Citations (102)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (6)
Philip Campbell, Huw Morris & Anthony Schapira. (2018) Chaperone-mediated autophagy as a therapeutic target for Parkinson disease. Expert Opinion on Therapeutic Targets 22:10, pages 823-832.
Read now
Read now
Georgia Minakaki, Stefanie Menges, Agnes Kittel, Evangelia Emmanouilidou, Iris Schaeffner, Katalin Barkovits, Anna Bergmann, Edward Rockenstein, Anthony Adame, Franz Marxreiter, Brit Mollenhauer, Douglas Galasko, Edit Irén Buzás, Ursula Schlötzer-Schrehardt, Katrin Marcus, Wei Xiang, Dieter Chichung Lie, Kostas Vekrellis, Eliezer Masliah, Jürgen Winkler & Jochen Klucken. (2018) Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype. Autophagy 14:1, pages 98-119.
Read now
Read now
Dong-Kyu Kim, Hee-Sun Lim, Ichiro Kawasaki, Yhong-Hee Shim, Nishant N. Vaikath, Omar M. A. El-Agnaf, He-Jin Lee & Seung-Jae Lee. (2016) Anti-aging treatments slow propagation of synucleinopathy by restoring lysosomal function. Autophagy 12:10, pages 1849-1863.
Read now
Read now
Ting-Ting Du, Le Wang, Chun-Li Duan, Ling-Ling Lu, Jian-Liang Zhang, Ge Gao, Xiao-Bo Qiu, Xiao-Min Wang & Hui Yang. (2015) GBA deficiency promotes SNCA/α-synuclein accumulation through autophagic inhibition by inactivated PPP2A. Autophagy 11:10, pages 1803-1820.
Read now
Read now
Yi-Sheng Hou, Jun-Jie Guan, Hai-Dong Xu, Feng Wu, Rui Sheng & Zheng-Hong Qin. (2015) Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation. Molecular and Cellular Biology 35:16, pages 2740-2751.
Read now
Read now
Anne-Maria Poehler, Wei Xiang, Philipp Spitzer, Verena Elisabeth Luise May, Holger Meixner, Edward Rockenstein, Oldriska Chutna, Tiago Fleming Outeiro, Juergen Winkler, Eliezer Masliah & Jochen Klucken. (2014) Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment. Autophagy 10:12, pages 2171-2192.
Read now
Read now
Articles from other publishers (96)
Beom Jin Kim, Hye Rin Noh, Hyongjun Jeon & Sang Myun Park. (2023)
Monitoring α-synuclein Aggregation Induced by Preformed α-synuclein Fibrils in an
In Vitro
Model System
. Experimental Neurobiology 32:3, pages 147-156.
Crossref
Crossref
Su Min Lim, Minyeop Nahm & Seung Hyun Kim. (2023) Proteostasis and Ribostasis Impairment as Common Cell Death Mechanisms in Neurodegenerative Diseases. Journal of Clinical Neurology 19:2, pages 101.
Crossref
Crossref
Anne Louise Grønnemose, Eva Christina Østerlund, Daniel Erik Otzen & Thomas J.D. Jørgensen. (2022) EGCG has Dual and Opposing Effects on the N-terminal Region of Self-associating α-synuclein Oligomers. Journal of Molecular Biology 434:23, pages 167855.
Crossref
Crossref
Shuanglong Yi, Linfang Wang, Honglei Wang, Margaret S. Ho & Shiping Zhang. (2022) Pathogenesis of α-Synuclein in Parkinson’s Disease: From a Neuron-Glia Crosstalk Perspective. International Journal of Molecular Sciences 23:23, pages 14753.
Crossref
Crossref
Taylor J. Stevenson, Rebecca H. Johnson, Jimmy Savistchenko, Justin Rustenhoven, Zoe Woolf, Leon C. D. Smyth, Helen C. Murray, Richard L. M. Faull, Jason Correia, Patrick Schweder, Peter Heppner, Clinton Turner, Ronald Melki, Birger V. Dieriks, Maurice A. Curtis & Michael Dragunow. (2022) Pericytes take up and degrade α-synuclein but succumb to apoptosis under cellular stress. Scientific Reports 12:1.
Crossref
Crossref
Subhashree Sahoo, Amrita Arpita Padhy, Varsha Kumari & Parul Mishra. (2022) Role of Ubiquitin–Proteasome and Autophagy-Lysosome Pathways in α-Synuclein Aggregate Clearance. Molecular Neurobiology 59:9, pages 5379-5407.
Crossref
Crossref
Laura Smith & Anthony H. V. Schapira. (2022) GBA Variants and Parkinson Disease: Mechanisms and Treatments. Cells 11:8, pages 1261.
