Citations (77)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (8)
Qiannan Ren, Qiming Sun & Junfen Fu. (2023) Dysfunction of autophagy in high-fat diet-induced nonalcoholic fatty liver disease. Autophagy 0:0, pages 1-21.
Read now
Read now
Ming Tong, Qing Zheng, Meng Liu, Liang Chen, Yi-He Lin, Shi–Gang Tang & Yi-Min Zhu. (2021) 5-methoxytryptophan alleviates liver fibrosis by modulating FOXO3a/miR-21/ATG5 signaling pathway mediated autophagy. Cell Cycle 20:7, pages 676-688.
Read now
Read now
Monique Bernard, Bing Yang, Francis Migneault, Julie Turgeon, Mélanie Dieudé, Marc-Alexandre Olivier, Guillaume B Cardin, Mostafa El-Diwany, Katy Underwood, Francis Rodier & Marie-Josée Hébert. (2020) Autophagy drives fibroblast senescence through MTORC2 regulation. Autophagy 16:11, pages 2004-2016.
Read now
Read now
Zili Zhang, Mei Guo, Yujia Li, Min Shen, Desong Kong, Jiangjuan Shao, Hai Ding, Shanzhong Tan, Anping Chen, Feng Zhang & Shizhong Zheng. (2020) RNA-binding protein ZFP36/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells. Autophagy 16:8, pages 1482-1505.
Read now
Read now
Zili Zhang, Zhen Yao, Ling Wang, Hai Ding, Jiangjuan Shao, Anping Chen, Feng Zhang & Shizhong Zheng. (2018) Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells. Autophagy 14:12, pages 2083-2103.
Read now
Read now
Shi Chen, Juxiang Yuan, Sanqiao Yao, Yulan Jin, Gang Chen, Wei Tian, Jinkun Xi, Zhelong Xu, Dong Weng & Jie Chen. (2015) Lipopolysaccharides may aggravate apoptosis through accumulation of autophagosomes in alveolar macrophages of human silicosis. Autophagy 11:12, pages 2346-2357.
Read now
Read now
Yu Fujita, Jun Araya, Saburo Ito, Kenji Kobayashi, Nobuyoshi Kosaka, Yusuke Yoshioka, Tsukasa Kadota, Hiromichi Hara, Kazuyoshi Kuwano & Takahiro Ochiya. (2015) Suppression of autophagy by extracellular vesicles promotes myofibroblast differentiation in COPD pathogenesis. Journal of Extracellular Vesicles 4:1.
Read now
Read now
Monique Bernard, Mélanie Dieudé, Bing Yang, Katia Hamelin, Katy Underwood & Marie-Josée Hébert. (2014) Autophagy fosters myofibroblast differentiation through MTORC2 activation and downstream upregulation of CTGF. Autophagy 10:12, pages 2193-2207.
Read now
Read now
Articles from other publishers (69)
YuChen Jiang, LiShuang Hou, JiaYi Dou, MeiYan Xuan, ZhenYu Cui, LiHua Lian, JiXing Nan & YanLing Wu. (2024) Sesamol as a potential candidate for the treatment of hepatic fibrosis, based on its regulation of FXR/LXR axis-mediated inhibition of autophagy through crosstalk between hepatic cells and macrophage. Phytomedicine 123, pages 155145.
Crossref
Crossref
Ying Wu, Ai-Hong Yin, Jun-Tao Sun, Wei-Hua Xu & Chun-Qing Zhang. (2023) Angiotensin-converting enzyme 2 improves liver fibrosis in mice by regulating autophagy of hepatic stellate cells. World Journal of Gastroenterology 29:33, pages 4975-4990.
Crossref
Crossref
Jinsheng Huang, Huiling Huang, Yiyao Wang, Bin Xu, Minzhao Lin, Shisong Han, Yuanyuan Yuan, Yong Wang & Xintao Shuai. (2023) Retinol-binding protein-hijacking nanopolyplex delivering siRNA to cytoplasm of hepatic stellate cell for liver fibrosis alleviation. Biomaterials, pages 122134.
