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Cancer Biology & Therapy Volume 15, 2014 - Issue 12
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RESEARCH PAPER

DR4 specific TRAIL variants are more efficacious than wild-type TRAIL in pancreatic cancer

Rui YuNational University of Ireland; Galway; National Centre for Biomedical Engineering Science and Apoptosis Research Centre; Molecular Therapeutics Group; Galway, Ireland
,
Stella Maris AlbarenqueNational University of Ireland; Galway; National Centre for Biomedical Engineering Science and Apoptosis Research Centre; Molecular Therapeutics Group; Galway, Ireland
,
Robbert H CoolUniversity of Groningen; Medical Center Groningen; Department of Pharmaceutical Biology; Groningen, The Netherlands;Triskel Therapeutics B.V., A. Deusinglaan 1; Groningen, The Netherlands
,
Wim J QuaxUniversity of Groningen; Medical Center Groningen; Department of Pharmaceutical Biology; Groningen, The Netherlands
,
Andrea MohrSchool of Biological Sciences; University of Essex; Colchester, UK
&
Ralf M ZwackaNational University of Ireland; Galway; National Centre for Biomedical Engineering Science and Apoptosis Research Centre; Molecular Therapeutics Group; Galway, Ireland;School of Biological Sciences; University of Essex; Colchester, UKCorrespondence[email protected]
Pages 1658-1666 | Received 04 Mar 2014, Accepted 28 Sep 2014, Published online: 23 Dec 2014

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Anna Hagenhoff, Christiane J. Bruns, Yue Zhao, Irene von Lüttichau, Hanno Niess, Christine Spitzweg & Peter J. Nelson. (2016) Harnessing mesenchymal stem cell homing as an anticancer therapy. Expert Opinion on Biological Therapy 16:9, pages 1079-1092.
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Martin S. Staege, Stefanie Kewitz, Toralf Bernig, Caspar Kühnöl & Christine Mauz-Körholz. (2015) Prognostic Biomarkers for Hodgkin Lymphoma. Pediatric Hematology and Oncology 32:7, pages 433-454.
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Articles from other publishers (24)