Crossref
Crossref
Eva M. Szegö, Chris Van den Haute, Lennart Höfs, Veerle Baekelandt, Anke Van der Perren & Björn H. Falkenburger. (2022) Rab7 reduces α-synuclein toxicity in rats and primary neurons. Experimental Neurology 347, pages 113900.
Crossref
Crossref
Kevin S. Chen, Krystal Menezes, Jarlath B. Rodgers, Darren M. O’Hara, Nhat Tran, Kazuko Fujisawa, Seiya Ishikura, Shahin Khodaei, Hien Chau, Anna Cranston, Minesh Kapadia, Grishma Pawar, Susan Ping, Aldis Krizus, Alix Lacoste, Scott Spangler, Naomi P. Visanji, Connie Marras, Nour K. Majbour, Omar M. A. El-Agnaf, Andres M. Lozano, Joseph Culotti, Satoshi Suo, William S. Ryu, Suneil K. Kalia & Lorraine V. Kalia. (2021) Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans. Molecular Neurodegeneration 16:1.
Crossref
Crossref
Francesca Biagioni, Rosangela Ferese, Filippo Sean Giorgi, Nicola Modugno, Enrica Olivola, Paola Lenzi, Stefano Gambardella, Diego Centonze, Stefano Ruggieri & Francesco Fornai. (2021) An attempt to dissect a peripheral marker based on cell pathology in Parkinson's disease. Journal of Neural Transmission 128:10, pages 1599-1610.
Crossref
Crossref
Qilin Tang, Pan Gao, Thomas Arzberger, Matthias Höllerhage, Jochen Herms, Günter Höglinger & Thomas Koeglsperger. (2021) Alpha-Synuclein defects autophagy by impairing SNAP29-mediated autophagosome-lysosome fusion. Cell Death & Disease 12:10.
Crossref
Crossref
Debashis Dutta, Malabendu Jana, Moumita Majumder, Susanta Mondal, Avik Roy & Kalipada Pahan. (2021) Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo. Nature Communications 12:1.
Crossref
Crossref
Maxime Teixeira, Razan Sheta, Walid Idi & Abid Oueslati. (2021) Alpha-Synuclein and the Endolysosomal System in Parkinson’s Disease: Guilty by Association. Biomolecules 11:9, pages 1333.
Crossref
Crossref
Souvarish Sarkar, Abby L. Olsen, Katja Sygnecka, Kelly M. Lohr & Mel B. Feany. (2021) α-synuclein impairs autophagosome maturation through abnormal actin stabilization. PLOS Genetics 17:2, pages e1009359.
Crossref
Crossref
Carlotta Giorgi, Esmaa Bouhamida, Alberto Danese, Maurizio Previati, Paolo Pinton & Simone Patergnani. (2021) Relevance of Autophagy and Mitophagy Dynamics and Markers in Neurodegenerative Diseases. Biomedicines 9:2, pages 149.
Crossref
Crossref
Zihua Liu, Qiang Ye, Fang Wang, Yanan Guo, Rong Cui, Jianlin Wang & Degui Wang. (2020) Overexpression of thioredoxin reductase 1 can reduce DNA damage, mitochondrial autophagy and endoplasmic reticulum stress in Parkinson's disease. Experimental Brain Research 239:2, pages 475-490.
Crossref
Crossref
Young Rae Jo, Hye Ran Kim, So Young Jang, Hana Go, Min‐Young Song, Da Kyeong Park, Yuna Oh, Juyeon Jo, Yoon Kyung Shin, Sung Joong Lee, Sang‐Myung Cheon, Hyun Kyoung Lee, Kyung Eun Lee, Young Hye Kim & Hwan Tae Park. (2020) Potential neuron‐autonomous Purkinje cell degeneration by 2′,3′‐cyclic nucleotide 3′‐phosphodiesterase promoter/Cre‐mediated autophagy impairments. The FASEB Journal 35:1.
Crossref
Crossref
Zi-Ying Wang, Jia Liu, Zhou Zhu, Cheng-Fu Su, Sravan Gopalkrishnashetty Sreenivasmurthy, Ashok Iyaswamy, Jia-Hong Lu, Gang Chen, Ju-Xian Song & Min Li. (2021) Traditional Chinese medicine compounds regulate autophagy for treating neurodegenerative disease: A mechanism review. Biomedicine & Pharmacotherapy 133, pages 110968.
Crossref
Crossref
Patrícia I. Santos & Tiago F. Outeiro. (2020) Protein trapping leads to altered synaptic proteostasis in synucleinopathies. The FEBS Journal 287:24, pages 5294-5303.
