2,682
Views
54
CrossRef citations to date
0
Altmetric
Basic Research Paper

Autophagy promotes radiation-induced senescence but inhibits bystander effects in human breast cancer cells

, , , , , & show all
Pages 1212-1228 | Received 17 Apr 2013, Accepted 03 Apr 2014, Published online: 30 Apr 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Longhao Sun, Limei Hu, David Cogdell, Li Lu, Chao Gao, Weijun Tian, Zhixiang Zhang, Ya'an Kang, Jason B. Fleming & Wei Zhang. (2017) MIR506 induces autophagy-related cell death in pancreatic cancer cells by targeting the STAT3 pathway. Autophagy 13:4, pages 703-714.
Read now
Eduardo Cremonese Filippi-Chiela, Mardja Manssur Bueno e Silva, Marcos Paulo Thomé & Guido Lenz. (2015) Single-cell analysis challenges the connection between autophagy and senescence induced by DNA damage . Autophagy 11:7, pages 1099-1113.
Read now

Articles from other publishers (52)

Hongkang Zhu, Fanglin Shen, Tingting Liao, He Qian & Yu Liu. (2023) Immunosenescence and macrophages: From basics to therapeutics. The International Journal of Biochemistry & Cell Biology 165, pages 106479.
Crossref
Li Zhang, Yuhan Zhang, Kaixuan Li & Shuai Xue. (2023) Hedgehog signaling and the glioma-associated oncogene in cancer radioresistance. Frontiers in Cell and Developmental Biology 11.
Crossref
Ke Zhang, Zhuojun Wu, Ying Zhao, Xinyu Qiu, Fang Li, Qiu Chen & Fengmei Cui. (2023) LC3 Accelerated Brain-Lung Axis Abscopal Effects after Fractionated Whole-Brain Radiation by Promoting Motoneurons to Secrete Periostin. Radiation Research 200:5.
Crossref
Francesko Hela & Cristina Aguayo-Mazzucato. (2023) Interaction between Autophagy and Senescence in Pancreatic Beta Cells. Biology 12:9, pages 1205.
Crossref
Jianchun Wu, Kaitrin Kramer & David L. Crowe. (2023) Lysine metabolism is a novel metabolic tumor suppressor pathway in breast cancer. Oncogene 42:31, pages 2402-2414.
Crossref
Junqiang Lin, Shihui Ye, Hao Ke, Liang Lin, Xia Wu, Mengfei Guo, Baowei Jiao, Ceshi Chen & Limin Zhao. (2023) Changes in the mammary gland during aging and its links with breast diseases. Acta Biochimica et Biophysica Sinica 55:6, pages 1001-1019.
Crossref
Xia Chen, Yan Du, Shanwei Luo, Ying Qu, Wenjie Jin, Shizhong Liu, Zhuanzi Wang, Xiao Liu, Zhuo Feng, Bi Qin & Libin Zhou. (2023) Physiological and Transcriptomic Analyses Reveal the Effects of Carbon-Ion Beam on Taraxacum kok-saghyz Rodin Adventitious Buds. International Journal of Molecular Sciences 24:11, pages 9287.
Crossref
Siamak Tabibzadeh. (2022) Role of autophagy in aging: The good, the bad, and the ugly. Aging Cell 22:1.
Crossref
Tayyab Ali, Fatma Hussain, Haroon Ur Rashid Kayani, Muhammad Naeem & Fozia Anjum. 2023. 93 115 .
Josiane W. Tessmann, Murilo R. Rocha & Jose A. Morgado‐Díaz. (2022) Mechanisms of radioresistance and the underlying signaling pathways in colorectal cancer cells. Journal of Cellular Biochemistry 124:1, pages 31-45.
Crossref
Amrita Roy, Soumen Bera, Luciano Saso & Bilikere S. Dwarakanath. (2022) Role of autophagy in tumor response to radiation: Implications for improving radiotherapy. Frontiers in Oncology 12.
Crossref
Sharmi Mukherjee, Anindita Dutta & Anindita Chakraborty. (2022) The interaction of oxidative stress with MAPK, PI3/AKT, NF-κB, and DNA damage kinases influences the fate of γ-radiation-induced bystander cells. Archives of Biochemistry and Biophysics 725, pages 109302.
