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Postgraduate Medicine Volume 124, 2012 - Issue 1
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Clinical Features

The Pharmacokinetic Parameters of a Single Dose of a Novel Nano–formulated, Lower-Dose Oral Diclofenac

Garen Manvelian Clinical and Medical Consultant, Iroko Pharmaceuticals, Philadelphia, PA
, MD,
Stephen Daniels Premier Research Group International, LLC, Austin, TX
, DO &
Allan Gibofsky Professor of Medicine and Public Health, Weill Medical College of Cornell University, New York, NY; Attending Rheumatologist, Hospital for Special Surgery, New York, NYCorrespondence[email protected]
, MD
Pages 117-123 | Published online: 13 Mar 2015

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Allan Gibofsky, Roy Altman, Stephen Daniels, Olaolu Imasogie & Clarence Young. (2015) Low-dose SoluMatrix diclofenac: a review of safety across two Phase III studies in patients with acute and osteoarthritis pain. Expert Opinion on Drug Safety 14:8, pages 1327-1339.
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Kemi Olugemo, Daniel Solorio, Claire Sheridan & Clarence L. Young. (2015) Pharmacokinetics and safety of low-dose submicron indomethacin 20 and 40 mg compared with indomethacin 50 mg. Postgraduate Medicine 127:2, pages 223-231.
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Charles V. Pollack$suffix/text()$suffix/text() & Eugene R. Viscusi. (2015) Improving acute pain management in emergency medicine. Hospital Practice 43:1, pages 36-45.
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Satomi Onoue, Shizuo Yamada & Hak-Kim Chan. (2014) Nanodrugs: pharmacokinetics and safety. International Journal of Nanomedicine 9, pages 1025-1037.
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Allan Gibofsky, Stephen Silberstein, Charles Argoff, Stephen Daniels, Steve Jensen & Clarence L. Young. (2013) Lower-Dose Diclofenac Submicron Particle Capsules Provide Early and Sustained Acute Patient Pain Relief in a Phase 3 Study. Postgraduate Medicine 125:5, pages 130-138.
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Articles from other publishers (17)

Fiza ur Rehman, Kehkashan Mazhar, Annum Malik, Syeda Sohaila Naz, Kifayat Ullah Shah, Adnan Khan, Salman Khan, Rizwan Ahmed & Sara Qaisar. (2021) Surface modified multifaceted nanocarriers for oral non-conventional cancer therapy; synthesis and evaluation. Materials Science and Engineering: C 123, pages 111940.
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Alejandro Schcolnik‑Cabrera, Alma Chavez‑Blanco, Guadalupe Dominguez‑Gomez, Mandy Juarez, Donna Lai, Sheng Hua, Armando Tovar, Jose Diaz‑Chavez & Alfonso Duenas‑Gonzalez. (2020) The combination of orlistat, lonidamine and 6‑diazo‑5‑oxo‑L‑norleucine induces a quiescent energetic phenotype and limits substrate flexibility in colon cancer cells. Oncology Letters 20:3, pages 3053-3060.
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Timothy J. Atkinson & Jeffrey Fudin. (2020) Nonsteroidal Antiinflammatory Drugs for Acute and Chronic Pain. Physical Medicine and Rehabilitation Clinics of North America 31:2, pages 219-231.
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Susanne Hellms, Faikah Gueler, Marcel Gutberlet, Nils Helge Schebb, Katharina Rund, Jan T Kielstein, VanDai VoChieu, Sebastian Rauhut, Robert Greite, Petros Martirosian, Hermann Haller, Frank Wacker & Katja Derlin. (2019) Single-dose diclofenac in healthy volunteers can cause decrease in renal perfusion measured by functional magnetic resonance imaging†. Journal of Pharmacy and Pharmacology 71:8, pages 1262-1270.
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Young Hee Choi & Hyo-Kyung Han. (2017) Nanomedicines: current status and future perspectives in aspect of drug delivery and pharmacokinetics. Journal of Pharmaceutical Investigation 48:1, pages 43-60.
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Koji Chiba, Keiko Shimizu, Motohiro Kato, Taichi Miyazaki, Takaaki Nishibayashi, Kazuki Terada & Yuichi Sugiyama. (2017) Estimation of Interindividual Variability of Pharmacokinetics of CYP2C9 Substrates in Humans. Journal of Pharmaceutical Sciences 106:9, pages 2695-2703.
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Deirdre Mladsi, Naoko Ronquest, Dawn Odom, LaStella Miles & Kenneth Saag. (2016) Cost-effectiveness of Low-dose Submicron Diclofenac Compared With Generic Diclofenac. Clinical Therapeutics 38:11, pages 2418-2429.
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Joseph V PergolizziJrJr, Robert B Raffa, Srinivas Nalamachu & Robert TaylorJrJr. (2016) Evolution to low-dose NSAID therapy. Pain Management 6:2, pages 175-189.
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Bill H. McCarberg & Byron Cryer. (2015) Evolving Therapeutic Strategies to Improve Nonsteroidal Anti-inflammatory Drug Safety. American Journal of Therapeutics 22:6, pages e167-e178.
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Sheena Derry, Philip J Wiffen & R Andrew Moore. (2015) Single dose oral diclofenac for acute postoperative pain in adults. Cochrane Database of Systematic Reviews 2019:5.
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Roy Altman, Bill Bosch, Kay Brune, Paola Patrignani & Clarence Young. (2015) Advances in NSAID Development: Evolution of Diclofenac Products Using Pharmaceutical Technology. Drugs 75:8, pages 859-877.
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Paul J. Desjardins, Kemi Olugemo, Daniel Solorio & Clarence L. Young. (2015) Pharmacokinetic Properties and Tolerability of Low-dose SoluMatrix Diclofenac. Clinical Therapeutics 37:2, pages 448-461.
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Garen Manvelian, Marc C. Hochberg, Stephen E. Daniels, Roy D. Altman & Clarence L. Young. (2014) A Phase 2 Study of Lower-dose, Indomethacin Submicron Particle Capsules Demonstrates Early Onset of Acute Pain Relief. The Clinical Journal of Pain 30:10, pages 846-851.
Crossref
Timothy J. Atkinson, Jeffrey Fudin, Heather Lynne Jahn, Natsuki Kubotera, Amanda Leigh Rennick & Mary Rhorer. (2013) What's New in NSAID Pharmacotherapy: Oral Agents to Injectables. Pain Medicine 14:suppl 1, pages S11-S17.
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Clarence L. Young, Vibeke Strand, Roy Altman & Stephen Daniels. (2013) A Phase 2 Study of Naproxen Submicron Particle Capsules in Patients with Post-Surgical Dental Pain. Advances in Therapy 30:10, pages 885-896.
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Sanford H Roth. (2013) Diclofenac in the treatment of osteoarthritis. International Journal of Clinical Rheumatology 8:2, pages 185-203.
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Hiroshi Imamura, Jiro Hata, Ai Iida, Noriaki Manabe & Ken Haruma. (2012) Evaluating the effects of diclofenac sodium and etodolac on renal hemodynamics with contrast-enhanced ultrasonography: a pilot study. European Journal of Clinical Pharmacology 69:2, pages 161-165.
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