Crossref
Crossref
Stephanie J. Guiney, Paul A. Adlard, Peng Lei, Celeste H. Mawal, Ashley I. Bush, David I. Finkelstein & Scott Ayton. (2020) Fibrillar α-synuclein toxicity depends on functional lysosomes. Journal of Biological Chemistry 295:51, pages 17497-17513.
Crossref
Crossref
Senthil T. Kumar, Somanath Jagannath, Cindy Francois, Hugo Vanderstichele, Erik Stoops & Hilal A. Lashuel. (2020) How specific are the conformation-specific α-synuclein antibodies? Characterization and validation of 16 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synuclein monomers, fibrils and oligomers with distinct structures and morphology. Neurobiology of Disease 146, pages 105086.
Crossref
Crossref
Erik L. Friesen, Yu Tong Zhang, Rebecca Earnshaw, Mitch L. De Snoo, Darren M. O’Hara, Victoria Agapova, Hien Chau, Sophie Ngana, Kevin S. Chen, Lorraine V. Kalia & Suneil K. Kalia. (2020) BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62. Frontiers in Cell and Developmental Biology 8.
Crossref
Crossref
Inês Caldeira Brás, Antonio Dominguez‐Meijide, Ellen Gerhardt, David Koss, Diana F. Lázaro, Patrícia I. Santos, Eftychia Vasili, Mary Xylaki & Tiago Fleming Outeiro. (2020) Synucleinopathies: Where we are and where we need to go. Journal of Neurochemistry 153:4, pages 433-454.
Crossref
Crossref
Eduardo P. De Mattos, Anne Wentink, Carmen Nussbaum-Krammer, Christian Hansen, Steven Bergink, Ronald Melki & Harm H. Kampinga. (2020) Protein Quality Control Pathways at the Crossroad of Synucleinopathies. Journal of Parkinson's Disease 10:2, pages 369-382.
Crossref
Crossref
Antonio Heras-Garvin & Nadia Stefanova. (2020) MSA: From basic mechanisms to experimental therapeutics. Parkinsonism & Related Disorders 73, pages 94-104.
Crossref
Crossref
Annika Höhn, Antonella Tramutola & Roberta Cascella. (2020) Proteostasis Failure in Neurodegenerative Diseases: Focus on Oxidative Stress. Oxidative Medicine and Cellular Longevity 2020, pages 1-21.
Crossref
Crossref
Alain Ndayisaba & Gregor K. Wenning. (2020) Inhibition of the mammalian target or rapamycin (mTOR): a potential therapeutic strategy for multiple system atrophy. Clinical Autonomic Research 30:1, pages 7-8.
Crossref
Crossref
Caterina Masaracchia, Annekatrin König, Ariel A. Valiente-Gabioud, Pablo Peralta, Filippo Favretto, Timo Strohäker, Diana F. Lázaro, Markus Zweckstetter, Claudio O. Fernandez & Tiago F. Outeiro. (2020) Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1868:1, pages 140298.
Crossref
Crossref
Giovanni Bellomo, Silvia Paciotti, Leonardo Gatticchi & Lucilla Parnetti. (2019)
The Vicious Cycle Between
α
‐Synuclein Aggregation and Autophagic‐Lysosomal Dysfunction
. Movement Disorders 35:1, pages 34-44.
Crossref
Crossref
Benjamin H.M. Hunn, Siv Vingill, Sarah Threlfell, Javier Alegre-Abarrategui, Morgane Magdelyns, Thierry Deltheil, Nora Bengoa-Vergniory, Peter L. Oliver, Milena Cioroch, Natalie M. Doig, David M. Bannerman, Stephanie J. Cragg & Richard Wade-Martins. (2019) Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior. Cell Reports 29:4, pages 920-931.e7.
Crossref
Crossref
Pathik Parekh, Nishant Sharma, Anagha Gadepalli, Abhishekh Shahane, Monika Sharma & Amit Khairnar. (2019) A Cleaning Crew: The Pursuit of Autophagy in Parkinson’s Disease. ACS Chemical Neuroscience 10:9, pages 3914-3926.
Crossref
Crossref
Silvia Cerri & Fabio Blandini. (2019) Role of Autophagy in Parkinson’s Disease. Current Medicinal Chemistry 26:20, pages 3702-3718.
Crossref
Crossref
Marion Delenclos, Jeremy D. Burgess, Agaristi Lamprokostopoulou, Tiago F. Outeiro, Kostas Vekrellis & Pamela J. McLean. (2019) Cellular models of alpha‐synuclein toxicity and aggregation. Journal of Neurochemistry 150:5, pages 566-576.
