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Clinical Focus: Hypertension and Related Disorders

Angiotensin Receptor Blocker and Dihydropyridine Calcium Channel Blocker Combinations: An Emerging Strategy in Hypertension Therapy

, MD & , MD
Pages 25-39 | Published online: 13 Mar 2015

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Read on this site (3)

Julian Segura & Luis Miguel Ruilope. (2013) A review of the benefits of early treatment initiation with single-pill combinations of telmisartan with amlodipine or hydrochlorothiazide. Vascular Health and Risk Management 9, pages 521-528.
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Carlos M Ferrario & Ronald D Smith. (2010) Role of olmesartan in combination therapy in blood pressure control and vascular function. Vascular Health and Risk Management 6, pages 701-709.
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Articles from other publishers (18)

Yasmeen El Hajj Abdallah, Sukhman Chahal, Fakhreddin Jamali & Sherif Hanafy Mahmoud. (2023) Drug-disease interaction: Clinical consequences of inflammation on drugs action and disposition. Journal of Pharmacy & Pharmaceutical Sciences 26.
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Kai Nagasawa, Keiji Takahashi, Natsumi Matsuura, Miwa Takatsu, Takuya Hattori, Shogo Watanabe, Eri Harada, Kazumi Niinuma, Toyoaki Murohara & Kohzo Nagata. (2014) Comparative effects of valsartan in combination with cilnidipine or amlodipine on cardiac remodeling and diastolic dysfunction in Dahl salt-sensitive rats. Hypertension Research 38:1, pages 39-47.
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Giuseppe Derosa, Arrigo F. G. Cicero, Anna Carbone, Fabrizio Querci, Elena Fogari, Angela D’Angelo & Pamela Maffioli. (2013) RETRACTED ARTICLE: Different Aspects of Sartan + Calcium Antagonist Association Compared to the Single Therapy on Inflammation and Metabolic Parameters in Hypertensive Patients. Inflammation 37:1, pages 154-162.
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Giuseppe Derosa, Arrigo F.G. Cicero, Anna Carbone, Fabrizio Querci, Elena Fogari, Angela D’Angelo & Pamela Maffioli. (2014) RETRACTED: Results from a 12 months, randomized, clinical trial comparing an olmesartan/amlodipine single pill combination to olmesartan and amlodipine monotherapies on blood pressure and inflammation. European Journal of Pharmaceutical Sciences 51, pages 26-33.
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Benjamin J. Epstein, Niren K. Shah & Nancy L. Borja-Hart. (2013) Management of hypertension with fixed-dose triple-combination treatments. Therapeutic Advances in Cardiovascular Disease 7:5, pages 246-259.
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Joel M. Neutel & David H. G. Smith. (2013) Hypertension Management: Rationale for Triple Therapy Based on Mechanisms of Action. Cardiovascular Therapeutics 31:5, pages 251-258.
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Carlos M. Ferrario, Sumeet Panjabi, Paul Buzinec & Jason P. Swindle. (2013) Clinical and economic outcomes associated with amlodipine/renin–angiotensin system blocker combinations. Therapeutic Advances in Cardiovascular Disease 7:1, pages 27-39.
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L G Christogiannis, M S Kostapanos, C C Tellis, H J Milionis, A D Tselepis & M S Elisaf. (2011) Distinct effects of fixed combinations of valsartan with either amlodipine or hydrochlorothiazide on lipoprotein subfraction profile in patients with hypertension. Journal of Human Hypertension 27:1, pages 44-50.
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Li-Xin Zhang, Xin-lin Chen, Peng-bo Yang, San-Qi Zhang & Yong-Xiao Cao. (2013) Vasorelaxant and antihypertensive effects of ZCM298, a dihydropyridine derivative, are through inhibiting extracellular calcium influx. Pharmacological Reports 65:1, pages 69-79.
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C. Venkata S. Ram, Joseph Vasey, Sumeet Panjabi, Chunlin Qian & Ruth Quah. (2012) Comparative Effectiveness Analysis of Amlodipine/Renin‐Angiotensin System Blocker Combinations. The Journal of Clinical Hypertension 14:9, pages 601-610.
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Steen Neldam, Colin Edwards, Margreet Lang & Russell Jones. (2012) Long-Term Tolerability and Efficacy of Single-Pill Combinations of Telmisartan 40–80 mg Plus Amlodipine 5 or 10 mg in Patients Whose Blood Pressure Was Not Initially Controlled by Amlodipine 5–10 mg: Open-Label, Long-Term Follow-Ups of the TEAMSTA-5 and TEAMSTA-10 Studies. Current Therapeutic Research 73:1-2, pages 65-84.
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Samir G Mallat. (2012) What is a preferred angiotensin II receptor blocker-based combination therapy for blood pressure control in hypertensive patients with diabetic and non-diabetic renal impairment?. Cardiovascular Diabetology 11:1, pages 32.
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Jing Zeng, Min Jia, Hua Ran, Hui Tang, Ye Zhang, Jun Zhang, Xukai Wang, Hongyong Wang, Chengming Yang & Chunyu Zeng. (2011) Fixed-combination of amlodipine and diuretic chronotherapy in the treatment of essential hypertension: improved blood pressure control with bedtime dosing—a multicenter, open-label randomized study. Hypertension Research 34:6, pages 767-772.
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Suzanne Oparil, Thomas Giles, Elizabeth O Ofili, Bertram Pitt, Yodit Seifu, Robert Hilkert, Rita Samuel & James R Sowers. (2011) Moderate versus intensive treatment of hypertension with amlodipine/valsartan for patients uncontrolled on angiotensin receptor blocker monotherapy. Journal of Hypertension 29:1, pages 161-170.
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Pedro Marques da Silva. (2010) Efficacy of Fixed-Dose Combination Therapy in the Treatment of Patients with Hypertension. Clinical Drug Investigation 30:9, pages 625-641.
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Jung-Jin Lee, Chang-Yong Shin, Hong-Joon Park, Wei-Yun Zhang, Yohan Kim, In-Su Kim, Kyu-Hyun Lee & Chang-Seon Myung. (2010) Drug synergism of antihypertensive action in combination of telmisartan with lercanidipine in spontaneous hypertensive rats. Archives of Pharmacal Research 33:9, pages 1411-1418.
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Julián Segura de La Morena, José Antonio García Donaire & Luis Miguel Ruilope Urioste. (2010) Nuevas estrategias terapéuticas para mejorar el control de la hipertensión arterial y simplificar la pauta de tratamiento farmacológico. Medicina Clínica 134:14, pages 635-642.
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Maria Czarina Acelajado & Suzanne Oparil. (2009) Hypertension in the Elderly. Clinics in Geriatric Medicine 25:3, pages 391-412.
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