Crossref
Xiaoyu Qi, Shuguo Zheng, Mingyue Ma, Naqi Lian, Hongting Wang, Lerong Chen, Anping Song, Chunfeng Lu, Shizhong Zheng & Huanhuan Jin. (2022) Curcumol Suppresses CCF-Mediated Hepatocyte Senescence Through Blocking LC3B–Lamin B1 Interaction in Alcoholic Fatty Liver Disease. Frontiers in Pharmacology 13.
Crossref
Zhaoshi Bai, Yaling Peng, Xinyue Ye, Zhixian Liu, Yupeng Li & Lingman Ma. (2022) Autophagy and cancer treatment: four functional forms of autophagy and their therapeutic applications自噬与癌症的治疗: 自噬的四种功能形式及其在癌症治疗中的应用. Journal of Zhejiang University-SCIENCE B 23:2, pages 89-101.
Crossref
Chen Chen, Wenjing Ding, Jun Li, Xuexia Geng, Haijun Zhang & Yuxuan Sun. (2021) WITHDRAWN: The anticancer activity of root extract from Quercus acutissima Carruth. Via regulating apoptosis and autophagy in breast cancer cells. Journal of Ethnopharmacology, pages 114730.
Crossref
Xiaona Xie, Xueding Cai, Yemeng Tang, Chunhui Jiang, Feng Zhou, Lehe Yang, Zhiguo Liu, Liangxing Wang, Haiyang Zhao, Chengguang Zhao & Xiaoying Huang. (2021) Flubendazole Elicits Antitumor Effects by Inhibiting STAT3 and Activating Autophagy in Non-small Cell Lung Cancer. Frontiers in Cell and Developmental Biology 9.
Crossref
Wangqiu Gong, Congwei Luo, Fenfen Peng, Jing Xiao, Yiqun Zeng, Bohui Yin, Xiaowen Chen, Shuting Li, Xiaoyang He, Yanxia Liu, Huihui Cao, Jiangping Xu & Haibo Long. (2021) Brahma-related gene-1 promotes tubular senescence and renal fibrosis through Wnt/β-catenin/autophagy axis. Clinical Science 135:15, pages 1873-1895.
Crossref
Alyssa Gabrielle Apilan & Carmel Mothersill. (2021) Targeted and Non-Targeted Mechanisms for Killing Hypoxic Tumour Cells—Are There New Avenues for Treatment?. International Journal of Molecular Sciences 22:16, pages 8651.
Crossref
Dawei Yang, Xiaoyu Tian, Yuchen Ye, Yin Liang, Jie Zhao, Tao Wu & Na Lu. (2021) Identification of GL-V9 as a novel senolytic agent against senescent breast cancer cells. Life Sciences 272, pages 119196.
Crossref
Giorgio Santoni, Consuelo Amantini, Massimo Nabissi, Federica Maggi, Antonietta Arcella, Oliviero Marinelli, Anna Maria Eleuteri, Matteo Santoni & Maria Beatrice Morelli. (2021) Knock-Down of Mucolipin 1 Channel Promotes Tumor Progression and Invasion in Human Glioblastoma Cell Lines. Frontiers in Oncology 11.
Crossref
Xinyue Yu, Baocai Liu, Ning Zhang, Qian Wang & Guanghui Cheng. (2021) Immune Response: A Missed Opportunity Between Vitamin D and Radiotherapy. Frontiers in Cell and Developmental Biology 9.
Crossref
Mohammad Mirza-Aghazadeh-Attari, Maria José Recio, Saber Ghazizadeh Darband, Mojtaba Kaviani, Amin Safa, Ainaz Mihanfar, Shirin Sadighparvar, Ansar Karimian, Forough Alemi, Maryam Majidinia & Bahman Yousefi. (2021) DNA damage response and breast cancer development: Possible therapeutic applications of ATR, ATM, PARP, BRCA1 inhibition. DNA Repair 98, pages 103032.
Crossref
Yanan Gao, Hong Ma, Changyin Lv, Fei Lan, Yunfeng Wang & Yulin Deng. (2021) Exosomes and exosomal microRNA in non-targeted radiation bystander and abscopal effects in the central nervous system. Cancer Letters 499, pages 73-84.
Crossref
Arishya Sharma & Alexandru Almasan. 2021. Autophagy and Senescence in Cancer Therapy. Autophagy and Senescence in Cancer Therapy 249 284 .