Crossref
Crossref
Bryan A. Killinger & Jeffrey H. Kordower. (2019) Spreading of alpha‐synuclein – relevant or epiphenomenon?. Journal of Neurochemistry 150:5, pages 605-611.
Crossref
Crossref
Fiona Limanaqi, Francesca Biagioni, Carla Letizia Busceti, Larisa Ryskalin, Maico Polzella, Alessandro Frati & Francesco Fornai. (2019) Phytochemicals Bridging Autophagy Induction and Alpha-Synuclein Degradation in Parkinsonism. International Journal of Molecular Sciences 20:13, pages 3274.
Crossref
Crossref
Marie-Laure Arotcarena, Margaux Teil & Benjamin Dehay. (2019) Autophagy in Synucleinopathy: The Overwhelmed and Defective Machinery. Cells 8:6, pages 565.
Crossref
Crossref
Šárka Lehtonen, Tuuli-Maria Sonninen, Sara Wojciechowski, Gundars Goldsteins & Jari Koistinaho. (2019) Dysfunction of Cellular Proteostasis in Parkinson’s Disease. Frontiers in Neuroscience 13.
Crossref
Crossref
Georgia Minakaki, Fabio Canneva, Frédéric Chevessier, Frederik Bode, Stefanie Menges, Ivanna K. Timotius, Liubov S. Kalinichenko, Holger Meixner, Christian P. Müller, Bjoern M. Eskofier, Nicolas Casadei, Olaf Riess, Rolf Schröder, Jürgen Winkler, Wei Xiang, Stephan von Hörsten & Jochen Klucken. (2019) Treadmill exercise intervention improves gait and postural control in alpha-synuclein mouse models without inducing cerebral autophagy. Behavioural Brain Research 363, pages 199-215.
Crossref
Crossref
Nahid Olfati, Ali Shoeibi & Irene Litvan. (2019) Progress in the treatment of Parkinson-Plus syndromes. Parkinsonism & Related Disorders 59, pages 101-110.
Crossref
Crossref
Anna-Carin Hoffmann, Georgia Minakaki, Stefanie Menges, Rachele Salvi, Sergey Savitskiy, Aida Kazman, Hugo Vicente Miranda, Dirk Mielenz, Jochen Klucken, Jürgen Winkler & Wei Xiang. (2019) Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose. Scientific Reports 9:1.
Crossref
Crossref
Julia Obergasteiger, Giulia Frapporti, Peter P. Pramstaller, Andrew A. Hicks & Mattia Volta. (2018) A new hypothesis for Parkinson’s disease pathogenesis: GTPase-p38 MAPK signaling and autophagy as convergence points of etiology and genomics. Molecular Neurodegeneration 13:1.
Crossref
Crossref
Lisa Fellner, Edith Buchinger, Dominik Brueck, Regina Irschick, Gregor K. Wenning & Nadia Stefanova. (2018) Limited effects of dysfunctional macroautophagy on the accumulation of extracellularly derived α-synuclein in oligodendroglia: implications for MSA pathogenesis. BMC Neuroscience 19:1.
Crossref
Crossref
Jinyoung Youn, Sang-Bin Lee, Hyo Sang Lee, Hyun Ok Yang, Jinse Park, Ji Sun Kim, Eungseok Oh, Suyeon Park & Wooyoung Jang. (2018) Cerebrospinal Fluid Levels of Autophagy-related Proteins Represent Potentially Novel Biomarkers of Early-Stage Parkinson’s Disease. Scientific Reports 8:1.
Crossref
Crossref
Giacomo Monzio Compagnoni, Giulio Kleiner, Maura Samarani, Massimo Aureli, Gaia Faustini, Arianna Bellucci, Dario Ronchi, Andreina Bordoni, Manuela Garbellini, Sabrina Salani, Francesco Fortunato, Emanuele Frattini, Elena Abati, Christian Bergamini, Romana Fato, Silvia Tabano, Monica Miozzo, Giulia Serratto, Maria Passafaro, Michela Deleidi, Rosamaria Silipigni, Monica Nizzardo, Nereo Bresolin, Giacomo P. Comi, Stefania Corti, Catarina M. Quinzii & Alessio Di Fonzo. (2018) Mitochondrial Dysregulation and Impaired Autophagy in iPSC-Derived Dopaminergic Neurons of Multiple System Atrophy. Stem Cell Reports 11:5, pages 1185-1198.
Crossref
Crossref
Suzanne Chartier & Charles Duyckaerts. (2018) Is Lewy pathology in the human nervous system chiefly an indicator of neuronal protection or of toxicity?. Cell and Tissue Research 373:1, pages 149-160.
