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Clinical Focus: Diabetes and Concomitant Disorders

Efficacy, Safety, and Tolerability of Exenatide Once Weekly in Patients With Type 2 Diabetes Mellitus: An Integrated Analysis of the DURATION Trials

, MD, , MS, , PhD, , BA, , PhD, , MS & , PhD show all
Pages 47-57 | Published online: 13 Mar 2015

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L. H. Chuang, B. G. Verheggen, M. Charokopou, D. Gibson, S. Grandy & B. Kartman. (2016) Cost-effectiveness analysis of exenatide once-weekly versus dulaglutide, liraglutide, and lixisenatide for the treatment of type 2 diabetes mellitus: an analysis from the UK NHS perspective. Journal of Medical Economics 19:12, pages 1127-1134.
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Sandro Gentile, Felice Strollo & Antonio Ceriello. (2016) Lipodystrophy in Insulin-Treated Subjects and Other Injection-Site Skin Reactions: Are We Sure Everything is Clear?. Diabetes Therapy 7:3, pages 401-409.
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Robert A. ScottDaniel F. FreitagLi LiAudrey Y. ChuPraveen SurendranRobin YoungNiels GrarupAlena StancákováYuning ChenTibor V. VargaHanieh YaghootkarJian’an LuanJing Hua ZhaoSara M. WillemsJennifer WesselShuai WangNisa MaruthurKyriaki MichailidouAilith PirieSven J. van der LeeChristopher GillsonAli Amin Al OlamaPhilippe AmouyelLarraitz ArriolaDominique ArveilerIciar Aviles-OlmosBeverley BalkauAurelio BarricarteInês BarrosoSara Benlloch GarciaJoshua C. BisStefan BlankenbergMichael BoehnkeHeiner BoeingEric BoerwinkleIngrid B. BoreckiJette Bork-JensenSarah BowdenCarlos CaldasMuriel CaslakeL. Adrienne CupplesCarlos CruchagaJacek CzajkowskiMarcel den HoedJanet A. DunnHelena M. EarlGeorg B. EhretEle FerranniniJean FerrieresThomas FoltynieIan FordNita G. ForouhiFrancesco GianfagnaCarlos GonzalezSara GrioniLouise HillerJan-Håkan JanssonMarit E. JørgensenJ. Wouter JukemaRudolf KaaksFrank KeeNicola D. KerrisonTimothy J. KeyJukka KonttoZsofia Kote-JaraiAldi T. KrajaKari KuulasmaaJohanna KuusistoAllan LinnebergChunyu LiuGaëlle MarenneKaren L. MohlkeAndrew P. MorrisKenneth MuirMartina Müller-NurasyidPatricia B. MunroeCarmen NavarroSune F. NielsenPeter M. NilssonBørge G. NordestgaardChris J. PackardDomenico PalliSalvatore PanicoGina M. PelosoMarkus PerolaAnnette PetersChristopher J. PooleJ. Ramón QuirósOlov RolandssonCarlotta SacerdoteVeikko SalomaaMaría-José SánchezNaveed SattarStephen J. SharpRebecca SimsNadia SlimaniJennifer A. SmithDeborah J. ThompsonStella TrompetRosario TuminoDaphne L. van der AYvonne T. van der SchouwJarmo VirtamoMark WalkerKlaudia WalterJean E. AbrahamLaufey T. AmundadottirJennifer L. AponteAdam S. ButterworthJosée DupuisDouglas F. EastonRosalind A. EelesJeanette ErdmannPaul W. FranksTimothy M. FraylingTorben HansenJoanna M. M. HowsonTorben JørgensenJaspal KoonerMarkku LaaksoClaudia LangenbergMark I. McCarthyJames S. PankowOluf PedersenElio RiboliJerome I. RotterDanish SaleheenNilesh J. SamaniHeribert SchunkertPeter VollenweiderStephen O’RahillyPanos DeloukasJohn DaneshMark O. GoodarziSekar KathiresanJames B. MeigsMargaret G. EhmNicholas J. WarehamDawn M. Waterworth. (2016) A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease . Science Translational Medicine 8:341.
Crossref
Michael E. Trautmann, Jenny Han & James Ruggles. (2016) Early Pharmacodynamic Effects of Exenatide Once Weekly in Type 2 Diabetes Are Independent of Weight Loss: A Pooled Analysis of Patient-level Data. Clinical Therapeutics 38:6, pages 1464-1473.
Crossref
Hui Peng, Laura L. Want & Vanita R. Aroda. (2016) Safety and Tolerability of Glucagon-Like Peptide-1 Receptor Agonists Utilizing Data from the Exenatide Clinical Trial Development Program. Current Diabetes Reports 16:5.
Crossref
Stephen Brunton & Jaime A. Davidson. (2016) Exenatide Once Weekly: A Review of Pharmacology and Treatment Considerations in Type 2 Diabetes. Clinical Therapeutics 38:3, pages 582-594.
Crossref
Curtis TriplittCarolina Solis-Herrera. (2015) GLP-1 Receptor Agonists. The Diabetes Educator 41:1_suppl, pages 32S-46S.
Crossref
Susan LaRue & Jaret Malloy. (2015) Evaluation of the Dual-Chamber Pen Design for the Injection of Exenatide Once Weekly for the Treatment of Type 2 Diabetes. Journal of Diabetes Science and Technology 9:4, pages 815-821.
Crossref
Yahiya Y. Syed & Paul L. McCormack. (2015) Exenatide Extended-Release: An Updated Review of Its Use in Type 2 Diabetes Mellitus. Drugs 75:10, pages 1141-1152.
Crossref
Jennifer D. Goldman-Levine. (2015) Combination Therapy When Metformin Is Not an Option for Type 2 Diabetes. Annals of Pharmacotherapy 49:6, pages 688-699.
Crossref
J.J. Gorgojo-Martínez. (2014) Nuevos fármacos antidiabéticos: avanzando hacia el control integral de la diabesidad. Hipertensión y Riesgo Vascular 31:2, pages 45-57.
Crossref

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