Crossref
Crossref
Ki M. Mak, Catherine Wu & Christopher P. Cheng. (2022) Lipid droplets, the Holy Grail of hepatic stellate cells: In health and hepatic fibrosis. The Anatomical Record 306:5, pages 983-1010.
Crossref
Crossref
Trinh Van Le, Hong-Thuy Phan-Thi, My-Xuan Huynh-Thi, Thanh Minh Dang, Ai Xuan Le Holterman, Gabriele Grassi, Thao-Uyen Nguyen-Luu & Nhung Hai Truong. (2023) Autophagy Inhibitor Chloroquine Downmodulates Hepatic Stellate Cell Activation and Liver Damage in Bile-Duct-Ligated Mice. Cells 12:7, pages 1025.
Crossref
Crossref
Xiangyun Tan, Xinyu Huang, Zhuhang Lu, Liang Chen, Junjie Hu, Xianxiang Tian & Zhenpeng Qiu. (2023) The essential effect of mTORC1-dependent lipophagy in non-alcoholic fatty liver disease. Frontiers in Pharmacology 14.
Crossref
Crossref
Lingxuan An, Ulrich Wirth, Dominik Koch, Malte Schirren, Moritz Drefs, Dionysios Koliogiannis, Hanno Niess, Joachim Andrassy, Markus Guba, Alexandr V. Bazhin, Jens Werner & Florian Kühn. (2023) Metabolic Role of Autophagy in the Pathogenesis and Development of NAFLD. Metabolites 13:1, pages 101.
Crossref
Crossref
Sarah B. White & Dilip Rajasekhar Maddirela. 2023.
Xue Wu, Xue-qi Liu, Zhen-ni Liu, Guo-qing Xia, Hong Zhu, Meng-da Zhang, Bao-ming Wu & Xiong-wen Lv. (2022) CD73 aggravates alcohol-related liver fibrosis by promoting autophagy mediated activation of hepatic stellate cells through AMPK/AKT/mTOR signaling pathway. International Immunopharmacology 113, pages 109229.
Crossref
Crossref
Yuqin Zhang, Liping Hua, Chunfeng Lin, Mingzhou Yuan, Wei Xu, Anand Raj D.Baskar Venkidasamy, Carlos L. Cespedes-Acuna, Shivraj Hariram Nile, Guohong Yan & Haiyin Zheng. (2022) Pien-Tze-Huang alleviates CCl4-induced liver fibrosis through the inhibition of HSC autophagy and the TGF-β1/Smad2 pathway. Frontiers in Pharmacology 13.
Crossref
Crossref
Siyu Chen, Ziwei He, Wei Xie, Xuan Chen, Zhuofeng Lin, Jisheng Ma, Zhi Liu, Shihai Yang & Yanfang Wang. (2022) Ginsenoside Rh2 attenuates CDAHFD-induced liver fibrosis in mice by improving intestinal microbial composition and regulating LPS-mediated autophagy. Phytomedicine 101, pages 154121.
Crossref
Crossref
Marcos F. Fondevila, Uxia Fernandez, Violeta Heras, Tamara Parracho, Maria J. Gonzalez-Rellan, Eva Novoa, Begoña Porteiro, Cristina Alonso, Rebeca Mayo, Natalia da Silva Lima, Cristina Iglesias, Aveline A. Filliol, Ana Senra, Teresa C. Delgado, Ashwin Woodhoo, Laura Herrero, Dolors Serra, Vincent Prevot, Markus Schwaninger, Miguel López, Carlos Dieguez, Oscar Millet, Jose M. Mato, Francisco J. Cubero, Marta Varela-Rey, Paula Iruzubieta, Javier Crespo, Maria L. Martinez-Chantar, Robert F. Schwabe & Ruben Nogueiras. (2022) Inhibition of carnitine palmitoyltransferase 1A in hepatic stellate cells protects against fibrosis. Journal of Hepatology 77:1, pages 15-28.
Crossref
Crossref
Xianzhi Liu, Lifu Wang, Siwei Tan, Zebin Chen, Bin Wu & Xiaoying Wu. (2022) Therapeutic Effects of Berberine on Liver Fibrosis are associated With Lipid Metabolism and Intestinal Flora. Frontiers in Pharmacology 13.