Crossref
Crossref
Qunxing Ding & Haiyan Zhu. (2018) Upregulation of PSMB8 and cathepsins in the human brains of dementia with Lewy bodies. Neuroscience Letters 678, pages 131-137.
Crossref
Crossref
Yung-Chih Kuo & Rajendiran Rajesh. (2018) Current development of nanocarrier delivery systems for Parkinson's disease pharmacotherapy. Journal of the Taiwan Institute of Chemical Engineers 87, pages 15-25.
Crossref
Crossref
Lilia Rodriguez, Maria M. Marano & Anurag Tandon. (2018) Import and Export of Misfolded α-Synuclein. Frontiers in Neuroscience 12.
Crossref
Crossref
Diana Macedo, Carolina Jardim, Inês Figueira, A. Filipa Almeida, Gordon J. McDougall, Derek Stewart, Jose E. Yuste, Francisco A. Tomás-Barberán, Sandra Tenreiro, Tiago F. Outeiro & Cláudia N. Santos. (2018) (Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis. Scientific Reports 8:1.
Crossref
Crossref
Elena Abati, Alessio Di Fonzo & Stefania Corti. (2018) In vitro models of multiple system atrophy from primary cells to induced pluripotent stem cells. Journal of Cellular and Molecular Medicine 22:5, pages 2536-2546.
Crossref
Crossref
Elvira Valera & Eliezer Masliah. (2018) The neuropathology of multiple system atrophy and its therapeutic implications. Autonomic Neuroscience 211, pages 1-6.
Crossref
Crossref
Jason Schapansky, Saurabh Khasnavis, Mark P. DeAndrade, Jonathan D. Nardozzi, Samuel R. Falkson, Justin D. Boyd, John B. Sanderson, Tim Bartels, Heather L. Melrose & Matthew J. LaVoie. (2018) Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons. Neurobiology of Disease 111, pages 26-35.
Crossref
Crossref
Michael P. Nelson, Michel Boutin, Tonia E. Tse, Hailin Lu, Emily D. Haley, Xiaosen Ouyang, Jianhua Zhang, Christiane Auray-Blais & John J. Shacka. (2018) The lysosomal enzyme alpha-Galactosidase A is deficient in Parkinson's disease brain in association with the pathologic accumulation of alpha-synuclein. Neurobiology of Disease 110, pages 68-81.
Crossref
Crossref
Ivanna K. Timotius, Fabio Canneva, Georgia Minakaki, Cristian Pasluosta, Sandra Moceri, Nicolas Casadei, Olaf Riess, Jürgen Winkler, Jochen Klucken, Stephan von Hörsten & Bjoern Eskofier. (2018) Dynamic footprint based locomotion sway assessment in α-synucleinopathic mice using Fast Fourier Transform and Low Pass Filter. Journal of Neuroscience Methods 296, pages 1-11.
Crossref
Crossref
Meng Zhang, Yong-Ning Deng, Jing-Yi Zhang, Jie Liu, Yan-Bo Li, Hua Su & Qiu-Min Qu. (2018) SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway. Aging and disease 9:2, pages 273.
Crossref
Crossref
Cassia Overk, Edward Rockenstein, Elvira Valera, Nadia Stefanova, Gregor Wenning & Eliezer Masliah. (2017) Multiple system atrophy: experimental models and reality. Acta Neuropathologica 135:1, pages 33-47.
Crossref
Crossref
Elvira Valera, Brian Spencer, Jennifer Mott, Margarita Trejo, Anthony Adame, Michael Mante, Edward Rockenstein, Juan C. Troncoso, Thomas G. Beach, Eliezer Masliah & Paula Desplats. (2017) MicroRNA-101 Modulates Autophagy and Oligodendroglial Alpha-Synuclein Accumulation in Multiple System Atrophy. Frontiers in Molecular Neuroscience 10.
Crossref
Crossref
Josephat M. Asiago, Trevor B. Doyle, Vartika Mishra, Aurélie de Rus Jacquet & Jean-Christophe Rochet. 2017. Oxidative Stress and Redox Signalling in Parkinson’s Disease. Oxidative Stress and Redox Signalling in Parkinson’s Disease
325
388
.
