418.
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Daniel F. Catanzaro & William H. Frishman. (2010) Angiotensin Receptor Blockers for Management of Hypertension. Southern Medical Journal 103:7, pages 669-673.
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