Crossref
Crossref
Yu Xiong, Jinyuan Hu, Chen Xuan, Jiayu Tian, Kaiyue Tan, Zhiwei Chen, Yan Luo, Xuqin Du, Junxiong Cheng, Lanyue Zhang & Wenfu Cao. (2021) Transcriptome analysis reveals the molecular mechanism of Yiqi Rougan decoction in reducing CCl4-induced liver fibrosis in rats. Chinese Medicine 16:1.
Crossref
Crossref
Chang-Hsun Ho, Jen-Hsuan Huang, Maw-Sheng Sun, I-Shiang Tzeng, Yi-Chiung Hsu & Chan-Yen Kuo. (2021) Wild Bitter Melon Extract Regulates LPS-Induced Hepatic Stellate Cell Activation, Inflammation, Endoplasmic Reticulum Stress, and Ferroptosis. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-11.
Crossref
Crossref
Don C. Rockey & Scott L. Friedman. (2021) Fibrosis Regression After Eradication of Hepatitis C Virus: From Bench to Bedside. Gastroenterology 160:5, pages 1502-1520.e1.
Crossref
Crossref
Parth Trivedi, Shuang Wang & Scott L. Friedman. (2021) The Power of Plasticity—Metabolic Regulation of Hepatic Stellate Cells. Cell Metabolism 33:2, pages 242-257.
Crossref
Crossref
Ye Tao, Tianming Qiu, Xiaofeng Yao, Liping Jiang, Ningning Wang, Jintong Jiang, Xue Jia, Sen Wei, Jingyuan Zhang, Yuhan Zhu, Wenyue Tian, Guang Yang, Xiaofang Liu, Shuang Liu, Yang Ding & Xiance Sun. (2020)
IRE1α/NOX4 signaling pathway mediates ROS‐dependent activation of hepatic stellate cells in NaAsO
2
‐induced liver fibrosis
. Journal of Cellular Physiology 236:2, pages 1469-1480.
Crossref
Crossref
Jie Ji, Qiang Yu, Weiqi Dai, Liwei Wu, Jiao Feng, Yuanyuan Zheng, Yan Li & Chuanyong Guo. (2021) Apigenin Alleviates Liver Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Autophagy via TGF-β1/Smad3 and p38/PPARα Pathways. PPAR Research 2021, pages 1-15.
Crossref
Crossref
Raquel Maeso-Díaz & Jordi Gracia-Sancho. (2020) Aging and Chronic Liver Disease. Seminars in Liver Disease 40:04, pages 373-384.
Crossref
Crossref
Naroa Insausti-Urkia, Estel Solsona-Vilarrasa, Carmen Garcia-Ruiz & Jose C. Fernandez-Checa. (2020) Sphingomyelinases and Liver Diseases. Biomolecules 10:11, pages 1497.
Crossref
Crossref
M. S. Abdel-Bakky, G. K. Helal, E. M. El-Sayed, A. H. Alhowail, A. M. Mansour, K. S. Alharbi, Elham Amin, S. Allam, S. A. Salama & A. S. Saad. (2020) Silencing of tissue factor by antisense deoxyoligonucleotide mitigates thioacetamide-induced liver injury. Naunyn-Schmiedeberg's Archives of Pharmacology 393:10, pages 1887-1898.
Crossref
Crossref
Ye Tao, Ningning Wang, Tianming Qiu & Xiance Sun. (2020) The Role of Autophagy and NLRP3 Inflammasome in Liver Fibrosis. BioMed Research International 2020, pages 1-8.
Crossref
Crossref
Jinku Bao, Bo Liu & Chuanfang Wu. 2020. Autophagy: Biology and Diseases. Autophagy: Biology and Diseases
689
697
.
Mirella Pastore, Alessandra Gentilini & Fabio Marra. 2020. Non-Alcoholic Fatty Liver Disease. Non-Alcoholic Fatty Liver Disease
97
127
.