Hugo Vicente Miranda, Éva M. Szegő, Luís M. A. Oliveira, Carlo Breda, Ekrem Darendelioglu, Rita M. de Oliveira, Diana G. Ferreira, Marcos A. Gomes, Ruth Rott, Márcia Oliveira, Francesca Munari, Francisco J. Enguita, Tânia Simões, Eva F. Rodrigues, Michael Heinrich, Ivo C. Martins, Irina Zamolo, Olaf Riess, Carlos Cordeiro, Ana Ponces-Freire, Hilal A. Lashuel, Nuno C. Santos, Luisa V. Lopes, Wei Xiang, Thomas M. Jovin, Deborah Penque, Simone Engelender, Markus Zweckstetter, Jochen Klucken, Flaviano Giorgini, Alexandre Quintas & Tiago F. Outeiro. (2017) Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies. Brain 140:5, pages 1399-1419.
Crossref
Crossref
Stefanie Menges, Georgia Minakaki, Patrick M. Schaefer, Holger Meixner, Iryna Prots, Ursula Schlötzer-Schrehardt, Kristina Friedland, Beate Winner, Tiago F. Outeiro, Konstanze F. Winklhofer, Christine A. F. von Arnim, Wei Xiang, Jürgen Winkler & Jochen Klucken. (2017) Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress. Scientific Reports 7:1.
Crossref
Crossref
KerriJ Kinghorn, AmirM Asghari & JorgeIván Castillo-Quan. (2017) The emerging role of autophagic-lysosomal dysfunction in Gaucher disease and Parkinson's disease. Neural Regeneration Research 12:3, pages 380.
Crossref
Crossref
John H. T. Power, Olivia L. Barnes & Fariba Chegini. (2017) Lewy Bodies and the Mechanisms of Neuronal Cell Death in Parkinson's Disease and Dementia with Lewy Bodies. Brain Pathology 27:1, pages 3-12.
Crossref
Crossref
Alana Hoffmann, Benjamin Ettle, Ariane Bruno, Anna Kulinich, Anna-Carin Hoffmann, Julia von Wittgenstein, Jürgen Winkler, Wei Xiang & Johannes C.M. Schlachetzki. (2016) Alpha-synuclein activates BV2 microglia dependent on its aggregation state. Biochemical and Biophysical Research Communications 479:4, pages 881-886.
Crossref
Crossref
Juliana Navarro-Yepes, Annadurai Anandhan, Erin Bradley, Iryna Bohovych, Bo Yarabe, Annemieke de Jong, Huib Ovaa, You Zhou, Oleh Khalimonchuk, Betzabet Quintanilla-Vega & Rodrigo Franco. (2015) Inhibition of Protein Ubiquitination by Paraquat and 1-Methyl-4-Phenylpyridinium Impairs Ubiquitin-Dependent Protein Degradation Pathways. Molecular Neurobiology 53:8, pages 5229-5251.
Crossref
Crossref
Ying Liu, Jin Zhou, Linlin Wang, Xiaoxiao Hu, Xiangjun Liu, Meirong Liu, Zehui Cao, Dihua Shangguan & Weihong Tan. (2016) A Cyanine Dye to Probe Mitophagy: Simultaneous Detection of Mitochondria and Autolysosomes in Live Cells. Journal of the American Chemical Society 138:38, pages 12368-12374.
Crossref
Crossref
Martin Ingelsson. (2016) Alpha-Synuclein Oligomers—Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders. Frontiers in Neuroscience 10.
Crossref
Crossref
Benjamin Ettle, Johannes C. M. Schlachetzki & Jürgen Winkler. (2015) Oligodendroglia and Myelin in Neurodegenerative Diseases: More Than Just Bystanders?. Molecular Neurobiology 53:5, pages 3046-3062.
Crossref
Crossref
Susana A. Gonçalves, Diana Macedo, Helena Raquel, Pedro D. Simões, Flaviano Giorgini, José S. Ramalho, Duarte C. Barral, Luís Ferreira Moita & Tiago Fleming Outeiro. (2016) shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity. PLOS Genetics 12:4, pages e1005995.
Crossref
Crossref
Camilla Lööv, Clemens R. Scherzer, Bradley T. Hyman, Xandra O. Breakefield & Martin Ingelsson. (2016) α-Synuclein in Extracellular Vesicles: Functional Implications and Diagnostic Opportunities. Cellular and Molecular Neurobiology 36:3, pages 437-448.
Crossref
Crossref
Hugo J.R. Fernandes, Elizabeth M. Hartfield, Helen C. Christian, Evangelia Emmanoulidou, Ying Zheng, Heather Booth, Helle Bogetofte, Charmaine Lang, Brent J. Ryan, S. Pablo Sardi, Jennifer Badger, Jane Vowles, Samuel Evetts, George K. Tofaris, Kostas Vekrellis, Kevin Talbot, Michele T. Hu, William James, Sally A. Cowley & Richard Wade-Martins. (2016) ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons. Stem Cell Reports 6:3, pages 342-356.
