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Autophagy Volume 8, 2012 - Issue 6
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Hormesis

Protecting neurons against cellular stress in Parkinson disease

Soledad Matus Biomedical Neuroscience Institute; Faculty of Medicine; University of Chile; Santiago, Chile; Center for Molecular Studies of the Cell; Institute of Biomedical Sciences; University of Chile; Santiago, Chile; Neurounion Biomedical Foundation; Santiago, ChileCorrespondence[email protected] [email protected]
,
Karen Castillo Biomedical Neuroscience Institute; Faculty of Medicine; University of Chile; Santiago, Chile; Center for Molecular Studies of the Cell; Institute of Biomedical Sciences; University of Chile; Santiago, Chile
&
Claudio Hetz Biomedical Neuroscience Institute; Faculty of Medicine; University of Chile; Santiago, Chile; Center for Molecular Studies of the Cell; Institute of Biomedical Sciences; University of Chile; Santiago, Chile; Neurounion Biomedical Foundation; Santiago, Chile; Department of Immunology and Infectious diseases; Harvard School of Public Health; Boston, MA USACorrespondence[email protected] [email protected]
Pages 997-1001 | Published online: 01 Jun 2012

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Huma Rizwan, Jagdeep Mohanta, Satyabrata Si & Arttatrana Pal. (2017) Gold nanoparticles reduce high glucose-induced oxidative-nitrosative stress regulated inflammation and apoptosis via tuberin-mTOR/NF-κB pathways in macrophages. International Journal of Nanomedicine 12, pages 5841-5862.
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Ilmari Parkkinen, Anna Their, Muhammad Yasir Asghar, Sreesha Sree, Eija Jokitalo & Mikko Airavaara. (2023) Pharmacological Regulation of Endoplasmic Reticulum Structure and Calcium Dynamics: Importance for Neurodegenerative Diseases. Pharmacological Reviews 75:5, pages 959-978.
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Michael N. Moore. (2020) Lysosomes, Autophagy, and Hormesis in Cell Physiology, Pathology, and Age-Related Disease. Dose-Response 18:3, pages 155932582093422.
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Zheng Mou, Yu-he Yuan, Zhao Zhang, Lian-kun Song & Nai-Hong Chen. (2020) Endoplasmic reticulum stress, an important factor in the development of Parkinson’s disease. Toxicology Letters 324, pages 20-29.
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Crossref
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Rehana K. Leak. (2013) Adaptation and Sensitization to Proteotoxic Stress. Dose-Response 12:1, pages dose-response.1.
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Saeid Ghavami, Shahla Shojaei, Behzad Yeganeh, Sudharsana R. Ande, Jaganmohan R. Jangamreddy, Maryam Mehrpour, Jonas Christoffersson, Wiem Chaabane, Adel Rezaei Moghadam, Hessam H. Kashani, Mohammad Hashemi, Ali A. Owji & Marek J. Łos. (2014) Autophagy and apoptosis dysfunction in neurodegenerative disorders. Progress in Neurobiology 112, pages 24-49.
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Akhlaq A. FarooquiAkhlaq A. Farooqui. 2014. Inflammation and Oxidative Stress in Neurological Disorders. Inflammation and Oxidative Stress in Neurological Disorders 263 285 .
Bin Xu, Ming Shan, Fei Wang, Yu Deng, Wei Liu, Shu Feng, Tian-Yao Yang & Zhao-Fa Xu. (2013) Endoplasmic reticulum stress signaling involvement in manganese-induced nerve cell damage in organotypic brain slice cultures. Toxicology Letters 222:3, pages 239-246.
Crossref
Carolin CorneliusRosalia CrupiVittorio CalabreseAntonio GrazianoPietro MiloneGiovanni PennisiZsolt RadakEdward J. CalabreseSalvatore Cuzzocrea. (2013) Traumatic Brain Injury: Oxidative Stress and Neuroprotection. Antioxidants & Redox Signaling 19:8, pages 836-853.
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Soledad Matus, Estefan?a Lopez, Vicente Valenzuela, Melissa Nassif & Claudio Hetz. (2013) Functional Contribution of the Transcription Factor ATF4 to the Pathogenesis of Amyotrophic Lateral Sclerosis. PLoS ONE 8:7, pages e66672.
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Lei Mao & Jacqueline Franke. (2013) Hormesis in Aging and Neurodegeneration—A Prodigy Awaiting Dissection. International Journal of Molecular Sciences 14:7, pages 13109-13128.
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Gabriela Mercado, Pamela Vald?s & Claudio Hetz. (2013) An ERcentric view of Parkinson's disease. Trends in Molecular Medicine 19:3, pages 165-175.
Crossref
Trevor Archer & Richard M. Kostrzewa. 2013. Adaptive and Maladaptive Aspects of Developmental Stress. Adaptive and Maladaptive Aspects of Developmental Stress 1 20 .

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