Zili Zhang, Mei Guo, Min Shen, Yujia Li, Shanzhong Tan, Jiangjuan Shao, Feng Zhang, Anping Chen, Shijun Wang & Shizhong Zheng. (2019) Oroxylin A regulates the turnover of lipid droplet via downregulating adipose triglyceride lipase (ATGL) in hepatic stellate cells. Life Sciences 238, pages 116934.
Crossref
Crossref
Gaurav Gupta, Forough Khadem & Jude E. Uzonna. (2019) Role of hepatic stellate cell (HSC)-derived cytokines in hepatic inflammation and immunity. Cytokine 124, pages 154542.
Crossref
Crossref
M. Prashanth Goud, Swarna Bale, Gauthami Pulivendala & Chandraiah Godugu. (2019) Therapeutic effects of Nimbolide, an autophagy regulator, in ameliorating pulmonary fibrosis through attenuation of TGF-β1 driven epithelial-to-mesenchymal transition. International Immunopharmacology 75, pages 105755.
Crossref
Crossref
Maeso-Díaz, Boyer-Diaz, Lozano, Ortega-Ribera, Peralta, Bosch & Gracia-Sancho. (2019) New Rat Model of Advanced NASH Mimicking Pathophysiological Features and Transcriptomic Signature of The Human Disease. Cells 8:9, pages 1062.
Crossref
Crossref
Ning Liu, Jiao Feng, Xiya Lu, Zhilu Yao, Qing Liu, Yang Lv, Yuru Han, Jingfan Deng & Yingqun Zhou. (2019)
Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-
β
1/Smad3 and TGF-
β
1/p38 MAPK Pathways
. Mediators of Inflammation 2019, pages 1-14.
Crossref
Crossref
Kebing Zhou, Pingbo Yao, Jun He & Hong Zhao. (2018) Lipophagy in nonliver tissues and some related diseases: Pathogenic and therapeutic implications. Journal of Cellular Physiology 234:6, pages 7938-7947.
Crossref
Crossref
Igor O. Shmarakov, Hongfeng Jiang, Jing Liu, Elias J. Fernandez & William S. Blaner. (2019) Hepatic stellate cell activation: A source for bioactive lipids. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1864:5, pages 629-642.
Crossref
Crossref
Guenter Haemmerle & Achim Lass. (2019) Genetically modified mouse models to study hepatic neutral lipid mobilization. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1865:5, pages 879-894.
Crossref
Crossref
Li-Hua Cui, Cai-Xia Li, Yu-Zhen Zhuo, Lei Yang, Nai-Qiang Cui & Shu-Kun Zhang. (2019) Saikosaponin d ameliorates pancreatic fibrosis by inhibiting autophagy of pancreatic stellate cells via PI3K/Akt/mTOR pathway. Chemico-Biological Interactions 300, pages 18-26.
Crossref
Crossref
Wei Hou & Wing-Kin Syn. (2018) Role of Metabolism in Hepatic Stellate Cell Activation and Fibrogenesis. Frontiers in Cell and Developmental Biology 6.
Crossref
Crossref
Marie Bobowski-Gerard, Francesco Zummo, Bart Staels, Philippe Lefebvre & Jérôme Eeckhoute. (2018) Retinoids Issued from Hepatic Stellate Cell Lipid Droplet Loss as Potential Signaling Molecules Orchestrating a Multicellular Liver Injury Response. Cells 7:9, pages 137.
Crossref
Crossref
Cai-Xia Li, Li-Hua Cui, Yu-Zhen Zhuo, Jian-Gong Hu, Nai-qiang Cui & Shu-Kun Zhang. (2018) Inhibiting autophagy promotes collagen degradation by regulating matrix metalloproteinases in pancreatic stellate cells. Life Sciences 208, pages 276-283.
Crossref
Crossref
Jing Li, Chuxiong Zeng, Beishi Zheng, Chun Liu, Min Tang, Yan Jiang, Yizhong Chang, Weiping Song, Yingxin Wang & Changqing Yang. (2018) HMGB1-induced autophagy facilitates hepatic stellate cells activation: a new pathway in liver fibrosis. Clinical Science 132:15, pages 1645-1667.