Crossref
Crossref
E. Valera, G. Monzio Compagnoni & E. Masliah. (2016) Review: Novel treatment strategies targeting alpha-synuclein in multiple system atrophy as a model of synucleinopathy. Neuropathology and Applied Neurobiology 42:1, pages 95-106.
Crossref
Crossref
Darius Ebrahimi-Fakhari, Afshin Saffari, Lara Wahlster, Jenny Lu, Susan Byrne, Georg F. Hoffmann, Heinz Jungbluth & Mustafa Sahin. (2016) Congenital disorders of autophagy: an emerging novel class of inborn errors of neuro-metabolism. Brain 139:2, pages 317-337.
Crossref
Crossref
Maria Xilouri, Oeystein Roed Brekk & Leonidas Stefanis. (2016) Autophagy and Alpha-Synuclein: Relevance to Parkinson's Disease and Related Synucleopathies. Movement Disorders 31:2, pages 178-192.
Crossref
Crossref
Arnaud Francois, Julie Verite, Agnès Rioux Bilan, Thierry Janet, Frédéric Calon, Bernard Fauconneau, Marc Paccalin & Guylène Page. 2016. Molecules to Medicine with mTOR. Molecules to Medicine with mTOR
85
104
.
Shamol Saha, Peter E. A. Ash, Vivek Gowda, Liqun Liu, Orian Shirihai & Benjamin Wolozin. (2015) Mutations in LRRK2 potentiate age-related impairment of autophagic flux. Molecular Neurodegeneration 10:1.
Crossref
Crossref
Annadurai Anandhan, Humberto Rodriguez-Rocha, Iryna Bohovych, Amy M. Griggs, Laura Zavala-Flores, Elsa M. Reyes-Reyes, Javier Seravalli, Lia A. Stanciu, Jaekwon Lee, Jean-Christophe Rochet, Oleh Khalimonchuk & Rodrigo Franco. (2015) Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways. Neurobiology of Disease 81, pages 76-92.
Crossref
Crossref
Warunee Dansithong, Sharan Paul, Daniel R. Scoles, Stefan M. Pulst & Duong P. Huynh. (2015) Generation of SNCA Cell Models Using Zinc Finger Nuclease (ZFN) Technology for Efficient High-Throughput Drug Screening. PLOS ONE 10:8, pages e0136930.
Crossref
Crossref
Diana Macedo, Lucélia Tavares, Gordon J. McDougall, Hugo Vicente Miranda, Derek Stewart, Ricardo B. Ferreira, Sandra Tenreiro, Tiago F. Outeiro & Cláudia N. Santos. (2015) (Poly)phenols protect from α-synuclein toxicity by reducing oxidative stress and promoting autophagy. Human Molecular Genetics 24:6, pages 1717-1732.
Crossref
Crossref
Wei Xiang, Stefanie Menges, Johannes Schlachetzki, Holger Meixner, Anna-Carin Hoffmann, Ursula Schlötzer-Schrehardt, Cord-Michael Becker, Jürgen Winkler & Jochen Klucken. (2015) Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity. Molecular Neurodegeneration 10:1, pages 8.
Crossref
Crossref
Atsushi Tsujimura, Katsutoshi Taguchi, Yoshihisa Watanabe, Harutsugu Tatebe, Takahiko Tokuda, Toshiki Mizuno & Masaki Tanaka. (2015) Lysosomal enzyme cathepsin B enhances the aggregate forming activity of exogenous α-synuclein fibrils. Neurobiology of Disease 73, pages 244-253.
Crossref
Crossref
Natacha Joyon & Charles Duyckaerts. 2015. La maladie de Parkinson. La maladie de Parkinson
33
44.e2
.
O. Chutna, S. Goncalves, A. Villar-Pique, P. Guerreiro, Z. Marijanovic, T. Mendes, J. Ramalho, E. Emmanouilidou, S. Ventura, J. Klucken, D. C. Barral, F. Giorgini, K. Vekrellis & T. F. Outeiro. (2014) The small GTPase Rab11 co-localizes with ?-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity. Human Molecular Genetics 23:25, pages 6732-6745.
Crossref
Crossref
Diana F. Lázaro, Eva F. Rodrigues, Ramona Langohr, Hedieh Shahpasandzadeh, Thales Ribeiro, Patrícia Guerreiro, Ellen Gerhardt, Katharina Kröhnert, Jochen Klucken, Marcos D. Pereira, Blagovesta Popova, Niels Kruse, Brit Mollenhauer, Silvio O. Rizzoli, Gerhard H. Braus, Karin M. Danzer & Tiago F. Outeiro. (2014) Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation. PLoS Genetics 10:11, pages e1004741.
