Cancer Biology & Therapy, Volume 15, Issue 12 (2014)

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Cancer Biology & Therapy, Volume 15, Issue 12 (2014)

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JOURNAL CLUB

Article
BET bromodomain inhibitors—A novel epigenetic approach in castration-resistant prostate cancer
Sarah E Lochrin, Douglas K Price & William D Figg
Pages: 1583-1585
Published online: 23 Dec 2014
AbstractforBET bromodomain inhibitors—A novel epigenetic approach in castration-resistant prostate cancer | Full Text | References | PDF (56.6 KB)
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Article
Aromatase inhibitor plus ovarian suppression as adjuvant therapy in premenopausal women with breast cancer
William D Figg II, Katherine Cook & Robert Clarke
Pages: 1586-1587
Published online: 23 Dec 2014
AbstractforAromatase inhibitor plus ovarian suppression as adjuvant therapy in premenopausal women with breast cancer | Full Text | References | PDF (56.2 KB)
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BEDSIDE TO BENCH REPORT

Article
Bioactive insulin-like growth factors as a possible molecular target for non-islet cell tumor hypoglycemia
Takeshi Setoyama, Shin’ichi Miyamoto, Takahiro Horimatsu, Taro Funakoshi, Mitsuhiro Nikaido, Yuzo Kodama, Sachiko Minamiguchi, Tomoko Yamabata, Manabu Muto & Tsutomu Chiba
Pages: 1588-1592
Published online: 23 Dec 2014
AbstractforBioactive insulin-like growth factors as a possible molecular target for non-islet cell tumor hypoglycemia | Full Text | References | PDF (293.7 KB)
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RESEARCH PAPER

Article
A breast cancer cell microarray (CMA) as a rapid method to characterize candidate biomarkers
Xinyan Wu, Muhammad S Zahari, Santosh Renuse, Harrys KC Jacob, Sruthi Sakamuri, Mukul Singal, Edward Gabrielson, Saraswati Sukumar & Akhilesh Pandey
Pages: 1593-1599
Published online: 23 Dec 2014
AbstractforA breast cancer cell microarray (CMA) as a rapid method to characterize candidate biomarkers | Full Text | References | PDF (5.1 MB)
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Article
Increasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1
Lei Duan, Ricardo E Perez, Michael Hansen, Steven Gitelis & Carl G Maki
Pages: 1600-1612
Published online: 23 Dec 2014
AbstractforIncreasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1 | Full Text | References | PDF (1.7 MB)
  • 1005 Views
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Article
Recurrent FGFR3-TACC3 fusion gene in nasopharyngeal carcinoma
Li Yuan, Zhi-Hua Liu, Zhi-Rui Lin, Li-Hua Xu, Qian Zhong & Mu-Sheng Zeng
Pages: 1613-1621
Published online: 23 Dec 2014
AbstractforRecurrent FGFR3-TACC3 fusion gene in nasopharyngeal carcinoma | Full Text | References | PDF (811.8 KB)
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Article
Enhancement of cellular radiation sensitivity through degradation of Chk1 by the XIAP-XAF1 complex
Kwang Seok Kim, Jong-Ik Heo, Kyu Jin Choi & Sangwoo Bae
Pages: 1622-1634
Published online: 23 Dec 2014
AbstractforEnhancement of cellular radiation sensitivity through degradation of Chk1 by the XIAP-XAF1 complex | Full Text | References | PDF (1,010.8 KB)
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Article
Discovery of fruquintinib, a potent and highly selective small molecule inhibitor of VEGFR 1, 2, 3 tyrosine kinases for cancer therapy
Qiaoling Sun, Jinghong Zhou, Zheng Zhang, Mingchuan Guo, Junqing Liang, Feng Zhou, Jingwen Long, Wei Zhang, Fang Yin, Huaqing Cai, Haibin Yang, Weihan Zhang, Yi Gu, Liang Ni, Yang Sai, Yumin Cui, Meifang Zhang, Minhua Hong, Junen Sun, Zheng Yang, Weiguo Qing, Weiguo Su & Yongxin Ren
Pages: 1635-1645
Published online: 23 Dec 2014
AbstractforDiscovery of fruquintinib, a potent and highly selective small molecule inhibitor of VEGFR 1, 2, 3 tyrosine kinases for cancer therapy | Full Text | References | PDF (1,011.7 KB)
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Article
Regulation of dimethyl-fumarate toxicity by proteasome inhibitors
Laurence Booth, Nichola Cruickshanks, Seyedmehrad Tavallai, Jane L Roberts, Matthew Peery, Andrew Poklepovic & Paul Dent
Pages: 1646-1657
Published online: 23 Dec 2014
AbstractforRegulation of dimethyl-fumarate toxicity by proteasome inhibitors | Full Text | References | PDF (1.4 MB)
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Article
DR4 specific TRAIL variants are more efficacious than wild-type TRAIL in pancreatic cancer
Rui Yu, Stella Maris Albarenque, Robbert H Cool, Wim J Quax, Andrea Mohr & Ralf M Zwacka
Pages: 1658-1666
Published online: 23 Dec 2014
AbstractforDR4 specific TRAIL variants are more efficacious than wild-type TRAIL in pancreatic cancer | Full Text | References | PDF (793.6 KB) | Supplemental
  • 1970 Views
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Article
Gli2 silencing enhances TRAIL-induced apoptosis and reduces tumor growth in human hepatoma cells in vivo
Da-wei Zhang, Hai-yan Li, Wan-yee Lau, Liang-qi Cao, Yue Li, Xiao-feng Jiang, Xue-wei Yang & Ping Xue
Pages: 1667-1676
Published online: 23 Dec 2014
AbstractforGli2 silencing enhances TRAIL-induced apoptosis and reduces tumor growth in human hepatoma cells in vivo | Full Text | References | PDF (1 MB)
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Article
EZH2 inhibition enhances the efficacy of an EGFR inhibitor in suppressing colon cancer cells
Bryson W Katona, Yuanyuan Liu, Anqi Ma, Jian Jin & Xianxin Hua
Pages: 1677-1687
Published online: 23 Dec 2014
AbstractforEZH2 inhibition enhances the efficacy of an EGFR inhibitor in suppressing colon cancer cells | Full Text | References | PDF (1.1 MB) | Supplemental
  • 2166 Views
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Article
Pyoluteorin derivatives induce Mcl-1 degradation and apoptosis in hematological cancer cells
Kenichiro Doi, Krishne Gowda, Qiang Liu, Jyh-Ming Lin, Shen-Shu Sung, Christopher Dower, David Claxton, Thomas P Loughran Jr, Shantu Amin & Hong-Gang Wang
Pages: 1688-1699
Published online: 23 Dec 2014
AbstractforPyoluteorin derivatives induce Mcl-1 degradation and apoptosis in hematological cancer cells | Full Text | References | PDF (758.8 KB) | Supplemental
  • 1581 Views
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Article
Distinct DNA damage determines differential phosphorylation of Chk2
Mutsuko Ouchi & Toru Ouchi
Pages: 1700-1704
Published online: 23 Dec 2014
AbstractforDistinct DNA damage determines differential phosphorylation of Chk2 | Full Text | References | PDF (389.9 KB)
  • 1083 Views
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