Crossref
Crossref
Paula Constanza Arriola Benitez, Ayelén Ivana Pesce Viglietti, Claudia Karina Herrmann, Vida A. Dennis, Diego José Comerci, Guillermo Hernán Giambartolomei & María Victoria Delpino. (2018) Brucella abortus Promotes a Fibrotic Phenotype in Hepatic Stellate Cells, with Concomitant Activation of the Autophagy Pathway. Infection and Immunity 86:1.
Crossref
Crossref
Zili Zhang, Zhen Yao, Yifan Chen, Lei Qian, Shuoyi Jiang, Jingyi Zhou, Jiangjuan Shao, Anping Chen, Feng Zhang & Shizhong Zheng. (2018) Lipophagy and liver disease: New perspectives to better understanding and therapy. Biomedicine & Pharmacotherapy 97, pages 339-348.
Crossref
Crossref
Kangkang Yu, Ning Li, Qi Cheng, Jianming Zheng, Mengqi Zhu, Suxia Bao, Mingquan Chen & Guangfeng Shi. (2017) miR-96-5p prevents hepatic stellate cell activation by inhibiting autophagy via ATG7. Journal of Molecular Medicine 96:1, pages 65-74.
Crossref
Crossref
Zili Zhang, Shifeng Zhao, Zhen Yao, Ling Wang, Jiangjuan Shao, Anping Chen, Feng Zhang & Shizhong Zheng. (2017) Autophagy regulates turnover of lipid droplets via ROS-dependent Rab25 activation in hepatic stellate cell. Redox Biology 11, pages 322-334.
Crossref
Crossref
Don C. Rockey. (2016) Liver Fibrosis Reversion After Suppression of Hepatitis B Virus. Clinics in Liver Disease 20:4, pages 667-679.
Crossref
Crossref
Benoit Lacoste, Valérie-Ann Raymond, Pascal Lapierre & Marc Bilodeau. (2016) Protection against Acute Hepatocellular Injury Afforded by Liver Fibrosis Is Independent of T Lymphocytes. PLOS ONE 11:10, pages e0165360.
Crossref
Crossref
Albert J. Czaja. (2016) Nature and Implications of Oxidative and Nitrosative Stresses in Autoimmune Hepatitis. Digestive Diseases and Sciences 61:10, pages 2784-2803.
Crossref
Crossref
M. Granato, C. Zompetta, E. Vescarelli, C. Rizzello, A. Cardi, S. Valia, G. Antonelli, C. Marchese, M. R. Torrisi, A. Faggioni & M. Cirone. (2016) HCV derived from sera of HCV-infected patients induces pro-fibrotic effects in human primary fibroblasts by activating GLI2. Scientific Reports 6:1.
Crossref
Crossref
Yusaku Miyamae, Yukina Nishito, Naomi Nakai, Yoko Nagumo, Takeo Usui, Seiji Masuda, Taiho Kambe & Masaya Nagao. (2016) Tetrandrine induces lipid accumulation through blockade of autophagy in a hepatic stellate cell line. Biochemical and Biophysical Research Communications 477:1, pages 40-46.
Crossref
Crossref
Jiang Li, Ting‑Ting Zhao, Peng Zhang, Chao‑Jin Xu, Zhuo‑Xiang Rong, Zi‑Yi Yan & Chang‑Yun Fang. (2016) Autophagy mediates oral submucous fibrosis. Experimental and Therapeutic Medicine.
Crossref
Crossref
Cecilia G. Sanchez. 2016. Advances in Geroscience. Advances in Geroscience
429
470
.
Don C Rockey. 2015. Yamada' s Textbook of Gastroenterology. Yamada' s Textbook of Gastroenterology
2070
2086
.
Carmen Garcia-Ruiz & José Fernández-Checa. 2015. Mitochondria in Liver Disease. Mitochondria in Liver Disease
433
450
.
Alessandra Caligiuri & Fabio Marra. 2015. Signaling Pathways in Liver Diseases. Signaling Pathways in Liver Diseases
34
60
.
Yingli He, Li Jin, Jing Wang, Zhi Yan, Tianyan Chen & Yingren Zhao. (2015) Mechanisms of fibrosis in acute liver failure. Liver International 35:7, pages 1877-1885.