Crossref
Crossref
Peizhou Jiang, Ming Gan, Wen-Lang Lin & Shu-Hui C. Yen. (2014) Nutrient deprivation induces α-synuclein aggregation through endoplasmic reticulum stress response and SREBP2 pathway. Frontiers in Aging Neuroscience 6.
Crossref
Crossref
Verena E.L. May, Benjamin Ettle, Anne-Maria Poehler, Silke Nuber, Kiren Ubhi, Edward Rockenstein, Beate Winner, Michael Wegner, Eliezer Masliah & Jürgen Winkler. (2014) α-Synuclein impairs oligodendrocyte progenitor maturation in multiple system atrophy. Neurobiology of Aging 35:10, pages 2357-2368.
Crossref
Crossref
Hyun Jung Park, Jin Young Shin, Ha Na Kim, Se Hee Oh & Phil Hyu Lee. (2014) Neuroprotective effects of mesenchymal stem cells through autophagy modulation in a parkinsonian model. Neurobiology of Aging 35:8, pages 1920-1928.
Crossref
Crossref
Matthias Höllerhage, Joachim N. Goebel, Anderson de Andrade, Tobias Hildebrandt, Amalia Dolga, Carsten Culmsee, Wolfgang H. Oertel, Bastian Hengerer & Günter U. Höglinger. (2014) Trifluoperazine rescues human dopaminergic cells from wild-type α-synuclein-induced toxicity. Neurobiology of Aging 35:7, pages 1700-1711.
Crossref
Crossref
N. Plotegher, E. Gratton & L. Bubacco. (2014) Number and Brightness analysis of alpha-synuclein oligomerization and the associated mitochondrial morphology alterations in live cells. Biochimica et Biophysica Acta (BBA) - General Subjects 1840:6, pages 2014-2024.
Crossref
Crossref
Leandra R. Mangieri, Burton J. Mader, Cailin E. Thomas, Charles A. Taylor, Austin M. Luker, Tonia E. Tse, Carrie Huisingh & John J. Shacka. (2014) ATP6V0C Knockdown in Neuroblastoma Cells Alters Autophagy-Lysosome Pathway Function and Metabolism of Proteins that Accumulate in Neurodegenerative Disease. PLoS ONE 9:4, pages e93257.
Crossref
Crossref
Sunyang Kang, Tae-Hwe Heo & Sung-Jo Kim. (2014) Altered levels of α-synuclein and sphingolipids in Batten disease lymphoblast cells. Gene 539:2, pages 181-185.
Crossref
Crossref
Nicolas Casadei, Anne-Maria Pöhler, Cristina Tomás-Zapico, Jesús Torres-Peraza, Ivo Schwedhelm, Annemarie Witz, Irina Zamolo, Raymond De Heer, Berry Spruijt, Lucas P.J.J. Noldus, Jochen Klucken, José J. Lucas, Philipp J. Kahle, Rejko Krüger, Olaf Riess & Silke Nuber. (2014) Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice. Human Molecular Genetics 23:3, pages 767-781.
Crossref
Crossref
Darius Ebrahimi-Fakhari, Laiq-Jan Saidi & Lara Wahlster. (2013) Molecular chaperones and protein folding as therapeutic targets in Parkinson’s disease and other synucleinopathies. Acta Neuropathologica Communications 1:1.
Crossref
Crossref
David Amschl, Jörg Neddens, Daniel Havas, Stefanie Flunkert, Roland Rabl, Heinrich Römer, Edward Rockenstein, Eliezer Masliah, Manfred Windisch & Birgit Hutter-Paier. (2013) Time course and progression of wild type α-Synuclein accumulation in a transgenic mouse model. BMC Neuroscience 14:1.
Crossref
Crossref
Maria Xilouri, Oeystein Roed Brekk, Natalie Landeck, Pothitos M. Pitychoutis, Themistoklis Papasilekas, Zoi Papadopoulou-Daifoti, Deniz Kirik & Leonidas Stefanis. (2013) Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration. Brain 136:7, pages 2130-2146.
Crossref
Crossref
Johannes C.M. Schlachetzki, Soraya Wilke Saliba & Antonio Carlos Pinheiro de Oliveira. (2013) Studying neurodegenerative diseases in culture models. Revista Brasileira de Psiquiatria 35:suppl 2, pages S92-S100.
Crossref
Crossref
Darius Ebrahimi-Fakhari, Lara Wahlster & Pamela J. McLean. (2012) Protein degradation pathways in Parkinson?s disease: curse or blessing. Acta Neuropathologica 124:2, pages 153-172.
Crossref
Crossref