Anne V. Yagolovich, Marine E. Gasparian & Dmitry A. Dolgikh. (2023) Recent Advances in the Development of Nanodelivery Systems Targeting the TRAIL Death Receptor Pathway. Pharmaceutics 15:2, pages 515.
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Hiroyuki Tani, Ryo Miyamoto, Tomokazu Nagashima, Masaki Michishita, Kyoichi Tamura & Makoto Bonkobara. (2021) Molecular characterization of canine SHP2 mutants and anti‐tumour effect of SHP2 inhibitor, SHP099 , in a xenograft mouse model of canine histiocytic sarcoma . Veterinary and Comparative Oncology 20:1, pages 109-117.
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Fengzhi Suo, Xinyu Zhou, Rita Setroikromo & Wim J. Quax. (2022) Receptor Specificity Engineering of TNF Superfamily Ligands. Pharmaceutics 14:1, pages 181.
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Abel Soto-Gamez, Yizhou Wang, Xinyu Zhou, Lorina Seras, Wim Quax & Marco Demaria. (2021) Enhanced extrinsic apoptosis of therapy-induced senescent cancer cells using a death receptor 5 (DR5) selective agonist. Cancer Letters.
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Olivia A. Diaz Arguello & Hidde J. Haisma. (2021) Apoptosis-Inducing TNF Superfamily Ligands for Cancer Therapy. Cancers 13:7, pages 1543.
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Anne V. Yagolovich, Artem A. Artykov, Tatiana A. Karmakova, Maria S. Vorontsova, Andrey A. Pankratov, Alexander A. Andreev-Andrievsky, Dmitry A. Dolgikh, Mikhail P. Kirpichnikov & Marine E. Gasparian. (2020) Genetically Modified DR5-Specific TRAIL Variant DR5-B Revealed Dual Antitumor and Protumoral Effect in Colon Cancer Xenografts and an Improved Pharmacokinetic Profile. Translational Oncology 13:4, pages 100762.
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Yan-Bin Sun, Guang-Hao Sun, Shun Xu & Jing-Jing Xu. (2020) Tumor-suppressive activity of sTRAIL on circulating CD44 + cells in patients with non-small cell lung cancer . Biological Chemistry 401:3, pages 417-422.
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Leon P. Bignold. 2020. Principles of Tumors. Principles of Tumors 439 451 .
So-Ra Lee, Khong Trong Quan, Hee Sun Byun, InWha Park, Kidong Kang, Xuezhe Piao, Eunjin Ju, Hyunju Ro, MinKyun Na & Gang Min Hur. (2019) Accelerated degradation of cFLIPL and sensitization of the TRAIL DISC-mediated apoptotic cascade by pinoresinol, a lignan isolated from Rubia philippinensis. Scientific Reports 9:1.
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Xuebo Xu, Yueyang Lai & Zi-Chun Hua. (2019) Apoptosis and apoptotic body: disease message and therapeutic target potentials. Bioscience Reports 39:1.
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Reyhaneh Moradi Marjaneh, Seyed Mahdi Hassanian, Niloofar Ghobadi, Gordon A. Ferns, Afshin Karimi, Mir Hadi Jazayeri, Mohammadreza Nasiri, Amir Avan & Majid Khazaei. (2018) Targeting the death receptor signaling pathway as a potential therapeutic target in the treatment of colorectal cancer. Journal of Cellular Physiology 233:10, pages 6538-6549.
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Anna-Laura Kretz, Silvia von Karstedt, Andreas Hillenbrand, Doris Henne-Bruns, Uwe Knippschild, Anna Trauzold & Johannes Lemke. (2018) Should We Keep Walking along the Trail for Pancreatic Cancer Treatment? Revisiting TNF-Related Apoptosis-Inducing Ligand for Anticancer Therapy. Cancers 10:3, pages 77.
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Zuzana Nahacka, Jan Svadlenka, Martin Peterka, Marie Ksandrova, Simona Benesova, Jiri Neuzil & Ladislav Andera. (2018) TRAIL induces apoptosis but not necroptosis in colorectal and pancreatic cancer cells preferentially via the TRAIL-R2/DR5 receptor. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1865:3, pages 522-531.
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Andrea Mohr & Ralf Zwacka. (2018) The future of mesenchymal stem cell-based therapeutic approaches for cancer – From cells to ghosts. Cancer Letters 414, pages 239-249.
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Joo-Young Kim, Young-Mi Kim, Jong-Min Park, Young Min Han, Kang Choon Lee, Ki Baik Hahm & Suntaek Hong. (2017) Cancer preventive effect of recombinant TRAIL by ablation of oncogenic inflammation in colitis-associated cancer rather than anticancer effect. Oncotarget 9:2, pages 1705-1716.
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宏海 洪. (2018) INF-Gamma Induces HepG2 Apoptosis via Down-Regulating the Level of ATGL Protein. World Journal of Cancer Research 08:01, pages 42-48.
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Katharina Beyer, Lars Ivo Partecke, Felicitas Roetz, Herbert Fluhr, Frank Ulrich Weiss, Claus-Dieter Heidecke & Wolfram von Bernstorff. (2017) LPS promotes resistance to TRAIL-induced apoptosis in pancreatic cancer. Infectious Agents and Cancer 12:1.
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Andrea Mohr & Ralf Zwacka. 2017. TRAIL, Fas Ligand, TNF and TLR3 in Cancer. TRAIL, Fas Ligand, TNF and TLR3 in Cancer 107 129 .
David I. Radke, Hendrik Ungefroren, Ole Helm, Susann Voigt, G?khan Alp, Hendrik Braun, Sebastian H?bner, Janine Dilchert, Susanne Sebens, Dieter Adam, Holger Kalthoff & Anna Trauzold. (2016) Negative control of TRAIL-R1 signaling by transforming growth factor ?1 in pancreatic tumor cells involves Smad-dependent down regulation of TRAIL-R1. Cellular Signalling 28:11, pages 1652-1662.
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Daniel Wilffert, Angela Asselman, Riccardo Donzelli, Jos Hermans, Natalia Govorukhina, Wim J Quax, Nico C van de Merbel & Rainer Bischoff. (2016) Highly sensitive antibody-free μLC–MS/MS quantification of rhTRAIL in serum. Bioanalysis 8:9, pages 881-890.
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Andrea Mohr, Rui Yu & Ralf M. Zwacka. (2015) TRAIL-receptor preferences in pancreatic cancer cells revisited: Both TRAIL-R1 and TRAIL-R2 have a licence to kill. BMC Cancer 15:1.
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Gustavo P. Amarante-Mendes & Thomas S. Griffith. (2015) Therapeutic applications of TRAIL receptor agonists in cancer and beyond. Pharmacology & Therapeutics 155, pages 117-131.
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Vidhyashankar Ramamurthy, Aaron P. Yamniuk, Eric J. Lawrence, Wei Yong, Lumelle A. Schneeweis, Lin Cheng, Melissa Murdock, Martin J. Corbett, Michael L. Doyle & Steven Sheriff. (2015) The structure of the death receptor 4–TNF-related apoptosis-inducing ligand (DR4–TRAIL) complex. Acta Crystallographica Section F Structural Biology Communications 71:10, pages 1273-1281.
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Fei Yuan, Yu-Hang Zhang, Sibao Wan, ShaoPeng Wang & Xiang-Yin Kong. (2015) Mining for Candidate Genes Related to Pancreatic Cancer Using Protein-Protein Interactions and a Shortest Path Approach. BioMed Research International 2015, pages 1-12.
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