Crossref
Crossref
Yu-Qing Mao. (2015) Autophagy: A new therapeutic target for liver fibrosis. World Journal of Hepatology 7:16, pages 1982.
Crossref
Crossref
Carmen Garcia-Ruiz, Jose M. Mato, Dennis Vance, Neil Kaplowitz & Jos? C. Fern?ndez-Checa. (2015) Acid sphingomyelinase-ceramide system in steatohepatitis: A novel target regulating multiple pathways. Journal of Hepatology 62:1, pages 219-233.
Crossref
Crossref
Daisuke Hasegawa, Michael C. Wallace & Scott L. Friedman. 2015. Stellate Cells in Health and Disease. Stellate Cells in Health and Disease
41
62
.
Flavia V. Castelino & John Varga. (2014) Emerging cellular and molecular targets in fibrosis. Current Opinion in Rheumatology 26:6, pages 607-614.
Crossref
Crossref
Jing Deng, Qin Huang, Yueqin Wang, Pei Shen, Fei Guan, Jianrong Li, Hanju Huang & Chunwei Shi. (2014) Hypoxia-inducible factor-1alpha regulates autophagy to activate hepatic stellate cells. Biochemical and Biophysical Research Communications 454:2, pages 328-334.
Crossref
Crossref
Kuan-Wei Lee, Varadharajan Thiyagarajan, Huei-Wun Sie, Ming-Fan Cheng, May-Jywan Tsai, Yi-Chen Chia & Ching-Feng Weng. (2014) Synergistic effect of natural compounds on the fatty acid-induced autophagy of activated hepatic stellate cells. The Journal of Nutritional Biochemistry 25:9, pages 903-913.
Crossref
Crossref
Yang Song, Yingying Zhao, Fei Wang, Lichan Tao, Junjie Xiao & Changqing Yang. (2014) Autophagy in Hepatic Fibrosis. BioMed Research International 2014, pages 1-8.
Crossref
Crossref
Abigale Lade, Luke A. Noon & Scott L. Friedman. (2014) Contributions of metabolic dysregulation and inflammation to nonalcoholic steatohepatitis, hepatic fibrosis, and cancer. Current Opinion in Oncology 26:1, pages 100-107.
Crossref
Crossref
D.C. Rockey. 2014. Pathobiology of Human Disease. Pathobiology of Human Disease
1809
1816
.
Xin-yan Jing, Xue-feng Yang, Kai Qing & Yan Ou-Yang. (2013) Roles of the Lipid Metabolism in Hepatic Stellate Cells Activation. Chinese Medical Sciences Journal 28:4, pages 233-236.
Crossref
Crossref
Victor J. Thannickal. (2013) Mechanistic links between aging and lung fibrosis. Biogerontology 14:6, pages 609-615.
Crossref
Crossref
Juan E. Puche, Yedidya Saiman & Scott L. Friedman. 2011. Comprehensive Physiology. Comprehensive Physiology
1473
1492
.
Xinyan JING & Xuefeng YANG. (2013) The effect of lipid metabolism on biological characteristics of hepatic stellate cell. Journal of Medical Colleges of PLA 28:5, pages 281-288.
Crossref
Crossref
Don C. Rockey. (2013) Translating an Understanding of the Pathogenesis of Hepatic Fibrosis to Novel Therapies. Clinical Gastroenterology and Hepatology 11:3, pages 224-231.e5.
Crossref
Crossref
Domenico Del Principe, Pasquale Lista, Walter Malorni & Anna Maria Giammarioli. (2012) Fibroblast autophagy in fibrotic disorders. The Journal of Pathology 229:2, pages 208-220.
Crossref
Crossref
XiongWen LV, Xue Wu, Zhenni Liu, Xueqi Liu, Guoqing Xia, Hong Zhu, Mengda Zhang & Baoming Wu. (2022) CD73 Aggravates Alcohol-Related Liver Fibrosis by Promoting Autophagy Mediated Activation of Hepatic Stellate Cells Through Ampk/Akt/Mtor Signaling Pathway. SSRN Electronic Journal.
Crossref
Crossref