Sarmistha Talukdar, Swadesh K. Das, Luni Emdad & Paul B. Fisher. 2021. Autophagy and Senescence in Cancer Therapy. Autophagy and Senescence in Cancer Therapy 147 208 .
Silvina Odete Bustos, Fernanda Antunes, Maria Cristina Rangel & Roger Chammas. (2020) Emerging Autophagy Functions Shape the Tumor Microenvironment and Play a Role in Cancer Progression - Implications for Cancer Therapy. Frontiers in Oncology 10.
Crossref
Liliya Tyutyunyk-Massey & David A. Gewirtz. (2020) Roles of autophagy in breast cancer treatment: Target, bystander or benefactor. Seminars in Cancer Biology 66, pages 155-162.
Crossref
Nipa H. Patel, Sahib S. Sohal, Masoud H Manjili, J. Chuck Harrell & David A. Gewirtz. (2020) The Roles of Autophagy and Senescence in the Tumor Cell Response to Radiation. Radiation Research 194:2, pages 103.
Crossref
Songling Hu & Chunlin Shao. (2020) Research progress of radiation induced bystander and abscopal effects in normal tissue. Radiation Medicine and Protection 1:2, pages 69-74.
Crossref
Prashanta Kumar Panda, Srimanta Patra, Prajna Paramita Naik, Prakash Priyadarshi Praharaj, Subhadip Mukhopadhyay, Biswa Ranjan Meher, Piyush Kumar Gupta, Rama S. Verma, Tapas K. Maiti & Sujit K. Bhutia. (2019) Deacetylation of LAMP1 drives lipophagy‐dependent generation of free fatty acids by Abrus agglutinin to promote senescence in prostate cancer . Journal of Cellular Physiology 235:3, pages 2776-2791.
Crossref
Maryam Farasat, Firoozeh Niazvand & Layasadat Khorsandi. (2019) Zinc oxide nanoparticles induce necroptosis and inhibit autophagy in MCF-7 human breast cancer cells. Biologia 75:1, pages 161-174.
Crossref
Nasrollah Jabbari, Muhammad Nawaz & Jafar Rezaie. (2019) Bystander effects of ionizing radiation: conditioned media from X-ray irradiated MCF-7 cells increases the angiogenic ability of endothelial cells. Cell Communication and Signaling 17:1.
Crossref
Peramaiyan Rajendran, Abdullah M Alzahrani, Hamza N Hanieh, Sekar Ashok Kumar, Rebai Ben Ammar, Thamaraiselavan Rengarajan & Mohammed A Alhoot. (2019) Autophagy and senescence: A new insight in selected human diseases. Journal of Cellular Physiology 234:12, pages 21485-21492.
Crossref
Dany Gaillard, Lauren A. Shechtman, Sarah E. Millar & Linda A. Barlow. (2019) Fractionated head and neck irradiation impacts taste progenitors, differentiated taste cells, and Wnt/β-catenin signaling in adult mice. Scientific Reports 9:1.
Crossref
Aisling B. Heeran, Helen P. Berrigan & Jacintha O'Sullivan. (2019) The Radiation-Induced Bystander Effect (RIBE) and its Connections with the Hallmarks of Cancer. Radiation Research 192:6, pages 668.
Crossref
Jieqiong You, Rong Dong, Meidan Ying, Qiaojun He, Ji Cao & Bo Yang. (2019) Cellular Senescence and Anti-Cancer Therapy. Current Drug Targets 20:7, pages 705-715.
Crossref
Hendrik Folkerts, Susan Hilgendorf, Edo Vellenga, Edwin Bremer & Valerie R. Wiersma. (2018) The multifaceted role of autophagy in cancer and the microenvironment. Medicinal Research Reviews 39:2, pages 517-560.
Crossref
Dan Hao, Xiang Wen, Lian Liu, Lian Wang, Xianli Zhou, Yanmei Li, Xin Zeng, Gu He & Xian Jiang. (2019) Sanshool improves UVB-induced skin photodamage by targeting JAK2/STAT3-dependent autophagy. Cell Death & Disease 10:1.
Crossref
Lingxiao Pan, Minghui Wan, Wenbo Zheng, Rui Wu, Wei Tang, Xiaoshen Zhang, Tong Yang & Changsheng Ye. (2019) Intrabeam Radiation Inhibits Proliferation, Migration, and Invasiveness and Promotes Apoptosis of MCF-7 Breast Cancer Cells. Technology in Cancer Research & Treatment 18, pages 153303381984070.
Crossref
Björn L.D.M. Brücher & Ijaz S. Jamall. (2019) Transition from normal to cancerous cell by precancerous niche (PCN) induced chronic cell-matrix stress. 4open 2, pages 14.
Crossref
Jingwen Xu, Nipa H. Patel, Tareq Saleh, Emmanuel K. Cudjoe, Moureq Alotaibi, Yingliang Wu, Santiago Lima, Adam M. Hawkridge & David A. Gewirtz. (2018) Differential Radiation Sensitivity in p53 Wild-Type and p53-Deficient Tumor Cells Associated with Senescence but not Apoptosis or (Nonprotective) Autophagy. Radiation Research 190:5, pages 538.
Crossref
Xiaoyao Yang, Shengmin Xu, Yao Su, Biao Chen, Hang Yuan, An Xu & Lijun Wu. (2018) Autophagy-Src Regulates Connexin43-Mediated Gap Junction Intercellular Communication in Irradiated HepG2 Cells. Radiation Research 190:5, pages 494.
Crossref
Eva Yi Kong, Shuk Han Cheng & Kwan Ngok Yu. (2018) Induction of autophagy and interleukin 6 secretion in bystander cells: metabolic cooperation for radiation-induced rescue effect?. Journal of Radiation Research 59:2, pages 129-140.
Crossref
Juan Wu, Qi Wu, Juan-Juan Li, Chuang Chen, Si Sun, Chang-Hua Wang & Sheng-Rong Sun. (2017) Autophagy mediates free fatty acid effects on MDA-MB-231 cell proliferation, migration and invasion. Oncology Letters 14:4, pages 4715-4721.
Crossref
Seyma Aydinlik, Merve Erkisa, Buse Cevatemre, Mehmet Sarimahmut, Egemen Dere, Ferda Ari & Engin Ulukaya. (2017) Enhanced cytotoxic activity of doxorubicin through the inhibition of autophagy in triple negative breast cancer cell line. Biochimica et Biophysica Acta (BBA) - General Subjects 1861:2, pages 49-57.
Crossref
Ni Chen, Rui Zhang, Teruaki Konishi & Jun Wang. (2017) Upregulation of NRF2 through autophagy/ERK 1/2 ameliorates ionizing radiation induced cell death of human osteosarcoma U-2 OS. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 813, pages 10-17.
Crossref
Lelin Hu, Hao Wang, Li Huang, Yong Zhao & Junjie Wang. (2016) Crosstalk between autophagy and intracellular radiation response (Review). International Journal of Oncology 49:6, pages 2217-2226.
Crossref
Francesca De Amicis, Carmela Guido, Marta Santoro, Francesca Giordano, Ada Donà, Pietro Rizza, Michele Pellegrino, Ida Perrotta, Daniela Bonofiglio, Diego Sisci, Maria Luisa Panno, Donatella Tramontano, Saveria Aquila & Sebastiano Andò. (2016) Ligand activated progesterone receptor B drives autophagy-senescence transition through a Beclin-1/Bcl-2 dependent mechanism in human breast cancer cells. Oncotarget 7:36, pages 57955-57969.
Crossref
Lisa Deloch, Anja Derer, Josefin Hartmann, Benjamin Frey, Rainer Fietkau & Udo S. Gaipl. (2016) Modern Radiotherapy Concepts and the Impact of Radiation on Immune Activation. Frontiers in Oncology 6.
Crossref
Fiona M. Frame, Huguette Savoie, Francesca Bryden, Francesca Giuntini, Vincent M. Mann, Matthew S. Simms, Ross W. Boyle & Norman J. Maitland. (2015) Mechanisms of growth inhibition of primary prostate epithelial cells following gamma irradiation or photodynamic therapy include senescence, necrosis, and autophagy, but not apoptosis. Cancer Medicine 5:1, pages 61-73.
Crossref
Nobuyuki Hamada & Yuki Fujimichi. (2015) Role of carcinogenesis related mechanisms in cataractogenesis and its implications for ionizing radiation cataractogenesis. Cancer Letters 368:2, pages 262-274.
Crossref
Joanna Magdalena Zarzynska. (2014) The Importance of Autophagy Regulation in Breast Cancer Development and Treatment. BioMed Research International 2014, pages 1-9.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.